Format:
7
ISSN:
1528-0020
Content:
Polymerase chain reaction-based screening of childhood acute lymphoblastic leukemia (ALL) samples showed that a TEL/AML 1 fusion transcript was detected in 27% of all cases, representing the most common known gene rearrangement in childhood cancer. The TEL/AML1 fusion results from a t(12;21)(p13;q22) chromosomal translocation, but was undetectable at the routine cytogenetic level. TEL/AML1-positive patients had exclusively B-lineage ALL, and most patients were between the ages of 2 and 9 years at diagnosis. Only 3/89 (3.4%) adult ALL patients were TEL/AML 7-positive. Most importantly, TEL/AML 1-positive children had a significantly lower rate of relapse compared with TEL/AML 1-negative patients (0/22 ν 16/54, P = .004). Co-immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together. The elucidation of the precise mechanism of transformation by TEL/AML1 and the role of TEL/AML1 testing in the treatment of childhood ALL will require additional studies.
Note:
Elektronische Reproduktion der Druck-Ausgabe 14. Dezember 2020
,
Gesehen am 14.12.2023
In:
Blood, Washington, DC : American Society of Hematology, 1946, 88(1996), 11, Seite 4252-4258, 1528-0020
In:
volume:88
In:
year:1996
In:
number:11
In:
pages:4252-4258
In:
extent:7
Language:
English
DOI:
10.1182/blood.V88.11.4252.4252
URL:
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