Format:
Online-Ressource (VII, 163 p. 30 illus., 18 illus. in color, online resource)
ISBN:
9783662437872
Series Statement:
Topics in Medicinal Chemistry 10
Content:
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors
Note:
Description based upon print version of record
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Preface; Contents; The Blood-Brain Barrier: An Introduction to Its Structure and Function; 1 The BBB: A Historical Perspective; 2 Evolutionary Development of a BBB; 3 Anatomic Principles of the BBB; 4 Pericytes; 5 Astrocyte: Endothelium Interactions; 6 Neurons; 7 Basal Membrane; 8 Junctional Complexes at the BBB; 9 Transport Proteins at the BBB; 10 Cytotic Processes at the BBB; 11 Outlook; References; In Vivo Approaches to Assessing the Blood-Brain Barrier; 1 Introduction; 2 Pharmacokinetic Principles of Blood-Brain Barrier Transport; 3 Methods
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3.1 Brain Uptake Index (Carotid Artery Single Injection Technique)3.2 The i.v. Injection Technique; 3.3 In Situ Brain Perfusion; 3.4 Brain Efflux Index; 3.5 Percentage of the Injected Dose; 3.6 Microdialysis; 3.7 CSF Sampling; 3.8 Positron Emission Tomography; 3.9 Combinatorial Mapping of Kp,uu,brain; 4 Conclusions; References; ABC Transporters at the Blood-Brain Barrier; 1 Introduction; 2 ABC Transporters at the Blood-Brain Barrier; 2.1 Assessing ABC Transporter Activity/Expression; 3 Modulation of ABC Transporter Expression and Activity; 3.1 Altered Transporter Expression
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3.1.1 Response to Xenobiotics3.1.2 Response to Disease; 3.2 Altered Transporter Activity Through Signaling; 3.2.1 Regulation of P-Glycoprotein Activity Through Sphingolipid Signaling; 3.2.2 Regulation of P-Glycoprotein Activity Through VEGF Signaling; 3.2.3 Regulation of BCRP Activity Through Estrogen Signaling; 3.2.4 Mechanisms Underlying Decreased Transporter Activity; 4 Perspectives; References; Nanoparticles as Blood-Brain Barrier Permeable CNS Targeted Drug Delivery Systems; 1 Introduction; 1.1 Blood-Brain Barrier; 1.2 Blood-Cerebrospinal Fluid Barrier (BCB) and CSF-Brain Barrier
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1.3 CNS Drug Delivery Strategies1.4 Nanomedicine Exploitation; 1.5 Nanomedicines for BBB Crossing: General Considerations; 2 BBB Crossing Nanocarriers; 2.1 Poly(n-butylcyanoacrylate) (PBCA) NPs; 2.2 Methoxypoly(ethylene glycol)-polylactide or Poly(lactide-co-glycolide) (mPEG-PLA/PLGA) NPs; 2.3 Liposomes; 2.4 Inorganic Nanosystems; 3 Conclusions; References; Blood-Brain Barrier and Stroke; 1 Introduction; 2 Injury to BBB Cell Components After Stroke; 2.1 Endothelial Cells; 2.2 Pericytes; 2.3 Astrocytes; 3 Basement Membrane, Extracellular Matrix, and Stroke
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4 Systemic and Local Inflammation and BBB Permeability After Stroke4.1 Chemokines, Adhesion Molecules, and Leukocyte Trafficking; 4.2 Parenchymal Brain Cells; 4.3 Perivascular Inflammatory Cells; 5 Post-ischemic Vascular and Brain Repair; 6 BBB Responses to Stroke in the Perinatal Period; 7 BBB Integrity, Angiogenesis, and Brain Repair After Stroke During the Perinatal Period; 8 Concluding Remarks; References; Inflammation at the Blood-Brain Barrier in Multiple Sclerosis; 1 Multiple Sclerosis and the Blood-Brain Barrier; 1.1 Clinical Features and Diagnosis of Multiple Sclerosis; 1.2 Etiology
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1.3 Pathogenesis
Additional Edition:
ISBN 9783662437865
Additional Edition:
Erscheint auch als Druck-Ausgabe The blood brain barrier (BBB) Heidelberg : Springer, 2014 ISBN 9783662437865
Additional Edition:
ISBN 3662437864
Language:
English
Keywords:
Blut-Hirn-Schranke
;
Blut-Hirn-Schranke
;
Aufsatzsammlung
DOI:
10.1007/978-3-662-43787-2
URL:
Volltext
(lizenzpflichtig)
Author information:
Fricker, Gert 1956-
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