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Berlin Brandenburg

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  • 1
    In: IIE Solutions, Sept, 1996, Vol.28(9), p.18(4)
    Description: The shifting role of functional managers has meant new responsibilities for engineers. In the past, the focus of their jobs was on what was being done, unlike in the present when their main task also includes how the work can be best done. The challenge for these engineers is to increase their value-added contributions to their company. Among their new responsibilities are setting goals and establishing priorities, adopting fresh management and motivational style, processing new data, finding solutions quickly, and dealing with people problems. They also need to look for more than just one solution, delegate, perform different tasks and focus on process. Among the skills they have to sharpen in their new roles are information processing skills, mental processing skills, problem solving skills and core content skills.
    Keywords: Engineers -- Management ; Middle Managers -- Practice
    ISSN: 1085-1259
    Source: Cengage Learning, Inc.
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  • 2
    Language: English
    Description: A unique low pressure pneumatic, high torque rotary actuation technique applicable to aircraft primary or standby flight control is described. This drive, the Bendix Dynavector actuator, incorporates an integrated captive vane orbital pneumatic motor with a high ratio epicyclic transmission. The demonstration of this rotary actuator technology has been accomplished by the design, fabrication and testing of two 10,000 lb-in torque capacity drives designated models PH-391-U1 and U2. (Author)
    Keywords: Attack and Fighter Aircraft ; Hydraulic and Pneumatic Equipment ; Pneumatic Servomechanisms ; Flight Control Systems ; Jet Fighters ; Aerial Rudders ; Actuators ; F-101 Aircraft
    Source: United States Defense Technical Information Center
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  • 3
    Language: English
    Description: A unique, high-torque rotary actuation technique applicable to aircraft vehicle control is described. This device, the Bendix Dynavector Actuator incorporates an integrated captive vane orbital hydraulic motor with a high ratio epicyclic transmission. The demonstration of this rotrary actuator technology has been accomplished by the design, fabrication and evaluation testing of a 100,000 in-lb torque capacity drive. (Author)
    Keywords: Aircraft ; Hydraulic and Pneumatic Equipment ; Hydraulic Actuators ; Aircraft Equipment ; Hydraulic Actuators ; Transmission Gears ; Torque ; Roller Bearings ; Drives ; Hydraulic Equipment ; Stresses ; Specifications ; Computer Aided Design ; Actuators
    Source: United States Defense Technical Information Center
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  • 4
    Language: English
    In: McGraw-Hill's AccessEngineering
    Description: Intro -- DEDICATION -- ADVISORY BOARD -- CONTRIBUTORS -- FOREWORD -- PREFACE -- ACKNOWLEDGMENTS -- CONTENTS—SECTIONS -- CONTENTS—CHAPTERS -- SECTION 1 INDUSTRIAL ENGINEERING: PAST, PRESENT, AND FUTURE -- CHAPTER 1.1 THE PURPOSE AND EVOLUTION OF INDUSTRIAL ENGINEERING -- CHAPTER 1.2 THE ROLE AND CAREER...
    Keywords: Industrial Engineering ; Industrial Engineers ; Systems Engineering ; Industrial Productivity ; Reengineering (Management) ; Industrial Management ; Industrial Management ; Teams in the Workplace ; Engineering Ethics ; Labor Costs ; Costs, Industrial ; Cost Control ; Engineering Economy ; Value Analysis (Cost Control) ; Budget ; Profit ; Cost Accounting ; Activity-Based Costing ; Pricing ; Life Cycle Costing ; Methods Engineering ; Offices ; Work Environment ; Manufacturing Industries ; Manufacturing Processes ; Work Design ; Work Measurement ; Labor Productivity ; Labor Laws and Legislation ; Human Engineering ; Industrial Safety ; Industrial Hygiene ; Overuse Injuries ; Human-Machine Systems ; ISO 14000 Series Standards ; Industrial Management ; Musculoskeletal System ; Incentives in Industry ; Job Evaluation ; Pay Equality ; Organizational Effectiveness ; Compensation Management ; Arbitration, Industrial ; Industrial Relations ; Labor Unions ; Industrial Location ; Plant Layout ; Plant Engineering ; Office Layout ; Computer-Aided Design ; Engineering Design ; Manufacturing Cells ; Business Relocation ; Flexible Manufacturing Systems ; System Design ; Production Control ; Production Management ; Just-in-Time Systems ; Business Logistics ; Production Scheduling ; Materials Management ; Materials Handling ; Warehouses ; Physical Distribution of Goods ; Marketing ; Operations Research ; Mathematical Optimization ; Queuing Theory ; Computer Simulation ; Bar Coding ; Automated Data Collection Systems ; Information Networks ; Artificial Intelligence ; Knowledge Management ; New Products ; Design, Industrial ; Concurrent Engineering ; Production Planning ; Total Quality Management ; Quality Control ; ISO 9000 Series Standards ; Process Control ; Manudfacturing Processes ; Machine Design ; Assembly-Line Methods ; Automation ; Packaging Machinery ; Robots, Industrial ; Food Service ; Plant Maintenance ; Industrial Equipment ; Total Productive Maintenance ; Statistics ; Time Study ; Work Sampling ; Cad/Cam Systems ; Project Management ; Group Technology ; Engineering ; Statistics
    ISBN: 0071449272
    ISBN: 9780070411029
    ISBN: 9780071449274
    ISBN: 0070411026
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  • 5
    Language: English
    In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 15 December 2016, Vol.63(12), pp.1668-1676
    Description:  In the Strategic Timing of Antiretroviral Treatment (START) study, immediate combination antiretroviral therapy (cART) initiation reduced cancer risk by 64%. We hypothesized that risk reduction was higher for infection-related cancer and determined by differences in CD4 cell counts and human immunodeficiency virus (HIV) RNA between the study arms.  Incident malignancies in START were categorized into infection-related and infection-unrelated cancer. We used Cox models to assess factors associated with both cancer categories. We used sequential adjustment for baseline covariates, cancer risk factors, and HIV-specific variables to investigate potential mediators of cancer risk reduction with immediate cART.  There were 14 cancers among persons randomized to immediate cART (6 infection-related and 8 infection-unrelated) and 39 cancers in the deferred arm (23 infection-related and 16 infection-unrelated); hazard ratios of immediate vs deferred cART initiation were 0.26 (95% confidence interval [CI], .11-.64) for infection-related and 0.49 (95% CI, .21-1.15) for infection-unrelated cancer. Independent predictors of infection-related cancer were older age, higher body mass index, low- to middle-income region, HIV RNA, and baseline CD8 cell count. Older age and baseline CD8 cell count were independent predictors of infection-unrelated cancer. Adjustment for latest HIV RNA level had little impact on the protective effect of immediate cART on infection-related cancer. Adjustment for latest HIV RNA level, but not for CD4 cell count or cancer risk factors, attenuated the effect of immediate cART on infection-unrelated cancer.  Immediate cART initiation significantly reduces risk of cancer. Although limited by small sample size, this benefit does not appear to be solely attributable to HIV RNA suppression and may be also mediated by other mechanisms.
    Keywords: HIV ; Kaposi Sarcoma ; Antiretroviral Therapy ; Cancer ; Non-Hodgkin Lymphoma ; Time-to-Treatment ; Anti-HIV Agents -- Therapeutic Use ; HIV Infections -- Drug Therapy ; Neoplasms -- Prevention & Control
    E-ISSN: 1537-6591
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  • 6
    Language: English
    In: Clinical Infectious Diseases, Dec 15, 2016, Vol.63(12), p.1668(9)
    Description: Background. In the Strategic Timing of Antiretroviral Treatment (START) study, immediate combination antiretroviral therapy (cART) initiation reduced cancer risk by 64%. We hypothesized that risk reduction was higher for infection-related cancer and determined by differences in CD4 cell counts and human immunodeficiency virus (HIV) RNA between the study arms. Methods. Incident malignancies in START were categorized into infection-related and infection-unrelated cancer. We used Cox models to assess factors associated with both cancer categories. We used sequential adjustment for baseline covariates, cancer risk factors, and HIV-specific variables to investigate potential mediators of cancer risk reduction with immediate cART. Results. There were 14 cancers among persons randomized to immediate cART (6 infection-related and 8 infection-unrelated) and 39 cancers in the deferred arm (23 infection-related and 16 infection-unrelated); hazard ratios of immediate vs deferred cART initiation were 0.26 (95% confidence interval [CI], .11-.64) for infection-related and 0.49 (95% CI, .21-1.15) for infection-unrelated cancer. Independent predictors of infection-related cancer were older age, higher body mass index, low- to middle-income region, HIV RNA, and baseline CD8 cell count. Older age and baseline CD8 cell count were independent predictors of infection-unrelated cancer. Adjustment for latest HIV RNA level had little impact on the protective effect of immediate cART on infection-related cancer. Adjustment for latest HIV RNA level, but not for CD4 cell count or cancer risk factors, attenuated the effect of immediate cART on infection-unrelated cancer. Conclusions. Immediate cART initiation significantly reduces risk of cancer. Although limited by small sample size, this benefit does not appear to be solely attributable to HIV RNA suppression and may be also mediated by other mechanisms.
    Keywords: Antiretroviral Agents – Dosage and Administration ; HIV Infections – Complications and Side Effects ; HIV Infections – Drug Therapy ; Cancer – Risk Factors ; Cancer – Control
    ISSN: 1058-4838
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  • 7
    Language: English
    In: The Journal of infectious diseases, 15 November 2014, Vol.210(10), pp.1549-54
    Description: Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits. NCT 01543958.
    Keywords: HIV ; LDL ; Lps ; Microbial Translocation ; Oxldl ; Scd14 ; Sevelamer ; Soluble Tissue Factor ; Bacterial Translocation ; Cardiovascular Agents -- Therapeutic Use ; Cholesterol, LDL -- Blood ; HIV Infections -- Complications ; Lipoproteins, LDL -- Blood ; Polyamines -- Therapeutic Use ; Thromboplastin -- Analysis
    ISSN: 00221899
    E-ISSN: 1537-6613
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  • 8
    Language: English
    In: Analytical chemistry, 21 October 2014, Vol.86(20), pp.10397-405
    Description: This work describes a new specific, sensitive, and rapid stable isotope dilution method for the simultaneous detection of the organophosphorus nerve agents (OPNAs) tabun (GA), sarin (GB), soman (GD), cyclosarin (GF), VR, VX, and VM adducts to tyrosine (Tyr). Serum, plasma, and lysed whole blood samples (50 μL) were prepared by protein precipitation followed by digestion with Pronase. Specific Tyr adducts were isolated from the digest by a single solid phase extraction (SPE) step, and the analytes were separated by reversed-phase ultra high performance liquid chromatography (UHPLC) gradient elution in less than 2 min. Detection was performed on a triple quadrupole tandem mass spectrometer using time-triggered selected reaction monitoring (SRM) in positive electrospray ionization (ESI) mode. The calibration range was characterized from 0.100-50.0 ng/mL for GB- and VR-Tyr and 0.250-50.0 ng/mL for GA-, GD-, GF-, and VX/VM-Tyr (R(2) ≥ 0.995). Inter- and intra-assay precision had coefficients of variation of ≤17 and ≤10%, respectively, and the measured concentration accuracies of spiked samples were within 15% of the targeted value for multiple spiking levels. The limit of detection was calculated to be 0.097, 0.027, 0.018, 0.074, 0.023, and 0.083 ng/mL for GA-, GB-, GD-, GF-, VR-, and VX/VM-Tyr, respectively. A convenience set of 96 serum samples with no known nerve agent exposure was screened and revealed no baseline values or potential interferences. This method provides a simple and highly specific diagnostic tool that may extend the time postevent that a confirmation of nerve agent exposure can be made with confidence.
    Keywords: Chromatography, High Pressure Liquid ; Spectrometry, Mass, Electrospray Ionization ; Blood Chemical Analysis -- Methods ; Chemical Warfare Agents -- Analysis
    ISSN: 00032700
    E-ISSN: 1520-6882
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  • 9
    In: Journal of Antimicrobial Chemotherapy, 2000, Vol.46(1), pp.19-26
    Description: Pathogen virulence factors and the host inflammatory response cause tissue injury associated with respiratory tract infections. The azalide azithromycin has demonstrated efficacy in the treatment of these infections. It has been demonstrated previously that induction of polymorphonuclear leucocyte (PMN) apoptosis is associated with minimization of tissue damage and inflammation in the lung. We hypothesized that, in addition to its antibacterial effects, azithromycin may promote apoptosis. The aim of the study was to determine the effects of azithromycin on PMN apoptosis, oxidative function and interleukin-8 (IL-8) production in the presence or absence of Streptococcus pneumoniae , in comparison with penicillin, erythromycin, dexamethasone or phosphate-buffered saline. Human circulating PMNs were assessed for apoptosis (by annexin V labelling and ELISA), oxidative function (by nitroblue tetrazolium reduction) and IL-8 production (by ELISA). Azithromycin significantly induced PMN apoptosis in the absence of S. pneumoniae after 1 h (10.27% 1.48%, compared with 2.19% 0.42% in controls) to levels similar to those after 3 h induction with tumour necrosis factor- (8.73% 1.86%). This effect was abolished in the presence of S. pneumoniae . Apoptosis in PMNs exposed to the other drugs was not significantly different from that in controls. Azithromycin did not affect PMN oxidative metabolism or IL-8 production. In summary, azithromycin-induced PMN apoptosis may be detected in the absence of any effect on PMN function, and the pro-apoptotic properties of azithromycin are inhibited in the presence of S. pneumoniae.
    Keywords: Streptococcus Pneumoniae ; Apoptosis ; Interleukin 8 ; Azithromycin ; Virulence ; Inflammation ; Respiratory Tract Diseases ; Macrolide Antibiotics;
    ISSN: 0305-7453
    E-ISSN: 1460-2091
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  • 10
    Language: English
    In: Experimental Eye Research, October 2002, Vol.75(4), pp.415-420
    Description: Retinal degeneration results from the apoptotic cell death of photoreceptors. While mutations in a large number of genes give rise to retinal degeneration, the specific mechanisms are not well understood. One hypothesis involves mediation of apoptosis by high concentrations of intracellular Ca(2+). We used a mouse line that carries the rd mutation but also lacks the major L-type voltage-dependent Ca(2+) channel at the photoreceptor synapse to examine whether this route of Ca(2+) entry plays a role in photoreceptor degeneration. In both experimental and control mice, the photoreceptors degenerate. However, at postnatal days 16, 18, and 21 there is a delay in photoreceptor cell loss in the experimental mice, which lack L-type voltage-dependent Ca(2+) channels, compared to controls. These data indicate that Ca(2+) entry via the L-type voltage-dependent Ca(2+) channel contributes to the mechanisms responsible for photoreceptor cell death in this mouse model of retinitis pigmentosa.
    Keywords: Calcium Channel ; Retinal Degeneration ; Rd Mouse ; Retinitis Pigmentosa ; Medicine ; Anatomy & Physiology
    ISSN: 0014-4835
    E-ISSN: 1096-0007
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