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  • 1
    Language: English
    In: Behavioral Ecology and Sociobiology, 1 June 2014, Vol.68(6), pp.935-945
    Description: Social organization is often studied through point estimates of individual association or interaction patterns, which does not account for temporal changes in the course of familiarization processes and the establishment of social dominance. Here, we present new insights on short-term temporal dynamics in social organization of mixed-sex groups that have the potential to affect sexual selection patterns. Using the live-bearing Atlantic molly (Poecilia mexicana), a species with pronounced male size polymorphism, we investigated social network dynamics of mixed sex experimental groups consisting of eight females and three different-sized males over a period of 5 days. Analyzing association-based social networks as well as direct measures of spatial proximity, we found that large males tended to monopolize most females, while excluding small-and medium-bodied males from access to females. This effect, however, emerged only gradually over time, and different-sized males had equal access to females on day 1 as well as day 2, though to a lesser extent. In this highly aggressive species with strong social dominance stratifications, the observed temporal dynamics in male-female association patterns may balance the presumed reproductive skew among differentially competitive male phenotypes when social structures are unstable (i.e., when individual turnover rates are moderate to high). Ultimately, our results point toward context-dependent sexual selection arising from temporal shifts in social organization.
    Keywords: Behavioral sciences -- Ethology -- Animal behavior ; Biological sciences -- Biology -- Zoology ; Biological sciences -- Biology -- Zoology ; Biological sciences -- Biology -- Physiology ; Behavioral sciences -- Psychology -- Social psychology ; Social sciences -- Human geography -- Social geography ; Behavioral sciences -- Human behavior -- Social behavior ; Biological sciences -- Biology -- Genetics ; Behavioral sciences -- Sociology -- Social organization ; Biological sciences -- Biology -- Zoology
    ISSN: 03405443
    E-ISSN: 14320762
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  • 2
    Language: English
    In: Cancer Research, 07/01/2017, Vol.77(13 Supplement), pp.3213-3213
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 3
    Language: English
    In: Clinical cancer research : an official journal of the American Association for Cancer Research, 17 December 2018
    Description: Dopamine receptor D2 (DRD2) is a G protein-coupled receptor antagonized by ONC201, an anti-cancer small molecule in clinical trials for high grade gliomas and other malignancies. DRD5 is a dopamine receptor family member that opposes DRD2 signaling. We investigated the expression of these dopamine receptors in cancer and their influence on tumor cell sensitivity to ONC201. The Cancer Genome Atlas was used to determine DRD2/DRD5 expression broadly across human cancers. Cell viability assays were performed with ONC201 in 〉1,000 Genomic of Drug Sensitivity in Cancer and NCI60 cell lines. Immunohistochemistry staining of DRD2/DRD5 was performed in tissue microarrays and archival tumor tissues of glioblastoma patients treated with ONC201. Whole exome sequencing was performed in RKO cells with and without acquired ONC201 resistance. Wild-type and mutant DRD5 constructs were generated for overexpression studies. DRD2 overexpression broadly occurs across tumor types and is associated with a poor prognosis. Whole exome sequencing of cancer cells with acquired resistance to ONC201 revealed a de novo Q366R mutation in the DRD5 gene. Expression of Q366R DRD5 was sufficient to induce tumor cell apoptosis, consistent with a gain-of-function. DRD5 overexpression in glioblastoma cells enhanced DRD2/DRD5 heterodimers and DRD5 expression was inversely correlated with innate tumor cell sensitivity to ONC201. Investigation of archival tumor samples from recurrent glioblastoma patients treated with ONC201 revealed that low DRD5 expression was associated with relatively superior clinical outcomes. These results implicate DRD5 as a negative regulator of DRD2 signaling and tumor sensitivity to ONC201 DRD2 antagonism.
    ISSN: 1078-0432
    E-ISSN: 15573265
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  • 4
    Language: French
    In: L'Expansion Management Review, 2013, Vol.150(3), pp.113-123
    Description: L'innovation inversée, processus par lequel des produits développés par des pays du Sud pour leurs populations gagnent les pays riches, est promise à un bel avenir.
    Keywords: Business
    ISSN: 1254-3179
    E-ISSN: 2271-7749
    Source: Cairn.info - Revues
    Source: Cairn.info
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  • 5
    Language: English
    In: American Journal of Gastroenterology, 2010, Vol.105, p.S456
    ISSN: 0002-9270
    Source: CrossRef
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  • 6
    Language: English
    In: Gastroenterology, 2011, Vol.140(5), pp.S-575-S-575
    Keywords: Medicine
    ISSN: 0016-5085
    E-ISSN: 1528-0012
    Source: ScienceDirect Journals (Elsevier)
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  • 7
    In: PLoS ONE, 2012, Vol.7(12)
    Description: Human and animal studies demonstrate that short sleep or poor sleep quality, e.g. in night shift workers, promote the development of obesity and diabetes. Effects of sleep disruption on glucose homeostasis and liver physiology are well documented. However, changes in adipokine levels after sleep disruption suggest that adipocytes might be another important peripheral target of sleep. Circadian clocks regulate metabolic homeostasis and clock disruption can result in obesity and the metabolic syndrome. The finding that sleep and clock disruption have very similar metabolic effects prompted us to ask whether the circadian clock machinery may mediate the metabolic consequences of sleep disruption. To test this we analyzed energy homeostasis and adipocyte transcriptome regulation in a mouse model of shift work, in which we prevented mice from sleeping during the first six hours of their normal inactive phase for five consecutive days ( timed sleep restriction – TSR). We compared the effects of TSR between wild-type and Per1/2 double mutant mice with the prediction that the absence of a circadian clock in Per1/2 mutants would result in a blunted metabolic response to TSR. In wild-types, TSR induces significant transcriptional reprogramming of white adipose tissue, suggestive of increased lipogenesis, together with increased secretion of the adipokine leptin and increased food intake, hallmarks of obesity and associated leptin resistance. Some of these changes persist for at least one week after the end of TSR, indicating that even short episodes of sleep disruption can induce prolonged physiological impairments. In contrast, Per1/2 deficient mice show blunted effects of TSR on food intake, leptin levels and adipose transcription. We conclude that the absence of a functional clock in Per1/2 double mutants protects these mice from TSR-induced metabolic reprogramming, suggesting a role of the circadian timing system in regulating the physiological effects of sleep disruption.
    Keywords: Research Article ; Biology ; Medicine
    E-ISSN: 1932-6203
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  • 8
    Language: English
    In: Analytical Biochemistry, 15 April 2013, Vol.435(2), pp.153-158
    Description: The development of a method for the quantification of genomic deoxyribonucleic acid is considered. The method is based on the quantification by inductively coupled plasma mass spectrometry (ICP–MS) of the mass fraction of phosphorus, stoichiometrically presented in the DNA molecules. Through the DNA sequencing data, it was possible to convert the ICP–MS analysis results into DNA genome units. DNA samples were analyzed using ICP–sector field MS and ICP–quadrupole MS with a collision/reaction cell. Spectrophotometric measurements of the absorbance at 260 nm and real-time PCR techniques were used to independently confirm the ICP–MS results. The comparison of the methods showed that the ICP–MS method provides better accuracy with respect to currently applied analytical techniques such as UV spectrophotometry, fluorescent dye methods, and real-time PCR. Moreover, with the use of calibration standards whose values are traceable to the International System of Units and the possibility of evaluating the contribution to the overall uncertainty of each step of the measurement procedure, the method enables long-term comparability of the measurement results. These advantages make the ICP–MS method suitable for nucleic acid investigation, from nucleotides to genomic DNA, as well as for the certification of the reference materials containing nucleic acids.
    Keywords: Legionella Pneumophila DNA ; Icp–MS Analysis ; Uncertainty Evaluation ; Method Validation ; Chemistry ; Anatomy & Physiology
    ISSN: 0003-2697
    E-ISSN: 1096-0309
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  • 9
    Language: English
    In: Accreditation and Quality Assurance, 2011, Vol.16(11), pp.545-552
    Description: This work addresses a metrological approach for the assessment of Se status in humans in terms of serum selenomethionine (SeMet). The quantification of SeMet was carried out using a primary method of chemical analysis, namely species-specific isotope dilution (SSID) in combination with HPLC coupled to collision/reaction cell inductively coupled plasma-mass spectrometry. SeMet was released from the serum selenoalbumin (a seleno-containing protein where SeMet is randomly incorporated) by enzymatic hydrolysis of the whole serum. This study is a follow-up of the analytical method development reported previously, and it focuses primarily on the evaluation of the uncertainty budget and the main uncertainty sources for SeMet determination in three commercial serums, namely BCR-637 (certified for total Se) and two serum standards, SERONORM level 1 (SERO-L1) and 2 (SERO-L2) (with indicative concentrations of total Se). The metrological approach reported here could be considered as a pilot study in terms of metrological determination of SeMet in human serum, hence being suitable for method validation and inter-laboratory comparison.
    Keywords: Human serum ; Selenomethionine ; Species-specific isotope dilution ; HPLC-ICP-MS Expanded uncertainty
    ISSN: 0949-1775
    E-ISSN: 1432-0517
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  • 10
    Language: German
    In: Psychotherapie, Psychosomatik, medizinische Psychologie, February 2016, Vol.66(2), pp.82-7
    Description: The aim of this study was to analyze the experiences of patients suffering from mostly chronic psychosomatic disorders in an ambulant art therapy in the group. Especially, the focus was on the experienced changes, helpful factors and specifics of the therapy as well as on the experienced benefit. For this, 30 patients were interviewed in a semi-standardized way. Additionally, the symptom-based strain was psychometrically recorded in a part of the patients (21) at the beginning of the therapy and after at least 6 months of participation. The evaluation of those interviews with the qualitative analysis of the therapy subjects surrendered an improvement of the health state in most of the participants. Especially group factors, art as a mean of communication, becoming aware of feelings but also diversion and fun were proved to be beneficial. The art therapy also serves for structuring the week as well as a contact point and a resource in the interpersonal communication of everyday life. Nearly all of the patients referred to some important turning point pictures. Mostly, the benefit was valued as being high. But, in contrast, the psychometric measure did not show any significant change. The results emphasize the stabilizing function of art therapy in the examined patients, whereat the classification of the psychometric result is complicated by the absence of a control group.
    Keywords: Art Therapy -- Methods ; Psychophysiologic Disorders -- Psychology
    ISSN: 09372032
    E-ISSN: 1439-1058
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