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  • 1
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2014, Vol.53(5), pp.356-361
    Description: 〈b〉目的〈/b〉 : 甲状腺細胞診検査における偽陰性率を低減させることを目的として血中 TSH 値について検討した.〈br〉〈b〉方法〈/b〉 : 甲状腺穿刺細胞診検査が施行され, その後甲状腺切除術および病理組織検査が行われた 276 例を対象として, 術前の血中 TSH 値と病理診断との関係について総計学的に解析した.〈br〉〈b〉成績〈/b〉 : 病理診断が良性の 156 例と悪性の 120 例の間で TSH の平均値に有意差を認めた (p=0.011, t 検定). TSH 1.8μIU/m〈i〉l〈/i〉 以上の 79 例では 1.8 未満の 197 例に比べ有意に悪性が多く (p〈0.001, χ〈sup〉2〈/sup〉検定), オッズ比は 5.06 倍であった. 術前の細胞診検査が陰性であった 170 例においても, TSH 1.8 以上の 30 例では 1.8 未満の 140 例に比べ有意に悪性が多く (p=0.020, χ〈sup〉2〈/sup〉検定), オッズ比は 3.25 倍であった. 細胞診検査が陰性であった 170 例に対して TSH 1.8 以上を悪性の疑いと判定することにより偽陰性例は 19 例から 12 例に減少した.〈br〉〈b〉結論〈/b〉 : 細胞診検査が陰性の症例においても, TSH 1.8 以上は悪性を疑う所見として再検査や外科手術を促すことが細胞診検査の偽陰性率を低下させる有効な手段である.
    Description: 〈b〉〈i〉Objectives〈/i〉〈/b〉 : The serum levels of thyroid stimulating hormone (TSH) were investigated in relation to thyroid malignancy, in order to lower the false-negative rate in thyroid fine-needle aspiration cytology.〈br〉〈b〉〈i〉Study Design〈/i〉〈/b〉 : The preoperative serum TSH levels of 276 thyroid patients were tested. All patients had fine-needle aspiration cytology, then underwent surgical treatments, the histological diagnoses were confirmed, and the significance of the TSH levels was statistically investigated.〈br〉〈b〉〈i〉Results〈/i〉〈/b〉 : TSH levels were significantly different between benign and malignant thyroid diseases (p=0.011, t test). Thyroid cancers were more frequent in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 compared to those with TSH levels less than 1.8μIU/m〈i〉l〈/i〉 (p〈0.001, χ〈sup〉2〈/sup〉 test). The odds ratio was 5.06. Furthermore, even in 170 patients with a negative diagnosis based on the cytology, thyroid cancers were more frequent also in those with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 (p=0.020, χ〈sup〉2〈/sup〉 test), and the odds ratio was 3.25. By combining the serum TSH test for 170 patients with negative cytology diagnosis, false-negative cases were reduced to 12 cases from 19 cases.〈br〉〈b〉〈i〉Conclusion〈/i〉〈/b〉 : Even if the result of cytology examinations are negative, patients with TSH levels of more than 1.8μIU/m〈i〉l〈/i〉 have a higher risk of malignancy, and should be further examined or surgically treated. This may result in fewer false-negative cases in thyroid cytology.
    Keywords: Thyroid Cancer ; Fine-Needle Aspiration Cytology (Fna) ; Tsh ; False-Negative
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 2
    Language: English
    In: Bulletin of Shubun University, 2016, Issue 8, pp.1-9
    Description: [Abstract] Objectives : Serum levels of thyroid-stimulating hormone (TSH) and thyroglobulin (TG) were investigated in relation to thyroid malignancy to confirm the significance of both markers for cancer diagnosis, and also to decrease the false-negative rate in thyroid fine-needle aspiration (FNA) cytology. Methods : Preoperative serum levels of TSH and TG from 597 thyroid patients were statistically investigated. All patients had fine-needle aspiration cytology, then underwent surgical treatments, and their histological diagnoses were confirmed. The statistical significance of the TSH and TG levels was investigated. Results : TSH was significantly higher in cancer patients (P1.80 μIU/ml (P180 ng/ml (P1.80 μIU/ml have a higher risk of papillary carcinoma, and patients with TG〉180 ng/ml have a higher risk of follicular carcinoma. Even in patients with benign or inadequate results from FNA examinations, those with TSH〉1.80 μIU/ml have a higher risk of malignancy. Such patients should be further examined by repeat cytology or treated surgically to determine whether the lesion is malignant or not.
    ISSN: 1884-9806
    Source: Medical*Online (Meteo, Inc.)
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  • 3
    Language: English
    In: Bulletin of Shubun University, 2016, Issue 8, pp.1-9
    Description: [Abstract] Objectives : Serum levels of thyroid-stimulating hormone (TSH) and thyroglobulin (TG) were investigated in relation to thyroid malignancy to confirm the significance of both markers for cancer diagnosis, and also to decrease the false-negative rate in thyroid fine-needle aspiration (FNA) cytology. Methods : Preoperative serum levels of TSH and TG from 597 thyroid patients were statistically investigated. All patients had fine-needle aspiration cytology, then underwent surgical treatments, and their histological diagnoses were confirmed. The statistical significance of the TSH and TG levels was investigated. Results : TSH was significantly higher in cancer patients (P1.80 μIU/ml (P180 ng/ml (P1.80 μIU/ml have a higher risk of papillary carcinoma, and patients with TG〉180 ng/ml have a higher risk of follicular carcinoma. Even in patients with benign or inadequate results from FNA examinations, those with TSH〉1.80 μIU/ml have a higher risk of malignancy. Such patients should be further examined by repeat cytology or treated surgically to determine whether the lesion is malignant or not.
    ISSN: 1884-9806
    Source: Medical*Online-E (Meteo, Inc.)
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  • 4
    Language: English
    In: Zoological science, 1998-02, Vol.15(1), pp.27~34
    Description: Title Transcription: Compositional changes in glycoconjugate
    Description: Material Type: 記事・論文
    Keywords: Zoology;
    ISSN: 02890003
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  • 5
    Language: Japanese
    In: 日本臨床細胞学会雑誌, 2010, Vol.49(6), pp.437-442
    Description: 〈b〉目的〈/b〉 : リンパ節穿刺細胞診における精度管理, 特に検体不適正率の改善について考察した.〈br〉対象と〈b〉方法〈/b〉 : 対象は主に 2002∼2007 年 (6 年間) に愛知県がんセンター中央病院で施行された 1691 件と 2005∼2007 年での群馬県立がんセンターでの 159 件である. 愛知県がんセンター中央病院での検体採取法は, (1)穿刺セット (Diff-Quik : D-Q 染色, 顕微鏡など) 搭載カートを用意し細胞診専門医および細胞検査士 (ときに臨床検査技師) が臨床現場に出向いた. (2)超音波下に 24 G 針のみで穿刺し, 回転・非吸引式穿刺法で行った. 穿刺後, 針をシリンジに装着し検体を吹き出した. (3)スライドガラスとカバーガラスでなす内角部分の検体を薄く進展させて塗抹した. (4)採取現場で D-Q 染色を行い, 採取状態を確認した. (5)通常 D-Q 染色とパパニコロウ染色を併用した. 一方, 群馬県立がんセンターでは, 超音波ガイド下で, 22 G 針を付けた注射器 (20 m〈i〉l〈/i〉) を装着したピストル式器具で吸引細胞診が行われている. ガラスに吹き出された採取検体はすり合わせ法で塗抹, 95%エタノール固定され, 検査室にていずれもパパニコロウ染色がされるが, これら穿刺∼塗抹∼固定まですべて臨床医によりなされている.〈br〉〈b〉成績〈/b〉 : 愛知県がんセンター中央病院では, 2002∼2004 年の平均検体不適正率は 9.6%であったが, 2005∼2007 年では年平均 3.8%, 各年 5%以内であった. 群馬県立がんセンターでの検体不適正率は年平均 3.1%であった.〈br〉〈b〉結論〈/b〉 : 両施設とも, リンパ節穿刺細胞診の年平均検体不適正率が 5%以内に維持されている. 検体適正率の向上のためには, 超音波ガイド下で確実に病変に針を的中させることが肝要であり, そのためには採取者の十分なトレーニングが必要とされる. 施設の事情にもよるが, 採取者と検体処理を担当する細胞検査士とのチームワークによる体制づくりが, 穿刺現場での作業の効率性の面から, また安定した検体適正率の維持を図るうえからも望ましいと考えられた.
    Description: 〈b〉〈i〉Objectives〈/i〉〈/b〉 : We studied quality control for improving cellular specimen adequacy in lymph-node fine-needle biopsy (FNB).〈br〉〈b〉〈i〉Study Design〈/i〉〈/b〉 : Subjects numbered 1,850 cases, i. e., 1,691 from 2002 to 2007 at site 1 and 159 from 2005 to 2007 years at site 2, with FNB as shown in Figure 1 as follows : 〈br〉1. A cart with a FNB needle, glass specimen slide, fixative, Diff-Quik staining material, and a microscope were taken to the examination site by a physician and a technologist.〈br〉2. At site 1, Echo-guided FNB lymph node aspiration conducted by inserting a 24 G needle, turning it without aspiration, withdrowing it, attaching it to a syringe, then extruding the cellular specimen onto the specimen slide.〈br〉3. The smear was made by pressing a second specimen slide onto the specimen on the first slide.〈br〉4. Sampling was confirmed using the microscope immediately after Diff-Quik staining.〈br〉5. Diff-Quik and with Papanicolaou staining have been used to improve cytodiagnostic precision.〈br〉At site 2, echo-guided FNB with aspiration cytology was conducted using a “pistol” attached to a syringe (20 m〈i〉l〈/i〉) with a 22 G needle. The cellular sample smear was made and immediately fixed in 95% ethanol, then stained by the Papanicolaou method in the laboratory.〈br〉〈b〉〈i〉Results〈/i〉〈/b〉 : The annual average specimen inadequacy at site 1 from 2002 to 2004 was 9.6%, and 3.8% from 2005 to 2007, versus an annual average of 3.1% at site 2.〈br〉〈b〉〈i〉Conclusions〈/i〉〈/b〉 : Annual average specimen inadequacy in echo-guided lymph-node FNB was less than 5%. A needle must hit a lesion under ultrasonography to improve specimen adequacy, and physicians must be trained sufficiently in echo-guided FNB cytology. The physician-cytotechnologist team is thus desirable in planning effectiveness for the puncture site and stable specimen adequacy.
    Keywords: Fine Needle Biopsy Cytology ; Ultrasonography ; Lymph Node ; Sampling ; Inadequate Specimen Rate
    ISSN: 0387-1193
    E-ISSN: 18827233
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  • 6
    Language: Japanese
    In: 日本内分泌・甲状腺外科学会雑誌, 2014, Vol.31(2), pp.108-114
    Description: 甲状腺外科学会病理小委員会では甲状腺細胞診の報告様式を現在の甲状腺癌取扱い規約の様式から甲状腺細胞診ベセスダシステムへ移行することを検討中である。本稿では,取扱い規約とベセスダシステムの報告様式の違いを紹介すると共に,自験例の診断成績を用いて甲状腺細胞診ベセスダシステムの妥当性について検討した。取扱い規約とベセスダシステムの主な違いは,①細胞学的に鑑別困難な症例を,濾胞性腫瘍を疑う群(FN/SFN)とそうでない群(AUS/FLUS)の2つの診断カテゴリーに分けた点,②不適正の判定基準を明確にした点,③各診断カテゴリーについて悪性の危険度を数値で示した点の3点である。両者の基本的な考え方は類似しているので,大きな混乱なくベセスダシステムへの移行が可能と考えている。
    Keywords: 甲状腺癌 ; 穿刺吸引細胞診 ; 報告様式 ; 甲状腺癌取扱い規約 ; 甲状腺ベセスダシステム ; Thyroid Cancer ; Fine-Needle Aspiration Cytology ; Reporting System ; Japanese General Rules For Thyroid Cancer ; Bethesda System For Thyroid Cancer
    ISSN: 2186-9545
    ISSN: 03871193
    E-ISSN: 18827233
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  • 7
    Language: English
    In: Biomedical Research, 1996, Vol.17(3), pp.231-235
    Description: The effects of the combination of treatments with tin-protoporphyrin (SnPP) and irradiation on hepatic lysosomes were examined in vitro and in vivo. SnPP caused no release of arylsulfatase from lysosomes in the dark, but the combined treatment with irradiation induced the release of arylsulfatase from lysosomes in vitro. The positive correlation between incident photoenergy and the release of arylsulfatase was analyzed. The administration of L-ascorbic acid prevented the release of the enzyme in a dose-dependent manner. The irradiation-induced release of arylsulfatase from lysosomes occurred in hepatocytes, which are known to concentrate SnPP. Studies using histochemical and biochemical methods revealed the release of arylsulfatase from lysosomes in the hepatocytes of SnPP-injected rats.
    Keywords: Medicine;
    ISSN: 0388-6107
    E-ISSN: 1880313X
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  • 8
    Language: English
    In: Asian Pacific journal of cancer prevention : APJCP, 2001, Vol.2(1), pp.57-62
    Description: Cyclooxygenase 2 (COX2) is an inducible enzyme synthesizing prostaglandins from arachidonic acid, which is thought to play an important role in colorectal carcinogenesis. Since the COX2 polymorphisms, if functional, may modify the carcinogenesis pathway, the associations between the reported polymorphisms and colorectal cancer risk were examined in a hospital-based case-control study. Six polymorphisms of the gene encoding COX2 were genotyped for 241 non-cancer individuals (controls) and 148 colorectal cancer patients (74 colon cancer, 73 rectal cancer, and 1 colorectal cancer date, 22 polymorphisms including the above six have been reported for COX2. The other polymorphisms remain to be examined.
    Keywords: Medicine;
    E-ISSN: 2476-762X
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
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  • 9
    Language: English
    In: Neuroscience Research, 1998, Vol.31, pp.S200-S200
    Keywords: Medicine ; Anatomy & Physiology
    ISSN: 0168-0102
    E-ISSN: 1872-8111
    Source: ScienceDirect Journals (Elsevier)
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  • 10
    Language: English
    In: Neuroscience Research, 1997, Vol.28, pp.S163-S163
    Keywords: Medicine ; Anatomy & Physiology
    ISSN: 0168-0102
    E-ISSN: 1872-8111
    Source: ScienceDirect Journals (Elsevier)
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