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  • 1
    In: Brain, 2017, Vol. 140(3), pp.e17-e17
    Keywords: Medicine;
    ISSN: 0006-8950
    E-ISSN: 1460-2156
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  • 2
    Article
    Article
    Language: English
    In: European Journal of Cancer, June 2018, Vol.96, pp.1-5
    Description: Neuro-oncology has evolved as a growing, but still small, highly specialised and multidisciplinary field at the interface of several diagnostic and therapeutic disciplines. The major challenge in the field of primary tumours is to translate the almost unique progress in deciphering the highly complex molecular genetic nature of many primary brain tumours, notably glioblastoma, into advances that allow for clinical benefit for affected patients. Furthermore, metastases to the central nervous system are an increasingly prevalent complication in many systemic cancers. Their diagnosis and management require major expertise, notably with consideration of several new systemic therapy options, such as targeted therapy and immuno-oncology approaches. These new treatments contribute to challenges within the third major domain of neuro-oncology, the diagnosis, treatment and prevention of nervous system toxicity of old and new anti-cancer treatments. All these considerations strongly argue for the development of specialised centres of excellence to improve care for patients with brain tumour across Europe.
    Keywords: Brain ; Future ; Nervous ; System ; Tumour ; Medicine
    ISSN: 0959-8049
    E-ISSN: 1879-0852
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  • 3
    Language: English
    In: Archives of neurology, 01 July 2012, Vol.69(7), pp.937
    Keywords: Medicine;
    ISSN: 00039942
    E-ISSN: 1538-3687
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  • 4
    In: Brain, 2010, Vol. 133(4), pp.955-956
    Keywords: Angiogenesis Inhibitors–Administration & Dosage ; Animals–Trends ; Drug Delivery Systems–Blood Supply ; Glioblastoma–Drug Therapy ; Humans–Metabolism ; Neovascularization, Pathologic–Drug Therapy ; Neovascularization, Pathologic–Metabolism ; Abridged ; Angiogenesis Inhibitors;
    ISSN: 0006-8950
    E-ISSN: 1460-2156
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  • 5
    In: Brain, 2015, Vol. 138(12), pp.3468-3470
    Description: This scientific commentary refers to ‘c-Myc–miR-29c–REV3L signalling pathway drives the acquisition of temozolomide resistance in glioblastoma’ by Luo et al. (doi: 10.1093/brain/awv287 )
    Keywords: Medicine;
    ISSN: 0006-8950
    E-ISSN: 1460-2156
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  • 6
    In: Cancer, 01 December 2016, Vol.122(23), pp.3740-3741
    Keywords: Medicine;
    ISSN: 0008-543X
    E-ISSN: 1097-0142
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  • 7
    Language: English
    In: Tetrahedron Letters, 2010, Vol.51(37), pp.4823-4826
    Description: Ialibinones A and B were prepared in four steps from phloroglucinol by acylation under Friedel–Crafts conditions, double prenylation and dearomatising methylation, followed by oxidative free radical cyclisation using manganese(III) acetate. The tricyclic natural products ialibinone A and ialibinone B were prepared as a 41:59 mixture in four steps starting from phloroglucinol. The synthetic sequence involved (i) acylation of phloroglucinol under Friedel–Crafts conditions, (ii) double prenylation using phase-transfer methodology, (iii) dearomatising methylation, and (iv) oxidative free radical cyclisation using manganese(III) acetate.
    Keywords: Acylphloroglucinol ; Dearomatisation ; Free Radical Cyclisation ; Electron-Rich Aromatics ; Total Synthesis ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 8
    Language: English
    In: Analytical and Bioanalytical Chemistry, Sept, 2011, Vol.401(4), p.1203(7)
    Description: Byline: Gunnar Schwarz (1), Sebastian Beck (1), Michael G. Weller (2), Michael W. Linscheid (1) Keywords: Quantitative proteomics; Mass spectrometry; Metal labeling; Stable isotope labeling; Lanthanide DOTA Abstract: Besides protein identification via mass spectrometric methods, protein and peptide quantification has become more and more important in order to tackle biological questions. Methods like differential gel electrophoresis or enzyme-linked immunosorbent assays have been used to assess protein concentrations, while stable isotope labeling methods are also well established in quantitative proteomics. Recently, we developed metal-coded affinity tagging (MeCAT) as an alternative for accurate and sensitive quantification of peptides and proteins. In addition to absolute quantification via inductively coupled plasma mass spectrometry, MeCAT also enables sequence analysis via electrospray ionization tandem mass spectrometry. In the current study, we developed a new labeling approach utilizing an iodoacetamide MeCAT reagent (MeCAT-IA). The MeCAT-IA approach shows distinct advantages over the previously used MeCAT with maleinimide reactivity such as higher labeling efficiency and the lack of diastereomer formation during labeling. Here, we present a careful characterization of this new method focusing on the labeling process, which yields complete tagging with an excess of reagent of 1.6 to 1, less complex chromatographic behavior, and fragmentation characteristics of the tagged peptides using the iodoacetamide MeCAT reagent. Author Affiliation: (1) Department of Chemistry, Humboldt-Universitaet zu Berlin, Brook-Taylor Str. 2, 12489, Berlin, Germany (2) BAM Federal Institute for Materials Research and Testing, Richard-Willstatter-Str. 11, 12489, Berlin, Germany (3) Applied Analytical and Environmental Chemistry, Department of Chemistry, Humboldt-Universitaet zu Berlin, Brook-Taylor-Str. 2, 12489, Berlin, Germany Article History: Registration Date: 15/06/2011 Received Date: 21/12/2010 Accepted Date: 14/06/2011 Online Date: 30/06/2011 Article note: Electronic supplementary material The online version of this article (doi: 10.1007/s00216-011-5189-7) contains supplementary material, which is available to authorized users.
    Keywords: Chromatography -- Analysis ; Rare Earth Metals -- Analysis ; Proteins -- Analysis ; Mass Spectrometry -- Analysis ; Rare Earth Metal Compounds -- Analysis ; Reagents -- Analysis ; Green Technology -- Analysis ; Ionization -- Analysis
    ISSN: 1618-2642
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Journal of Neuro-Oncology, 2011, Vol.104(2), pp.613-614
    Description: Byline: Michael Weller (1), Wolfgang Wick (2) Author Affiliation: (1) Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091, Zurich, Switzerland (2) Department of Neuro-Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany Article History: Registration Date: 13/12/2010 Received Date: 16/10/2010 Accepted Date: 13/12/2010 Online Date: 25/12/2010
    Keywords: Medicine;
    ISSN: 0167-594X
    E-ISSN: 1573-7373
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  • 10
    Language: English
    In: Lancet Oncology, September 2012, Vol.13(9), pp.e375-e382
    Description: The lifetime risk of having epileptic seizures is profoundly increased in patients with cancer: about 20% of all patients with systemic cancer may develop brain metastases. These patients and those with primary brain tumours have a lifetime risk of epilepsy of 20–80%. Moreover, exposure to chemotherapy or radiotherapy to the brain, cancer-related metabolic disturbances, stroke, and infection can provoke seizures. The management of epilepsy in patients with cancer includes diagnosis and treatment of the underlying cerebral pathological changes, secondary prophylaxis with antiepileptic drugs, and limiting of the effect of epilepsy and its treatment on the efficacy and tolerability of anticancer treatments, cognitive function, and quality of life. Because of the concern of drug–drug interactions, the pharmacological approach to epilepsy requires a multidisciplinary approach, specifically in a setting of rapidly increasing choices of agents both to treat cancer and cancer-associated epilepsy.
    Keywords: Medicine
    ISSN: 1470-2045
    E-ISSN: 1474-5488
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