Format:
Online-Ressource
ISBN:
9781461423645
Series Statement:
Advances in Experimental Medicine and Biology 744
Content:
Narayanan Parameswaran
Content:
Among the many GPCRs discovered, the calcitonin family of receptors comprise of members that regulate a number of physiological processes and are involved in many pathological conditions. Therefore, understanding how these receptors function is a critical question in the field. When Foord and his colleagues discovered that a single transmembrane protein called Receptor Activity Modifying Proteins (RAMPs) could modulate the surface expression of GPCRs of the calcitonin family, it widely opened the field of receptor life cycle. Hundreds of studies have confirmed the importance of RAMPs in the life cycle of this receptor family. Receptor biology is a rapidly expanding field and with the advances in cell and molecular biology and in vivo techniques, it is very likely that the field of RAMPs will explode further and many unanswered questions will be answered with in the next few years. William S. Spielman is a Professor of Physiology and former Chairperson of the Department of Physiology, Michigan State University, East Lansing, Michigan, USA. His research interests include receptor biology and signal transduction and renal physiology. He is a member of many national and international scientific societies including the American Physiological Society. Spielman earned the BS degree in Biology from Westminister College and the PhD degree in Physiology from the University of Missouri. Narayanan Parameswaran is an Associate Professor in the Department of Physiology and Division of Pathology at Michigan State University, East Lansing, Michigan, USA. His main research interests include receptor biology, cell signaling, inflammation and inflammatory diseases. He is a member of the American Association of Immunology, Society of Leukocyte Biology and the Shock Society. Parameswaran received the Veterinary Medicine degree from Madras Veterinary College (India), the Master's degree in Veterinary Physiology and Pharmacology from the Ohio State University and the Doctor of Philosophy degree in Physiology from the Michigan State University.
Note:
Description based upon print version of record
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Title Page; Copyright Page; PREFACE; ABOUT THE EDITORS...; ABOUT THE EDITORS...; PARTICIPANTS; Table of Content; CHAPTER 1 INTRODUCTION TO RAMPs; INTRODUCTION; REGULATION OF CGRP RESPONSIVENESS BY RAMP1; REGULATION OF CLR LIFE-CYCLE BY RAMPs; RAMPs AND CALCIUM SENSING RECEPTOR; ANIMALS MODELS AND RAMPs; RAMPs AS DRUG TARGETS; RTP AND REEP; REGULATION OF RAMPs EXPRESSION; CONCLUSION; REFERENCES; CHAPTER 2 RAMPs AND CGRP RECEPTORS; INTRODUCTION; RAMPs and CGRP Receptors; CLR and CGRP; RAMP1 AND CGRP RECEPTOR PHARMACOLOGY; Complex Formation between CLR and RAMP1; RAMP1, CLR and CGRP Binding
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Antagonist BindingOTHER ROLES OF RAMP1 IN THE CGRP RECEPTOR; Receptor Chaperones; Glycosylation; Receptor Signalling and Internalisation; RAMP EXPRESSION AND CGRP FUNCTION; CONCLUSION; NOTE ADDED AFTER PROOFS; REFERENCES; CHAPTER 3 REGULATION OF GPCR TRAFFICKING BY RAMPs; INTRODUCTION; REGULATION OF RECEPTOR DESENSITIZATION; REGULATION OF RECEPTOR INTERNALIZATION/ENDOCYTOSIS; REGULATION OF RECEPTOR RECYCLING VS DEGRADATION; CONCLUSION; REFERENCES; CHAPTER 4 REGULATION OF CALCIUM SENSING RECEPTOR TRAFFICKING BY RAMPs
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INTRODUCTION TO THE CaSR, THE PROTOTYPE OF CLASS C GPCR INTERACTING WITH RAMPsSEP-CaSR: A TOOL TO TRACK CaSR TRAFFIC; THE CaSR IN EXPRESSED AT THE SURFACE OF HEK293 BUT ABSENT FROM COS7 CELL SURFACE; RAMP1 AND RAMP3, BUT NOT RAMP2, PROMOTE CELL SURFACE DELIVERY OF THE CaSR; RAMPs AND CaSR FORM A COMPLEX ALONG THE SORTING PATHWAY; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 5 UNDERSTANDING RAMPs THROUGH GENETICALLY ENGINEERED MOUSE MODELS; INTRODUCTION; RAMP1; Gene Targeted Deletion of RAMP1; Transgenic Overexpression of RAMP1; RAMP2; Gene Targeted Deletion of RAMP2
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Haploinsufficiency for RAMP2Transgenic Overexpression of RAMP2; RAMP3; Gene Targeted Deletion of Ramp3; Lessons Learned from Comparative Phenotyping; CONCLUSION AND FUTURE DEVELOPMENTS; ACKNOWLEDGEMENTS; REFERENCES; CHAPTER 6 RAMPs AS DRUG TARGETS; INTRODUCTION; RAMPs AND THEIR INTERACTIONS WITH RECEPTORS; THE CONSEQUENCES OF RAMP-RECEPTOR REGULATION; RAMP-Regulation of GPCR Pharmacology; RAMP-Regulated Receptor Signalling; RAMP-Regulated Receptor Trafficking; Consequences of Changes in RAMP Expression/Activity; MECHANISMS OF TARGETING RAMPS BY DRUGS; Overview; Direct Targeting of RAMPs
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Targeting the RAMP-Receptor ComplexCONCLUSION; REFERENCES; CHAPTER 7 RAMP LIKE PROTEINS RTP and REEP Family of Proteins; INTRODUCTION; RTP FAMILY; REEP FAMILY; ROLE IN OLFACTION; MECHANISM; Promote Correct Folding; Facilitate Transport to the Plasma Membrane; Coreceptor; CROSS-PARTNERING; CONCLUSION; REFERENCES; CHAPTER 8 REGULATION OF RAMP EXPRESSION IN DISEASES; INTRODUCTION; REGULATION OF RAMP IN HEART FAILURE; REGULATION OF RAMP IN CARCINOGENESIS; REGULATION OF RAMP IN SEPSIS; REGULATION OF RAMP IN OTHER DISEASES; CONCLUSION; ACKNOWLEDGEMENTS; REFERENCES
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CHAPTER 9 PERSPECTIVES ON SOME RECENT STUDIES ON RAMPs
Additional Edition:
ISBN 9781461423638
Additional Edition:
Buchausg. u.d.T. ISBN 978-1-461-42363-8
Language:
English
DOI:
10.1007/978-1-4614-2364-5
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