Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (897 p.)

Edition: 2nd ed. / edited by Yehuda Shoenfeld, M.Eric Gershwin, Pier-Luigi Meroni.

ISBN: 1-280-72930-9 , 9786610729302 , 0-08-046723-7

Content: Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focussed on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, di

Note: Previous ed.: 1996. , Front Cover; Title Page; Copyright Page; Table of Contents; Foreword; Preface; About the Editors; List of Contributors; Introduction; Part I Introduction: Autoantibodies-Unique Characteristics; Chapter 1 What is an Autoantibody?; Abstract; Introduction; Characterization of autoimmune diseases; Tolerance; Concluding remarks; References; Chapter 2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity; Abstract; Historical notes; The origin of NAbs; NAbs and autoimmunity; NAbs and the innate immune system; Apoptosis and NAbs; Protective NAbs; References , Chapter 3 Molecular MimicryAbstract; Historical notes; Forms of molecular mimicry; Natural autoantibodies and molecular mimicry; Animal model of molecular mimicry; Clinical utility; Conclusion; References; Chapter 4 Affinity and Avidity of Autoantibodies; Abstract; Historical notes; Avidity and affinity; Clinical utility in autoimmune disorders; Take-home messages; References; Chapter 5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies; Abstract; Introduction; Cell surface binding and lysis (cytotoxicity); Binding to cell surface receptors without cytolysis , Immune complex-mediated damageTranslocation of intracellular antigens to cell membrane; Penetration into living cells; Binding to extracellular molecules; Take-home messages; References; Chapter 6 Native Autoantigens Versus Recombinant Autoantigens; Abstract; Introduction; Detection of autoantibodies; ELISA; Native autoantigens; Recombinant autoantigens; Criteria for usage of autoantigens in immunoassays; Limitations of recombinant technology for the production of autoantigens; Acknowledgements; Take-home messages; References; Chapter 7 Redox-Reactive Autoantibodies; Abstract , Historical notesAutoantigens; Autoantibodies; Acknowledgements; Take-home messages; References; Chapter 8 Predictive Autoantibodies; Abstract; Introduction; Prediction of disease; Prediction of specific clinical manifestations; Hierarchy of autoantibodies; Combining HLA and predictive antibodies in prediction; Combining specific genes and antibody testing; Implications and future directions; Take-home messages; References; Chapter 9 Autoantibody Subclasses; Abstract; Historical notes; The findings; The methods; The causes; The consequences; Conclusion; References , Chapter 10 Idiotypes and Anti-IdiotypesAbstract; Historical notes; The autoantigen(s); Structure of idiotypes; Genetics; Autoantibodies; Physiologic role; Pathogenic role; Clinical utility; Summary; Take-home messages; References; Chapter 11 Novel Diagnostic Methods for Autoantibody Detection; Abstract; The use of single autoantibody tests in the diagnosis and classification of autoimmune diseases: The 'old' technologies; Multiplex technologies for the study of autoantibody profiles: The 'new' technologies; The predictive role of autoantibody profiles; Take-home messages; References , Part II Allergic Disease Autoantibodies , English

Additional Edition: ISBN 0-444-52763-X

Language: English

UID:

Format: 1 Online-Ressource (xxxiv, 838 Seiten).

Edition: 2nd ed

ISBN: 0-08-046723-7 , 978-0-08-046723-8 , 978-0-444-52763-9 , 0-444-52763-X

Note: Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focused on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference for anyone involved in the field of autoimmune diseases. Includes and exhaustive list of autoantibodies not covered by other publications * Short reviews can easily be checked for quick reference information * Both basic and clinical aspects are covered. - Includes bibliographical references and index

Language: English

Keywords: Autoantikörper

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Gershwin, M. Eric 1946-

Author information: Shoenfeld, Yehuda 1948-

UID:

Format: 1 Online-Ressource (xxxiv, 838 Seiten).

Edition: 2nd ed

ISBN: 0-08-046723-7 , 978-0-08-046723-8 , 978-0-444-52763-9 , 0-444-52763-X

Note: Autoimmune diseases are characterized by the occurrence of antibodies reacting with self constituents of the body. This exciting new reference is an exhaustive review of the main autoantibodies identified up to now, with particular emphasis on those autoantibodies that display a clinical value. Each chapter is focused on a single family of autoantibodies by reviewing their historical notes, definition, origin and source(s) of the antigen(s) recognized, genetic associations, pathogenic mechanisms that are mediated, method(s) of detection and clinical utility (disease prevalence/association, diagnostic value, sensitivity and specificity, prognostic value). An ideal reference for anyone involved in the field of autoimmune diseases. Includes and exhaustive list of autoantibodies not covered by other publications * Short reviews can easily be checked for quick reference information * Both basic and clinical aspects are covered. - Includes bibliographical references and index

Language: English

Keywords: Autoantikörper

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Gershwin, M. Eric 1946-

Author information: Shoenfeld, Yehuda 1948-

UID:

Format: 1 online resource (916 pages) : , illustrations (some color).

Edition: Third edition.

ISBN: 9780444593771 (e-book)

Series Statement: Elsevier science & technology books

Note: part 1. Introduction : autoantibodies-unique characteristics -- part 2. Allergic disease autoantibodies -- part 3. Antineutrophil antibodies -- part 4. Introduction : antinuclear antibodies -- part 5. Autoantibodies to biologic factors/structures -- part 6. Cardiac autoantibodies -- part 7. Endocrine autoantibodies -- part 8. GI and liver autoantibodies -- part 9. Hematologic autoantibodies -- part 10. Kidney autoantibodies -- part 11. Neurological system autoantibodies -- part 12. Rheumatic disease autoantibodies -- part 13. Skin disease autoantibodies -- part 14. Unique clinical situations.

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (lx, 855 pages) : , illustrations (some color)

Edition: Third edition.

ISBN: 0-444-59377-2

Series Statement: Gale eBooks

Content: The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). -- Publisher

Content: This book covers recent scientific advances, diagnostic techniques, and therapeutic technologies in the field of autoimmune diseases. Each chapter is focused on a single family of autoantibodies, providing historical notes, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value).

Note: Description based upon print version of record. , part 1. Introduction : autoantibodies-unique characteristics -- part 2. Allergic disease autoantibodies -- part 3. Antineutrophil antibodies -- part 4. Introduction : antinuclear antibodies -- part 5. Autoantibodies to biologic factors/structures -- part 6. Cardiac autoantibodies -- part 7. Endocrine autoantibodies -- part 8. GI and liver autoantibodies -- part 9. Hematologic autoantibodies -- part 10. Kidney autoantibodies -- part 11. Neurological system autoantibodies -- part 12. Rheumatic disease autoantibodies -- part 13. Skin disease autoantibodies -- part 14. Unique clinical situations.

Additional Edition: ISBN 0-444-56378-4

Additional Edition: ISBN 1-306-16780-9

Language: English

UID:

Format: 1 online resource (lx, 855 pages) : , illustrations (some color)

Edition: Third edition.

ISBN: 0-444-59377-2

Series Statement: Gale eBooks

Content: The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). -- Publisher

Content: This book covers recent scientific advances, diagnostic techniques, and therapeutic technologies in the field of autoimmune diseases. Each chapter is focused on a single family of autoantibodies, providing historical notes, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value).

Note: Description based upon print version of record. , part 1. Introduction : autoantibodies-unique characteristics -- part 2. Allergic disease autoantibodies -- part 3. Antineutrophil antibodies -- part 4. Introduction : antinuclear antibodies -- part 5. Autoantibodies to biologic factors/structures -- part 6. Cardiac autoantibodies -- part 7. Endocrine autoantibodies -- part 8. GI and liver autoantibodies -- part 9. Hematologic autoantibodies -- part 10. Kidney autoantibodies -- part 11. Neurological system autoantibodies -- part 12. Rheumatic disease autoantibodies -- part 13. Skin disease autoantibodies -- part 14. Unique clinical situations.

Additional Edition: ISBN 0-444-56378-4

Additional Edition: ISBN 1-306-16780-9

Language: English

UID:

Format: 1 online resource (1 streaming video file (28 min.)) : , sound, color

Series Statement: Autoimmunity : etiology, pathogenesis, clinical manifestation and diagnostic methodologies,

Note: Animated audio-visual presentation with synchronized narration. , Title from title frames. , Contents: Fertility in women with systemic autoimmune rheumatic disease (SARD) -- Disease control and pregnancy management -- Pregnancy risk profiling -- Strict and multidisciplinary pregnancy monitoring -- Therapy tuned to disease and drugs allowed during pregnancy -- Post-partum monitoring as an additional step.

Language: English

UID:

Format: 1 streaming video file (47 min.) : , digital, mono, SWF file, sound, color , 004631

Content: Audio-visual presentation : Physiological functions of the endothelium ; Endothelium as a target and player of immune responses ; Endothelium in autoimmune vasculitis and vasculopathies ; Anti-endothelial cell antibodies ; Anti-phospholipid syndrome ; Scleroderma ; Markers of endothelial perturbation.

Note: Retrieved April 6, 2024, from https://hstalks.com/bs/190/. , Introduction -- Endothelium - one of the largest tissues in body -- Endothelium is an active tissue -- Endothelial cells (EC) heterogeneity (1) -- Endothelial cells (EC) heterogeneity (2) -- Endothelial cells activity -- Vasoregulation -- EC and coagulation -- Regulatory mechanisms - anti and procoagulant -- EC and fibrinolysis -- The leukocyte adhesion cascade -- EC and inflammation/innate immunity -- Triggering of the cell mediated immune responses -- Role of the endothelium in autoimmune diseases -- Endothelium and autoimmunity -- EC and immune responses -- Endothelium as a target -- EC as target: anti-EC antibodies (AECA) -- AutoAbs against ECs (AECA) -- Endothelial planted antigens recognized by AECA -- AECA and pro-inflammatory/coagulant phenotype -- AECA may induce an endothelial lysis -- AECA may induce an endothelial apoptosis -- EC as target: ANCA -- ANCA-associated vasculitis -- EC as target: systemic vasculitis -- Giant cell arteritis -- EC as target: immunocomplexes -- Immune complex-mediated vasculitis -- Endothelium in autoimmune atherosclerosis -- Atherosclerosis: response to injury hypothesis -- EC as target: atherosclerosis -- EC as player: atherosclerosis -- EC activation in autoimmune diseases -- Vasculopathy vs. vasculitis -- Endothelium and antiphospholipid syndrome (APS) -- Endothelium as a target for antiphospholipid (aPL) -- Activated ECs as players in APS -- APS: pathogenic mechanisms -- Possible receptors for bGlycoprotein I (bGPI) -- Endothelium and scleroderma (SSc) -- Role of vascular damage in SSc pathogenesis -- Markers of EC perturbation -- Circulating markers: von Willebrand factor -- Circulating markers: endothelin-1 -- Circulating markers: TPA and PAI-1 -- Circulating markers: soluble adhesion molecules -- Circulating markers: sTM -- Circulating ECs (CEC) -- Increased occurrence of CECs -- Brachial FMD (omeral artery).

Language: English

UID:

Format: 1 online resource (lx, 855 pages) : , illustrations (some color)

Edition: Third edition.

ISBN: 0-444-59377-2

Series Statement: Gale eBooks

Content: The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). -- Publisher

Content: This book covers recent scientific advances, diagnostic techniques, and therapeutic technologies in the field of autoimmune diseases. Each chapter is focused on a single family of autoantibodies, providing historical notes, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value).

Note: Description based upon print version of record. , part 1. Introduction : autoantibodies-unique characteristics -- part 2. Allergic disease autoantibodies -- part 3. Antineutrophil antibodies -- part 4. Introduction : antinuclear antibodies -- part 5. Autoantibodies to biologic factors/structures -- part 6. Cardiac autoantibodies -- part 7. Endocrine autoantibodies -- part 8. GI and liver autoantibodies -- part 9. Hematologic autoantibodies -- part 10. Kidney autoantibodies -- part 11. Neurological system autoantibodies -- part 12. Rheumatic disease autoantibodies -- part 13. Skin disease autoantibodies -- part 14. Unique clinical situations.

Additional Edition: ISBN 0-444-56378-4

Additional Edition: ISBN 1-306-16780-9

Language: English

UID:

ISSN: 1437-4331

In: Clinical chemistry and laboratory medicine, Berlin [u.a.] : De Gruyter, 1998, 53(2015), 12, Seite 1991-2002, 1437-4331

In: volume:53

In: year:2015

In: number:12

In: pages:1991-2002

Language: English

DOI: 10.1515/cclm-2015-0083

URL: https://www.degruyter.com/document/doi/10.1515/cclm-2015-0083/html

Author information: Großmann, Kai 1978-

Author information: Knütter, Ilka 1972-

Author information: Hiemann, Rico Frank 1980-

Author information: Conrad, Karsten 1956-