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Berlin Brandenburg

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  • 1
    Language: English
    In: Journal of the American Chemical Society, 06 March 2013, Vol.135(9), pp.3303-6
    Description: Stereospecific coupling of benzylic carbamates and pivalates with aryl- and heteroarylboronic esters has been developed. The reaction proceeds with selective inversion or retention at the electrophilic carbon, depending on the nature of the ligand. Tricyclohexylphosphine ligand provides the product with retention, while an N-heterocyclic carbene ligand provides the product with inversion.
    Keywords: Benzyl Compounds -- Chemistry ; Boronic Acids -- Chemistry ; Carbamates -- Chemistry ; Esters -- Chemistry ; Methane -- Chemical Synthesis ; Organometallic Compounds -- Chemistry
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 2
    In: The American Journal of Surgical Pathology, 2017, Vol.41(3), pp.334-342
    Description: Tumor expression of programmed cell death ligand 1 (PD-L1) is associated with immune evasion in a variety of malignancies, including a subset of triple-negative breast carcinomas, and may mark cancers as susceptible to PD-1/PD-L1 inhibitor therapies. We herein characterize PD-L1 expression in breast cancers across the full range of histomorphologies and investigate its intratumoral heterogeneity and fidelity across primaries and metastases. A total of 245 primary and 40 metastatic (20 nodal, 20 distant) breast carcinomas were evaluated with PD-L1 immunohistochemistry on tissue microarray. Tumor PD-L1 staining was seen in 12% of all primaries including 32% of triple-negative cancers. Staining was common in ductal cancers with medullary (54%), apocrine (27%), and metaplastic features (40%). However, diffuse (〉50%) staining was rare (2% of all cancers and 5% of triple negatives). Immune staining was seen in 29% of all primaries and 61% of triple negatives. Tumor expression of PD-L1 was conserved in 94% of matched primary/metastasis pairs, while immune staining showed fidelity in 71%; the remaining cases acquired PD-L1 immune cell expression in the metastasis. Only half of cases with positive tumor staining showed concordance across all analyzed cores. These data demonstrate that PD-L1 expression is prevalent among high-grade, hormone receptor–negative breast cancers with a range of histomorphologies and shows fidelity between primary and metastatic sites in treatment-naive cancers, although acquisition of immune PD-L1 staining in metastases is not uncommon. There is considerable intratumoral heterogeneity in PD-L1 expression, undermining the suitability of core biopsy in the determination of PD-L1 status. Clinical trials are needed to determine PD-L1 staining thresholds required for therapeutic response, as diffuse staining is rare.
    Keywords: B7-H1 Antigen -- Metabolism ; Biomarkers, Tumor -- Metabolism ; Breast Neoplasms -- Metabolism;
    ISSN: 0147-5185
    E-ISSN: 15320979
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  • 3
    Language: English
    In: Journal of the American Chemical Society, 31 August 2011, Vol.133(34), pp.13311-3
    Description: The pyrroloquinoline alkaloid family of natural products, which includes the immunosuppressant lymphostin, has long been postulated to arise from tryptophan. We now report the molecular basis of lymphostin biosynthesis in three marine Salinispora species that maintain conserved biosynthetic gene clusters harboring a hybrid nonribosomal peptide synthetase-polyketide synthase that is central to lymphostin assembly. Through a series of experiments involving gene mutations, stable isotope profiling, and natural product discovery, we report the assembly-line biosynthesis of lymphostin and nine new analogues that exhibit potent mTOR inhibitory activity.
    Keywords: Actinomycetales -- Metabolism ; Alkaloids -- Metabolism ; Enzyme Inhibitors -- Metabolism ; Pyrroles -- Metabolism ; Quinolines -- Metabolism ; Tor Serine-Threonine Kinases -- Antagonists & Inhibitors
    ISSN: 00027863
    E-ISSN: 1520-5126
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  • 4
    Language: English
    In: Medical Reference Services Quarterly, 27 August 2004, Vol.23(3), pp.71-79
    Description: This paper addresses the following questions: What makes the community of practice concept an intriguing framework for developing library services for bioinformatics? What is the campus context and setting? What has been the Health Sciences Library's role in bio-informatics at the University...
    Keywords: Bioinformatics ; Communities of Practice ; Computational Biology ; Library User Education ; Medicine
    ISSN: 0276-3869
    E-ISSN: 1540-9597
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  • 5
    In: College & Research Libraries, 07/01/2004, Vol.65(4), pp.320-333
    Description: This article describes a planning process for the development of bioinformatics education and information services in an academic health sciences library. The project’s five goals were to:(1) understand the changing environment for information related to bioinformatics;(2) understand the information needs of faculty whose work involves bioinformatics; (3) explore potential service offerings; (4) anticipate factors influencing the implementation of new services; and (5) envision strategies for recruiting and training information professionals to fill these roles. The authors describe the library’s practice environment and review recent research on the information needs of biomedical researchers and clinicians. A variety of potential library-based services in relation to bioinformatics are enumerated, and the institutional, environmental, and personnel factors affecting the deployment of services are examined. Finally, the authors describe the educational and training context of the library, and explore potential roles for librarians and information professionals in the context of bioinformatics services.
    Keywords: Library & Information Science;
    ISSN: 0010-0870
    E-ISSN: 2150-6701
    Source: CrossRef
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  • 6
    Language: English
    In: Medical Reference Services Quarterly, 01 March 2002, Vol.21(2), pp.75-79
    Keywords: Medicine
    ISSN: 0276-3869
    E-ISSN: 1540-9597
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  • 7
    Language: English
    In: Medical Reference Services Quarterly, 18 November 2003, Vol.22(4), pp.75-82
    Description: What is the organizational impact of becoming a digital library, as well as a physical entity with facilities and collections? Is the digital library an add-on or an integrated component of the overall library package? Librarians see sweeping environmental and technological changes. The staff...
    Keywords: Knowledge Management ; Integrated Access ; Digital Libraries ; Health Sciences Libraries ; Customized Presentation ; Information Sharing ; Interface Development ; Medicine
    ISSN: 0276-3869
    E-ISSN: 1540-9597
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  • 8
    Language: English
    In: Medical Reference Services Quarterly, 01 December 2000, Vol.19(4), pp.99-103
    Keywords: Medicine
    ISSN: 0276-3869
    E-ISSN: 1540-9597
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  • 9
    Language: English
    In: Journal of Professional Nursing, 2010, Vol.26(6), pp.341-345
    Description: Math proficiency is a prerequisite to the performance of many nursing functions, including medication calculations, but many nursing students have difficulty performing this basic clinical skill. Research has demonstrated that math aptitude alone does not fully explain student outcomes on medication calculation assessments (MCAs), and contextual factors associated with reading and interpreting written medication questions are important for nurse educators to better understand. Reading and English aptitude are proposed as two potential contextual factors that may help explain the nursing student's ability to pass a written MCA. The purpose of this study was to describe the effects of reading and English aptitude on baccalaureate nursing students' ability to pass an MCA taken during the junior year of the nursing curriculum.
    Keywords: Math Proficiency ; Mca ; Nursing Student ; Reading Aptitude ; Nursing
    ISSN: 8755-7223
    E-ISSN: 1532-8481
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  • 10
    Language: English
    In: Medical Reference Services Quarterly, 10 December 2007, Vol.26(4), pp.93-98
    Description: This is the last Informatics Education column under the current editors. The outgoing editors identify six key themes that reflect the changes in informatics education over their seven-year tenure. The themes are picked from the 29 previous...
    Keywords: Informatics Education ; Information Literacy ; Technology ; Medicine
    ISSN: 0276-3869
    E-ISSN: 1540-9597
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