Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Language
Year
  • 1
    Language: English
    In: Emerging infectious diseases, June 2011, Vol.17(6), pp.1083-5
    Description: To estimate failure rates after treatment with benzathine penicillin and to identify determinants of failure that affected outcomes for yaws, we conducted a cohort study of 138 patients; treatment failed in 24 (17.4%). Having low initial titers on Venereal Disease Research Laboratory test and living in a village where yaws baseline incidence was high were associated with increased likelihood of treatment failure.
    Keywords: Anti-Bacterial Agents -- Therapeutic Use ; Penicillin G Benzathine -- Therapeutic Use ; Yaws -- Diagnosis
    ISSN: 10806040
    E-ISSN: 1080-6059
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Article
    Article
    Language: English
    In: The Lancet, 02 March 2013, Vol.381(9868), pp.763-773
    Description: Yaws is an infectious disease caused by —a bacterium that closely resembles the causative agent of syphilis—and is spread by skin-to-skin contact in humid tropical regions. Yaws causes disfiguring, and sometimes painful lesions of the skin and bones. As with syphilis, clinical manifestations can be divided into three stages; however, unlike syphilis, mother-to-child transmission does not occur. A major campaign to eradicate yaws in the 1950s and 1960s, by mass treatment of affected communities with longacting, injectable penicillin, reduced the number of cases by 95% worldwide, but yaws has reappeared in recent years in Africa, Asia, and the western Pacific. In 2012, one oral dose of azithromycin was shown to be as effective as intramuscular penicillin in the treatment of the disease, and WHO launched a new initiative to eradicate yaws by 2020.
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: The Lancet, 28 January 2012, Vol.379(9813), pp.342-347
    Description: Yaws—an endemic treponematosis and, as such, a neglected tropical disease—is re-emerging in children in rural, tropical areas. Oral azithromycin is effective for syphilis. We assessed the efficacy of azithromycin compared with intramuscular long-acting penicillin to treat patients with yaws. We did an open-label, non-inferiority, randomised trial at Lihir Medical Centre, Papua New Guinea, between Sept 1, 2010, and Feb 1, 2011. Children aged 6 months to 15 years with a serologically confirmed diagnosis of yaws were randomly allocated, by a computer-generated randomisation sequence, to receive either one 30 mg/kg oral dose of azithromycin or an intramuscular injection of 50 000 units per kg benzathine benzylpenicillin. Investigators were masked to group assignment. The primary endpoint was treatment efficacy, with cure rate defined serologically as a decrease in rapid plasma reagin titre of at least two dilutions by 6 months after treatment, and, in participants with primary ulcers, also by epithelialisation of lesions within 2 weeks. Non-inferiority was shown if the upper limit of the two-sided 95% CI for the difference in rates was lower than 10%. The primary analysis was per protocol. This trial is registered with , number . We allocated 124 patients to the azithromycin group and 126 to the benzathine benzylpenicillin group. In the per-protocol analysis, after 6 months of follow-up, 106 (96%) of 110 patients in the azithromycin group were cured, compared with 105 (93%) of 113 in the benzathine benzylpenicillin group (treatment difference −3·4%; 95% CI −9·3 to 2·4), thus meeting prespecified criteria for non-inferiority. The number of drug-related adverse events (all mild or moderate) was similar in both treatment groups (ten [8%] in the azithromycin group eight [7%] in the benzathine benzylpenicillin group). A single oral dose of azithromycin is non-inferior to benzathine benzylpenicillin and avoids the need for injection equipment and medically trained personnel. A change to the simpler azithromycin treatment regimen could enable yaws elimination through mass drug administration programmes. International SOS and Newcrest Mining.
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Clinical Infectious Diseases, 15 March 2011, Vol.52(6), pp.771-774
    Description: We describe the clinical and radiological manifestations and outcome after treatment of 7 children who received a diagnosis of early yaws osteoperiostitis. Osteoperiostitis occurred some weeks after the primary infection, and the most common finding was hypertrophic periostitis of long bones. All treated patients had excellent responses to benzyl-penicillin therapy.
    Keywords: Biological sciences -- Biology -- Anatomy ; Health sciences -- Medical conditions -- Physical trauma ; Health sciences -- Medical specialties -- Allied health ; Health sciences -- Medical conditions -- Infections ; Health sciences -- Medical conditions -- Diseases ; Biological sciences -- Biology -- Anatomy ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical conditions -- Symptoms ; Health sciences -- Medical conditions -- Symptoms ; Biological sciences -- Biology -- Anatomy
    ISSN: 10584838
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Clinical Infectious Diseases, 1 August 2012, Vol.55(3), pp.406-412
    Keywords: Health sciences -- Medical conditions -- Infections ; Health sciences -- Medical sciences -- Pharmaceutics ; Social sciences -- Population studies -- Human populations ; Health sciences -- Medical conditions -- Infections ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Health and wellness -- Public health ; Health sciences -- Medical sciences -- Pharmacology ; Health sciences -- Medical conditions -- Diseases ; Health sciences -- Medical conditions -- Infections
    ISSN: 10584838
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: 2013, Vol.7(10), p.e2283
    Description: Improved understanding of the differential diagnosis of endemic treponematoses is needed to inform clinical practice and to ensure the best outcome for a new global initiative for the eradication of yaws, bejel, and pinta. Traditionally, the human treponematoses have been differentiated based upon their clinical manifestations and epidemiologic characteristics because the etiologic agents are indistinguishable in the laboratory. Serological tests are still considered standard laboratory methods for the diagnosis of endemic treponematoses and new rapid point-of-care treponemal tests have become available which are extremely useful in low-resource settings. In the past ten years, there has been an increasing effort to apply polymerase chain reaction to treponematoses and whole genome fingerprinting techniques have identified genetic signatures that can differentiate the existing treponemal strains; however, definitive diagnosis is also hampered by widespread unavailability of molecular diagnostics. We review the dilemmas in the diagnosis of endemic treponematoses, and advances in the discovery of new diagnostic tools.
    Keywords: Review
    ISSN: 19352727
    E-ISSN: 1935-2735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Expert Review of Anti-infective Therapy, Oct, 2013, Vol.11(10), p.1115(7)
    Description: Yaws, a chronic and debilitating infectious disease caused by Treponema pallidum subsp. pertenue, and closely related to syphilis, although transmitted by skin-to-skin contact, remains an important public health challenge, causing a significant burden of morbidity in children in certain areas of the Pacific and Africa. Recent advances in its diagnosis and treatment have led to an enthusiastic upsurge of activities related to its control, and exciting perspectives of global eradication. Although possibly considered among the most neglected of all neglected diseases during decades, there seems to be now agreement that massive drug administration of the antibiotic azithromycin, coupled with adequate surveillance of foci of transmission could result in its eradication. In this review, we summarize current knowledge regarding the therapeutics of yaws and its diagnosis.
    Keywords: Azithromycin -- Dosage And Administration ; Azithromycin -- Research ; Yaws -- Drug Therapy ; Yaws -- Risk Factors ; Yaws -- Diagnosis ; Yaws -- Research
    ISSN: 1478-7210
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Sexually Transmitted Infections, 09/2015, Vol.91(Suppl 2), pp.A10.1-A10
    Description: Skin infections with ulceration are a major health problem in the South Pacific countries. Yaws, diagnosed by the presence of cutaneous ulcers (CU) and a reactive syphilis serology, is one important cause, but this can be confused clinically with ulcers due to other aetiologies. In a prospective cohort study in yaws-endemic villages of a Papua New Guinean (PNG) island we showed that Haemophilus ducreyi is the leading cause of chronic CU in children; nearly 60% of patients with ulcers had detectable lesional H. ducreyi DNA, while 35% were Treponema pallidum subsp. pertenue positive. Similar findings were reported from yaws endemic communities in the Solomon Islands, Vanuatu and Ghana. Unlike yaws, H. ducreyi lesions appear to be restricted to the skin and, if left untreated, do not result in inflammatory lesions of the bones. Whole-genome sequencing studies have shown that CU strains of H. ducreyi are remarkably similar to class I genital ulcer (GU) strains with an overall sequence similarity of 99.98%, and that CU strains diverged from class I strains ≈0.18mya which supports the idea that CU with H. ducreyi preceded syndromic management of GU. A single oral dose of azithromcycin (AZ, 30 mg/Kg) is effective for treatment of yaws and, cutaneous strains of H. ducreyi have been shown to be susceptible to macrolides. In the context of new efforts to eradicate yaws, the use of mass treatment with azithromycin in PNG reduced the absolute prevalence of yaws CU from 2.4 to 0.3 percent at 12 months after treatment, and H. ducreyi CU from 2.7% to 0.6%. The persistence of skin ulcers in the population raises the possibility that the bacteria may exist in an environmental reservoir or are so infectious that MDA at less than 100% above coverage rate fails to eradicate the diseases from a community.
    Keywords: Medicine;
    ISSN: 1368-4973
    E-ISSN: 1472-3263
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: PLoS Neglected Tropical Diseases, 2011, Vol.5(8), p.e1286
    Description: Annual mass drug administration (MDA) over five years is the WHO's recommended strategy to eliminate lymphatic filariasis (LF). Some experts, however, consider that longer periods of treatment might be necessary in certain high prevalence and transmission environments based upon past unsuccessful field experience and modelling. ; To evaluate predictors of success in a LF control program we conducted an ecological study during a pre-existing MDA program. We studied 27 villages in Lihir Island, Papua New Guinea, from two areas with different infection rates before MDA. We undertook surveys to collect information on variables potentially having an influence on the outcome of the program, including epidemiological (baseline prevalence of infection, immigration rate), entomological (vector density) and operational (treatment coverage, vector control strategies) variables. The success in a village was defined using variables related to the infection (circulating filarial antigenemia prevalence 〈1%) and transmission (antigenemia prevalence 〈1 in 1000 children born since start of MDA). 8709 people were involved in the MDA program and average coverage rates were around 70%. The overall prevalence of filariasis fell from an initial 17.91% to 3.76% at round 5 (p〈0.001). Viewed on a village by village basis, 12/27 (44%) villages achieved success. In multivariate analysis, low baseline prevalence was the only factor predicting both success in reducing infection rates (OR 19,26; CI 95% 1,12 to 331,82) and success in preventing new infections (OR 27,44; CI 95% 1,05 to 719,6). Low vector density and the use of an optimal vector control strategy were also associated with success in reducing infection rates, but this did not reach statistical significance. ; Our results provide the data that supports the recommendation that high endemic areas may require longer duration MDA programs, or alternative control strategies. ; Large-scale intervention programmes to control filariasis are currently underway worldwide. However, a major unresolved question remains: what is the appropriate duration for these programmes? Recent theoretical work and clinical field experience has highlighted how the ecological diversity between different endemic regions hinders decision making processes of when to stop ongoing MDA programs. The goal of our study was to identify the factors determining success for a five year LF elimination program. We undertook different types of surveys together with a pre-existing MDA program in villages from two regions that had different infection prevalence rates. Our study shows that the five yearly cycles of MDA could neither eliminate the disease nor stop transmission in the high prevalence villages, such that low baseline lymphatic filariasis prevalence has a positive influence on the outcome of a program. Thus, the study provides data supporting the recommendation that in certain high prevalence and transmission environments more sustained efforts may be necessary.
    Keywords: Research Article ; Medicine ; Infectious Diseases
    ISSN: 19352727
    E-ISSN: 1935-2735
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: The Lancet, 21 April 2018, Vol.391(10130), pp.1599-1607
    Description: Yaws is a substantial cause of chronic disfiguring ulcers in children in at least 14 countries in the tropics. WHO's newly adopted strategy for yaws eradication uses a single round of mass azithromycin treatment followed by targeted treatment programmes, and data from pilot studies have shown a short-term significant reduction of yaws. We assessed the long-term efficacy of the WHO strategy for yaws eradication. Between April 15, 2013, and Oct 24, 2016, we did a longitudinal study on a Papua New Guinea island (Lihir; 16 092 population) in which yaws was endemic. In the initial study, the participants were followed for 12 months; in this extended follow-up study, clinical, serological, and PCR surveys were continued every 6 months for 42 months. We used genotyping and travel history to identify importation events. Active yaws confirmed by PCR specific for was the primary outcome indicator. The study is registered with , number . Mass azithromycin treatment (coverage rate of 84%) followed by targeted treatment programmes reduced the prevalence of active yaws from 1·8% to a minimum of 0·1% at 18 months (difference from baseline −1·7%, 95% CI, −1·9 to −1·4; p〈0·0001), but the infection began to re-emerge after 24 months with a significant increase to 0·4% at 42 months (difference from 18 months 0·3%, 95% CI 0·1 to 0·4; p〈0·0001). At each timepoint after baseline, more than 70% of the total community burden of yaws was found in individuals who had not had the mass treatment or as new infections in non-travelling residents. At months 36 and 42, five cases of active yaws, all from the same village, showed clinical failure following azithromycin treatment, with PCR-detected mutations in the 23S ribosomal RNA genes conferring resistance to azithromycin. A sustained decrease in the prevalence of high-titre latent yaws from 13·7% to 〈1·5% in asymptomatic children aged 1–5 years old and of genetic diversity of yaws strains from 0·139 to less than 0·046 between months 24 and 42 indicated a reduction in transmission of infection. The implementation of the WHO strategy did not, in the long-term, achieve elimination in a high-endemic community mainly due to the individuals who were absent at the time of mass treatment in whom yaws reactivated; repeated mass treatment might be necessary to eliminate yaws. To our knowledge, this is the first report of the emergence of azithromycin-resistant and spread within one village. Communities' surveillance should be strengthened to detect any possible treatment failure and biological markers of resistance. ISDIN laboratories, Newcrest Mining Limited, and US Public Health Service National Institutes of Health.
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages