Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Article
    Article
    Language: English
    In: Urology, November 2016, Vol.97, pp.116-117
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Article
    Article
    Language: English
    In: Urology, 2011, Vol.77(1), pp.129-130
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: The Journal of Urology, April 2011, Vol.185(4), pp.e854-e854
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: BJU International, Nov, 2012, p.1359(7)
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2012.11082.x/abstract Byline: Florian Roghmann(1), Christian von Bodman(1), Bjorn Loppenberg(1), Andreas Hinkel(1), Juri Palisaar(1), Joachim Noldus(1) Keywords: Fournier's gangrene/mortality; treatment outcome; severity of illness index; genital diseases; male/mortality Study Type - Prognosis (prospective cohort) Level of Evidence 2a What's known on the subject? and What does the study add? Fournier's gangrene (FG) is a rare but life-threatening disease challenging the treating medical staff. Despite the fact that antibiotic therapy combined with surgery and intensive care surveillance are performed as standard treatment, mortality rates remain high. There have been efforts to develop a reliable tool to predict severity of the disease, not only to identify patients at highest risk of major complications or death but also to provide a target for medical teams and researchers aiming to improve outcome and to gather information for counselling patients. Laor et al. published the FG severity index (FGSI) in 1995 presenting a complex prediction score solely for patients with FG. Fifteen years later, Yilmazlar et al. suggested a new and supposedly more powerful scoring system, the Uludag FGSI (UFGSI), adding an age score and an extent of disease score to the FGSI. In the present study population we applied two scoring systems for outcome prediction that are solitarily applicable in patients with FG (FGSI, UFGSI), as well as two general scoring systems such as the established age-adjusted Charlson Comorbidity Index (ACCI) and the recently introduced surgical Apgar Score (sAPGAR) to compare them and to test whether one system might be superior to the other. In addition, we identified potential prognostic factors in the study population. By contrast to many earlier studies, we performed a combined prospective and retrospective analysis and provided a 30-day follow up. In the cohort of the present study, older patients with comorbidities as well as a need for mechanical ventilation and blood transfusion are at higher risk of lethal outcome. All scores are useful to predict mortality. Despite including more variables, the UFGSI does not seem to be more powerful than the FGSI. In daily routine we suggest applying ACCI and sAPGAR, as they are more easily calculated, generally applicable and well validated. OBJECTIVE To compare four published scoring systems for outcome prediction (Fournier's gangrene severity index [FGSI], Uludag FGSI [UFGSI], age-adjusted Charlson Comorbidity Index [ACCI] and surgical Apgar Score [sAPGAR]) and evaluate risk factors in patients with Fournier's gangrene (FG). PATIENTS AND METHODS In all, 44 patients were analysed. The scores were applied. A Mann-Whitney U-test, Fisher's exact test, receiver operator characteristic (ROC) analysis and Pearson correlation analysis were performed. RESULTS The results of the present study show a significant association among FGSI (P= 0.002), UFGSI (P= 0.002), ACCI (P= 0.004), sAPGAR (P= 0.018) and death. The differences between the area under the receiver operating characteristic curve of the scores were not significant. Non-survivors were older (P= 0.046), had a greater incidence of acute renal failure (P 0.001) and coagulopathy (P= 0.041), were treated more often with mechanical ventilation (P= 0.001) and received more packed red blood cells (RBCs; P= 0.001). CONCLUSION Older patients with comorbidities and need for mechanical ventilation and RBCs are at higher risk for death. In the present cohort, scores calculated easily at the bedside, such as ACCI and sAPGAR, seemed to be as good at predicting outcome in patients with FG as FGSI and UFGSI. Author Affiliation: (1)Department of Urology, Ruhr-University Bochum, Marienhospital, Widumer Strasse 8, D-44627 Herne, Germany Correspondence: (*) Florian Roghmann, Department of Urology, Ruhr-University Bochum, Marienhospital, Widumer Strasse 8, D-44627 Herne, Germany. e-mail: florian.roghmann@marienhospital-herne.de Accepted for publication 10 November 2011 CAPTION(S): Supporting info item
    ISSN: 1464-4096
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: BJU International, Nov, 2012, p.1359(7)
    ISSN: 1464-4096
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: BJU International, December 2014, Vol.114(6), pp.793-794
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/bju.12889/abstract Byline: Julian Hanske, Florian Roghmann, Joachim Noldus,Quoc-Dien Trinh ***** No abstract is available for this article. *****
    Keywords: Medicine;
    ISSN: 1464-4096
    E-ISSN: 1464-410X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: The Journal of Urology, 2010, Vol.184(3), pp.944-948
    Description: In 2002, 10 Martin criteria were proposed that should be met when reporting complications following surgery. To date, few studies have evaluated complication rates after radical prostatectomy using these criteria. Therefore, we assessed complications in a contemporary series of open retropubic radical prostatectomy using a standardized reporting methodology. Complications in 2,893 consecutive patients who underwent radical prostatectomy at a single center between 2003 and 2009 were recorded prospectively. All 10 Martin criteria for a high quality report of complications were fulfilled. Complications within a 30-day postoperative period were graded retrospectively according to the Clavien-Dindo classification. The overall complication rate was 27.7% (801 of 2,893), and 943 medical and surgical complications were recorded in 801 patients. Of these complications 596 were grade I (63.2%), 183 grade II (19.5%), 142 grade III (15.1%) and 15 grade IV (1.8%). The mortality rate (grade V) was 0.1% (4 of 2,893). Independent predictors of high grade complications (grade III or greater) on multivariate analysis were patient age (HR 1.051, p = 0.002), prostate volume (HR 1.013, p = 0.004) and lymphadenectomy (HR 2.023, p = 0.005). Complications after radical prostatectomy should be reported using a standardized methodology. Using the Clavien-Dindo classification we observed an acceptable overall complication rate. In the majority of cases lower grade complications occurred. Patients of older age, those with greater prostate volume and those who had undergone simultaneous lymphadenectomy were at risk for higher grade complications.
    Keywords: Classification ; Postoperative Complications ; Reference Standards ; Prostatic Neoplasms ; Prostatectomy ; Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: BJU International, Sept, 2012, p.E172(10)
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2012.10935.x/abstract Byline: Juri R. Palisaar(1), Joachim Noldus(1), Bjorn Loppenberg(1), Christian von Bodman(1), Florian Sommerer(2), Thilo Eggert(1) Keywords: prostate cancer; histopathological outcome; radical prostatectomy; active surveillance; low risk; misclassification Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Prostate cancer characterisation, based on laboratory findings, clinical examination and histopathological cancer features that are used to define selection criteria for AS, is not ideal. Consequently, a panel of strict or more lenient criteria to select patients for AS have been published. Studies investigating the relationship between pretreatment variables and final pathology have been done in the past showing the risk of cancer misclassification for some criteria. No study has presented an overview of cancer selection using a panel of 16 currently used AS criteria that is presented in the present study. In an exactly defined cohort after radical prostatectomy, each set of criteria was used as a diagnostic test to separate between patients with more favourable (pT2, no Gleason upgrade between biopsy grading and final pathology) and unfavourable cancer features (pT3, pN+, Gleason upgrade). To the best of our knowledge a comparison of test quality criteria for AS criteria given by sensitivity, specificity, positive and negative predictive value and likelihood ratio has not yet been reported. Moreover, we showed that tumour characterisation, by a formally sufficient 12-core biopsy, in the present dataset harboured a risk of a20% that unfavourable cancer features were missed regardless of whether strict or more lenient selection criteria for AS were chosen. OBJECTIVE * To evaluate final histopathological features among men diagnosed with prostate cancer eligible for low-risk (LR) or active surveillance (AS) criteria. PATIENTS AND METHODS * Retrospective application of 16 definitions for AS or LR prostate cancer to a contemporary (January 2008 to March 2011) open retropubic radical prostatectomy (RRP) series of 1745 patients. * Exclusion criteria: neoadjuvant hormones, radiotherapy, inadequate histopathological reports, 10 biopsy cores. * Report on the number of men with insignificant tumours (defined as: [less than or equal to]pT2, Gleason score [less than or equal to]6, tumour volume 0.5 mL) and men who had unfavourable tumour characteristics on final pathology (defined as: extracapsular extension or seminal vesicle invasion or lymph node metastasis or Gleason upgrading). * Sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV) were calculated. RESULTS * Eligibility of patients in the final study cohort (n= 1070) varied from 5.1% to 92.7% depending on the AS or LR criteria used. * Final pathology revealed 77 insignificant cancers and 578 patients who had unfavourable histopathological criteria. * The detection rate for insignificant cancers on final pathology was variable ranging from 7.8% to 28.3% depending on the AS- or LR-prediction tool used; unfavourable tumour characteristics were found in up to 33.5% on final pathology. * The sensitivity, specificity, PPV and NPV were 8.5-97.9%, 24.7-97.8%, 67.7-89.1% and 45.3-78.2%, respectively. * The likelihood ratio to correctly identify a patient with LR disease on final pathology ranged from 1.3 to 8. CONCLUSIONS * AS or LR criteria have a significant risk of cancer misclassification. * Better prediction tools are needed to improve these criteria. * Re-biopsy might improve safety and should be considered more frequently in patients who opt for AS. Author Affiliation: (1)Department of Urology, Ruhr-University Bochum, Marienhospital Herne (2)Department of Pathology, Ruhr-University Bochum, Bergmannsheil GmbH, Germany Correspondence: (*) Rein Juri Palisaar, Department of Urology, Ruhr-University Bochum, Marienhospital Herne, Widumer Strasse 8, 44627 Herne, Germany. e-mail: Rein-jueri.palisaar@marienhospital-herne.de Accepted for publication 9 November 2011
    Keywords: Tumors -- Reports ; Prostate Cancer -- Reports
    ISSN: 1464-4096
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: BJU International, Sept, 2012, p.E172(10)
    Keywords: Tumors -- Reports ; Prostate Cancer -- Reports
    ISSN: 1464-4096
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: The Journal of Urology, August 2013, Vol.190(2), pp.811-812
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages