UID:
edoccha_9961427409302883
Format:
videorecording (36 min., 55 sec.)
,
003655
Content:
Audio-visual presentation : Jewish history and genetics ; Classification of Jews ; Genetic diseases found in Jews, particularly Ashkenazi Jews ; Lysosomal storage diseases ; Natural selection (heterozygote advantage) vs. genetic drift ; Mutation frequencies, ages and geographic distributions ; Bottlenecks in Jewish history.
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/321/.
,
Introduction -- Jewish history and genetics -- Jewish roots and diaspora -- Babylonian exile -- Under the Persians -- After the Roman expulsion -- Modern times -- Classification of Jews -- Jewish subgroups -- Genetic diseases -- Population distributions -- Population specificity -- Diseases found in Ashkenazim -- Lysosomal storage diseases (1) -- Lysosomal storage diseases (2) -- Diseases in Ashkenazim - four LSDs -- Genetic drift -- Heterozygote advantage (selection) -- Hemoglobinopathies -- Malaria -- Arguments for selection -- Arguments for drift -- Other diseases affect Ashkenazim -- Other diseases in Ashkenazim -- Comparing diseases by group -- LSDs versus non-LSDs -- Expected patterns -- Geographic disparities -- Ordered frequencies for LSD mutations -- Ordered frequencies for non-LSD mutations -- Mutation frequencies -- Dating mutations -- Number of generations -- Dating of various mutations -- Times of origin -- LSD and non-LSD are similar -- Geographic distributions -- Diseases tested -- Data analyzed -- Geographic categories -- Mutation frequencies for LSDs -- Mutation frequencies for non-LSDs -- Frequency of TSD 1421 -- Difference in distribution of LSDs and non-LSDs -- The TSD-1277 mutation distribution -- The TSD-1421 mutation distribution -- The origin of the TSD mutation -- The genetic drift: explanation for these mutations -- Conclusions concerning the AJ LSD mutations -- Bottlenecks in the Jewish population -- Three bottlenecks -- Selection versus drift.
Language:
English
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