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  • 1
    Language: English
    In: JAMA, 05 September 2017, Vol.318(9), pp.795-796
    Description: The article discusses the decision of International Medical Tribunal in Nuremberg delivered 70 years ago against doctors and bureaucrats accused of war crimes and crimes against humanity for their roles in cruel and often lethal concentration camp medical experiments. The court came up with a 10-point Nuremberg Code, which is followed till date. The need for physicians even 70 years later to pay heed to the code and follow it is highlighted.
    Keywords: Codes of Ethics -- History ; Ethics, Medical -- History
    ISSN: 00987484
    E-ISSN: 1538-3598
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  • 2
    Language: English
    In: Nature, Dec 20, 2012, Vol.492(7429), p.345(3)
    Keywords: Influenza Research – Censorship ; Influenza Research – Ethical Aspects
    ISSN: 0028-0836
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  • 3
    Language: English
    In: Canadian Medical Association Journal, 10/20/2015, Vol.187(15), pp.1163-1164
    Description: Once in New York, J.L. took about ten years to obtain the support to purchase his Beacon Hill Sanitarium in 1935, where he put in place his program of psychodrama therapy - the systematic use of role playing to explore and resolve interpersonal conflicts - and from which he engaged in the energetic and...
    Keywords: Moreno, Jacob Levy (1889-1974) ; Psychotherapy ; Psychiatrists ; Recall;
    ISSN: 0820-3946
    E-ISSN: 1488-2329
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  • 4
    In: Nature Biotechnology, 2017, Vol.35(1), p.20
    Keywords: Medicine ; Engineering ; Biology;
    ISSN: 1087-0156
    E-ISSN: 1546-1696
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  • 5
    Language: English
    In: The Lancet, 2011, Vol.377(9766), pp.621-622
    Description: The National Institutes of Health has taken a position that the informed consent framework seems to demand, by refusing to declare existing lines eligible for funding unless documented consent can be obtained. [...] this consent cannot limit research to a particular disease or condition.8 The complications...
    Keywords: Medicine
    ISSN: 0140-6736
    E-ISSN: 1474-547X
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  • 6
    Language: English
    In: PLoS ONE, 01 January 2016, Vol.11(3), p.e0150761
    Description: Since the first Hodgkin and Huxley ion channel model was described in the 1950s, there has been an explosion in mathematical models to describe ion channel function. As experimental data has become richer, models have concomitantly been improved to better represent ion channel kinetic processes, although these improvements have generally resulted in more model complexity and an increase in the number of parameters necessary to populate the models. Models have also been developed to explicitly model drug interactions with ion channels. Recent models of drug-channel interactions account for the discrete kinetics of drug interaction with distinct ion channel state conformations, as it has become clear that such interactions underlie complex emergent kinetics such as use-dependent block. Here, we describe an approach for developing a model for ion channel drug interactions. The method describes the process of extracting rate constants from experimental electrophysiological function data to use as initial conditions for the model parameters. We then describe implementation of a parameter optimization method to refine the model rate constants describing ion channel drug kinetics. The algorithm takes advantage of readily available parallel computing tools to speed up the optimization. Finally, we describe some potential applications of the platform including the potential for gaining fundamental mechanistic insights into ion channel function and applications to in silico drug screening and development.
    Keywords: Sciences (General)
    E-ISSN: 1932-6203
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  • 7
    Language: English
    In: Foreign Affairs, 2018, Vol.97(3), p.171(6)
    Description: The possibility of rewriting the genome of an organism, or even of an entire species, has long been the stuff of science fiction. But with the development of crispr (which stands for "clustered regularly interspaced short palindromic repeats"), a method for editing dna far more precisely and efficiently than was possible with older technologies, fiction has edged closer to reality. Crispr exploits an ancient system that allows bacteria to acquire immunity from viruses. It uses an enzyme called Cas9 to cut strands of dna at precisely targeted locations, allowing researchers to insert new genetic material into the gap. Crispr promises to revolutionize gene editing, which comprises two distinct but related fields. The first involves a technique to modify inherited genes in nonhuman organisms in order to spread a trait throughout a population, using a process known as a gene drive. The other involves editing the human genome, either in normal body cells (known as somatic cells) or in the germline, the cells that pass genes down to offspring. The advances made possible by crispr could bring vast benefits to society, but the technology also poses risks. An out-ofcontrol gene drive could drastically alter or even threaten a species. And editing the human genome raises risks both for individuals and for society as a whole. To head off those dangers, governments and scientific institutions will have to respond by establishing standards that both enable promising research to go forward and reassure the public that the work is being conducted responsibly. Yet especially when the science is at such an early stage, there is a risk that governments will do too much rather than too little. To avoid that problem, the global scientific and biological ethics communities must take the lead, designing standards and procedures that reduce the dangers of these powerful new technologies without forgoing the benefits.
    Keywords: Genetic Engineering – Ethical Aspects ; Genetic Engineering – Forecasts and Trends ; Genetic Engineering – Methods ; Genetic Engineering – Standards
    ISSN: 0015-7120
    E-ISSN: 23277793
    Source: Cengage Learning, Inc.
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  • 8
    Language: English
    In: Zeitschrift fur Psychodrama und Soziometrie, June, 2014, Vol.13(1), p.55(4)
    Description: Byline: Jonathan D. Moreno (1) Author Affiliation: (1) Department of Medical Ethics and Health Policy, University of Pennsylvania, 19104, Philadelphia, PA, USA Article History: Registration Date: 08/05/2014 Online Date: 22/05/2014
    ISSN: 1619-5507
    Source: Cengage Learning, Inc.
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  • 9
    Article
    Article
    Language: English
    In: Monash Bioethics Review, 2013, Vol.31(2), pp.83-99
    Description: This article is based on a public lecture hosted by the Monash University Centre for Human Bioethics in Melbourne, Australia on 11 April 2013. The lecture recording was transcribed by Vicky Ryan; and, the original transcript has been edited — for clarity and brevity — by Vicky Ryan, Michael Selgelid and Jonathan Moreno.
    ISSN: 1321-2753
    E-ISSN: 1836-6716
    Source: Springer Science & Business Media B.V.
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  • 10
    Language: English
    In: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 14 September 2015
    E-ISSN: 1488-2329
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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