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  • 1
    Language: English
    In: BJU international, August 2013, Vol.112(4), pp.E383-90
    Description: What's known on the subject? and what does the study add?: Only little and partly contradictory data are currently published about the prognostic role of immunohistochemically detectable proliferation-associated biomarkers in surgically treated squamous cell carcinoma of the penis (SCCP), and no data are available at present about their usefulness for refining the delineation between different Broders' grading categories (e.g. still G2 or just G3 SCCP?). Moreover, the accuracy of various conventional histopathological parameters for predicting cancer-specific survival (CSS) in surgically treated SCCP has not been systematically evaluated yet. Based on the so far largest study cohort encompassing 158 consecutive patients with surgically treated PSCCs characterised by means of a central histopathological review, our data add the following to the currently available literature: (i) Ki-67, mini-chromosome maintenance 2 protein (MCM2), and geminin indicate a more aggressive behaviour in SCPP but do not represent independent prognostic parameters in the multivariable analysis in terms of CSS, (ii) these three biomarkers are not helpful for refining the delineation between different Broders' grading categories at the immunohistochemical level, and (iii) the conventional histopathological parameters staging, grading, nodal involvement, and lymphovascular invasion are independent prognostic parameters that together achieve a predictive accuracy of 82% for CSS. To assess the role of cell proliferation-associated biomarkers to predict cancer-specific survival (CSS) in patients with surgically treated squamous cell carcinoma of the penis (SCCP). A multicentre study enrolling 158 consecutive patients with surgically treated SCCP was performed. After conducting a central histopathological review, the staining profiles of Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin were evaluated for their correlation with conventional histopathological criteria and their prognostic relevance for predicting CSS in a multivariable Cox proportional hazards regression model (median [interquartile range] follow-up 33 [6-63] months). Staining evaluation showed high interobserver agreement (92-96%). Ki-67 and MCM2 displayed a significant positive correlation with histological tumour grade, lymphovascular invasion (LVI) and nodal status, whereas geminin expression only correlated with tumour grade. The 5-year CSS for the entire study cohort was 62%. Univariable analysis showed a significant prognostic impact of Ki-67 (P = 0.026), MCM2 (P = 0.007), and geminin (P = 0.036). In multivariable analysis, only pT (hazard ratio [HR] 1.67; P = 0.003) and pN stage (HR 2.62; P = 0.015) as well as tumour grade (HR 1.89; P = 0.036) and LVI (HR 2.66; P = 0.028) were identified as independent prognostic parameters for CSS. The accuracy of the Cox model for CSS prediction was 0.820 (95% confidence interval 0.741-0.898). At present, conventional histopathological criteria remain the most powerful predictors of CSS in surgically treated SCCP. Due to overlapping staining profiles, Ki-67, MCM2 and geminin, either singly or in various combinations, failed to immunohistochemically refine the boundaries between Broders' grading categories. Ki-67, MCM2 and geminin do not represent independent prognostic parameters but reflect a more aggressive behaviour in surgically treated SCCP. Further studies are needed to clarify the currently contradictory predictive role of proliferation-associated biomarkers in terms of predicting nodal involvement in SCCPs.
    Keywords: Ki-67 ; Geminin ; Immunohistochemistry ; Mini-Chromosome Maintenance 2 Protein (Mcm2) ; Proliferation-Related Biomarkers ; Squamous Cell Carcinoma of the Penis (Sccp) ; Carcinoma, Squamous Cell -- Chemistry ; Cell Cycle Proteins -- Analysis ; Ki-67 Antigen -- Analysis ; Nuclear Proteins -- Analysis ; Penile Neoplasms -- Chemistry
    ISSN: 14644096
    E-ISSN: 1464-410X
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  • 2
    Language: English
    In: Physical review letters, 21 October 2011, Vol.107(17), pp.176405
    Description: The charge-density-wave phase of TiSe(2) was studied by angle-resolved photoelectron spectroscopy and resistivity measurements investigating the influence of the band gap size and of a varying population of the conduction band. A gradual suppression of the charge-density-wave-induced electronic superstructure is observed for a variation of the band gap in the ternary compounds TiC(x)Se(2-x) with C=(S,Te) as well as for an occupation of only the conduction band by H(2)O adsorption-induced band bending. These observations point to an optimum band gap and support an excitonic driving force for the charge-density wave.
    Keywords: Physics;
    ISSN: 00319007
    E-ISSN: 1079-7114
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  • 3
    Language: English
    In: Journal of Physical Chemistry. C, 12 August 2014, Vol.118(33)
    Description: Semiconductors designated for solar water-splitting need to be simultaneously stable and efficient in the charge transfer over the interface to the aqueous electrolyte. Although InP(100) has been employed as photocathode for several decades, no experimental data on its initial interaction with water is available. We study reaction mechanisms of well-defined surfaces with water and oxygen employing photoelectron and in situ reflection anisotropy spectroscopy. Our findings show that reaction path and stability differ significantly with atomic surface reconstruction. While the mixed-dimer In-rich surface exhibits dissociative water adsorption featuring In–O–P rather than unfavorable In–O–In bond topologies, the H-terminated, P-rich surface reconstruction is irreversibly removed. Oxygen exposure attacks the In-rich surface more efficiently and additionally modifies, unlike water exposure, bulk-related optical transitions. Hydroxyl is not observed, which suggests a dehydrogenation of adsorbed species already a...
    Keywords: Chemistry
    ISSN: 1932-7447
    E-ISSN: 1932-7455
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  • 4
    Language: English
    In: Journal of Applied Physics, 21 March 2014, Vol.115(11)
    Description: Energy storage is a key challenge in solar-driven renewable energy conversion. We promote a photochemical diode based on dilute nitride GaPN grown lattice-matched on Si(100), which could reach both high photovoltaic efficiencies and evolve hydrogen directly without external bias. Homoepitaxial GaP(100) surface preparation was shown to have a significant impact on the semiconductor-water interface formation. Here, we grow a thin, pseudomorphic GaP nucleation buffer on almost single-domain Si(100) prior to GaPN growth and compare the GaP 0.98 N 0.02 /Si(100) surface preparation to established P- and Ga-rich surfaces of GaP/Si(100). We apply reflection anisotropy spectroscopy to study the surface preparation of GaP 0.98 N 0.02 in situ in vapor phase epitaxy ambient and benchmark the signals to low energy electron diffraction, photoelectron spectroscopy, and x-ray diffraction. While the preparation of the Ga-rich surface is hardly influenced by the presence of the nitrogen precursor 1,1-dimethylhydrazine (UDMH), we find that stabilization with UDMH after growth hinders well-defined formation of the V-rich GaP 0.98 N 0.02 /Si(100) surface. Additional features in the reflection anisotropy spectra are suggested to be related to nitrogen incorporation in the GaP bulk.
    Keywords: Articles
    ISSN: 0021-8979
    E-ISSN: 1089-7550
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  • 5
    Language: English
    In: PLoS ONE, 01 January 2015, Vol.10(5), p.e0127142
    Description: Radiation exposure occurs in X-ray guided interventional procedures or computed tomography (CT) and γ-H2AX-foci are recognized to represent DNA double-strand breaks (DSBs) as a biomarker for radiation induced damage. Antioxidants may reduce the induction of γ-H2AX-foci by binding free radicals. The aim of this study was to establish a dose-effect relationship and a time-effect relationship for the individual antioxidants on DSBs in human blood lymphocytes.Blood samples from volunteers were irradiated with 10 mGy before and after pre-incubation with different antioxidants (zinc, trolox, lipoic acid, ß-carotene, selenium, vitamin E, vitamin C, N-acetyl-L-cysteine (NAC) and Q 10). Thereby, different pre-incubation times, concentrations and combinations of drugs were evaluated. For assessment of DSBs, lymphocytes were stained against the phosphorylated histone variant γ-H2AX.For zinc, trolox and lipoic acid regardless of concentration or pre-incubation time, no significant decrease of γ-H2AX-foci was found. However, ß-carotene (15%), selenium (14%), vitamin E (12%), vitamin C (25%), NAC (43%) and Q 10 (18%) led to a significant reduction of γ-H2AX-foci at a pre-incubation time of 1 hour. The combination of different antioxidants did not have an additive effect.Antioxidants administered prior to irradiation demonstrated the potential to reduce γ-H2AX-foci in blood lymphocytes.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 6
    Language: English
    In: Physical Review B, 4/2014, Vol.89(16)
    Description: The electronic structures of two significant atomically well-defined (100)-surface reconstructions of gallium phosphide were investigated with two-photon-photoemission spectroscopy (2PPE). We allocated a series of occupied and unoccupied surface states and deduced the influence of each particular reconstruction on the electronic structure of the surface. Photoemission signals arising from bulk optical transitions were distinguished from surface-state related signals by studying the influence of oxygen exposure to the surfaces and by comparing our results to reflectance anisotropy spectroscopy (RAS) measurements. This revealed that the features in the RAS signal correlate with the transition energies between unoccupied and occupied surface-related states that were observed in the 2PPE measurements. An anisotropy around the E' sub(0) critical point, previously known from RA spectra, was also investigated with 2PPE and is ascribed to modifications of the bulk electronic structure in the vicinity of the surface.
    Keywords: Optical Transition ; Reconstruction ; Gallium Phosphides ; Electronic Structure ; Correlation Analysis ; Spectroscopy ; Condensed Matter ; Spectra ; Photoemission ; Condensed Matter Physics (General) (So) ; Solid-State Physics (Ah);
    ISSN: 1098-0121
    E-ISSN: 1550-235X
    Source: American Physical Society (APS) (via CrossRef)
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  • 7
    In: Cancer, 15 November 2014, Vol.120(22), pp.3584-3584
    Keywords: Cystectomy ; Neoplasm Recurrence, Local -- Etiology ; Urinary Bladder Neoplasms -- Surgery;
    ISSN: 0008-543X
    E-ISSN: 1097-0142
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  • 8
    Language: English
    In: The Journal of Physical Chemistry C, 07/03/2014, Vol.118(26), pp.14073-14081
    ISSN: 1932-7447
    E-ISSN: 1932-7455
    Source: American Chemical Society (via CrossRef)
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  • 9
    Language: English
    In: The Journal of Urology, March 2012, Vol.187(3), pp.899-907
    Description: We assessed the prognostic role of p16 expression in penile cancer with respect to cancer specific survival. Based on a multi-institutional collaboration wax embedded tissues from 92 surgically treated patients, including 27 with total and 65 with partial penectomy, were retrospectively evaluated. After a central histopathological review by 1 pathologist a tissue microarray was constructed for p16 immunostaining. Two independent pathologists evaluated p16 expression, which was correlated with cancer specific survival. The κ statistic was used to assess interobserver variability. Univariate and multivariate Cox proportional hazards analysis was applied to assess the independent effects of prognostic factors on cancer specific survival during a median postoperative followup of 32 months (IQR 6–66). The κ statistic revealed excellent interobserver agreement (κ 0.934, p 〈0.001). Two and 5-year cancer specific survival rates for the entire study cohort were 86% and 74%, respectively. The 2 and 5-year rates for patients without and with p16 expression differed significantly (73% and 57% vs 95% and 85%, respectively, p = 0.011). Univariate analysis revealed p16 expression as a significant prognostic factor with respect to cancer specific survival (p = 0.018). Multivariate analysis identified koilocytosis (HR 0.24, 95% CI 0.07–0.83, p = 0.024), p16 expression (HR 0.44, 95% CI 0.23–0.84, p = 0.013), and histological stage (HR 3.54, 95% CI 1.88–6.67, p 〈0.001) and grade (HR 2.47, 95% CI 1.00–6.09, p = 0.049) as independent prognostic factors for cancer specific survival. Results show that p16 seems to be a prognostic parameter for primary invasive penile cancer with excellent interobserver reproducibility. At pathology laboratories without antibodies against p16 conventional histological determination of koilocytosis by the pathologist also appears to provide important prognostic information for cancer specific survival.
    Keywords: Penis ; Carcinoma ; Squamous Cell ; Cyclin-Dependent Kinase Inhibitor P16 ; Prognosis ; Mortality ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
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  • 10
    Language: German
    In: Der Onkologe, 2017, Vol.23(11), pp.938-939
    Description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s00761-017-0285-8 Byline: Matthias May (1), Ingmar Wolff (2,3) Author Affiliation: (1) Urologische Klinik, St. Elisabeth-Klinikum (SEK), St. Elisabeth-Str. 23, 94315, Straubing, Deutschland (2) Urologische Klinik, Carl-Thiem-Klinikum (CTK), Cottbus, Deutschland (3) Klinik f?r Urologie und Neurourologie, Unfallkrankenhaus Berlin (UKB), Berlin, Deutschland Article History: Registration Date: 03/08/2017 Online Date: 18/08/2017
    Keywords: Cancer – Care and Treatment;
    ISSN: 0947-8965
    E-ISSN: 1433-0415
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