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Berlin Brandenburg

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  • 1
    Language: English
    In: IEEE Transactions on Applied Superconductivity, June 2015, Vol.25(3), pp.1-5
    Description: By using LEKIDs the prospect rises to multi-pixel arrays with an extremely small footprint. Moreover, these arrays have the advantage of frequency-division multiplex readout method (FDM). However, the increase of packing density of LEKIDs leads to an increase of crosstalk between adjacent pixels and complicates the readout process significantly. In this paper, we present a newly developed LEKID structure with reduced crosstalk and present their improved performance in terms of equally spaced resonance frequencies within an array. Thus, the array can be realized with a large number of pixels in a small analog readout bandwidth. We present simulation and measurement results of various linear arrays with 5 pixels, which are constructed with the new LEKID structures. When designing the resonance frequencies importance was attached to an equal spacing between the resonance frequencies at around 6 GHz within our available analog readout bandwidth of 400 MHz. The samples were fabricated in niobium thin film technology on silicon and sapphire substrates and then measured at liquid helium temperatures.
    Keywords: Resonant Frequency ; Microwave Measurement ; Simulation ; Detectors ; Silicon ; Crosstalk ; Substrates ; Superconducting ; Microwave ; Resonator ; Transmission Lines ; Kinetic-Inductance Detector ; Engineering ; Physics
    ISSN: 1051-8223
    E-ISSN: 1558-2515
    Source: IEEE Conference Publications
    Source: IEEE Journals & Magazines 
    Source: IEEE Xplore
    Source: IEEE Journals & Magazines
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  • 2
    Language: English
    In: IEEE Transactions on Applied Superconductivity, June 2017, Vol.27(4), pp.1-5
    Description: The most developed integrated receivers for THz radiation nowadays are based on Josephson junction superconductor-insulator-superconductor devices. In this kind of devices, the highest receivable frequency is determined by the energy gap of the superconducting electrodes and limited to approximately 700 GHz in case of Nb/AlO〈sub〉x〈/sub〉/Nb multilayers. We have developed a technology for NbN/AlN/NbN Josephson junctions on sapphire substrates which allow operation at frequencies above 1 THz. The trilayers are deposited in situ in a three-chamber dc-magnetron sputtering system at temperatures as high as 775 °C. Each layer is reactively sputtered in an argon and nitrogen atmosphere. By variation of the partial gas pressures and discharge current of the plasma, optimum deposition conditions for the tri-layers were found. So far, gap voltages as high as 5.1 mV at 4.2 K have been achieved which allows the operation frequency of the JJ devices to exceed 1 THz.
    Keywords: Electrodes ; Nitrogen ; Josephson Junctions ; Argon ; Plasma Temperature ; Films ; Josephson Junctions ; Superconducting Devices ; Superconducting Films ; Submillimeter Wave Integrated Circuits ; Engineering ; Physics
    ISSN: 1051-8223
    E-ISSN: 1558-2515
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  • 3
    Language: English
    In: Bone marrow transplantation, July 2018, Vol.53(7), pp.891-894
    Keywords: Hematopoietic Stem Cell Transplantation -- Methods ; Sarcoma -- Therapy ; Transplantation Conditioning -- Methods ; Transplantation, Homologous -- Methods
    ISSN: 02683369
    E-ISSN: 1476-5365
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  • 4
    Language: English
    In: Advances In Cryogenic Engineering: Transactions of the Cryogenic Engineering Conference - Cec, Volume 57, Spokane, Washington, USA (13–17 June 2011):
    In: AIP Conference Proceedings, 12 June 2012, Vol.1434(1), pp.573-580
    Description: We report on an alternative approach to the fabrication of low heat leak high temperature superconductor (HTS) current leads designed to supply low currents to devices mounted on cryocoolers operating at a typical temperature of 4K. With the aim of reducing the parasitic wiring heat loads to the coldest stage of a cryocooler, we start with a commercially available YBCO coated conductor; the main task is to pattern the tape into long, narrow lines that show a low thermal conduction in the temperature range from 4K to 50 K. A dicing machine was used to cut the tape to the appropriate geometry. Since the tape is coated with silver, a process involving electro-etching had to be developed to remove the silver coat, to minimize the total thermal conductance. The obtained leads exhibited a critical current lower than suggested by the bulk critical current, but in most cases it was still high enough for our targeted application. Given the thermal properties of the materials used, we have demonstrated low current leads ( I ≈ 100 mA) with a calculated heat load that is more than an order of magnitude lower than that of optimized normal metal leads.
    Keywords: Current Leads
    ISBN: 978-0-7354-1020-6
    ISSN: 0094-243X
    E-ISSN: 1551-7616
    Source: © 2012 American Institute of Physics (AIP)〈img src=http://exlibris-pub.s3.amazonaws.com/AIP_edited.gif style="vertical-align:middle;margin-left:7px"〉
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  • 5
    Language: English
    In: IEEE Transactions on Applied Superconductivity, June 2017, Vol.27(4), pp.1-5
    Description: Silicon nitride membrane based cryogenic bolometers exhibit high sensitivity and enable ultra-sensitive detector applications. Multi-pixel instruments were already introduced as devices for submillimeter-wave imaging. Nevertheless, the numbers of pixels are limited by the readout process which is typically a time-division multiplexing or code-division multiplexing technique. To overcome this challenge, a replacement of the transition-edge sensor as thermometer by a lumped-element resonance circuit seems to be a promising solution. Therefore, one can benefit from the intrinsic capability of frequency-division multiplexing that allows the readout of large detector arrays simultaneously and in real-time. The number of pixels is then limited by the available readout bandwidth and the quality factors of each individual resonance circuit. We successfully demonstrated, based on our feasibility study, the principal operation of such a device, what we call kinetic-inductance bolometer (KIBO). But the overall performance of the achievable noise-equivalent power (NEP) was limited by implementation and operation temperature of KIBO. Therefore, improved KIBO designs were developed and fabricated with niobium thin-film technology. In this paper, we describe the improvement procedure and estimate the expected NEP value.
    Keywords: Couplings ; Rlc Circuits ; Detectors ; Temperature Measurement ; Resonant Frequency ; Transmission Line Measurements ; Windings ; Bolometer ; Kinetic-Inductance ; Lumped-Element ; Resonator ; Microwave ; Engineering ; Physics
    ISSN: 1051-8223
    E-ISSN: 1558-2515
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  • 6
    Language: English
    In: IEEE Transactions on Applied Superconductivity, June 2017, Vol.27(4), pp.1-5
    Description: Our new detector and readout concept brings together TES (Transition Edge Sensor) and MKID (Microwave Kinetic Inductance Detector) technologies and exploits the idea of a microwave-induced superconducting transition in a small thin-film microbridge. The superconducting transition of the bridge manifests itself as variation in the Q -factor of niobium resonators at 5-8 GHz, somewhat similar to MKID operation. We present data showing the potential for developing this concept into multipixel detector arrays. Single-pixel sensitivity was measured at 4.5 K for an input band of 600-700 GHz using a prototype 10-nm-thick Nb bridge of size 1 μm × 500 nm. Radiation from human skin was detected with a resolution better than 1 K/rtHz, which is encouraging for terahertz imaging applications. To further improve device sensitivity, we are also developing Hf-based devices that operate near 0.35 K. Details about the physics and stability of these devices are discussed.
    Keywords: Superconducting Microwave Devices ; Detectors ; Radio Frequency ; Impedance ; Resonant Frequency ; Niobium ; Frequency Division Multiplexing ; Terahertz Range ; Superconducting Bolometer ; Transition Edge Sensor (Tes) ; Heb Microbolometer ; Electrothermal Feedback ; High-Q Resonator ; Microwave Kinetic Inductance Detector (Mkid) ; Fdm Readout ; Microwave Bias ; Superconductor Impedance ; Blackbody Calibration ; Engineering ; Physics
    ISSN: 1051-8223
    E-ISSN: 1558-2515
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  • 7
    Language: English
    In: Cytotherapy, June 2014, Vol.16(6), pp.835-844
    Description: Cytokine-induced killer (CIK) cells may offer a novel therapeutic approach for patients with malignancies relapsing after allogeneic stem cell transplantation. Although CIK cells display negligible alloreactivity and cause minimal graft versus-host-disease (GVHD), high CIK cell doses required during relapse may pose a risk for severe GVHD, specifically in the mismatched or haploidentical transplantation setting. Manipulation of CIK cells may reduce risk for GVHD without affecting the anti-tumor potential. In this pre-clinical study, we provide a detailed functional comparison of conventional and irradiated, CD56-enriched or T-cell receptor α/β-depleted CIK cells. analysis showed retained anti-leukemic and anti-tumor potential after CIK cell manipulation. Even being sequentially infused into immunodeficient mice grafted with malignant cells, cytotoxic effects were fewest after irradiation but were improved by CD56 enrichment and were best with conventional CIK cells. Hence, considering the proliferative capacity of inoculated malignancies and effector cells, a single dose of conventional CIK cells resulted in prolonged disease-free survival and elimination of rhabdomyosarcoma cells, whereas sequential infusions were needed to achieve comparable results in leukemia-bearing mice. However, this mouse model has limitations: highly effective conventional CIK cells demonstrated both limited xenogenic GVHD and low alloreactive potential . Our study revealed that conventional CIK cells demonstrate no significant alloreactive potential but provide the strongest anti-tumor efficacy compared with manipulated CIK cells. Conventional CIK cells may therefore be tested in high numbers and short-term intervals in patients with impending relapse even after mismatched transplantation.
    Keywords: Anti-Tumor Potential ; Cytokine-Induced Killer Cells ; Mouse Model ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1465-3249
    E-ISSN: 1477-2566
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  • 8
    Language: English
    In: Oncotarget, 12 September 2017, Vol.8(39), pp.66137-66153
    Description: Pediatric patients with recurrent, refractory or advanced soft tissue sarcoma (STS) who are simultaneously showing signs of cumulative treatment toxicity are in need of novel therapies. In this preclinical analysis, we identified ErbB2 as a targetable antigen on STS cells and used cytokine-induced killer (CIK) cells transduced with the lentiviral 2-generation chimeric antigen receptor (CAR) vector pS-5.28.z-IEW to target ErbB2-positive tumors. Solely CIK cell subsets with the CD3 T cell phenotype showed up to 85% cell surface expression of the respective CAR. A comparison of wildtype (WT), mock-vector and ErbB2-CAR-CIK cells showed, that engineered cells exhibited diminished expansion, retained WT CIK cell phenotype with higher percentages of differentiated effector memory/effector cells. Activating natural killer (NK) cell receptor NKG2D-restricted target cell recognition and killing of WT and ErbB2-CAR-CIK cells was maintained against ErbB2-negative tumors, while ErbB2-CAR-CIK cells demonstrated significantly increased cytotoxicity against ErbB2-positive targets, including primary tumors. ErbB2-CAR- but not WT CIK cells proliferated, infiltrated and efficiently lysed tumor cell monolayers as well as 3D tumor spheroids. Here, we demonstrate a potential cell therapeutic approach using ErbB2-CAR-CIK cells for the recognition and elimination of tumor cells expressing ErbB2, which we identified as a targetable antigen on high-risk STS cells.
    Keywords: Cell Therapy ; Chimeric Antigen Receptor ; Cytokine-Induced Killer Cells ; Pediatric Cancer ; Soft Tissue Sarcoma
    E-ISSN: 1949-2553
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  • 9
    Language: English
    In: Haematologica, April 2016, Vol.101(4), pp.e153-6
    Keywords: Hsct ; Il-15-Activated ; Cytokine-Induced Killer Cells ; Efficacy ; Immunological Control ; Relapse ; Hematopoietic Stem Cell Transplantation ; Cytokine-Induced Killer Cells -- Transplantation ; Leukemia, Myelogenous, Chronic, BCR-Abl Positive -- Therapy ; Leukemia, Myeloid, Acute -- Therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma -- Therapy
    ISSN: 03906078
    E-ISSN: 1592-8721
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  • 10
    Language: English
    In: Cytotherapy, August 2015, Vol.17(8), pp.1139-1151
    Description: Human cytomegalovirus (CMV) infection and reactivation is a leading complication of allogeneic hematopoietic stem cell transplantation (HSCT). In addition to drug treatment, the adoptive transfer of virus-specific T cells to restore cellular immunity has become a standard therapy after allogeneic HSCT. We recently demonstrated potent anti-leukemic activity of interleukin (IL)-15–activated cytokine-induced killer (CIK) cells. With the use of the same expansion protocol, we asked whether concurrent CMV antigen-pulsing might generate CIK cells with anti-leukemic and anti-CMV activity. CIK cells expanded in the presence of interferon-γ, IL-2, IL-15 and anti-CD3 antibody were pulsed once with CMVpp65 peptide pool. CMV-specific CIK (CIK ) and conventional CIK cells were phenotypically and functionally characterized according to their cytokine secretion pattern, degranulation capacity and T-cell receptor (TCR)-mediated and NKG2D-mediated cytotoxicity. We demonstrated that among CIK cells generated from CMV-seropositive donors, a single stimulation with CMVpp65 protein co-expanded cytotoxic CMV-specific cells without sacrificing anti-tumor reactivity. Cells generated in this fashion lysed CMVpp65-loaded target cells and CMV-infected fibroblasts but also leukemic cells. Meanwhile, the alloreactive potential of CIK cells remained low. Interestingly, CMV reactivity was TCR-mediated and CMV-specific cells could be found in CD3 CD8 CD56 cytotoxic T-cell subpopulations. We provide an efficient method to generate CIK cells that may represent a useful cell therapy approach for preemptive immunotherapy in patients who have both an apparent risk of CMV and impending leukemic relapse after allogeneic stem cell transplantation.
    Keywords: Cik Cells ; Cmv ; Cytotoxicity ; Immunotherapy ; Leukemia ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 1465-3249
    E-ISSN: 1477-2566
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