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  • 1
    In: Soft Matter, 2011, Vol.7(8), pp.3735-3738
    Description: Non-close packed two-dimensional arrays of hydrogel microspheres with exceptional long range order are fabricated by exploiting the remarkable properties of hydrogels such as tunable solubility and self-healing. By addition of alcohol hydrogel microspheres self-assemble at the air/liquid interface into highly crystalline domains which can be merged using mechanical force.
    Keywords: Arrays ; Crystal Structure ; Hydrogels ; Liquids ; Long Range Order ; Microspheres ; Solubility ; Two Dimensional ; Condensed Matter Physics (General) (So);
    ISSN: 1744-683X
    E-ISSN: 1744-6848
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  • 2
    In: Chemical Communications, 2014, Vol.50(97), pp.15419-15422
    Description: A chemical route to periodic hole arrays in gold films whose holes are loaded with single gold nanoparticles is presented, paving the road to mass production of highly sensitive plasmonic sensors on large areas.
    Keywords: Nanopores ; Gold -- Chemistry ; Metal Nanoparticles -- Chemistry ; Surface Plasmon Resonance -- Instrumentation;
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 3
    In: Journal of Materials Chemistry, 2009, Vol.19(33), pp.5906-5908
    Description: Sub-wavelength hole arrays in gold films showing extraordinary transmission of light are prepared by solely chemical methods. Hydrogel microspheres self-assemble into a highly ordered array of discs with defined spacing which is used as a mask for the deposition of a gold film by electroless plating.
    Keywords: Arrays ; Gold ; Electroless Plating ; Deposition ; Discs ; Disks ; Hydrogels ; Microspheres ; Chemical and Electrochemical Properties (MD) ; Chemical and Electrochemical Properties (EC) ; Chemical and Electrochemical Properties (Ed) ; Chemical and Electrochemical Properties (Ep) ; Thin Films, Surfaces, and Interfaces (So) ; Article;
    ISSN: 0959-9428
    E-ISSN: 1364-5501
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  • 4
    Language: English
    In: Cell, 12 July 2018, Vol.174(2), pp.448-464.e24
    Description: Land plants evolved from charophytic algae, among which Charophyceae possess the most complex body plans. We present the genome of ; comparison of the genome to those of land plants identified evolutionary novelties for plant terrestrialization and land plant heritage genes. employs unique xylan synthases for cell wall biosynthesis, a phragmoplast (cell separation) mechanism similar to that of land plants, and many phytohormones. plastids are controlled via land-plant-like retrograde signaling, and transcriptional regulation is more elaborate than in other algae. The morphological complexity of this organism may result from expanded gene families, with three cases of particular note: genes effecting tolerance to reactive oxygen species (ROS), LysM receptor-like kinases, and transcription factors (TFs). Transcriptomic analysis of sexual reproductive structures reveals intricate control by TFs, activity of the ROS gene network, and the ancestral use of plant-like storage and stress protection proteins in the zygote. The draft genome of reveals many plant-like features important for colonization of land that evolved in charophytic algae and therefore prior to the earliest land plants.
    Keywords: Plant Evolution ; Charophyte ; Phytohormones ; Transcriptional Regulation ; Phragmoplastophyta ; Chara ; Streptophyte ; Reactive Oxygen Species ; Phragmoplast ; Biology
    ISSN: 0092-8674
    E-ISSN: 1097-4172
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  • 5
    Keywords: Chemistry And Allied Sciences
    Source: DataCite
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  • 6
    Language: English
    In: Koh, D., S. C. Kaste, S. J. Vinnicombe, G. Morana, A. Rossi, C. J. Herold, T. C. McLoud, et al. 2016. “Proceedings of the International Cancer Imaging Society (ICIS) 16th Annual Teaching Course: Glasgow, UK. 3–5 October 2016.” Cancer Imaging 16 (Suppl 1): 28. doi:10.1186/s40644-016-0079-z. http://dx.doi.org/10.1186/s40644-016-0079-z.
    Description: Table of contents O1 Tumour heterogeneity: what does it mean? Dow-Mu Koh O2 Skeletal sequelae in adult survivors of childhood cancer Sue Creviston Kaste O3 Locoregional effects of breast cancer treatment Sarah J Vinnicombe O4 Imaging of cancer therapy-induced CNS toxicity Giovanni Morana, Andrea Rossi O5 Screening for lung cancer Christian J. Herold O6Risk stratification of lung nodules Theresa C. McLoud O7 PET imaging of pulmonary nodules Kirk A Frey O8 Transarterial tumour therapy Bernhard Gebauer O9 Interventional radiology in paediatric oncology Derek Roebuck O10 Image guided prostate interventions Jurgen J. Fütterer O11 Imaging cancer predisposition syndromes Alexander J. Towbin O12Chest and chest wall masses Thierry AG Huisman O13 Abdominal masses: good or bad? Anne MJB Smets O14 Hepatobiliary MR contrast: enhanced liver MRI for HCC diagnosis and management Giovanni Morana O15 Role of US elastography and multimodality fusion for managing patients with chronic liver disease and HCC Jeong Min Lee O16 Opportunities and challenges in imaging metastatic disease Hersh Chandarana O17 Diagnosis, treatment monitoring, and follow-up of lymphoma Marius E. Mayerhoefer, Markus Raderer, Alexander Haug O18 Managing high-risk and advanced prostate cancer Matthias Eiber O19 Immunotherapy: imaging challenges Bernhard Gebauer O20 RECIST and RECIST 1.1 Andrea Rockall O21 Challenges of RECIST in oncology imaging basics for the trainee and novice Aslam Sohaib O22 Lymphoma: PET for interim and end of treatment response assessment: a users’ guide to the Deauville Score Victoria S Warbey O23 Available resources Hebert Alberto Vargas O24 ICIS e-portal and the online learning community Dow-Mu Koh O25 Benign lesions that mimic pancreatic cancer Jay P Heiken O26 Staging and reporting pancreatic malignancies Isaac R Francis, Mahmoud, M Al-Hawary, Ravi K Kaza O27 Intraductal papillary mucinous neoplasm Giovanni Morana O28 Cystic pancreatic tumours Mirko D’Onofrio O29 Diffusion-weighted imaging of head and neck tumours Harriet C. Thoeny O30 Radiation injury in the head and neck Ann D King O31 PET/MR of paediatric brain tumours Giovanni Morana, Arnoldo Piccardo, Maria Luisa Garrè, Andrea Rossi O32 Structured reporting and beyond Hebert Alberto Vargas O33 Massachusetts General Hospital experience with structured reporting Theresa C. McLoud O34 The oncologist’s perspective: what the oncologist needs to know Nick Reed O35 Towards the cure of all children with cancer: global initiatives in pediatric oncology Carlos Rodriguez-Galindo O36 Multiparametric imaging of renal cancers Hersh Chandarana O37 Linking imaging features of renal disease and their impact on management strategies Hebert Alberto Vargas O38 Adrenals, retroperitoneum and peritoneum Isaac R Francis, Ashish P Wasnik O39 Lung and pleura Stefan Diederich O40 Advances in MRI Jurgen J. Fütterer O41 Advances in molecular imaging Wim J.G. Oyen O42 Incorporating advanced imaging, impact on treatment selection and patient outcome Cheng Lee Chaw, Nicholas van As S1 Combining ADC-histogram features improves performance of MR diffusion-weighted imaging for Lymph node characterisation in cervical cancer Igor Vieira, Frederik De Keyzer, Elleke Dresen, Sileny Han, Ignace Vergote, Philippe Moerman, Frederic Amant, Michel Koole, Vincent Vandecaveye S2 Whole-body diffusion-weighted MRI for surgical planning in patients with colorectal cancer and peritoneal metastases R Dresen, S De Vuysere, F De Keyzer, E Van Cutsem, A D’Hoore, A Wolthuis, V Vandecaveye S3 Role of apparent diffusion coefficient (ADC) diffusion-weighted MRI for predicting extra capsular extension of prostate cancer. P. Pricolo (paola.pricolo@ieo.it), S. Alessi, P. Summers, E. Tagliabue, G. Petralia S4 Generating evidence for clinical benefit of PET/CT – are management studies sufficient as surrogate for patient outcome? C. Pfannenberg, B. Gückel, SC Schüle, AC Müller, S. Kaufmann, N. Schwenzer, M. Reimold,C. la Fougere, K. Nikolaou, P. Martus S5 Heterogeneity of treatment response in skeletal metastases from breast cancer with 18F-fluoride and 18F-FDG PET GJ Cook, GK Azad, BP Taylor, M Siddique, J John, J Mansi, M Harries, V Goh S6 Accuracy of suspicious breast imaging—can we tell the patient? S Seth, R Burgul, A Seth S7 Measurement method of tumour volume changes during neoadjuvant chemotherapy affects ability to predict pathological response S Waugh, N Muhammad Gowdh, C Purdie, A Evans, E Crowe, A Thompson, S Vinnicombe S8 Diagnostic yield of CT IVU in haematuria screening F. Arfeen, T. Campion, E. Goldstraw S9 Percutaneous radiofrequency ablation of unresectable locally advanced pancreatic cancer: preliminary results D’Onofrio M, Ciaravino V, Crosara S, De Robertis R, Pozzi Mucelli R S10 Iodine maps from dual energy CT improve detection of metastases in staging examinations of melanoma patients M. Uhrig, D. Simons, H. Schlemmer S11Can contrast enhanced CT predict pelvic nodal status in malignant melanoma of the lower limb? Kate Downey S12 Current practice in the investigation for suspected Paraneoplastic Neurological Syndromes (PNS) and positive malignancy yield. S Murdoch, AS Al-adhami, S Viswanathan P1 Technical success and efficacy of Pulmonary Radiofrequency ablation: an analysis of 207 ablations S Smith, P Jennings, D Bowers, R Soomal P2 Lesion control and patient outcome: prospective analysis of radiofrequency abaltion in pulmonary colorectal cancer metastatic disease S Smith, P Jennings, D Bowers, R Soomal P3 Hepatocellular carcinoma in a post-TB patient: case of tropical infections and oncologic imaging challenges TM Mutala, AO Odhiambo, N Harish P4 Role of apparent diffusion coefficient (ADC) diffusion-weighted MRI for predicting extracapsular extension of prostate cancer P. Pricolo, S. Alessi, P. Summers, E. Tagliabue, G. Petralia P5 What a difference a decade makes; comparison of lung biopsies in Glasgow 2005 and 2015 M. Hall, M. Sproule, S. Sheridan P6 Solid pseudopapillary tumour of pancreas: imaging features of a rare neoplasm KY Thein, CH Tan, YL Thian, CM Ho P7 MDCT - pathological correlation in colon adenocarcinoma staging: preliminary experience S De Luca, C Carrera, V Blanchet, L Alarcón, E Eyheremnedy P8 Image guided biopsy of thoracic masses and reduction of pneumothorax risk: 25 years experience B K Choudhury, K Bujarbarua, G Barman P9 Tumour heterogeneity analysis of 18F-FDG-PET for characterisation of malignant peripheral nerve sheath tumours in neurofibromatosis-1 GJ Cook, E Lovat, M Siddique, V Goh, R Ferner, VS Warbey P10 Impact of introduction of vacuum assisted excision (VAE) on screen detected high risk breast lesions L Potti, B Kaye, A Beattie, K Dutton P11 Can we reduce prevalent recall rate in breast screening? AA Seth, F Constantinidis, H Dobson P12 How to reduce prevalent recall rate? Identifying mammographic lesions with low Positive Predictive Value (PPV) AA Seth (archana.seth@nhs.net), F Constantinidis, H Dobson P13 Behaviour of untreated pulmonary thrombus in oncology patients diagnosed with incidental pulmonary embolism on CT R. Bradley, G. Bozas, G. Avery, A. Stephens, A. Maraveyas P14 A one-stop lymphoma biopsy service – is it possible? S Bhuva, CA Johnson, M Subesinghe, N Taylor P15 Changes in the new TNM classification for lung cancer (8th edition, effective January 2017) LE Quint, RM Reddy, GP Kalemkerian P16 Cancer immunotherapy: a review of adequate imaging assessment G González Zapico, E Gainza Jauregui, R Álvarez Francisco, S Ibáñez Alonso, I Tavera Bahillo, L Múgica Álvarez P17 Succinate dehydrogenase mutations and their associated tumours O Francies, R Wheeler, L Childs, A Adams, A Sahdev P18 Initial experience in the usefulness of dual energy technique in the abdomen SE De Luca, ME Casalini Vañek, MD Pascuzzi, T Gillanders, PM Ramos, EP Eyheremendy P19 Recognising the serious complication of Richter’s transformation in CLL patients C Stove, M Digby P20 Body diffusion-weighted MRI in oncologic practice: truths, tricks and tips M. Nazar, M. Wirtz, MD. Pascuzzi, F. Troncoso, F. Saguier, EP. Eyheremendy P21 Methotrexate-induced leukoencephalopathy in paediatric ALL Patients D.J. Quint, L. Dang, M. Carlson, S. Leber, F. Silverstein P22 Pitfalls in oncology CT reporting. A pictorial review R Rueben, S Viswanathan P23 Imaging of perineural extension in head and neck tumours B Nazir, TH Teo, JB Khoo P24 MRI findings of molecular subtypes of breast cancer: a pictorial primer K Sharma, N Gupta, B Mathew, T Jeyakumar, K Harkins P25 When cancer can’t wait! A pictorial review of oncological emergencies K Sharma, B Mathew, N Gupta, T Jeyakumar, S Joshua P26 MRI of pancreatic neuroendocrine tumours: an approach to interpretation D Christodoulou, S Gourtsoyianni, A Jacques, N Griffin, V Goh P27 Gynaecological cancers in pregnancy: a review of imaging CA Johnson, J Lee P28 Suspected paraneoplastic neurological syndromes - review of published recommendations to date, with proposed guideline/flowchart JA Goodfellow, AS Al-adhami, S Viswanathan P29 Multi-parametric MRI of the pelvis for suspected local recurrence of prostate cancer after radical prostatectomy R Bradley P30 Utilisation of PI-RADS version 2 in multi-parametric MRI of the prostate; 12-months experience R Bradley P31 Radiological assessment of the post-chemotherapy liver A Yong, S Jenkins, G Joseph P32 Skeletal staging with MRI in breast cancer – what the radiologist needs to know S Bhuva, K Partington P33 Perineural spread of lympoma: an educational review of an unusual distribution of disease CA Johnson, S Bhuva, M Subesinghe, N Taylor P34 Visually isoattenuating pancreatic adenocarcinoma. Diagnostic imaging tools. C Carrera, A Zanfardini, S De Luca, L Alarcón, V Blanchet, EP Eyheremendy P35 Imaging of larynx cancer: when is CT, MRI or FDG PET/CT the best test? K Cavanagh, E Lau
    Keywords: Diagnostic Imaging -- Conferences, Meetings And Seminars ; Cancer Diagnosis -- Conferences, Meetings And Seminars ; Medical Societies -- Conferences, Meetings And Seminars;
    ISSN: 1740-5025
    ISSN: 14707330
    E-ISSN: 14707330
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  • 7
    Language: English
    In: Diabetologia, 2004, Vol.47(Supplement 1), pp.A1-A464
    Description: Background and aims: Recent data suggest that the use of insulin to maintain intensive glycaemic control amongst surgical ICU patients can improve morbidity and mortality. The value of this procedure in non-surgical patients is not known. Current insulin therapy for non-surgical patients in many ICUs aims to keep plasma glucose below 9 mmolll. The effect of this insulin therapy protocol on the catabolic response of critical illness, characterised by increased glucose production, increased lipolysis and proteolysis is unknown. Materials and methods: A prospective study was conducted in seven critically ill non-surgical patients (6M:1F, age 64±2.72 years; BMI 24.77 ± 0.77 kg/m2) within 36 hours of their admission to the ICU. Patients with diabetes mellitus, pancreatitis, oral steroid use within 1 month of entering the ICU, or liver disease (LFTs 〉 twice normal range), were excluded. All patients were receiving 20% dextrose intravenously to provide 25kcal.kg-lday-l. Insulin was infused at a variable rate to maintain plasma glucose below 9 mmollL. Glucose production rate (Ra) and rate of uptake (Rd), glycerol Ra (a measure oflipolysis) and leucine Ra (a measure of proteolysis) were measured with a 3 hour primed infusion of [6,6- 2H2]glucose (l70mg, 1.7mg.min-I), [2H5]glycerol (0.15mg/kg, 0.61mg· kg-lhc1) and [l-l3C]leucine (1 mg/kg, 1 mg.kg-lhcl). Steady state sampling was performed at 150 to 180 minutes. Results are compared with fasting values from an age and weight matched healthy control group. All data presented are mean ± SEM. Results: The mean APACHE II score on the day of study was 15.43 ± 1.87. Mean plasma glucose at steady state was 7.95±0.73mmol· L-l. The mean glucose infusion rate was 22.83 ± 0.74 f.lmol.kg-lmin-l. The average insulin infusion rate was 4.31 ±0.73 U.hr-l which achieved plasma insulin concentrations of 655.21 ± 181.38 pmol.L-I. Endogenous glucose Ra was decreased (2.24±3.02f.lmol.kg-lmin-l, p〈0.03) and glucose Rd was increased (25.08±3.07f.lmol.kg-lmin-l, P〈O.OOOl) compared to fasting glucose Ra/Rd in the control subjects (8.7 ± 0.39 f.lmol.kg-lmin-l). Glycerol Ra and concentration (1.66±0.23f.lmol.kg-lmin-1 and 46.72 ± 12.25 f.lmol.L-1 respectively) were reduced (p〈0.02, P=0.07) compared to the control subjects (2.89 ± 0.47 f.lmol.kg-lmin-l and 70.03 ± 8.53 f.lmol.L -1). Plasma NEFA concentrations were very low at 0.10 ±0.03 mmol.L-1 compared to fasting values in the control subjects (0.71 ±0.09mmol.L-I, P〈O.OOOl). Leucine Ra was 2.16±0.31 f.lmol.kg-lmin-l, which was not significantly different to fasting control subjects (1.71 ±O.ll f.lmol.kg-lmin-l, P=O.ll). Conclusion: In non-surgical ICU patients, the use of insulin to maintain glycaemic control below 9 mmolll was effective in suppressing glucose production rate, increasing glucose uptake and decreasing lipolysis, but did not suppress proteolysis to levels below that seen in fasting control subjects. If full suppression of proteolysis is to be of benefit in this catabolic group of subjects, then higher doses of insulin will be necessary.
    Keywords: Medicine;
    ISSN: 0012-186X
    E-ISSN: 1432-0428
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