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  • 1
    Language: English
    In: Rechtsmedizin, Oct, 2010, Vol.20(5), p.437(10)
    Description: Byline: J. Matschke (1,651,2,651), M. Glatzel (2,651), K. Puschel (3,651), H. Andresen (3,651) Keywords: Epilepsie; Plotzlicher Tod; aSudden unexpected death in epilepsy"; Obduktion; Toxikologie; Epilepsy; Sudden death; Sudden unexpected death in epilepsy; Autopsy; Toxicology Abstract (German): Epilepsien gehoren zu den haufigsten neurologischen Erkrankungen. Sie konnen aus unterschiedlicher Ursache und in jedem Lebensalter auftreten und zeigen variable Symptome. Epilepsiepatienten haben im Vergleich zur Gesamtbevolkerung eine zwei- bis dreifach hohere Mortalitatsrate. Rechtsmedizinisch bedeutsam sind die epilepsieassoziierten Todesfalle, worunter Suizide, Unfalle, Status epilepticus (SE) und der plotzliche unerwartete Tod des Epileptikers (asudden unexpected death in epilepsy", SUDEP) fallen. Definiert als plotzlicher Todesfall ohne erkennbare Ursache, sind die pathophysiologischen Vorgange des SUDEP weiterhin ungeklart. Wahrscheinlich handelt es sich um ein periiktales Phanomen mit einer Kombination aus zentraler, kardialer und respiratorischer Dysregulation. Bei Verstorbenen mit Hinweisen auf eine Epilepsie ist neben der grundlichen Exploration der Vorgeschichte die Obduktion mitsamt neuropathologischen und toxikologischen Untersuchungen angezeigt. Abstract: Epilepsy is one of the most common neurologic disorders, which can occur at all ages and has many possible presentations and causes. Patients with epilepsy show a two to threefold increase in mortality compared with the general population. The most important forensic aspects are the direct epilepsy-related causes of death, such as suicide, accidental death, status epilepticus and sudden unexpected death in epilepsy (SUDEP). SUDEP is defined as sudden death without an identifiable cause and the underlying pathophysiology remains an enigma but is most probably a peri-ictal phenomenon occurring as a consequence of central, cardial and respiratory dysregulation. A thorough post-mortem investigation of fatalities possibly due to epilepsy must include a detailed clinical history as well as a complete autopsy including neuropathologic and toxicologic studies. Author Affiliation: (1651) Forensische Neuropathologie, Universitatsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland (2651) Institut fur Neuropathologie, Universitatsklinikum Hamburg-Eppendorf, Hamburg, Deutschland (3651) Institut fur Rechtsmedizin, Universitatsklinikum Hamburg-Eppendorf, Hamburg, Deutschland Article History: Registration Date: 18/12/2009 Online Date: 04/08/2010
    Keywords: Nervous System Diseases ; Mortality ; Epilepsy
    ISSN: 0937-9819
    Source: Cengage Learning, Inc.
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  • 2
    Language: English
    In: European Journal of Cancer, July 2016, Vol.61, pp.S158-S158
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/S0959-8049(16)61558-7 Byline: V. Ritter, J. Rudner, J. Matschke, V. Jendrossek
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 3
    Language: German
    In: Rechtsmedizin, 2011, Vol.21(3), pp.191-196
    Description: Prinzipiell besteht für Teilnehmer vieler Sportarten das Risiko eines Schädel-Hirn-Traumas. Man unterscheidet zwischen sportunfallassoziierten Geschehnissen (etwa im Rahmen von Sturzgeschehen oder unbeabsichtigten Kollisionen) und sportspezifischen Ereignissen (wie etwa beim Boxen und anderen Kampfsportarten). In jüngerer Zeit hat sich die medizinische Aufmerksamkeit von den akzidentellen akuten schweren Schädel-Hirn-Traumata mit oftmals tödlichem Ausgang auf die vermeintlich geringfügigen chronisch-repetitiven subletalen Traumata und den möglichen Zusammenhang zu neurodegenerativen Prozessen verlagert. Der vorliegende Beitrag gibt eine Übersicht über die wichtigsten Formen des akuten und chronischen Neurotraumas im Sport. Die Bedeutung des Themas wird durch die weltweit unüberschaubare Zahl sportlich aktiver Personen unterstrichen. In virtually any sports discipline the participants are at risk to suffer traumatic brain injury. Injury may occur with accidental falls or with non-intentional collisions with other athletes. Boxing and other combat sports, however, are unique with intentional and voluntary infliction of traumatic injury on the combatant. Recently, the medical focus has shifted from accidental acute often fatal forms of traumatic brain injury to potentially hazardous chronic repetitive mild head injury, such as concussion and the possible relationship to neurodegenerative processes. In this review the main issues of acute and chronic neurotrauma related to sports activities are discussed. Because of the extreme popularity of sports worldwide the implications of head injuries are enormous.
    Keywords: Sports ; Traumatic brain injury ; Chronic traumatic encephalopathy ; Dementia ; Amyotrophic lateral sclerosis
    ISSN: 0937-9819
    E-ISSN: 1434-5196
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  • 4
    Language: English
    In: European Journal of Cancer, July 2014, Vol.50, pp.S51-S51
    Keywords: Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    Language: English
    In: Journal of Physiology, Jan, 2013, Vol.591, p.571(22)
    Keywords: Creatine -- Physiological Aspects
    ISSN: 0022-3751
    Source: Cengage Learning, Inc.
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  • 6
    Language: English
    In: Journal of Physiology, Jan, 2013, Vol.591, p.571(22)
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2012.241760/abstract Byline: C. I. Nabuurs(1), C. U. Choe(2)(3), A. Veltien(1), H. E. Kan(1), L. J. C. van Loon(4), R. J. T. Rodenburg(5), J. Matschke(6), B. Wieringa(7), G. J. Kemp(8), D. Isbrandt(2), A. Heerschap(1) Key points Creatine (Cr) plays an important role in muscle energy homeostasis as a substrate in the creatine kinase phosphoryl exchange reaction, but the consequences of creatine depletion are incompletely understood. We assessed the morphological, metabolic and functional consequences of systemic creatine depletion on skeletal muscle in a mouse model with deficiency of an essential enzyme in the biosynthesis of creatine (AGAT.sub.-/- mice). We show that Cr depletion leads to several metabolic abnormalities in muscle, including reduced ATP, increased inorganic phosphate levels and reduced activities of proton-pumping respiratory chain enzymes and an elevated glycolytic contribution in ischaemic circumstances. The Cr-depleted muscle suffers from reduced grip strength, severe atrophy and abnormal mitochondrial structures, increased overall mitochondrial content and an increased number of lipid droplets. Oral Cr administration led to rapid accumulation in skeletal muscle (faster than in brain) and reversed all the muscle abnormalities, revealing that the condition of the AGAT.sub.-/- mice can be switched between Cr deficient and normal simply by dietary manipulation. Abstract Creatine (Cr) plays an important role in muscle energy homeostasis by its participation in the ATP-phosphocreatine phosphoryl exchange reaction mediated by creatine kinase. Given that the consequences of Cr depletion are incompletely understood, we assessed the morphological, metabolic and functional consequences of systemic depletion on skeletal muscle in a mouse model with deficiency of l-arginine:glycine amidinotransferase (AGAT.sub.-/-), which catalyses the first step of Cr biosynthesis. In vivo magnetic resonance spectroscopy showed a near-complete absence of Cr and phosphocreatine in resting hindlimb muscle of AGAT.sub.-/- mice. Compared with wild-type, the inorganic phosphate/[beta]-ATP ratio was increased fourfold, while ATP levels were reduced by nearly half. Activities of proton-pumping respiratory chain enzymes were reduced, whereas F.sub.1F.sub.0-ATPase activity and overall mitochondrial content were increased. The Cr-deficient AGAT.sub.-/- mice had a reduced grip strength and suffered from severe muscle atrophy. Electron microscopy revealed increased amounts of intramyocellular lipid droplets and crystal formation within mitochondria of AGAT.sub.-/- muscle fibres. Ischaemia resulted in exacerbation of the decrease of pH and increased glycolytic ATP synthesis. Oral Cr administration led to rapid accumulation in skeletal muscle (faster than in brain) and reversed all the muscle abnormalities, revealing that the condition of the AGAT.sub.-/- mice can be switched between Cr deficient and normal simply by dietary manipulation. Systemic creatine depletion results in mitochondrial dysfunction and intracellular energy deficiency, as well as structural and physiological abnormalities. The consequences of AGAT deficiency are more pronounced than those of muscle-specific creatine kinase deficiency, which suggests a multifaceted involvement of creatine in muscle energy homeostasis in addition to its role in the phosphocreatine-creatine kinase system. Author Affiliation: (1)Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands (2)Experimental Neuropediatrics, Center for Molecular Neurobiology Hamburg Zentrum fur Molekular Neurobiologie Hamburg and Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (3)Neurology (6)Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (4)Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre+, Maastricht, The Netherlands (5)Department of Pediatrics (7)Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands (8)Department of Musculoskeletal Biology & Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, UK Correspondence: (*) A. Heerschap: Department of Radiology 667, Geert Grooteplein 10, 6500HB Nijmegen, The Netherlands. Email: a.heerschap@rad.umcn.nl Article Note: C. I. Nabuurs and C. U. Choe contributed equally to this work. (Received 26 July 2012; accepted after revision 30 October 2012; first published online 5 November 2012) CAPTION(S): Supporting info item Supporting info item Supporting info item Supporting info item Supporting info item Supporting info item
    Keywords: Creatine -- Physiological Aspects
    ISSN: 0022-3751
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: Cancer Research, 02/15/2016, Vol.76(4 Supplement), pp.P6-17-06-P6-17-06
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 8
    Language: German
    In: Rechtsmedizin, 2018, Vol.28(6), pp.482-485
    Description: Impfstoffe gehören zu den wirksamsten medizinischen Präventionsmaßnahmen gegen Infektionserkrankungen. Trotz generell hoher Nutzen-Risiko-Relationen steigt in der öffentlichen Wahrnehmung die Gefahr echter oder vermeintlicher Nebenwirkungen einer Impfung. Die Berichte hinsichtlich einer möglichen Assoziation zwischen einer Impfung und dem Auftreten von Autismus gelten aus wissenschaftlicher Sicht zwar als widerlegt. Trotzdem hat die Zahl erklärter Impfgegner, insbesondere in den USA oder in Großbritannien, deutlich zugenommen. In jüngster Zeit wurden auch Stimmen laut, die einen angeblichen Zusammenhang zwischen einer stattgehabten Impfung und dem Auftreten von Symptomen die als typisch für ein so genanntes Schütteltrauma-Syndrome gelten, postulieren. Die vorliegende Arbeit untersucht die wissenschaftlichen Grundlagen dieser Behauptungen genauer. In clinical practice, vaccines are among the most effective medical preventive measures against infectious diseases. Despite a excellent risk-benefit ratio, public concern about real or perceived adverse events associated with vaccines has increased in recent years. Reports on a purported association between a vaccination and autism, although not supported by a credible body of scientific evidence, have led increasing numbers of parents to blatantly refuse vaccinations for their children, especially in the USA and the UK. Recently, it has been postulated that symptoms generally believed to form the basis of a diagnosis of the so-called shaken baby syndrome in infants, could be the adverse effects of a preceding vaccination. The authors of this article investigated the scientific facts behind these allegations in detail.
    Keywords: Adverse effects ; Evidence-based medicine ; Shaken-baby-syndrome ; Vaccination
    ISSN: 0937-9819
    E-ISSN: 1434-5196
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  • 9
    Language: English
    In: Forensic Science International, 2001, Vol.115(3), pp.199-205
    Description: Infections of the leptomeninges with the infectious agent gaining access to the intracranial compartment by traumatic means are termed post-traumatic. In cases with fatal outcome, the manner of death has to be classified as non-natural. Six cases of post-traumatic meningitis as the cause of death from the archives of the Institute of Legal Medicine in Hamburg, Germany with histological and microbiological investigations are presented. There were all males, age varying between 24 and 90 years (mean 58 years); range of the interval between original trauma and beginning of symptoms was 2 days up to 8 years; in 50% of the cases meningeal swabs yielded Streptococcus pneumoniae . Findings concerning origin and mechanism of post-traumatic meningitis as well as microbiological studies are compared with selected cases from the literature.
    Keywords: Meningitis ; Post-Traumatic Microbiology ; Postmortem Cranial Injury ; Non-Natural Cause of Death ; Public Health
    ISSN: 0379-0738
    E-ISSN: 1872-6283
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  • 10
    Language: English
    In: Int. J. of Entrepreneurial Venturing, 2012, Vol 4 Issue 3, pp 239 - 256
    Description: "A small business is not a little big business" (Welsh and White, 1981) - this also holds true for valuing small businesses. Such companies act in utmost imperfect markets, are generally unique and the forecast of their future profit is rather difficult. These characteristics impede the use of DCF and real option methods, as well as of multiples. Therefore, this paper presents the functional valuation theory as an alternative approach to valuation. Its partial and general models allow a better adaption to the characteristics of entrepreneurial businesses, especially when these models are combined with a Monte Carlo simulation.
    Keywords: entrepreneurial businesses; company valuation; decision value; future earnings method; state marginal price model; discounted cash flow method; multiples; real options; functional valuation theory; entrepreneurship; small business; small firms; Monte Carlo simulation.
    ISSN: 1742-5360
    ISSN: 17425360
    ISSN: 1742-5379
    ISSN: 17425379
    E-ISSN: 1742-5379
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