Food Chemistry, 01 December 2011, Vol.129(3), pp.753-760
► Essential oils from Rwandese hepatoprotective herbs present antioxidant properties. ► GC–MS analysis determined the composition of all four essential oils. ► Major components with antioxidant properties are unsaturated mono-and sesquiterpenes. ► The lipid peroxidation inhibitory activity is superior for the total methanolic extracts. Following an ethnobotanical survey in Southern Rwanda for hepatoprotective remedies, four food and medicinal plants, , , and , were selected for pharmacological and chemical investigations aiming to validate their reported properties. The chemical compositions of essential oils obtained from leaves were investigated by GC–MS; essential oils and methanolic extracts were evaluated for antioxidant activity by 1,1-diphenyl-2-picryhydrazyl (DPPH) and linoleic acid peroxidation assays. [limonene (34.8%), (E)-β-ocimene (21.8%), β-pinene (8.5%), α-pinene (6.6%), myrcene (6.3%)], [germacrene- (25.5%), limonene (9.7%), (E)-β-ocimene (6.6%)], [germacrene- (58.3%)] and [sabinene (12.2%), alpha phellandrene (11.6%)] volatile oils scavenge DPPH (10%, 39%, 27%, and 11% quercetin equivalents) and inhibit linoleic acid peroxidation (13%, 23%, 20%, and 13% Trolox® equivalents). The four methanolic extracts were quite active on the lipid peroxidation model (93%, 93%, 70%, and 67% Trolox equivalents) with modest activity on DPPH (5%, 10%, 8%, and 11% quercetin equivalents). These properties most probably participate in the four plants hepatoprotective activities reported in ethnopharmacological and/or pharmacological studies.
Essential Oils ; Chemical Composition ; Antioxidant ; Ocimum Lamiifolium ; Crassocephalum Vitellinum ; Guizotia Scabra ; Microglossa Pyrifolia ; Lamiaceae ; Asteraceae ; Chemistry ; Diet & Clinical Nutrition ; Economics
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