Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Language: English
    In: Cancer control : journal of the Moffitt Cancer Center, April 2015, Vol.22(2), pp.259-60
    Keywords: Androgen Antagonists -- Therapeutic Use ; Colorectal Neoplasms -- Epidemiology ; Prostatic Neoplasms -- Drug Therapy
    ISSN: 10732748
    E-ISSN: 1526-2359
    E-ISSN: 10732748
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Article
    Article
    Language: English
    In: Urology, 2011, Vol.77(2), pp.367-367
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    In: BJU International, December 2012, Vol.110(11b), pp.E470-E474
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2012.11155.x/abstract Byline: Philippe E. Spiess(1), Tony Kurian(1), Hui-Yi Lin(2), Bhupendra Rawal(2), Tim Kim(1), Wade J. Sexton(1), Julio M. Pow-Sang(1) Keywords: renal cell carcinoma; IVC thrombus; body mass index; overall survival; prognostic factors Study Type - Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Little is known about the prognostic impact of body mass index (BMI) and obesity on patients with locally advanced kidney cancer. Previous studies suggest that clinical/pathological stage, the proximal extent of the tumour thrombus, direct vascular wall invasion, and preoperative performance status may all constitute important prognostic factors within this patient population. The present study shows that a patient's metastatic status, higher level of tumour thrombus, and lower BMI all constitute adverse predictors of overall survival in patients who have RCC with inferior vena cava tumour thrombus. OBJECTIVE To determine which clinical variables, including body mass index (BMI), predict overall survival (OS) after nephrectomy with inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC) with tumour thrombus. PATIENTS AND METHODS After institutional review board approval, a retrospective analysis of all patients (N= 100) undergoing nephrectomy and IVC thrombectomy for RCC from 1989 to 2010 were reviewed. One patient was excluded owing to missing clinical information leaving 99 patients in the study cohort. Patients were placed into one of two subgroups, based on their preoperative BMI (BMI [less than or equal to]30 kg/m.sub.2 or BMI 〉30 kg/m.sub.2). Complications, blood loss, level of tumour thrombus, side of tumour and follow-up data were tabulated. RESULTS Fifty-six patients had a BMI [less than or equal to]30 kg/m.sub.2 and 43 patients had a BMI 〉30 kg/m.sub.2. Intraoperative complications occurred in 14% of those with BMI 〉30 kg/m.sub.2 and 5.4% of those with a BMI [less than or equal to]30 kg/m.sub.2 (P= 0.171). On multivariate analysis, a higher thrombus level (III/IV vs I/II) and the presence of metastatic disease at time of diagnosis was associated with a worse OS (P= 0.041 and P 0.001, respectively). The subgroup with a higher preoperative BMI had a significantly better OS (hazard ratio 0.42; 95% confidence interval 0.22-0.80, P= 0.009). Similarly, our Kaplan-Meier survival analysis showed an improved OS in the patient cohort with a BMI 〉30 kg/m.sub.2 (P= 0.016). CONCLUSION Important predictors of outcome in patients undergoing nephrectomy with IVC thrombectomy for RCC with tumour thrombus include preoperative BMI, level of IVC tumour thrombus, and metastatic status at time of surgery. Author Affiliation: (1)Departments of Genitourinary Oncology (2)Biostatistics, Moffitt Cancer Center, Tampa, FL, USA Correspondence: (*) Philippe E. Spiess, Department of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Office 12538, Tampa, FL 33612, USA. e-mail: philippe.spiess@moffitt.org Accepted for publication 8 February 2012 CAPTION(S): Supporting info item
    Keywords: Renal Cell Carcinoma ; Ivc Thrombus ; Body Mass Index ; Overall Survival ; Prognostic Factors
    ISSN: 1464-4096
    E-ISSN: 1464-410X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: Urology, 2010, Vol.76(2), pp.S2-S6
    Description: An extensive literature search was performed using the key words squamous cell carcinoma of the penis, phimosis, circumcision, chronic balanitis, cigarette smoking, genital warts and human papillomavirus (HPV) infection. All selected studies were classified according to the level of evidence (LE). The final grades of recommendation were assigned after discussion by the full panel of the International Consultation on Penile Cancer in November 2008. The factors positively associated with invasive penile cancers include the presence of phimosis (LE 3a), tobacco smoking (LE 3a-4), chewing tobacco (LE 3a), injury to the penis (LE 3a), balanitis (LE 3a), genital warts (LE 3a), and high-risk HPV infection (LE 3a-4).
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: BJU International, Nov, 2010, Vol.106(10), p.1494(5)
    Description: To authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1464-410X.2010.09293.x Byline: Surendra B. Kolla, Cesar Ercole, Philippe E. Spiess, Julio M. Pow-Sang, Wade J. Sexton Keywords: nephron-sparing surgery; renal cell carcinoma; renal vein thrombus Abstract: Study Type - Therapy (case series)Level of Evidence 4 OBJECTIVE To report the functional and oncological outcome of nephron-sparing surgery (NSS) for pathological stage pT3bNxMx (2002 Tumour-Node-Metastasis staging) renal cell carcinoma (RCC) with tumour thrombus confined to the renal vein. PATIENTS AND METHODS Of the 305 patients who underwent NSS at our institute from October 2004 to July 2009, seven (2%) were found to have stage T3bNxMx RCC on final pathology. Their charts were reviewed to identify demographic, operative and pathology details of these patients, in addition to obtaining functional and oncological outcome data. RESULTS All seven patients had centrally located endophytic tumours. There were absolute indications for NSS in six patients (solitary kidney in five, renal insufficiency in one). The clinical stage was T1a in five and T3b in two patients; in those with cT1a, thrombus was first identified with intraoperative ultrasonography in two and by palpation of the renal vein or during the NSS in the remaining three. Renal surface hypothermia was applied in four cases (mean 77 min) and warm ischaemia in three (mean 38 min). The mean (range) tumour size was 3.9 (2.5-6) cm and all the tumours were clear cell RCC on histology, and all had negative surgical margins. The mean estimated glomerular filtration rate (eGFR) decreased by 24% after surgery. One patient developed new-onset renal failure (eGFR 〈30 mL/min/1.73 m.sup.2). Postoperative urine leak occurred in one patient successfully managed with a JJ stent. One patient developed a local recurrence with level III inferior vena caval (IVC) tumour thrombus 9 months after NSS and was managed with radical excision and IVC thrombectomy followed by postoperative dialysis. Six other patients were free of recurrence with no need for dialysis at a mean follow-up of 30 months. CONCLUSIONS In selected patients with pathological stage T3b RCC and tumour thrombus confined to the renal vein, NSS is a feasible treatment option with acceptable oncological and renal functional outcomes. Article History: Accepted for publication 4 January 2010 Article note: Wade J. Sexton, Associate Member, Genitourinary Oncology Program, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612-9416, USA., e-mail: Wade.Sexton@Moffitt.org
    Keywords: Cancer Research ; Renal Cell Carcinoma
    ISSN: 1464-4096
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Language: English
    In: The Journal of Urology, April 2014, Vol.191(4), pp.e500-e501
    Keywords: Medicine
    ISSN: 0022-5347
    E-ISSN: 1527-3792
    Source: ScienceDirect Journals (Elsevier)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Cancer Control, July, 2015, Vol.22(3), p.278(2)
    Keywords: Robotic Surgery -- Methods ; Cancer Treatment -- Innovations ; Excision (Surgery) -- Innovations
    ISSN: 1073-2748
    Source: Cengage Learning, Inc.
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: Cancer control : journal of the Moffitt Cancer Center, July 2013, Vol.20(3), pp.158-9
    Keywords: Periodicals As Topic ; Precision Medicine ; Urologic Neoplasms -- Prevention & Control
    ISSN: 10732748
    E-ISSN: 1526-2359
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    In: BJU International, August 2015, Vol.116(2), pp.196-201
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/bju.13009/abstract Byline: Jared M. Gopman, Rosa S. Djajadiningrat, Adam S. Baumgarten, Patrick N. Espiritu, Simon Horenblas, Yao Zhu, Chris Protzel, Julio M. Pow-Sang, Timothy Kim, Wade J. Sexton, Michael A. Poch, Philippe E. Spiess Keywords: complications; inguinal lymph node dissection; penile cancer Objectives To assess the potential complications associated with inguinal lymph node dissection (ILND) across international tertiary care referral centres, and to determine the prognostic factors that best predict the development of these complications. Materials and Methods A retrospective chart review was conducted across four international cancer centres. The study population of 327 patients underwent diagnostic/therapeutic ILND. The endpoint was the overall incidence of complications and their respective severity (major/minor). The Clavien-Dindo classification system was used to standardize the reporting of complications. Results A total of 181 patients (55.4%) had a postoperative complication, with minor complications in 119 cases (65.7%) and major in 62 (34.3%). The total number of lymph nodes removed was an independent predictor of experiencing any complication, while the median number of lymph nodes removed was an independent predictor of major complications. The American Joint Committee on Cancer stage was an independent predictor of all wound infections, while the patient's age, ILND with Sartorius flap transposition, and surgery performed before the year 2008 were independent predictors of major wound infections. Conclusions This is the largest report of complication rates after ILND for squamous cell carcinoma of the penis and it shows that the majority of complications associated with ILND are minor and resolve without prolonged morbidity. Variables pertaining to the extent of disease burden have been found to be prognostic of increased postoperative morbidity.
    Keywords: Complications ; Inguinal Lymph Node Dissection ; Penile Cancer
    ISSN: 1464-4096
    E-ISSN: 1464-410X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    In: BJU International, December 2012, Vol.110(11b), pp.E475-E480
    Description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1111/j.1464-410X.2012.11170.x/abstract Byline: Sandhya R. Rao(1), Jose J. Correa(1), Wade J. Sexton(1), Julio M. Pow-Sang(1), Shohreh I. Dickinson(2), Hui-Yi Lin(3), Philippe E. Spiess(1) Keywords: urothelial carcinoma; lymph node dissection; upper urinary tract Study Type - Therapy (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Very little is known about the safety and potential oncological benefit of performing a retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract tumours. This study is the first clinical trial to prospectively validate the safety and feasibility of a retroperitoneal lymph node dissection at time of nephroureterectomy for upper tract tumours. The onus is now on the scientific community at large to conduct adequately powered multicentre clinical trials to evaluate the potential oncological benefit it may impart to patients with upper tract tumours. OBJECTIVE To determine the safety and feasibility of modified retroperitoneal lymph node dissection (RPLND) at the time of radical nephroureterectomy (RNU). PATIENTS AND METHODS Between 2009 and 2011, 20 patients with suspected upper urinary tract urothelial carcinoma (UUT-UC) underwent open (n= 10), laparoscopic (n= 4), or robot-assisted (n= 6) RNU with modified RPLND. Demographic, clinical and pathological data, histological nodal status, peri-operative complications and recurrence data were collected. RESULTS On histopathological review, one patient had a benign angioma and was excluded from the final data analysis. Of the remaining 19 patients, 10 had pTa, five had pT1, one had pT2, and three pT3 disease. The mean (range) lymph node count was 7 (2-17), with one patient having pathologically proven lymph node metastasis. The mean (range) operating time was 279 (146-500) min. The mean EBL was 396 (100-1100) mL, with the mean (range) hospital stay 7.1 (4-18) days. The mean (range) duration of follow-up after surgery was 12 (2-24) months. Overall, nine patients developed postoperative complications, which included eight minor (Clavien Grade I-II) and one major complication (Clavien grade IIIb). The major complication was a postoperative chylous lymphatic leak requiring surgical exploration. CONCLUSION The present results indicate that modified RPLND during RNU for UUT-UC is a feasible procedure with acceptable morbidity. A larger prospective clinical trial is needed to adequately assess its potential therapeutic benefit. Author Affiliation: (1)Departments of Genitourinary Oncology (2)Pathology (3)Biostatistics, Moffitt Cancer Center, Tampa, FL, USA Correspondence: (*) Philippe E. Spiess, Department of Genitourinary Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Office 12538, Tampa, FL 33612, USA. e-mail: philippe.spiess@moffitt.org Accepted for publication 8 February 2012 CAPTION(S): Supporting info item
    Keywords: Urothelial Carcinoma ; Lymph Node Dissection ; Upper Urinary Tract
    ISSN: 1464-4096
    E-ISSN: 1464-410X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages