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  • 1
    Language: German
    In: Corporate finance : Finanzierung, Kapitalmarkt, Bewertung, Mergers & Acquisitions, 2015, Vol.6(5), pp. 135-140
    Keywords: Management ; Rationalität ; Unternehmensfinanzierung ; Kapitalkosten
    ISSN: 21988889
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 2
    Language: English
    In: PLoS ONE, 2011, Vol.6(7), p.e22146
    Description: MicroRNAs are 22 nucleotides long non-coding RNAs and exert their function either by transcriptional or translational inhibition. Although many microRNA profiles in different tissues and disease states have already been discovered, only little is known about their target proteins. The microRNA miR-155 is deregulated in many diseases, including cancer, where it might function as an oncoMir. ; We employed a proteomics technique called “stable isotope labelling by amino acids in cell culture” (SILAC) allowing relative quantification to reliably identify target proteins of miR-155. Using SILAC, we identified 46 putative miR-155 target proteins, some of which were previously reported. With luciferase reporter assays, CKAP5 was confirmed as a new target of miR-155. Functional annotation of miR-155 target proteins pointed to a role in cell cycle regulation. ; To the best of our knowledge we have investigated for the first time miR-155 target proteins in the HEK293T cell line in large scale. In addition, by comparing our results to previously identified miR-155 target proteins in other cell lines, we provided further evidence for the cell line specificity of microRNAs.
    Keywords: Research Article ; Biology ; Biochemistry
    E-ISSN: 1932-6203
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  • 3
    Language: English
    In: ChemMedChem, April 2014, Vol.9(4), pp.762-775
    Description: Bioreversible protection of the β‐phosphate group of nucleoside diphosphates (NDPs) as bis(acyloxybenzyl)phosphate esters is presented. To investigate the structure–activity relationship of these potential NDP prodrugs (Diro drugs) a series of Diro compounds was synthesized bearing fatty acids of various lengths and d4T as a model nucleoside. For synthesis of the lipophilically modified diphosphate group, preformed phosphoramidites were allowed to react with nucleotides, and the β‐P moiety was subsequently oxidized. The chemical and enzymatic stability of these prodrugs was studied in different media such as phosphate buffer (pH 7.3) or CEM cell extracts. In all media, the hydrolysis rate was clearly dependent on the acyl moiety and decreased with increasing alkyl chain length. The compounds showed a markedly lower half‐life in cell extracts than in pH 7.3 phosphate buffer due to the presence of enzyme‐catalyzed cleavage. In all media, the Diro compounds released d4T diphosphate (d4TDP) as the main product beside d4TMP. In antiviral assays, the compounds proved to be at least as potent as d4T against HIV‐1 and 2 in wild‐type CEM/0 cells. As a proof of concept, compounds with longer acyl residues showed very good anti‐HIV activities in thymidine‐kinase‐deficient cells (CEM/TK), indicating their ability to penetrate cell membranes and the delivery of phosphorylated metabolites. A structure–activity relationship of bioreversibly protected Diro–d4TDP was performed. The stability of the compounds was studied in various media such as cell extracts. Stability increased with increasing lipophilicity of the acyl chain. D4TDP was released as main product. Compounds with long acyl residues showed good anti‐HIV activities in TK‐deficient cells, proving intracellular uptake of the compounds.
    Keywords: Antivirals ; Bioreversible Protection ; Nucleoside Diphosphates ; Prodrugs ; Pronucleotides
    ISSN: 1860-7179
    E-ISSN: 1860-7187
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  • 4
    Language: German
    In: KoR : internationale und kapitalmarktorientierte Rechnungslegung : IFRS, 2018, Vol.18(4), pp. 185-190
    ISSN: 16178084
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 5
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 26 April 2011, Vol.108(17), pp.7218-23
    Description: Human aging is accompanied by dramatic changes in daily sleep-wake behavior: Activity shifts to an earlier phase, and the consolidation of sleep and wake is disturbed. Although this daily circadian rhythm is brain-controlled, its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell of the body. In fact, human clock properties measured in peripheral cells such as fibroblasts closely mimic those measured physiologically and behaviorally in the same subjects. To understand better the molecular mechanisms by which human aging affects circadian clocks, we characterized the clock properties of fibroblasts cultivated from dermal biopsies of young and older subjects. Fibroblast period length, amplitude, and phase were identical in the two groups even though behavior was not, thereby suggesting that basic clock properties of peripheral cells do not change during aging. Interestingly, measurement of the same cells in the presence of human serum from older donors shortened period length and advanced the phase of cellular circadian rhythms compared with treatment with serum from young subjects, indicating that a circulating factor might alter human chronotype. Further experiments demonstrated that this effect is caused by a thermolabile factor present in serum of older individuals. Thus, even though the molecular machinery of peripheral circadian clocks does not change with age, some age-related circadian dysfunction observed in vivo might be of hormonal origin and therefore might be pharmacologically remediable.
    Keywords: Aging -- Metabolism ; Circadian Clocks -- Physiology ; Circadian Rhythm -- Physiology ; Fibroblasts -- Metabolism ; Intercellular Signaling Peptides and Proteins -- Blood
    ISSN: 00278424
    E-ISSN: 1091-6490
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  • 6
    Language: English
    In: RNA Biology, 01 June 2013, Vol.10(6), pp.1017-1029
    Description: MicroRNAs (miRNAs) are single-stranded, small, non-coding RNAs, which fine-tune protein expression by degrading and/or translationally inhibiting mRNAs. Manipulation of miRNA expression in animal models frequently results in severe phenotypes indicating their relevance in controlling cellular...
    Keywords: RIP-Seq ; Ago2-Ip ; Mir-155 ; Translational Inhibition ; Mirna Target Profiling ; Mirna Activity ; Anatomy & Physiology
    ISSN: 1547-6286
    E-ISSN: 1555-8584
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  • 7
    Language: German
    In: Die Bank : Zeitschrift für Bankpolitik und Praxis, 2012, pp. 44-50
    ISSN: 03423182
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 8
    Language: German
    In: Die Bank : Zeitschrift für Bankpolitik und Praxis, 2017, pp. 38-42
    ISSN: 03423182
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 9
    Language: English
    In: Journal of Applied Physics, May 1, 2009, Vol.105(9), p.093714-1-093714-4
    Description: The generation of highly spin-polarized currents and their detection in cascaded InAs spin filters via transport measurements below 300 mK is described. The experiments have agreed well with ballistic quantum simulations, which have mimicked the double-Y-shaped structure constricted by quantum-point contacts, and the intrinsic spin-Hall effect is used in the first filter to generate two oppositely spin-polarized currents.
    Keywords: Arsenic -- Electric Properties ; Arsenic -- Magnetic Properties ; Hall Effect -- Analysis ; Indium -- Electric Properties ; Indium -- Magnetic Properties ; Spin Coupling -- Analysis
    ISSN: 0021-8979
    Source: Cengage Learning, Inc.
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  • 10
    Language: German
    In: Innovationen und Innovationsmanagement in der Finanzbranche, pp. 335-355
    Keywords: Unternehmenskultur ; Risikomanagement ; Regulierung ; Innovation ; Arbeitsgruppe ; Projektbewertung
    ISBN: 3-658-15647-3
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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