In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-31), p. e0241097-
Abstract:
Clinical manifestations of SARS-CoV-2 infection range from mild to critically severe. The aim of the study was to highlight the immunological events associated with the severity of SARS-CoV-2 infection, with an emphasis on cells of innate immunity. Thirty COVID-19 patients with mild/moderate symptoms and 27 patients with severe/critically severe symptoms were recruited from the Clinical Center of Kragujevac during April 2020. Flow cytometric analysis was performed to reveal phenotypic and functional alterations of peripheral blood cells and to correlate them with the severity of the disease. In severe cases, the number of T and B lymphocytes, dendritic cells, NK cells, and HLA-DR-expressing cells was drastically decreased. In the monocyte population proportion between certain subsets was disturbed and cells coexpressing markers of M1 and M2 monocytes were found in intermediate and non-classical subsets. In mild cases decline in lymphocyte number was less pronounced and innate immunity was preserved as indicated by an increased number of myeloid and activated dendritic cells, NK cells that expressed activation marker at the same level as in control and by low expression of M2 marker in monocyte population. In patients with severe disease, both innate and adoptive immunity are devastated, while in patients with mild symptoms decline in lymphocyte number is lesser, and the innate immunity is preserved.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0241097
DOI:
10.1371/journal.pone.0241097.g001
DOI:
10.1371/journal.pone.0241097.g002
DOI:
10.1371/journal.pone.0241097.g003
DOI:
10.1371/journal.pone.0241097.g004
DOI:
10.1371/journal.pone.0241097.g005
DOI:
10.1371/journal.pone.0241097.g006
DOI:
10.1371/journal.pone.0241097.t001
DOI:
10.1371/journal.pone.0241097.t002
DOI:
10.1371/journal.pone.0241097.t003
DOI:
10.1371/journal.pone.0241097.s001
DOI:
10.1371/journal.pone.0241097.s002
DOI:
10.1371/journal.pone.0241097.s003
DOI:
10.1371/journal.pone.0241097.s004
DOI:
10.1371/journal.pone.0241097.s005
DOI:
10.1371/journal.pone.0241097.r001
DOI:
10.1371/journal.pone.0241097.r002
DOI:
10.1371/journal.pone.0241097.r003
DOI:
10.1371/journal.pone.0241097.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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