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  • 1
    Online Resource
    Online Resource
    New York, NY :Springer New York :
    UID:
    almahu_9949251668202882
    Format: 1 online resource (XI, 268 p. 72 illus., 57 illus. in color.)
    Edition: 1st ed. 2019.
    ISBN: 1-4939-9004-7
    Series Statement: Methods in Molecular Biology, 1908
    Content: This book provides a practical guide to current methods for profiling and interpreting genomic alterations in tumors. Chapters detail methods to interrogate DNA variation, RNA expression, and epigenetic changes using both next-generation sequencing and microarray techniques, common bioinformatics and annotation tools to glean relevant driver genomic events, and different performance characteristics as well as quality metrics necessary for the robust validation of tumor profiling as a diagnostic test for medical laboratories. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Tumor Profiling: Methods and Protocols aims to be a useful resource for learning about technical details, applications, and strengths and limitations of the latest technologies as applied to this increasingly important field. .
    Note: Amplicon-based Targeted Next Generation Sequencing of Formalin Fixed Paraffin Embedded Tissue -- Library preparation using FFPE-derived Tumor DNA for High Throughput Hybridization-based Targeted or Exome Sequencing -- Bioinformatics Basics for High Throughput Hybridization-based Targeted DNA Sequencing From FFPE-Derived Tumor Specimens: From Reads to Variants -- Annotation of Variant Data from High Throughput DNA Sequencing from Tumor Specimens: Filtering Strategies to Identify Driver Mutations -- Biological Interpretation of Complex Genomic Data -- Clinical Validation of Targeted Solid Tumor Profiling -- Whole Genome Single Nucleotide Polymorphism Microarray for Copy Number and Loss of Heterozygosity Analysis in Tumors -- Genome-Wide Copy Number Variation Detection using NGS: Data Analysis and Interpretation -- Overview of Fusion Detection Strategies Using Next Generation Sequencing -- Clinical Application of Fusion Gene Detection Using Next-generation Sequencing and the NanoString Technology -- Pipeline for Integrated Microarray Expression Normalization Toolkit (PIMENTo) for Tumor Microarray Profiling Experiment -- Molecular Profiling of RNA Tumors using High Throughput RNA Sequencing: Overview of Library Preparation Methods -- Molecular Profiling of RNA Tumors using High Throughput RNA Sequencing: From Raw Data to Systems Level Analyses -- Methylation Analysis using Microarrays: Analysis and Interpretation -- High-Throughput Targeted Repeat Element Bisulfite Sequencing (HT-TREBS) -- A Pipeline for ctDNA Detection Following Primary Tumor Profiling Using A Cancer-related Gene Sequencing Panel -- Single-cell Analysis of Circulating Tumor Cells.
    Additional Edition: ISBN 1-4939-9002-0
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    UID:
    almahu_BV047117547
    Format: xii, 167 Seiten : , Illustrationen.
    ISBN: 978-0-367-89873-1
    Series Statement: Routledge studies in First World War history
    Content: "The First World War's centenary generated a mass of commemorative activity worldwide. Officially and unofficially; individually, collectively and commercially; locally, nationally and internationally, efforts were made to respond to the legacies of this vast conflict. This book explores some of these responses from areas previously tied to the British Empire, including Australia, Britain, Canada, India and New Zealand. Showcasing insights from historians of commemoration and heritage professionals, it provides revealing insider and outsider perspectives of the centenary. How far did commemoration become celebration, and how merited were such responses? To what extent did the centenary serve wider social and political functions? Was it a time for new knowledge and understanding of the events of a century ago, for recovery of lost or marginalised voices, or for confirming existing clichés? And what can be learned from the experience of this centenary that might inform the approach to future commemorative activities? The contributors to this book grapple with these questions, coming to different answers and demonstrating the connections and disconnections between those involved in building public knowledge of the 'war to end all wars'"--
    Note: Colonial Commemoration in a Time of Multiculturalism: South Asia and the First World War / Santanu Das -- Resurrecting Heroes ... or Reinventing Them? Interpretations of the Heroic in Australian First World War Centenary Commemorations / Bryce Abraham -- The First Time he Felt Truly Australian: Anzac Sport and Australian Nationalism, 1995 -- Today / Xavier Fowler -- 'Our War': National Memory, New Zealand and Te Papa's Gallipoli / Rowan Light -- Voicing War: Canadian Soldiers' Oral Culture during and after the First World War / Tim Cook -- New Zealand's War in the Air: A Centenary Exhibition in Review / Louisa Hormann -- Uncovering the Hidden Stories of the Voices Against War in a New Zealand Province / Margaret Lovell-Smith -- Reclaiming Salute to Valour: The Official Canadian Film of the Pilgrimage to the Vimy Monument / Sarah Cook
    Additional Edition: Erscheint auch als Online-Ausgabe, ebk ISBN 978-1-00-302162-9
    Language: English
    Subjects: History
    RVK:
    RVK:
    Keywords: Erster Weltkrieg ; Kollektives Gedächtnis ; Hundertjahrfeier ; Aufsatzsammlung
    Library Location Call Number Volume/Issue/Year Availability
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