Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Language
Year
  • 1
    In: PS: Political Science & Politics, 2014, Vol.47(2), pp.351-356
    Description: The inconsistent and tempered effects of corruption scandals pose a challenge to one interpretation about how Democrats regained control of Congress after the 2006 midterm elections. We do not find evidence to support the contention that corruption was central to voting decisions in 2006. Citizens might...
    Keywords: Symposium: Political Scandal In American Politics
    ISSN: 1049-0965
    E-ISSN: 1537-5935
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Nature, 2017
    Keywords: Gliomas -- Care And Treatment ; Gliomas -- Development And Progression ; Cellular Signal Transduction -- Health Aspects;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: Nature Genetics, 2015, Vol.47(8), p.851
    Description: Relapsed neuroblastoma is common, frequently lethal and poorly studied and poses a major treatment challenge. Two new studies shed light on the genomic landscape of recurrent neuroblastoma and demonstrate profound differences between the disease at diagnosis and relapse.
    Keywords: Genomics ; Neoplasm Recurrence, Local -- Genetics ; Neuroblastoma -- Genetics;
    ISSN: 1061-4036
    E-ISSN: 15461718
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    In: Nature Medicine, 2014, Vol.20(12), p.1378
    Description: Despite advances in chemotherapy and radiation over the past 40 years, the outcome for children with diffuse intrinsic pontine gliomas (DIPGs) remains almost uniformly fatal, with survival of less than 12 months despite numerous trials of chemotherapy, targeted agents and radiation therapy. Recently, large genome-sequencing studies of pediatric high-grade gliomas have been carried out and have consistently identified a lysine to methionine (K27M) substitution in histones H3.1 and H3.3 in over 80% of midline high-grade gliomas and DIPGs2.
    Keywords: Tumors ; Chemotherapy ; Radiation Therapy ; Medical Research ; Epigenetics;
    ISSN: 1078-8956
    E-ISSN: 1546170X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Journal of the American College of Cardiology, 29 November 2016, Vol.68(21), pp.2308-2310
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jacc.2016.09.922 Byline: Michael D. Taylor, Jeffrey A. Towbin Abstract: Display Omitted Author Affiliation: (a) Division of Pediatric Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio (b) Division of Cardiology, University of Tennessee Health Science Center, Memphis, Tennessee (c) Division of Cardiology, St. Jude Children's Research Hospital, Memphis, Tennessee (d) The Heart Institute, Le Bonheur Children's Hospital, Memphis, Tennessee Article Note: (footnote) Both authors have reported that they have no relationships relevant to the contents of this paper to disclose.
    Keywords: Atrial Fibrillation ; Cardiomyopathy ; Genetic ; Inherited ; Laminopathy ; Neuromuscular ; Medicine
    ISSN: 0735-1097
    E-ISSN: 1558-3597
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: Nature Genetics, 2017, Vol.49(7), p.975
    Description: To search for new cancer driver genes and to better understand the underlying mechanism of genomic rearrangements in cancer, Alex Kentsis and colleagues1 looked outside typical coding regions into the noncoding domain of the genome, which has historically been considered to be non-functional 'leftover'...
    Keywords: Cancer ; Tumors ; Tumor Suppressor Genes ; Algorithms ; Genes ; Cancer ; Genomes ; Mutation ; Gene Mapping ; Chromatin ; Tumors ; Genomes ; Historical Account ; Nucleotide Sequence ; Maps ; Genes ; Cancer ; Tumors ; Chromosome Rearrangements ; Transposase ; Gene Sequencing ; Cancer ; Biological Evolution ; Algorithms ; Deoxyribonucleic Acid–DNA ; Genomic Analysis ; Tumors ; Transcription Factors ; Deoxyribonucleic Acid–DNA;
    ISSN: 1061-4036
    E-ISSN: 1546-1718
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Biological Conservation, 2010, Vol.143(3), pp.813-822
    Description: Field margins have been widely advocated as a means of integrating agronomic and biodiversity objectives and are included in agri-environment schemes across Europe. However, information on the long-term development of field margin plant communities remains limited. We describe a long-term experiment on the effects of field margin management on biodiversity and weed species. Swards were established by natural regeneration or sowing a grass and wildflower seed mixture, and treatments manipulated the frequency and timing of mowing, application of herbicide and leaving of hay. Vegetation was monitored to evaluate the extent to which early conclusions remained valid after 13 years. Although early successional trends suggested that naturally regenerated swards would rapidly become dominated by pernicious perennial weeds, and that sown swards would exclude such species, neither was true in the longer term. Sown swards were eventually invaded by unsown perennials, but they remained distinct from naturally regenerated swards. Plant species richness declined throughout the experiment. Annuals were lost most rapidly from sown swards but, under natural regeneration, loss could be modified by mowing. Perennial species initially increased during natural regeneration before stabilising. In sown swards they declined under all treatments. Species richness in naturally regenerating swards was promoted initially by mowing twice annually. After 13 years, timing and frequency of mowing had no significant effect on species richness although it still influenced sward composition. Leaving cut hay lying produced species-poor swards. We conclude that the choice of establishment and management methods for arable field margins significantly affects the long-term conservation value of the swards.
    Keywords: Agriculture ; Biodiversity ; Agri-Environment Schemes ; Weed Control ; Mowing Regimes ; Species Richness ; Agriculture ; Biology ; Ecology
    ISSN: 0006-3207
    E-ISSN: 18732917
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: PloS one, 2018, Vol.13(11), pp.e0207703
    Description: Knowledge of marine ecosystems that grow and reside on and around subsea oil and gas infrastructure is required to understand impacts of this offshore industry on the marine environment and inform decommissioning decisions. This study used baited remote underwater stereo-video systems (stereo-BRUVs) to compare species richness, fish abundance and size along 42.3 km of subsea pipeline and in adjacent areas of varying habitats. The pipeline is laid in an onshore-offshore direction enabling surveys to encompass a range of depths from 9 m nearshore out to 140 m depth offshore. Surveys off the pipeline were performed across this depth range and in an array of natural habitats (sand, macroalgae, coral reef) between 1 km and 40 km distance from the pipeline. A total of 14,953 fish were observed comprising 240 species (131 on the pipeline and 225 off-pipeline) and 59 families (39 on the pipeline and 56 off-pipeline) and the length of 8,610 fish were measured. The fish assemblage on and off the pipeline was similar in depths of 〈80 m. In depths beyond 80 m, the predominant habitat off-pipeline was sand and differences between fish assemblages on and off-pipeline were more pronounced. The pipeline was characterised by higher biomass and abundances of larger-bodied, commercially important species such as: Pristipomoides multidens (goldband snapper), Lutjanus malabaricus (saddletail snapper) and Lutjanus russellii (Moses' snapper) among others, and possessed a catch value 2-3 times higher per stereo-BRUV deployment than that of fish observed off-pipeline. Adjacent natural seabed habitats possessed higher abundances of Atule mate (yellowtail scad), Nemipterus spp. (threadfin bream) and Terapon jarbua (crescent grunter), species of no or low commercial value. This is the first published study to use stereo-BRUVs to report on the importance of subsea infrastructure to commercially important fishes over a depth gradient and increases our knowledge of the fish assemblage associated with subsea infrastructure off north-west Australia. These results provide a greater understanding of ecological and fisheries implications of decommissioning subsea infrastructure on the north-west shelf, and will help better inform decision-making on the fate of infrastructure at different depths.
    Keywords: Environmental Monitoring ; Fishes -- Physiology
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: Nature, 2017
    Description: Human cells have twenty-three pairs of chromosomes. In cancer, however, genes can be amplified in chromosomes or in circular extrachromosomal DNA (ecDNA), although the frequency and functional importance of ecDNA are not understood. We performed whole-genome sequencing, structural modelling and cytogenetic analyses of 17 different cancer types, including analysis of the structure and function of chromosomes during metaphase of 2,572 dividing cells, and developed a software package called ECdetect to conduct unbiased, integrated ecDNA detection and analysis. Here we show that ecDNA was found in nearly half of human cancers; its frequency varied by tumour type, but it was almost never found in normal cells. Driver oncogenes were amplified most commonly in ecDNA, thereby increasing transcript level. Mathematical modelling predicted that ecDNA amplification would increase oncogene copy number and intratumoural heterogeneity more effectively than chromosomal amplification. We validated these predictions by quantitative analyses of cancer samples. The results presented here suggest that ecDNA contributes to accelerated evolution in cancer.
    Keywords: Sciences (General) ; Physics;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    In: Lab on a Chip, 2013, Vol.13(4), pp.522-526
    Description: Electrical stimulation of nervous tissue is used clinically for the treatment of multiple neurological disorders and experimentally for basic research. With the increase of optical probes to record neuronal activity, simple and user-friendly methods are desired to stimulate neurons and their subcellular compartments for biological experimentation. Here we describe the novel integration of liquid metal electrodes with microfluidic culture platforms to accomplish this goal. We integrated electrode and cell channels into a single poly(dimethylsiloxane) (PDMS) chip, eliminating entirely the need to align electrodes with microchannels. We designed the electrode channels such that the metal can be injected by hand and when the device is non-covalently bound to glass. We demonstrated the biocompatibility of the electrodes for long-term cultures (12 days) using hippocampal neurons. We demonstrated the use of these electrodes to depolarize neurons and recorded neuronal activity using the calcium indicator dye, Fluo-4. We established optimal stimulation parameters that induce neuronal spiking without inducing damage. We showed that the liquid metal electrode evoked larger calcium responses in somata than bath electrodes using the same stimulus parameters. Lastly we demonstrated the use of these liquid metal electrodes to target and depolarize axons. In summary, the integration of liquid metal electrodes with neuronal culture platforms provides a user-friendly and targeted method to stimulate neurons and their subcellular compartments, thus providing a novel tool for future biological investigations.
    Keywords: Electric Stimulation ; Microfluidic Analytical Techniques ; Nervous System Physiological Phenomena ; Hippocampus -- Physiology ; Metals -- Chemistry;
    ISSN: 1473-0197
    E-ISSN: 1473-0189
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages