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  • 1
    In: Pediatric Blood & Cancer, July 2014, Vol.61(7), pp.1149-1150
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/pbc.25003/abstract Byline: Roger J. Packer ***** No abstract is available for this article. *****
    Keywords: Gliomas – Public Opinion ; Parenting – Public Opinion;
    ISSN: 1545-5009
    E-ISSN: 1545-5017
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  • 2
    Language: English
    In: Current Neurology and Neuroscience Reports, 2012, Vol.12(2), pp.111-113
    Description: Byline: Roger J. Packer (1) Author Affiliation: (1) Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Gilbert Neurofibromatosis Institute, Brain Tumor Institute, 111 Michigan Avenue, NW, Washington, DC, 20010, USA Article History: Registration Date: 06/01/2012 Online Date: 17/01/2012
    Keywords: Antineoplastic Agents ; Temozolomide ; Gliomas ; Pediatrics;
    ISSN: 1528-4042
    E-ISSN: 1534-6293
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  • 3
    Language: English
    In: Current Neurology and Neuroscience Reports, 2011, Vol.11(2), pp.124-126
    Description: Byline: Roger J. Packer (1) Author Affiliation: (1) Center for Neuroscience and Behavioral Medicine, Gilbert Neurofibromatosis Institute, Brain Tumor Institute, Children's National Medical Center, 111 Michigan Avenue, NW, Washington, DC, 20010, USA Article History: Registration Date: 24/11/2010 Online Date: 04/12/2010
    Keywords: Brain Tumors ; Gliomas ; Strategic Planning (Business);
    ISSN: 1528-4042
    E-ISSN: 1534-6293
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  • 4
    In: Cancer, 01 December 2013, Vol.119(23), pp.4180-4187
    Description: The combination of bevacizumab and irinotecan (CPT‐11) was fairly well tolerated in children with recurrent central nervous system tumors. Most severe bevacizumab‐related toxicities were rare, self‐limiting, and manageable.
    Keywords: Pediatric ; Bevacizumab ; Toxicity ; Central Nervous System Tumors ; Clinical Trials
    ISSN: 0008-543X
    E-ISSN: 1097-0142
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  • 5
    Language: English
    In: Cancer Research, 07/01/2017, Vol.77(13 Supplement), pp.4887-4887
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 6
    Language: English
    In: Cancer Research, 07/01/2017, Vol.77(13 Supplement), pp.5145-5145
    ISSN: 0008-5472
    E-ISSN: 1538-7445
    Source: CrossRef
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  • 7
    Language: English
    In: Seminars in Pediatric Neurology, March 2012, Vol.19(1), pp.43-48
    Description: Despite remarkable strides in the treatment of pediatric malignancies over the last 50 years, long-lasting sequelae and secondary malignancies continue to plague this population. This article reviews the incidence, diagnosis, and etiology of secondary central nervous system tumors in the setting of a history of primary pediatric malignancy. Particular attention is paid to central nervous system tumors presenting after treatment of leukemia and primary brain tumors, as well as the role of treatment and underlying cancer predisposition syndromes in the risk of developing these secondary tumors.
    Keywords: Medicine
    ISSN: 1071-9091
    E-ISSN: 1558-0776
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  • 8
    In: Neurology, 2016, Vol.86(24), pp.2264-2270
    Description: OBJECTIVE:: To determine quantitative size thresholds for enlargement of the optic nerve, chiasm, and tract in children with neurofibromatosis type 1 (NF1). METHODS:: Children 0.5–18.6 years of age who underwent high-resolution T1-weighted MRI were eligible for inclusion. This consisted of children with NF1 with or without optic pathway gliomas (OPGs) and a control group who did not have other acquired, systemic, or genetic conditions that could alter their anterior visual pathway (AVP). Maximum and average diameter and volume of AVP structures were calculated from reconstructed MRI images. Values above the 95th percentile from the controls were considered the threshold for defining an abnormally large AVP measure. RESULTS:: A total of 186 children (controls = 82; NF1noOPG = 54; NF1+OPG = 50) met inclusion criteria. NF1noOPG and NF1+OPG participants demonstrated greater maximum optic nerve diameter and volume, optic chiasm volume, and total brain volume compared to controls (p 〈 0.05, all comparisons). Total brain volume, rather than age, predicted optic nerve and chiasm volume in controls (p 〈 0.05). Applying the 95th percentile threshold to all NF1 participants, the maximum optic nerve diameter (3.9 mm) and AVP volumes resulted in few false-positive errors (specificity 〉80%, all comparisons). CONCLUSIONS:: Quantitative reference values for AVP enlargement will enhance the development of objective diagnostic criteria for OPGs secondary to NF1.
    Keywords: Brain Tumors ; Optic Chiasm ; Optic Nerve ; Visual Pathways ; Age ; Magnetic Resonance Imaging ; Brain ; Glioma ; Recklinghausen'S Disease ; Children ; Neurology & Neuropathology;
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 9
    In: Neurology, 2016, Vol.87(23), pp.2403-2407
    Description: OBJECTIVE:: To determine whether tumor size is associated with retinal nerve fiber layer (RNFL) thickness, a measure of axonal degeneration and an established biomarker of visual impairment in children with optic pathway gliomas (OPGs) secondary to neurofibromatosis type 1 (NF1). METHODS:: Children with NF1-OPGs involving the optic nerve (extension into the chiasm and tracts permitted) who underwent both volumetric MRI analysis and optical coherence tomography (OCT) within 2 weeks of each other were included. Volumetric measurement of the entire anterior visual pathway (AVP; optic nerve, chiasm, and tract) was performed using high-resolution T1-weighted MRI. OCT measured the average RNFL thickness around the optic nerve. Linear regression models evaluated the relationship between RNFL thickness and AVP dimensions and volume. RESULTS:: Thirty-eight participants contributed 55 study eyes. The mean age was 5.78 years. Twenty-two participants (58%) were female. RNFL thickness had a significant negative relationship to total AVP volume and total brain volume (p 〈 0.05, all comparisons). For every 1 mL increase in AVP volume, RNFL thickness declined by approximately 5 microns. A greater AVP volume of OPGs involving the optic nerve and chiasm, but not the tracts, was independently associated with a lower RNFL thickness (p 〈 0.05). All participants with an optic chiasm volume 〉1.3 mL demonstrated axonal damage (i.e., RNFL thickness 〈80 microns). CONCLUSIONS:: Greater OPG and AVP volume predicts axonal degeneration, a biomarker of vision loss, in children with NF1-OPGs. MRI volumetric measures may help stratify the risk of visual loss from NF1-OPGs.
    Keywords: Medicine;
    ISSN: 0028-3878
    E-ISSN: 1526632X
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  • 10
    Language: English
    In: Current Neurology and Neuroscience Reports, 2010, Vol.10(1), pp.10-13
    Description: Byline: Roger J. Packer (1) Author Affiliation: (1) Department of Neurology, Children's National Medical Center, 111 Michigan Avenue Northwest, Washington, DC, 20010, USA Article History: Registration Date: 04/12/2009 Online Date: 10/01/2010
    Keywords: Gliomas -- Care And Treatment ; Pediatrics ; Radiation (Physics) ; Radiotherapy ; Antineoplastic Agents;
    ISSN: 1528-4042
    E-ISSN: 1534-6293
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