Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Medium
Language
Year
  • 1
    Language: English
    In: Psychopharmacology, 1992, Vol.106 Suppl, pp.S87-9
    Description: Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the "effect size", such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few dose-response studies have been performed. However, trials of both tricyclic antidepressants and phenelzine have shown that statistically significant improvements in outcome result from the use of higher dosages; the length of treatment may also affect results. In some studies, the proportion of patients showing a clear-cut response increased significantly among patients treated with active drug instead of placebo when the treatment period was extended from 4 to 6 weeks, independent of the dose used. There may thus be a distinct advantage in extending trials of antidepressants for a minimum of 6 weeks. Two-phase drug trials can be used to extend the trial period still further in responding patients, to emphasize the contrast between treatment and placebo effects and to eliminate type-2 errors. Twelve-week trials might increase the statistical power of the evaluation by 10-20%, in studies where the drug effect size is small. Pattern analysis of the timing and duration of patients' responses has been shown to aid the distinction of true responses from non-specific or placebo effects, and may be useful for evaluating data from studies of antidepressant agents which yield ambiguous results.
    Keywords: Clinical Trials As Topic ; Antidepressive Agents -- Therapeutic Use ; Depression -- Drug Therapy
    ISSN: 0033-3158
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Language: English
    In: Psychopharmacology, 1992, Vol.106, pp.S87-S89
    Description: Evaluation of the efficacy of antidepressant agents needs to take into account factors which increase the “effect size”, such as dosage, treatment duration, the use of two-phase trials, and pattern analysis of responders. Although many patients are thought to receive inadequate doses of antidepressants, relatively few dose-response studies have been performed. However, trials of both tricyclic antidepressants and phenelzine have shown that statistically significant improvements in outcome result from the use of higher dosages; the length of treatment may also affect results. In some studies, the proportion of patients showing a clear-cut response increased significantly among patients treated with active drug instead of placebo when the treatment period was extended from 4 to 6 weeks, independent of the dose used. There may thus be a distinct advantage in extending trials of antidepressants for a minimum of 6 weeks. Two-phase drug trials can be used to extend the trial period still further in responding patients, to emphasise the contrast between treatment and placebo effects and to eliminate type-2 errors. Twelve-week trials might increase the statistical power of the evaluation by 10–20%, in studies where the drug effect size is small. Pattern analysis of the timing and duration of patients' responses has been shown to aid the distinction of true responses from non-specific or placebo effects, and may be useful for evaluating data from studies of antidepressant agents which yield ambiguous results.
    Keywords: Antidepressant agents ; Trial methodology ; Pattern analysis ; Two-phase trial design
    ISSN: 0033-3158
    E-ISSN: 1432-2072
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: The British journal of psychiatry : the journal of mental science, December 1985, Vol.147, pp.593-7
    Description: The treatment of depressive disorders was significantly altered by the introduction of the tricyclic antidepressants and the monoamine oxidase inhibitors. One salient factor in determining efficacy is the dose prescribed. The few good dose response studies which are available indicate that patients should receive 300 mg of imipramine or equivalent, and a separate trial of 90 mg of phenelzine or equivalent, before concluding they are treatment refractory. Data are reviewed which suggest many patients receive inadequate doses.
    Keywords: Antidepressive Agents, Tricyclic -- Administration & Dosage ; Monoamine Oxidase Inhibitors -- Administration & Dosage
    ISSN: 0007-1250
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: The Journal of clinical psychiatry, May 2001, Vol.62(5), pp.358-61
    Description: A single study utilizing a cross-sectional analysis of scores on the Hamilton Rating Scale for Depression (HAM-D) suggested that mirtazapine has a more rapid onset than selective serotonin reuptake inhibitors (SSRIs). Analysis based on the HAM-D may favor drugs with sleep-producing effects. The purpose of the present study was to determine if a review of all studies comparing an SSRI with mirtazapine, utilizing persistent improvement as the dependent variable, would suggest that mirtazapine had a more rapid onset than SSRIs. All double-blind studies comparing mirtazapine with SSRIs were analyzed. Included in the analysis to determine speed of onset were 298 patients taking mirtazapine and 285 taking an SSRI. Pattern analysis, which has been described and used by other researchers, was employed to study speed of onset. At the end of each of the 3 studies, the total number of responders for each of the drugs did not differ. However, the proportion of responders with onset of persistent improvement in week 1 was greater for mirtazapine (13%, 38/298) than for the SSRIs (6%, 18/285; chi2 = 6.95, df = 1, p = .008). These data support the possibility that mirtazapine may have a more rapid onset than SSRIs. This observation should be considered preliminary because of the retrospective nature of the analysis and the absence of a placebo group.
    Keywords: Antidepressive Agents, Tricyclic -- Pharmacology ; Depressive Disorder -- Drug Therapy ; Mianserin -- Pharmacology ; Serotonin Uptake Inhibitors -- Pharmacology
    ISSN: 0160-6689
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Article
    Article
    Language: English
    In: The British journal of psychiatry : the journal of mental science, August 1998, Vol.173, pp.181
    Keywords: Antidepressive Agents -- Therapeutic Use
    ISSN: 0007-1250
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Article
    Article
    Language: English
    In: British Journal of Psychiatry, 08/1998, Vol.173(2), pp.181-181
    Description: This initial attempt to gain more recognition for our journal did not appear to give the results we had hoped for. So, after listening to the suggestions and criticisms of many fellow editors of internationally renowned journals, we have now decided to rename our Genetics and Molecular Biology, reprogramming the objectives and editorial structure to adapt to this new title. We could no longer ignore the way in which genetics and molecular biology have become interrelated, working with the same techniques and towards the same goals. So why not include this "new" area of science, instead of letting this important part of what we know as genetics become detached as if it were somehow something "foreign". Genetics has changed tremendously during the last decade. New techniques and the knowledge that they have provided have made us realize that there is no distinct line that can separate genetics from evolution, or from the rest of biology, chemistry of medicine. All the many excellent scientists, who use these new tools and thus aproximate domains that were once unique to geneticists, should certainly feel welcome to publish in, and thus enrich our journal. This kind of integration will fortify our efforts to make this journal an effective partner in the drive to internationalize Brazilian and regional science.
    Keywords: Languages & Literatures;
    ISSN: 0007-1250
    ISSN: 01024450
    E-ISSN: 1472-1465
    E-ISSN: 1678460X
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    In: Acta Psychiatrica Scandinavica, February 2007, Vol.115, pp.58-71
    Description: The Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV, 1994) included atypical features as an illness specifier for major depression and dysthymia. We asked whether subsequent literature supported its validity and addressed the relationship between depression with atypical features and melancholia. Literature review focusing on studies addressing the validity of atypical depression, supplemented by the authors’ previously unpublished data. Most studies support the discriminant validity of depression with atypical features relative to melancholia and depression having neither melancholic nor atypical features. However, studies addressing illness course suggest that criteria for depression with atypical features define a heterogeneous patient population. DSM‐IV criteria for depression with atypical features define a valid, but heterogeneous disorder. Criteria including age of onset and chronicity may define a more homogeneous group that is distinct from both melancholia and other depressed patients.
    Keywords: Atypical Depression ; Melancholia ; Validity ; Dsm‐Iv Criteria ; Review Of The Literature
    ISSN: 0001-690X
    E-ISSN: 1600-0447
    E-ISSN: 00651591
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    In: Neuropsychopharmacology, 1996, Vol.15(4), p.390
    Description: Recently the claim that there is a lag in the time of onset of antidepressant effects has been questioned. This issue rests on contrasting the time course of ultimate responders versus nonresponders on imipramine and amitriptyline. It is concluded that in 1 week on antidepressants "clinicians were capable of detecting changes in general states between the groups and the specific effects of depressed mood and anxiety and the physical expression of distress" (Katz et al. 1987). To examine this issue, we first used the design in which ultimate responders and ultimate nonresponders to antidepressants were compared at 1 and 2 weeks. Clearly there were statistically significant differences between ultimate responders and nonresponders on drug. However, the same was true on placebo. When the ultimate responders on placebo were contrasted to the ultimate responders on drug at 1 and 2 weeks using the Clinical global Impression (CGI) scale and the Hamilton Depression Rating Scale (HDRS), there was no difference between drug and placebo. This was also true for a subgroup of patients who met the criteria for melancholia. We conclude that, if the effects of nonspecific improvement are partialed out, there is no evidence of a medication effect at 1 and 2 weeks.
    Keywords: Medicine ; Pharmacy, Therapeutics, & Pharmacology ; Anatomy & Physiology;
    ISSN: 0893-133X
    E-ISSN: 1740634X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Language: English
    In: The British journal of psychiatry : the journal of mental science, October 1985, Vol.147, pp.455-6
    Keywords: Schizophrenia -- Drug Therapy
    ISSN: 0007-1250
    Source: MEDLINE/PubMed (U.S. National Library of Medicine)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: British Journal of Psychiatry, 10/1985, Vol.147(4), pp.455-456
    ISSN: 0007-1250
    E-ISSN: 1472-1465
    Source: CrossRef
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages