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  • 1
    Language: English
    In: Automatica, 2015, Vol.59, p.48(6)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.automatica.2015.06.006 Byline: Mohammad Fuad Mohammad Naser, Faycal Ikhouane Abstract: The LuGre friction model is used in the current literature to describe the friction phenomenon for mechanical systems. In this paper, we focus on the hysteresis behaviour of the model. More precisely, we describe analytically the hysteresis loop of the model through the concepts of consistency and strong consistency. The description is illustrated by numerical simulations. Article History: Received 16 May 2014; Revised 4 February 2015; Accepted 21 May 2015 Article Note: (footnote) [star] Supported by grant DPI2011-25822 of the Spanish Ministry of Economy and Competitiveness and by FI-DGR-grant IUE/2365/2009 of the Agency for Management of University and Research Grants (AGAUR). The material in this paper was not presented at any conference. This paper was recommended for publication in revised form by Associate Editor Alessandro Astolfi under the direction of Editor Andrew R. Teel.
    ISSN: 0005-1098
    Source: Cengage Learning, Inc.
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  • 2
    Language: English
    In: Journal of Crystal Growth, June 15, 2013, Vol.373, p.20(12)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jcrysgro.2012.11.048 Byline: Mohammad Fuad Aljishi (a), An-Cheng Ruo (b), Jay Hoon Park (a), Bader Nasser (a), Woo-Sik Kim (b), Yong Lak Joo (a) Keywords: A1 Fluid flows; A1 Crystal morphology; A2 Industrial crystallization; B1 Barium compounds; B1 Nanomaterials Abstract: The effect of the vortex flow by primary instability on the precipitation of barium sulfate crystals was examined in Taylor-Couette crystallizers. Experiments involving precipitation of barium sulfate under laminar flow (before the onset of instability) and vortex flow (after the onset of primary instability) at three different axial flow rates revealed that the vortex motion plays a critical role in fine-tuning crystal properties such as internal crystal structure, particle microstructure and morphology. While no clear trends in crystalline size were observed for laminar flow, all flowrates at the onset of instability resulted in smaller crystalline sizes that ranged between 40nm and 50nm. A decrease in the unit cell dimensions of the orthorhombic lattice structure was also observed after the onset of instability. For both laminar and vortex flow, shortening the residence time by increasing axial flow rate led to a substantial decrease in crystal size. It is also observed that the crystal size distribution (CSD) became much narrower after the emergence of vortices. Under vortex flow, an increase in axial flow resulted in even narrower crystal size distributions. Finally, the observed phenomena of smaller crystal size and narrow crystal size distribution under vortex flow are qualitatively explained by the analysis of particle trajetory. Author Affiliation: (a) Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA (b) Chemical Engineering, Kyung Hee University, Yongin Kiheung Seochun 1, Kyungki-do 449-701, Republic of Korea
    Keywords: Flow (Dynamics) -- Analysis ; Nanotechnology -- Analysis ; Crystal Structure -- Analysis ; Rain -- Analysis ; Barium Sulfate -- Analysis ; Barium -- Analysis
    ISSN: 0022-0248
    Source: Cengage Learning, Inc.
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  • 3
    In: Applied Mathematical Sciences, 2017, Vol.11, pp.887-895
    Keywords: Mathematics;
    ISSN: Applied Mathematical Sciences
    E-ISSN: 13147552
    Source: CrossRef
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  • 4
    Language: English
    In: The Journal of biological chemistry, 20 June 2014, Vol.289(25), pp.17350-64
    Description: Alternative splicing of the oncogene MDM2 is a phenomenon that occurs in cells in response to genotoxic stress and is also a hallmark of several cancer types with important implications in carcinogenesis. However, the mechanisms regulating this splicing event remain unclear. Previously, we uncovered the importance of intron 11 in MDM2 that affects the splicing of a damage-responsive MDM2 minigene. Here, we have identified discrete cis regulatory elements within intron 11 and report the binding of FUBP1 (Far Upstream element-Binding Protein 1) to these elements and the role it plays in MDM2 splicing. Best known for its oncogenic role as a transcription factor in the context of c-MYC, FUBP1 was recently described as a splicing regulator with splicing repressive functions. In the case of MDM2, we describe FUBP1 as a positive splicing regulatory factor. We observed that blocking the function of FUBP1 in in vitro splicing reactions caused a decrease in splicing efficiency of the introns of the MDM2 minigene. Moreover, knockdown of FUBP1 in cells induced the formation of MDM2-ALT1, a stress-induced splice variant of MDM2, even under normal conditions. These results indicate that FUBP1 is also a strong positive splicing regulator that facilitates efficient splicing of the MDM2 pre-mRNA by binding its introns. These findings are the first report describing the regulation of alternative splicing of MDM2 mediated by the oncogenic factor FUBP1.
    Keywords: Cancer ; Mdm2 ; Oncogene ; RNA ; RNA Splicing ; RNA-Protein Interaction ; RNA-Binding Protein ; P53 ; Alternative Splicing -- Physiology ; DNA Helicases -- Metabolism ; DNA-Binding Proteins -- Biosynthesis ; Introns -- Physiology ; Nuclear Proteins -- Biosynthesis ; RNA Precursors -- Metabolism ; Transcription Factors -- Biosynthesis
    E-ISSN: 1083-351X
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  • 5
    Language: English
    In: Nucleic acids research, 01 February 2013, Vol.41(3), pp.1885-94
    Description: The additional G(-1) nucleotide on tRNA(His) is a nearly universal feature that specifies tRNA(His) identity in all three domains of life. In eukaryotes, the G(-1) identity element is obtained by a post-transcriptional pathway, through the unusual 3'-5' polymerase activity of the highly conserved tRNA(His) guanylyltransferase (Thg1) enzyme, and no examples of eukaryotic histidyl-tRNAs that lack this essential element have been identified. Here we report that the eukaryote Acanthamoeba castellanii lacks the G(-1) identity element on its tRNA(His), consistent with the lack of a gene encoding a bona fide Thg1 ortholog in the A. castellanii genome. Moreover, the cytosolic histidyl-tRNA synthetase in A. castellanii exhibits an unusual tRNA substrate specificity, efficiently aminoacylating tRNA(His) regardless of the presence of G(-1). A. castellanii does contain two Thg1-related genes (encoding Thg1-like proteins, TLPs), but the biochemical properties we associate here with these proteins are consistent with a function for these TLPs in separate pathways unrelated to tRNA(His) metabolism, such as mitochondrial tRNA repair during 5'-editing.
    Keywords: Acanthamoeba Castellanii -- Genetics ; RNA, Transfer, His -- Chemistry
    ISSN: 03051048
    E-ISSN: 1362-4962
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  • 6
    Language: English
    In: Asia Pacific Journal of Management, 2018, Vol.35(4), pp.919-942
    Description: Merger waves are periods of intense and concentrated merger activity which exhibit a wave-like pattern. Drawing upon the resource-based view, we examine the timing of entry and early-mover advantage within merger waves. Following a robust simulation-based methodology of wave analysis, we identify merger waves in eight industries during the time period 2000–2014. Firms affiliated to business groups were found to be early movers. A higher degree of internationalization is also associated with early movement of a firm. Within business groups, their multi-entity character is positively associated with early entry whereas their board interlock was negatively related with entry-timing. Further, early moving acquirers reap superior post-acquisition performance, thereby suggesting that early-mover advantages exist within merger waves.
    Keywords: Merger and acquisition waves ; Business groups ; Timing ; Resource-based view ; Early-mover advantage
    ISSN: 0217-4561
    E-ISSN: 1572-9958
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  • 7
    Language: English
    In: Journal of Computers, May, 2013, Vol.8(5), p.1127(9)
    Description: A self-healing application brings itself into a stable state after a failure put the software into an unstable state. For such self-healing software application, finding fix for a fault is a grand challenge. Asking the user to provide fixes for every fault is bad for productivity, especially when the users are non-savvy in technical aspect of computing. If failure scenarios come into existence, the user wants the runtime environment to handle those situations autonomically. This paper presents a new technique of finding self-healing actions by matching a fault scenario to already established fault models. By statically analyzing the code and transforming it in a way to allow the program to profile itself, it is possible to capture runtime parameters and execution pathways during runtime. The transformed program then can establish stable execution models that can be used later to match with an unstable execution scenario. Experimentation and results are presented that showed that even with additional overheads; this technique can prove beneficial for autonomically healing faults and reliving system administrators from repeated and routine troubleshooting situations. Index Terms--Self-adaptive application, Autonomic computing, Code transformation, Fault similarity.
    Keywords: Data Processing -- Research ; Fault Location (Engineering) -- Research ; Software Engineering -- Research
    ISSN: 1796-203X
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  • 8
    Language: English
    In: IMA Journal of Mathematical Control and Information, 12/22/2017
    ISSN: 0265-0754
    E-ISSN: 1471-6887
    Source: Oxford University Press (via CrossRef)
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  • 9
    Language: English
    In: Automatica, September 2015, Vol.59, pp.48-53
    Description: The LuGre friction model is used in the current literature to describe the friction phenomenon for mechanical systems. In this paper, we focus on the hysteresis behaviour of the model. More precisely, we describe analytically the hysteresis loop of the model through the concepts of consistency and strong consistency. The description is illustrated by numerical simulations.
    Keywords: Lugre Model ; Hysteresis ; (Strong) Consistency ; Engineering
    ISSN: 0005-1098
    E-ISSN: 1873-2836
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  • 10
    In: Mathematical Problems in Engineering, 2013, Vol.2013, 16 pages
    Description: The Duhem model, widely used in structural, electrical, and mechanical engineering, gives an analytical description of a smooth hysteretic behavior. In practice, the Duhem model is mostly used within the following black-box approach: given a set of experimental input-output data, how to tune the model so that its output matches the experimental data. It may happen that a Duhem model presents a good match with the experimental real data for a specific input but does not necessarily keep significant physical properties which are inherent to the real data, independent of the exciting input. This paper presents a characterization of different classes of Duhem models in terms of their consistency with the hysteresis behavior.
    Keywords: Physical Properties ; Mathematical Models ; Mechanical Engineering ; Hysteresis ; Excitation ; Consistency ; Mathematical Analysis ; Mathematics and Computation (Mt) ; Mathematics and Computation (CE);
    ISSN: 1024-123X
    E-ISSN: 1563-5147
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