Kooperativer Bibliotheksverbund

Berlin Brandenburg

and
and

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Year
  • 1
    Language: English
    In: The Journal of Allergy and Clinical Immunology, 2015, Vol.135(2), p.AB93
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaci.2014.12.1236 Byline: William Rae Author Affiliation: University Hospital Southampton, Southampton, United Kingdom Article Note: (miscellaneous) 298
    Keywords: Myasthenia Gravis – Care and Treatment
    ISSN: 0091-6749
    E-ISSN: 10976825
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    In: Journal of Pediatric Psychology, 2015, Vol. 40(6), pp.554-558
    Keywords: Child–History ; Cooperative Behavior–History ; History, 20th Century–History ; History, 21st Century–History ; Humans–History ; Psychology, Child–History ; Rae;
    ISSN: 0146-8693
    E-ISSN: 1465-735X
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Language: English
    In: Archivum immunologiae et therapiae experimentalis, April 2017, Vol.65(2), pp.101-110
    Description: Primary immunodeficiencies (PIDs) are a group of rare genetic diseases resulting in the impairment of one or more functions of the human immune system. Common variable immunodeficiency (CVID) is one of the most prevalent PIDs, yet despite extensive genetic analysis, most patients do not have a monogenetic diagnosis. This has led to the theory that CVID must be a polygenetic condition. An alternative theory to a monogenetic or polygenetic underlying cause of CVID is that it is epigenetic phenomena that are causal in the majority of CVID patients. I will briefly discuss epigenetic regulation in B-cell biology and development, current examples of epigenetic diseases causing CVID-like primary antibody deficiencies, and how these observations may guide future investigation into the role of epigenetics in CVID.
    Keywords: B-Cell Development ; Common Variable Immunodeficiency ; Epigenetics ; Epigenesis, Genetic ; Common Variable Immunodeficiency -- Diagnosis
    ISSN: 0004069X
    E-ISSN: 1661-4917
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Language: English
    In: The Journal of Allergy and Clinical Immunology, 2015, Vol.135(2), p.AB64
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jaci.2014.12.1142 Byline: Xiaoying Zhou, Efrem Eren, William Rae, Andrew F. Walls Author Affiliation: (1) University of Southampton, Southampton General Hospital, Southampton, United Kingdom; University of Changzhou, Jiangsu, Changzhou, China (2) Southampton General Hospital, UK, Southampton, United Kingdom (3) University Hospital Southampton, Southampton, United Kingdom (4) University of Southampton, Southampton General Hospital, Southampton, United Kingdom Article Note: (miscellaneous) 205
    Keywords: Bradykinin ; Allergy
    ISSN: 0091-6749
    E-ISSN: 10976825
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Language: English
    In: Journal of Neuroimmunology, 15 April 2016, Vol.293, pp.82-85
    Description: Myasthenia gravis (MG) is an autoimmune neuromuscular disorder characterised by fatigable voluntary skeletal muscle weakness. The underlying pathogenesis is complex involving adaptive autoimmune responses. Azathioprine remains a first line broad acting immunosuppressant for MG. Due to varied clinical responses to azathioprine we aimed to investigate the relationship between azathioprine metabolites and symptom control. Mild correlations between Quantitative Myasthenia Gravis Score (QMG) vs. 6-thioguanine nucleotides (R = − 0.317 p = 0.186) and QMG vs. lymphocyte count (R = 0.402 p = 0.08) were found. Azathioprine metabolite measurement should be considered in MG patients with; pancytopenia, deranged liver function or recurrent infections.
    Keywords: Myasthenia Gravis ; Azathioprine ; Thiopurine Metabolites ; Lymphocytes ; Medicine ; Anatomy & Physiology
    ISSN: 0165-5728
    E-ISSN: 1872-8421
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    In: PLoS ONE, 2012, Vol.7(12)
    Description: Cryptococcal induced visual loss is a devastating complication in survivors of cryptococcal meningitis (CM). Early detection is paramount in prevention and treatment. Subclinical optic nerve dysfunction in CM has not hitherto been investigated by electrophysiological means. We undertook a prospective study on 90 HIV sero-positive patients with culture confirmed CM. Seventy-four patients underwent visual evoked potential (VEP) testing and 47 patients underwent Humphrey's visual field (HVF) testing. Decreased best corrected visual acuity (BCVA) was detected in 46.5% of patients. VEP was abnormal in 51/74 (68.9%) right eyes and 50/74 (67.6%) left eyes. VEP P100 latency was the main abnormality with mean latency values of 118.9 (±16.5) ms and 119.8 (±15.7) ms for the right and left eyes respectively, mildly prolonged when compared to our laboratory references of 104 (±10) ms (p〈0.001). Subclinical VEP abnormality was detected in 56.5% of normal eyes and constituted mostly latency abnormality. VEP amplitude was also significantly reduced in this cohort but minimally so in the visually unimpaired. HVF was abnormal in 36/47 (76.6%) right eyes and 32/45 (71.1%) left eyes. The predominant field defect was peripheral constriction with an enlarged blind spot suggesting the greater impact by raised intracranial pressure over that of optic neuritis. Whether this was due to papilloedema or a compartment syndrome is open to further investigation. Subclinical HVF abnormalities were minimal and therefore a poor screening test for early optic nerve dysfunction. However, early optic nerve dysfunction can be detected by testing of VEP P100 latency, which may precede the onset of visual loss in CM.
    Keywords: Research Article ; Medicine
    E-ISSN: 1932-6203
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Language: English
    In: Materials Characterization, October 2017, Vol.132, pp.10-19
    Description: The evolution of residual stress and microstructure has been investigated in electron-beam welded Ti-6Al-4V alloy rings in order to develop an understanding of how the distribution of through-thickness residual stress correlates with microstructural evolution. A multiple technique approach to residual stress measurement was employed using a combination of different measurement techniques including X-ray diffraction (XRD), hole drilling method based on electronic speckle pattern interferometry (ESPI), and the contour method. It was found that there is a strong correlation between the change in residual stress and alpha phase morphology across the weld. The fusion zone exhibited highly tensile residual stress which was typified by an entirely acicular α′ microstructure formed by a displacive transformation within prior β grains on cooling. The tensile residual stress in the centre of the weld reduced towards the heat affected zone, transitioning to a compressive residual stress upon increasing distance from the weld centre. The transition from tensile to compressive residual stress correlates with a significant decrease in the volume fraction of α′ and an increase in the bimodal morphology of equiaxed primary alpha in a diffusional transformed beta matrix leading to elongated alpha in the base material.
    Keywords: X-Ray Diffraction ; Weld ; Residual Stress ; Contour Method ; Titanium Alloys ; Phase Transformation ; Engineering ; Chemistry
    ISSN: 1044-5803
    E-ISSN: 1873-4189
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Language: English
    In: South African Journal of Radiology, 01 June 2012, Vol.16(2), pp.44-48
    Description: Background. Image post-processing gives computed radiography (CR) a considerable advantage over film-screen systems. After digitisation of information from CR plates, data are routinely processed using manufacturer-specific software. Agfa CR readers use MUSICA software, and an upgrade with significantly different image appearance was recently released: MUSICA2. Aim. This study quantitatively compares the image quality of images acquired without post-processing (flatfield) with images processed using these two software packages. Methods. Four aspects of image quality were evaluated. An aluminium step-wedge was imaged using constant mA at tube voltages varying from 40 to 117kV. Signal-to-noise ratios (SNRs) and contrast-to-noise Ratios (CNRs) were calculated from all steps. Contrast variation with object size was evaluated with visual assessment of images of a Perspex contrast-detail phantom, and an image quality figure (IQF) was calculated. Resolution was assessed using modulation transfer functions (MTFs). Results. SNRs for MUSICA2 were generally higher than the other two methods. The CNRs were comparable between the two software versions, although MUSICA2 had slightly higher values at lower kV. The flatfield CNR values were better than those for the processed images. All images showed a decrease in CNRs with tube voltage. The contrast-detail measurements showed that both MUSICA programmes improved the contrast of smaller objects. MUSICA2 was found to give the lowest (best) IQF; MTF measurements confirmed this, with values at 3.5 lp/mm of 10% for MUSICA2, 8% for MUSICA and 5% for flatfield. Conclusion. Both MUSICA software packages produced images with better contrast resolution than unprocessed images. MUSICA2 has slightly improved image quality than MUSICA.
    Keywords: Computed Radiography ; Image Processing
    ISSN: 1027-202X
    E-ISSN: 2078-6778
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Article
    Article
    In: Journal of Pediatric Psychology, 2004, Vol.29(1), pp.47-52
    Keywords: Managed Care; Pediatric Psychology
    ISSN: 0146-8693
    E-ISSN: 1465-735X
    Source: Oxford University Press
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Language: English
    In: Journal of Allergy and Clinical Immunology, 02/2015, Vol.135(2), S, p.AB40
    Description: RATIONALE: Adult onset Eosinophilic Oesophagitis (EoE) presents frequently to the allergy clinics in the UK. However, no study to date has attempted to describe these patients. . This case series set out to clinically characterise adults patients with EoE seen over the past four years in a tertiary care center in the UK. METHODS: We screened Allergy/Immunology clinic lists and the edocument systems at Southampton General Hospital (SGH) for patients given a diagnosis of EoE since 2010. RESULTS: Thirty six patients were identified with a diagnostic label of EoE. They were predominantly male (77.8%; 28/36) with an age range of 19 – 71 years. The majority (61%, 22/36) suffered from other atopic conditions/or showed a positive total IgE level and suspected a wide range of potential foods triggers. Interestingly, patients often considered food that are difficult to swallow such as meat, chicken and starchy food as the cause of their problems. SPT and specific IgE tests were not helpful in identifying offending foods. As expected the majority (58.3%; 21/36) were sensitised to aero-allergens with 14 being sensitised to tree/birch pollen. Dietary interventions varied widely between these patients, ranging from elemental diets, 6 food elimination diets to test directed diets. CONCLUSIONS: Male sex and atopy were found to be primary characteristics, but age did not influence the diagnosis. A wide range of foods are suspected to trigger EoE pathology in adults, and dietary measure seems to vary greatly. Studies are needed to identify which foods are implicated in adult EoE in the UK.
    Keywords: Medicine;
    ISSN: 00916749
    E-ISSN: 10976825
    Source: Elsevier (via CrossRef)
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages