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  • 1
    UID:
    gbv_1018368388
    Format: 1 Online-Ressource (xiv, 545 Seiten) , Illustrationen, Diagramme
    ISBN: 9780128113059
    Content: Front Cover -- The Molecular and Cellular Basis of Neurodegenerative Diseases -- Copyright Page -- Dedication -- Contents -- List of Contributors -- Preface -- 1 Solving the Puzzle of Neurodegeneration -- Introduction: The General Problem of Neurodegeneration -- Epidemiology and Clinical Presentation -- Molecular Pathology -- Genetics -- Molecular Clues to Mechanisms of Pathogenesis -- Common Themes and Controversies in Neurodegeneration -- Animal Models -- Prospects for Therapeutics -- Conclusions and Perspective -- References -- 2 Prion Diseases -- Introduction and Historical Perspective -- Molecular Mechanism of Prion Propagation -- The Cellular Prion Protein: Structure and Proteolytic Processing -- Physiological Function of PrPC -- Mechanisms of PrPSc Toxicity: The N-Terminal Domain of PrPC Possess a Toxic Effector Activity -- Human Prion Diseases -- Animal Prion Diseases -- Prion Strains and Species Barriers -- Methods for Propagation and Detection of Prions -- Therapeutic Approaches -- PrPC and the Alzheimer's Aβ Peptide -- Prion-like Propagation of Misfolded Proteins in Other Neurodegenerative Diseases -- Concluding Remarks -- References -- 3 Alzheimer's Disease: Toward a Quantitative Biological Approach in Describing its Natural History and Underlying Mechanisms -- Quantitative Approach to Basic AD Demographics -- Change Over Time: (i) Biogenesis, Production, and Turnover of Aβ -- Change Over Time: (ii) The Accumulation, Spread, Propagation of Aβ -- Change Over Time: (iii) The Growth and Accumulation of Plaque Cores -- Change Over Time: (iv) Brain Atrophy -- Change Over Time: (v) Cognition -- Clearance Mechanisms and Impaired Phagocytosis -- Calculating Polygenic Risk Scores -- Disease-Modifying Strategies: Models of Aβ Accumulation in Alzheimer's Disease-Implications for Aβ Amyloid-Targeting Therapies -- References.
    Additional Edition: ISBN 9780128113042
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780128113042
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 2
    Online Resource
    Online Resource
    Amsterdam :Academic Press,
    UID:
    edoccha_BV045381815
    Format: 1 Online-Ressource (xx, 656 Seiten).
    ISBN: 0-12-802164-0 , 978-0-12-802164-4
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-12-802173-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 012802173X
    Language: English
    Keywords: Alzheimerkrankheit ; Arzneimittelentwicklung
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 3
    UID:
    edoccha_9958145694302883
    Format: 1 online resource (xx, 656 pages) : , illustrations (some color)
    ISBN: 0-12-802164-0 , 0-12-802173-X
    Series Statement: Gale eBooks
    Content: Provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems.
    Note: 1. The complex pathways to mechanism-based therapeutics in Alzheimer's disease -- 2. The genetic basis of Alzheimer's disease -- 3. [beta]-secretase inhibition -- 4. [gamma]-secretase inhibitors : from chemical probes to drug development -- 5. Therapeutic targeting of A[beta]42 -- 6. Modulators of amyloid [beta]-Protein (A[beta]) self-assembly -- 7. Anti-amyloid-[beta] immunotherapy for Alzheimer's disease -- 8. Targeting A[beta] receptors to modify Alzheimer's disease progression -- 9. Blood-brain barrier transport of Alzheimer's amyloid [beta]-peptide -- 10. Alzheimer's disease therapeutics targeting apolipoprotein E -- 11. Microtubule stabilization -- 12. Tau phosphorylation as a therapeutic target in Alzheimer's disease -- 13. Stimulation of tau degradation -- 14. Passive immunotherapy for tau pathology -- 15. Inhibition of tau aggregation as a basis for treatment and prevention of Alzheimer's disease -- 16. Neuroprotective strategies for Alzheimer's disease prevention and therapy -- 17. Symptomatic cognitive enhancing agents -- 18. Tackling Alzheimer's disease by targeting oxidative stress and mitochondria -- 19. Clinical issues in Alzheimer drug development -- 20. Molecular imaging in Alzheimer clinical trials -- 21. Fluid biomarkers and diagnostics -- 22. Nonpharmacologic activity interventions to prevent Alzheimer's disease -- 23. Prospects and challenges for Alzheimer therapeutics.
    Language: English
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  • 4
    UID:
    edocfu_9958145694302883
    Format: 1 online resource (xx, 656 pages) : , illustrations (some color)
    ISBN: 0-12-802164-0 , 0-12-802173-X
    Series Statement: Gale eBooks
    Content: Provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer's disease, along with the major hurdles that still must be overcome and potential solutions to these problems.
    Note: 1. The complex pathways to mechanism-based therapeutics in Alzheimer's disease -- 2. The genetic basis of Alzheimer's disease -- 3. [beta]-secretase inhibition -- 4. [gamma]-secretase inhibitors : from chemical probes to drug development -- 5. Therapeutic targeting of A[beta]42 -- 6. Modulators of amyloid [beta]-Protein (A[beta]) self-assembly -- 7. Anti-amyloid-[beta] immunotherapy for Alzheimer's disease -- 8. Targeting A[beta] receptors to modify Alzheimer's disease progression -- 9. Blood-brain barrier transport of Alzheimer's amyloid [beta]-peptide -- 10. Alzheimer's disease therapeutics targeting apolipoprotein E -- 11. Microtubule stabilization -- 12. Tau phosphorylation as a therapeutic target in Alzheimer's disease -- 13. Stimulation of tau degradation -- 14. Passive immunotherapy for tau pathology -- 15. Inhibition of tau aggregation as a basis for treatment and prevention of Alzheimer's disease -- 16. Neuroprotective strategies for Alzheimer's disease prevention and therapy -- 17. Symptomatic cognitive enhancing agents -- 18. Tackling Alzheimer's disease by targeting oxidative stress and mitochondria -- 19. Clinical issues in Alzheimer drug development -- 20. Molecular imaging in Alzheimer clinical trials -- 21. Fluid biomarkers and diagnostics -- 22. Nonpharmacologic activity interventions to prevent Alzheimer's disease -- 23. Prospects and challenges for Alzheimer therapeutics.
    Language: English
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  • 5
    Online Resource
    Online Resource
    Amsterdam :Academic Press,
    UID:
    edocfu_BV045381815
    Format: 1 Online-Ressource (xx, 656 Seiten).
    ISBN: 0-12-802164-0 , 978-0-12-802164-4
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-12-802173-6
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 012802173X
    Language: English
    Keywords: Alzheimerkrankheit ; Arzneimittelentwicklung
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 6
    Book
    Book
    Amsterdam :Academic Press, an imprint of Elsevier,
    UID:
    almahu_BV045133386
    Format: xiv, 545 Seiten : , Illustrationen ; , 24 cm.
    ISBN: 978-0-12-811304-2
    Language: English
    Subjects: Medicine
    RVK:
    RVK:
    Keywords: Nervendegeneration ; Molekularbiologie ; Molekularpathologie ; Aufsatzsammlung
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  • 7
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    b3kat_BV044334280
    Format: 1 Online-Ressource (VII, 202 p. 90 illus., 33 illus. in color)
    ISBN: 9783319594606
    Series Statement: Topics in Medicinal Chemistry 24
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-59459-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 8
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edocfu_BV044334280
    Format: 1 Online-Ressource (VII, 202 p. 90 illus., 33 illus. in color).
    ISBN: 978-3-319-59460-6
    Series Statement: Topics in Medicinal Chemistry 24
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-59459-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 9
    Online Resource
    Online Resource
    Cham :Springer International Publishing,
    UID:
    edoccha_BV044334280
    Format: 1 Online-Ressource (VII, 202 p. 90 illus., 33 illus. in color).
    ISBN: 978-3-319-59460-6
    Series Statement: Topics in Medicinal Chemistry 24
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-59459-0
    Language: English
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 10
    UID:
    edocfu_9961089681702883
    Format: 1 online resource (561 pages)
    ISBN: 0-12-811305-7 , 0-12-811304-9
    Content: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field.
    Note: Solving the puzzle of neurodegeneration / Michael S. Wolfe -- Prion diseases / Robert C.C. Mercer, Alex J. McDonald, Erin Bove-Fenderson, Cheng Fang, Bei Wu and David A. Harris -- Alzheimer's Disease: toward a quantitative biological approach in describing its natural history and underlying mechanisms / Colin L. Masters, Ben Gu, Simon Laws, Yen Y Lim, Blaine Roberts, Victor L. Villemagne and Konrad Beyreuther -- , Neurodegeneration and the ordered assembly of tau / Michel Goedert -- Amyotrophic lateral sclerosis and other TDP-43 proteinopathies / Jorge Gomez-Deza and Christopher E. Shaw -- Parkinson's disease and other synucleinopathies / Mark R. Cookson -- Huntington's disease and other polyglutamine repeat diseases: molecular mechanisms and pathogenic pathways / Audrey S. Dickey and Albert R. La Spada -- , Prion-like propagation in neurogenerative diseases / Wouter Peelaerts, Veerle Baekelandt and Patrik Brundin -- Neurodegenerative diseases as protein folding disorders / Jermey D. Baker, Jack M. Webster, Lindsey B. Shelton, John Koren, III, Vladimir N. Uversky, Laura J. Blair and Chad A. Dickey -- Heat shock proteins and protein quality control in Alzheimer's disease / Fred W. Van Leeuwen and Harm H. Kampinga -- Neurodegenerative diseases and autophagy / Angeleen Fleming, Mariella Vicinanza, Maurizio Renna, Claudia Puri, Thomas Ricketts, Jens Füllgrabe, Ana Lopez, Sarah M. De Jager, Avraham Ashkenazi, Mariana Pavel, Floriana Licitra, Andrea Caricasole, Stephen P. Andrews, John Skidmore and David C. Rubinsztein -- Neurodegenerative Diseases and axonal transport / Lawrence S. Goldstein and Utpal Das -- Mitochondrial function and neurodegenerative diseases / Heather M. Wilkins, Ian Weidling, Scott Koppel, Xiaowan Wang, Alex Von Schulze and Russell H. Swerdlow -- , Non-cell autonomous degeneration: role of astrocytes in neurodegenerative diseases / Sarah E. Smith and Azad Bonni -- Neurodegenerative diseases and RNA-mediated toxicity / Tiffany W. Todd and Leonard Petrucelli -- Neuroinflammation in are-related neurodegenerative diseases / Kathryn P. MacPherson, Maria E. De Sousa Rodrigues, Amarallys F. Cintron and Malú G. Tansey -- Neurodegenerative diseases and the aging brain / Stephen K. Godin, Jinsoo Seo and Li-Huei Tsai -- Index.
    Language: English
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