UID:
edocfu_9960072254502883
Format:
1 online resource (499 p.)
ISBN:
1-281-01063-4
,
9786611010638
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0-08-049336-X
Series Statement:
Advances in protein chemistry ; 54
Content:
Amino acid sequence analysis is useful for the study of problems ranging from modifications of single molecules to complex networks and interactions of species. Many available amino acid sequences are providing the basis for various studies at the proteome level.The dynamics of protein expression and the simulation of complex biological systems in which proteins interact with certain kinetics and in their respective compartments are just about to be tackled. Amino acid sequences will be crucial reference points for such studies.Key Features* Mass spectrometric analysis of prote
Note:
Description based upon print version of record.
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Front Cover; Analysis of Amino Acid Sequences; Copyright Page; CONTENTS; PREFACE; Chapter 1. Mass Spectrometric Analysis of Proteins; I. Introduction; II. Ionization Techniques and Mass Spectrometers; III. Protein Identification and Sequencing with Mass Spectrometry; IV. Characterization of Posttranslational Modifications with Mass Spectrometry; V. Applications of Protein Characterization with Mass Spectrometry: Proteomics; References; Chapter 2. Protein Sequence Databases; I. Introduction; II. Protein Information Resource; III. SWISS-PROT; IV. TrEMBL
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V. Swiss-prot + TrEMBL: A Complete and Nonredundant View on Protein WorldVI. Specialized Protein Sequence Databases; References; Chapter 3. Amino Acid Substitution Matrices; I. Introduction; II. Scoring Basics; III. Theory; IV. Models for Substitution Scores; V. Special Substitution Scores; VI. Gap Scores; VII. Evaluating Scoring Functions; VIII. Position-Specific Scores; IX. Using Multiple Substitution Matrices; X. Conclusions; References; Chapter 4. Amino Acid-Based Phylogeny and Alignment; I. Introduction; II. Trees; III. Sequences; IV. Multiple Alignment.; V. Phylogenetic Reconstruction
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ReferencesChapter 5. Searching Databases to Find Protein Domain Organization; I. Introduction; II. Protein Domains; III. Domain Databases; IV. Finding New Domains; V. Profile Methods; References; Chapter 6. Identifying Nature's Protein Lego Set; I. Introduction; II. Background; III. Methods.; IV. Validation and Comparison; V. Sensitivity and Specificity; VI. Domain Recognition; VII. Conclusions; References; Chapter 7. Evolution of Domain Families; I. Introduction; II. Domain Families in Archaea, Bacteria, and Eukarya; III. Domain Orginating Early in Eukaryotic Lineage
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IV. Domain Families in Multicellular OrganismsV. Domains in Diverse Molecular Contexts; VI. Conclusions; References; Chapter 8. Protein Fold Recognition Using Sequence Profiles and Its Application in Structural Genomics; I. Introduction; II. Detecting Nontrivial Structural and Evolutionary Relationships between Proteins Using Position-Specific Scoring Matrices; III. Application of PSSMs in Structural-Genomic Analysis; IV. Conclusions and Perspective; References; Chapter 9. Protein Sorting Signals and Prediction of Subcellular Localization; I. Introduction; II. Sorting of Bacterial Proteins
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III. Sorting of Eukaryotic Proteins.IV. Concluding Remarks; References; Chapter 10. Gene and Context: Integrative Approaches to Genome Analysis; I. Introduction; II. Measuring Genome Evolution; III. Gene and Function Prediction by Conservation of Genomic Context; IV. Variation of Genomic Context; V. Discussion; References; Chapter 11. Pathway Databases and Higher Order Function; I. Introduction; II. KEGG Pathways and Ortholog Groups; III. Prediction of Higher Order Function; IV. Concluding Remarks; References; Chapter 12. Individual Variation in Protein-Coding Sequences of Human Genome
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I. Introduction
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English
Additional Edition:
ISBN 0-12-034254-5
Language:
English
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