Format:
Online-Ressource (IX, 319 p. 54 illus., 23 illus. in color, digital)
ISBN:
9789400742345
Series Statement:
SpringerLink
Content:
Carl Edward Sagans (1934-1996) one of the famous quotation was "Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people." From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named "Midkine This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.
Note:
Description based upon print version of record
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Midkine: From Embryogenesis to Pathogenesis and Therapy; Preface; Contents; Part I: General Aspects of Midkine; Chapter 1: General Information on Midkine; Introduction; Protein and Gene; MK Signaling; Development and Reproduction; Repair and Inflammation; Cancer; MK and MK Inhibitors as Therapeutics; References; Chapter 2: The Role of Midkine in Neural Development and Patterning; Midkine-Related Growth Factors and Their Function in the Nervous System; The Role of Midkine in Neurogenesis of Vertebrates
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Functional Divergence of Two Duplicated Midkine Genes in Zebra fish Reveals Distinct Roles During Neural DevelopmentMidkine-A Controls Floor Plate Formation in the Developing Spinal Cord of Zebra fish; The Role of Midkine-B in Cell Fate Speci fi cation at the Neural Plate Border; Downstream of Midkine: Anaplastic Lymphoma Kinase (ALK), A Putative Midkine Receptor Mutated in Neuroblastoma; Other Midkine Receptor Candidates in the Nervous System; References; Chapter 3: Midkine: A Player in Innate Immunity; Innate and Adaptive Immunity; AMPs: Effector Molecules of Innate Immunity
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Characteristics of AMPsMechanism of AMPs; Bacterial Resistance to AMPs; MK: A Host Defence Protein?; Influence from Salt; Evolutionary Aspects on the Antibacterial Activity; Interaction with Phagocytes; Roles in Health and Disease?; Conclusions and Perspectives; References; Chapter 4: Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition; Epithelial-Mesenchymal Transition and Cancer; Epithelial-Mesenchymal Transition and Growth Factors; Transcriptional Regulation of Epithelial-Mesenchymal Transition; Midkine/P63 Axis in Epithelial-Mesenchymal Transition; References
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Chapter 5: Immunochemical Methods for the Detection of Midkine in Samples of Human OriginIntroduction; MK-Specific Antibodies; Overview; Polyclonal MK-Specific Antibodies; Monoclonal MK-Specific Antibodies; Immunochemical Applications of MK-Specific Antibodies; Immunohistochemistry and Its Applications; Western Blot Analytics and Its Applications; ELISA and Its Applications; Overview on ELISA Method; Details and Applications of Non-commercial ELISAs; Details and Applications of Commercial ELISAs; Comparative Study for Midkine ELISA Determination; References
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Chapter 6: Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic ReviewIntroduction; Materials and Methods; Literature Search and Selection of Publications; Evaluation of the Quality of the Research; Data Analysis; Results; Interpretative Synthesis of Data; Circulating Midkine in Cancer; Midkine as a Tumor Marker; Midkine in the Blood; Midkine in Inflammatory and Infectious Diseases; Conclusions; References; Part II: Midkine and Inflammation; Chapter 7: Midkine in Inflammation and Inflammatory Diseases; Midkine and Inflammation
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Midkine in Inflammatory and Infectious Diseases
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pt. 1.GENERAL ASPECTS OF MIDKINEGeneral Information on Midkine
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The Role of Midkine in Neural Development and Patterning
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Midkine: A Player in Innate Immunity
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Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition
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Immunochemical Methods for the Detection of Midkine in Samples of Human Origin
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Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review
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pt. 2.MIDKINE AND INFLAMMATIONMidkine in Inflammation and Inflammatory Diseases
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Rheumatoid Arthritis and Midkine
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pt. 3.MIDKINE AND THE CARDIOVASCULAR SYSTEMMidkine and Heart Failure
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Vascular Restenosis and Midkine
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The Potential of MK Through the Renin-Angiotensin System
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pt. 4.MIDKINE AND THE NERVOUS SYSTEMMidkine and Multiple Sclerosis
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Midkine Gene Transfer in Brain Infarction
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Midkine in Psychiatric and Neurodegenerative Diseases
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pt. 5.MIDKINE AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGINGRole of Midkine in Nephrogenesis and Kidney Disease
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Midkine, a Factor Promoting Cytoplasmic Maturation of Oocytes
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Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles
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Stem Cells and Midkine
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Midkine in Skeletal Physiology
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pt. 6.MIDKINE AND CANCERMidkine and Chemoresistance in Cancers
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A Gene Medicine with the Midkine-mediated Transcriptional Regulation as New Cancer Therapeutics
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Midkine as a Tumor-Shared Antigen
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Midkine in Prostate Cancer
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Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma
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Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival
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Colon Cancer and Midkine
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Osteosarcoma and Midkine
Additional Edition:
ISBN 9789400742338
Additional Edition:
Buchausg. u.d.T. ISBN 978-94-007-4233-8
Language:
English
DOI:
10.1007/978-94-007-4234-5
URL:
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