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  • 1
    Language: German
    In: Zeitschrift für das gesamte Kreditwesen : Pflichtblatt der Frankfurter Wertpapierbörse, 2012, Vol.65(4), pp. 168-172
    ISSN: 03414019
    Source: Deutsche Zentralbibliothek für Wirtschaftswissenschaften
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  • 2
    Language: English
    In: BMC Oral Health, April 9, 2011, Vol.11, p.13
    Description: Background Hyposalivation is caused by various syndromes, diabetes, drugs, inflammation, infection, or radiotherapy of the salivary glands. Patients with hyposalivation often show an increased caries incidence. Moreover, hyposalivation is frequently accompanied by oral discomfort and impaired oral functions, and saliva substitutes are widely used to alleviate oral symptoms. However, preference of saliva substitutes due to taste, handling, and relief of oral symptoms has been discussed controversially. Some of the marketed products have shown demineralizing effects on dental hard tissues in vitro. This demineralizing potential is attributed to the undersaturation with respect to calcium phosphates. Therefore, it is important to modify the mineralizing potential of saliva substitutes to prevent carious lesions. Thus, the aim of the present study was to evaluate the effects of a possible remineralizing saliva substitute (SN; modified Saliva natura) compared to a demineralizing one (G; Glandosane) on mineral parameters of sound bovine dentin and enamel as well as on artificially demineralized enamel specimens in situ. Moreover, oral well-being after use of each saliva substitute was recorded. Methods/Design Using a randomized, double-blind, crossover, phase II/III in situ trial, volunteers with hyposalivation utilize removable dentures containing bovine specimens during the experimental period. The volunteers are divided into two groups, and are required to apply both saliva substitutes for seven weeks each. After both test periods, differences in mineral loss and lesion depth between values before and after exposure are evaluated based on microradiographs. The oral well-being of the volunteers before and after therapy is determined using questionnaires. With respect to the microradiographic analysis, equal mineral losses and lesion depths of enamel and dentin specimens during treatment with SN and G, and no differences in patients' experienced oral comfort after SN compared to G usage are expected (H.sub.0 ). Discussion Up to now, 14 patients have been included in the study, and no reasons for early termination of the trial have been identified. The design seems suitable for determining the effects of saliva substitutes on dental hard tissues in situ, and should provide detailed information on the oral well-being after use of different saliva substitutes in patients with hyposalivation. Trial registration ClinicalTrials.gov ID. NCT01165970
    Keywords: Dental Caries -- Risk Factors ; Dental Caries -- Care And Treatment ; Dental Caries -- Research ; Dentin -- Physiological Aspects ; Dentin -- Research ; Xerostomia -- Risk Factors ; Xerostomia -- Diagnosis ; Xerostomia -- Care And Treatment ; Xerostomia -- Research
    ISSN: 1472-6831
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: BMC Oral Health, April 9, 2011, Vol.11, p.13
    Description: Background Hyposalivation is caused by various syndromes, diabetes, drugs, inflammation, infection, or radiotherapy of the salivary glands. Patients with hyposalivation often show an increased caries incidence. Moreover, hyposalivation is frequently accompanied by oral discomfort and impaired oral functions, and saliva substitutes are widely used to alleviate oral symptoms. However, preference of saliva substitutes due to taste, handling, and relief of oral symptoms has been discussed controversially. Some of the marketed products have shown demineralizing effects on dental hard tissues in vitro. This demineralizing potential is attributed to the undersaturation with respect to calcium phosphates. Therefore, it is important to modify the mineralizing potential of saliva substitutes to prevent carious lesions. Thus, the aim of the present study was to evaluate the effects of a possible remineralizing saliva substitute (SN; modified Saliva natura) compared to a demineralizing one (G; Glandosane) on mineral parameters of sound bovine dentin and enamel as well as on artificially demineralized enamel specimens in situ. Moreover, oral well-being after use of each saliva substitute was recorded. Methods/Design Using a randomized, double-blind, crossover, phase II/III in situ trial, volunteers with hyposalivation utilize removable dentures containing bovine specimens during the experimental period. The volunteers are divided into two groups, and are required to apply both saliva substitutes for seven weeks each. After both test periods, differences in mineral loss and lesion depth between values before and after exposure are evaluated based on microradiographs. The oral well-being of the volunteers before and after therapy is determined using questionnaires. With respect to the microradiographic analysis, equal mineral losses and lesion depths of enamel and dentin specimens during treatment with SN and G, and no differences in patients' experienced oral comfort after SN compared to G usage are expected (H.sub.0 ). Discussion Up to now, 14 patients have been included in the study, and no reasons for early termination of the trial have been identified. The design seems suitable for determining the effects of saliva substitutes on dental hard tissues in situ, and should provide detailed information on the oral well-being after use of different saliva substitutes in patients with hyposalivation. Trial registration ClinicalTrials.gov ID. NCT01165970
    Keywords: Dental Caries -- Risk Factors ; Dental Caries -- Care And Treatment ; Dental Caries -- Research ; Dentin -- Physiological Aspects ; Dentin -- Research ; Xerostomia -- Risk Factors ; Xerostomia -- Diagnosis ; Xerostomia -- Care And Treatment ; Xerostomia -- Research
    ISSN: 1472-6831
    Source: Cengage Learning, Inc.
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  • 4
    Language: English
    In: Journal of International Banking Law and Regulation, August, 2014, Vol.29(8), p.513-518
    Description: Presents an adapted version of the benchmarking approach developed by Parcell and Collison for use in the Risk Assurance and Control Assessment (RACA) exercises of the Treasury departments of global banks to ensure that all the banks' business units are complying with the global liquidity policy...
    Keywords: International Banking -- Research ; Liquidation -- Management ; Benchmarking -- Usage
    ISSN: 1742-6812
    ISSN: 0267937X
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  • 5
    In: BMC Oral Health, 2011, Vol.11(1), p.13
    Description: Background Hyposalivation is caused by various syndromes, diabetes, drugs, inflammation, infection, or radiotherapy of the salivary glands. Patients with hyposalivation often show an increased caries incidence. Moreover, hyposalivation is frequently accompanied by oral discomfort and impaired oral functions, and saliva substitutes are widely used to alleviate oral symptoms. However, preference of saliva substitutes due to taste, handling, and relief of oral symptoms has been discussed controversially. Some of the marketed products have shown demineralizing effects on dental hard tissues in vitro. This demineralizing potential is attributed to the undersaturation with respect to calcium phosphates. Therefore, it is important to modify the mineralizing potential of saliva substitutes to prevent carious lesions. Thus, the aim of the present study was to evaluate the effects of a possible remineralizing saliva substitute (SN; modified Saliva natura) compared to a demineralizing one (G; Glandosane) on mineral parameters of sound bovine dentin and enamel as well as on artificially demineralized enamel specimens in situ. Moreover, oral well-being after use of each saliva substitute was recorded. Methods/Design Using a randomized, double-blind, crossover, phase II/III in situ trial, volunteers with hyposalivation utilize removable dentures containing bovine specimens during the experimental period. The volunteers are divided into two groups, and are required to apply both saliva substitutes for seven weeks each. After both test periods, differences in mineral loss and lesion depth between values before and after exposure are evaluated based on microradiographs. The oral well-being of the volunteers before and after therapy is determined using questionnaires. With respect to the microradiographic analysis, equal mineral losses and lesion depths of enamel and dentin specimens during treatment with SN and G, and no differences in patients' experienced oral comfort after SN compared to G usage are expected (H0). Discussion Up to now, 14 patients have been included in the study, and no reasons for early termination of the trial have been identified. The design seems suitable for determining the effects of saliva substitutes on dental hard tissues in situ, and should provide detailed information on the oral well-being after use of different saliva substitutes in patients with hyposalivation. Trial registration ClinicalTrials.gov ID. NCT01165970
    ISSN: 1472-6831
    Source: BioMed Central
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  • 6
    Language: English
    In: Journal of International Banking Law and Regulation, Feb, 2010, Vol.25(2), p.83-88
    Description: Summarises the key findings of an international study, undertaken at the University of Sunderland, of the management of operational risk within the financial services industry. Reviews the Basel Committee definition of operational risk and the methods for calculating operational risk capital...
    Keywords: Banking Industry -- Laws, Regulations And Rules ; Risk Management -- Laws, Regulations And Rules ; Secured Transactions -- Laws, Regulations And Rules
    ISSN: 1742-6812
    ISSN: 0267937X
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  • 7
    Language: English
    In: Journal of International Banking Law and Regulation, April, 2012, Vol.27(4), p.161-166
    Description: Discusses the findings of research exploring the views of 15 banking internal audit and operational risk management professionals on how the "three lines of defence" model employed by many banks to measure operational risk under the Basel II Accord could be improved. Identifies six themes emerging...
    Keywords: Internal Auditing -- Research ; Risk Management -- Research
    ISSN: 1742-6812
    ISSN: 0267937X
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  • 8
    Language: English
    In: Analytical Biochemistry, 15 December 2009, Vol.395(2), pp.178-188
    Description: A common technique for analysis of protein glycosylation is HPLC coupled to mass spectrometry (LC-MS). However, analysis is challenging due to a low abundance of glycopeptides in complex protein digests, microheterogeneity at the glycosylation site, ion suppression effects, and competition for ionization by coeluting peptides. Specific sample preparation is necessary for a comprehensive and site-specific glycosylation analysis by MS. In this study we qualitatively compared hydrophilic interaction chromatography (HILIC) and hydrazine chemistry for the enrichment of all N-linked glycopeptides and titanium dioxide for capturing sialylated glycopeptides from a complex peptide mixture. Bare silica, microcrystalline cellulose, amino-, amide- (TSKgel Amide-80), and sulfobetaine-(ZIC-HILIC) bonded phases were evaluated for HILIC enrichment. The experiments revealed that ZIC-HILIC and TSKgel Amide-80 are very specific for capturing glycopeptides under optimized conditions. Quantitative analysis of -glycosidase F-released and 2-aminobenzamide-labeled glycans of a ZIC-HILIC-enriched monoclonal antibody demonstrated that glycopeptides could be enriched without bias for particular glycan structures and without significant losses. Sialylated glycopeptides could be efficiently enriched by titanium dioxide and in addition to HILIC both methods enable a comprehensive analysis of protein glycosylation by MS. Enrichment of N-linked glycopeptides by hydrazine chemistry resulted in lower peptide recovery using a more complex enrichment scheme.
    Keywords: Glycopeptide Enrichment ; Glycosylation ; Glycan Profiling ; Quantitative ; Hilic ; Mass Spectrometry ; Titanium Dioxide ; Hydrazine Chemistry ; Chemistry ; Anatomy & Physiology
    ISSN: 0003-2697
    E-ISSN: 1096-0309
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  • 9
    Language: English
    In: Journal of International Banking Law and Regulation, Nov, 2010, Vol.25(11), p.543-548
    Description: Reports on a survey into the effectiveness of banks' internal audit (IA) functions in the operational risk management framework of Basel II. Reviews the role of internal auditing, its use in the "three lines of defence" model intended to safeguard banks against losses from operational risks,...
    Keywords: Risk Management -- Research ; Internal Auditing -- Research ; Financial Services -- Research
    ISSN: 1742-6812
    ISSN: 0267937X
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  • 10
    Language: English
    In: Future Internet, 01 February 2011, Vol.3(1), pp.14-30
    Description: In this article, a security extension for the HiiMap Next Generation Internet Architecture is presented. We regard a public key infrastructure which is integrated into the mapping infrastructure of the locator/identifier-split addressing scheme. The security approach is based on Threshold Cryptography...
    Keywords: Ngi ; Security ; Hiimap ; Pki ; Locator/Identifier-Split ; Threshold Cryptography ; Engineering
    ISSN: 1999-5903
    E-ISSN: 1999-5903
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