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  • 1
    Language: English
    In: Ceramics-Silikáty, 01 December 2011, Vol.55(4), pp.326-330
    Description: Silica glass layers containing silver nanoparticles were prepared by the sol-gel method. The layers were deposited on a glass substrate by the dip-coating method, dried and heat treated at various temperatures. The average silver particle size was determined from absorption spectra according to Mie’s theory. A good correlation was found between the calculated values and analysis of HRTEM images. A very narrow size distribution was obtained by this procedure. The average particle size of silver particles fell between 1 and 2 nm for dried samples; in case of glasses treated at 500 and 550°C the size ranged between 2 and 4 nm.
    Keywords: Sol-Gel ; Layers ; Silver ; Nanoparticles ; Silica ; Glass ; Engineering
    ISSN: 0862-5468
    E-ISSN: 1804-5847
    Source: Directory of Open Access Journals (DOAJ)
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  • 2
    Language: English
    In: Ceramics-Silikáty, 01 March 2011, Vol.55(1), pp.64-67
    Description: Silica layers containing silver were prepared by the sol-gel method and deposited on the Float glass substrate. Heat treatment at different temperatures (60 and 550°C) and time periods (1 to 6 hours) followed afterwards. Silica layer texture without any particles was observed by electron microscopy. Silver, sodium, tin and silicon concentration profiles on “tin” side of Float glass substrates and in the deposited layers were evaluated by the help of Secondary Neutral Mass Spectrometry and discussed with respect to diffusion process taking place at the interface of the system substrate-layer. The concentration profiles of Ag and Na confirmed exchange diffusion mechanism at 550°C by which silver moves quickly from the surface layer into glass substrate.
    Keywords: Silica Layers ; Sol-Gel ; Silver ; Glass Substrate ; Engineering
    ISSN: 0862-5468
    E-ISSN: 1804-5847
    Source: Directory of Open Access Journals (DOAJ)
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  • 3
    Language: Czech
    Description: The study concentrates on possible connection between phenomenological thought of Edmund Husserl and Jean-Paul Sartre by focusing on the way by which each of them frames pre-reflexive self-awareness of consciousness and its role in the process of constitution of the identity of the "Ego" as a subjective pole. Essential motivation derives from the effort of highlighting those moments of Husserl's thinking, which might have been or actually were a source of inspiration for Sartre and the formulation of these concepts in the early stages of his career. Subsequently, the quest is to clarify the scale of this inspiration and to shed some light on the question whether Sartre did not push his constructions over the boundaries of the scientific field set by Husserl. The study also incorporates several of Husserl's works which are in their conclusions tending to go against those presented as a possible source of Sartre's inspiration. That is done in order not to simplify the ambivalence of Husserl's work over the acceptable limit as well as to emphasize the nature of the investigations preferred by Sartre. These investigations lead in his work to the conceptualization of human existence as necessarily free, which is the conclusion of the presented study. Key words: Husserl, Sartre, consciousness,...
    Keywords: Subjectivity; Konstituce; Reflection; Consciousness; Temporalita; Intentionality; Subjektivita; Reflexe; Vědomí; Intencionalita; Husserl; Sartre; Temporality; Constitution
    Source: Networked Digital Library of Theses and Dissertations
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  • 4
    Language: English
    In: Journal of Controlled Release, 2002, Vol.82(1), pp.29-37
    Description: RNase A (bovine pancreatic ribonuclease) and BS-RNase (bovine seminal ribonuclease) are monomeric and dimeric enzymes, respectively, with aspermatogenic and antitumor activities. While the aspermatogenic and, in some experimental situations, the antitumor effects of the RNase A are only minor, the activity of BS-RNase in these phenomena is very significant. These differences can be annulled by means of conjugation of the enzymes with PEG (polyethylene glycol) chains. Aspermatogenic activity was studied histologically following subcutaneous injections of RNase A and BS-RNase conjugates in ICR mice, and the antitumor activity in athymic nude mice with growing human melanoma with i.p. injection of these conjugated ribonucleases. The experiments proved that RNase A, when conjugated to PEG, produced identical aspermatogenic and antitumour effects as BS-RNase conjugated to this polymer. Immunogenicity of RNase A and BS-RNase did not change substantially after the conjugation with PEG polymers. Binding of produced antibodies to both ribonucleases attached to PEG, however, was substantially reduced.
    Keywords: Antitumor ; Aspermatogenesis ; BS-Rnase ; Melanoma ; Mice ; Peg ; Ribonuclease A ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 16 July 1999, Vol.96(14), pp.7768-7773
    Description: Monomeric human pancreatic RNase, devoid of any biological activity other than its RNA degrading ability, was engineered into a dimeric protein with a cytotoxic action on mouse and human tumor cells, but lacking any appreciable toxicity on mouse and human normal cells. This dimeric variant of human pancreas RNase selectively sensitizes to apoptotic death cells derived from a human thyroid tumor. Because of its selectivity for tumor cells, and because of its human origin, this protein represents a potentially very attractive, novel tool for anticancer therapy.
    Keywords: Biological sciences -- Biology -- Cytology ; Biological sciences -- Biology -- Cytology ; Physical sciences -- Chemistry -- Chemical compounds ; Biological sciences -- Biology -- Cytology ; Health sciences -- Medical conditions -- Diseases ; Biological sciences -- Biology -- Genetics ; Health sciences -- Medical conditions -- Diseases ; Biological sciences -- Biology -- Cytology ; Physical sciences -- Physics -- Microphysics ; Biological sciences -- Biology -- Cytology
    ISSN: 00278424
    E-ISSN: 10916490
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  • 6
    In: Journal of the American Ceramic Society, November 1975, Vol.58(11‐12), pp.521-524
    Description: The influence of an external dc electric field on the Pb content near the interface between float glass and molten Pb was studied at 500°C. The diffusion coefficient and velocity of Pb ions in the external electric field were determined, and the theoretical time dependence of Pb content in the glass was calculated. A theoretical model of ion transport phenomena in the system is suggested.
    Keywords: Blei ; Diffusion ; Elektrisches Feld ; Silicatglas ; Floatglas ; Metallschmelze ; Grenzschicht ; Ionenbeweglichkeit ; Konzentrationsprofil ; Engineering ; Visual Arts;
    ISSN: 0002-7820
    E-ISSN: 1551-2916
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  • 7
    Language: English
    In: FEBS Letters, 2007, Vol.581(5), pp.930-934
    Description: The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
    Keywords: Oxidative Stress ; Glutathione ; Rnase Inhibitor ; Comet Assay ; RNA Silencing ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0014-5793
    E-ISSN: 1873-3468
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  • 8
    Language: English
    In: Journal of Controlled Release, 2004, Vol.94(2), pp.401-410
    Description: Subcutaneous application of bovine RNase A conjugated to HYase (bovine hyaluronidase), polyethylene glycol (PEG) and HYase+PEG resulted in a marked reduction of the width of the spermatogenic layers of the mouse testes. The number of sperms in caput epididymidis was significantly decreased in mice injected with conjugated RNase A. There was not any significant embryotoxic effect of free RNase A even conjugated with HYse, PEG and HYse+PEG. The immunogenicity, expressed in production of antibodies against free RNase A or conjugates with PEG, was very low. However, the immunogenic action of this enzyme conjugated only to HYase was much higher and produced the same immunogenicity as HYase itself. The immunogenic effect of RNase A+HYase conjugate decreased when PEG was joined to this conjugate. The inhibitory effect of RNase A conjugated to HYase, PEG and HYase+PEG on human ML-2 cells studied in vitro, was practically ineffective. On the other side, when RNase A conjugated to HYase or PEG was administered intraperitoneally into the mice bearing human melanoma, the antitumor effect was pronounced.
    Keywords: Antitumor ; Aspermatogenesis ; Embryotoxicity ; Hyaluronidase ; Melanoma ; Mice ; Peg ; Ribonuclease A ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 9
    Language: English
    In: Animal Reproduction Science, 1985, Vol.8(1), pp.1-40
    Description: This review comprises consideration of work on bulls, rams, goats, boars and laboratory mammals.
    Keywords: Agriculture ; Veterinary Medicine ; Anatomy & Physiology
    ISSN: 0378-4320
    E-ISSN: 1873-2232
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  • 10
    Language: English
    In: Animal Reproduction Science, 1998, Vol.51(2), pp.111-118
    Description: Bovine seminal ribonuclease (BS RNase) is synthetized in the ampulary gland and seminal vesicles of the bull as shown by indirect immunofluorescence and by using a sensitive sandwich-linked immunosorbent assay (ELISA). The ampullary and seminal vesicle BS RNase concentrations in samples from 15 bulls were 656 μ g/ml and 1285 μ g/ml, respectively. Seminal plasma BS RNase levels in 22 breeding bulls were slightly lower than in the seminal vesicles—1132 μ g/ml. There were no significant differences in the concentration of this enzyme in seminal plasma of 16 bulls ranked as having high and low fertility. Even with its immunosuppressive activity this enzyme does not seem important for the protection of sperm cells in the female reproductive tract.
    Keywords: Cattle-Male Reproduction ; Fertility ; ELISA ; Immunology ; Ribonuclease ; Agriculture ; Veterinary Medicine ; Anatomy & Physiology
    ISSN: 0378-4320
    E-ISSN: 1873-2232
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