Online Resource
London :Henry Stewart Talks,
UID:
edoccha_9961427320002883
Format:
1 videorecording (68 min.) :
,
sound, color
,
010818
Note:
Retrieved April 9, 2024, from https://hstalks.com/bs/2160/.
,
Introduction -- PI3K/Akt signal transduction pathway -- PI3K signaling - the big picture -- Mutations in the signaling pathway in cancer (1) -- Mutations in the signaling pathway in cancer (2) -- Inhibitors of PI3K-AKT signaling in development -- Key concepts -- Oncogene addiction/genetic dependency -- AKT1/2 inhibitor (AKTi-1/2) -- Breast cancer -- AKT inhibition in mutated cell lines -- AKTi-1/2 in PI3K mutatant vs. wt cancer cells -- AKTi causes G1 arrest and induces apoptosis -- AKTi effectively inhibits AKT signaling in vivo -- HER2-overexpressing cells retain AKT dependence -- AKT inhibition affects glucose levels -- Mutated elements in tumors -- AKTi sensitivity in cells with various mutations -- Loss of K-Ras mutation in PIK3CA mutant cells -- Different genes are mutated in the same cancer -- Integrators of multiple signaling pathways -- BAD as an integrating protein -- 4EBP1 as an integrating protein -- 4EBP1 is an integrator of PI3K and RAS signaling -- 4EBP1 knockdown affects translation -- 4EBP1 knockdown affects apoptosis -- PTEN expression synergizes with EGFR inhibition -- Questions -- AKTi synergizes with MEK inhibition -- Combined effects of AKT and ERK inhibition -- Feedback inhibition of insulin/IGF-1 signaling -- Rapamycin feedback on P-AKT but not P-S6K -- mTOR inhibition activates AKT in patients -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 mediated feedback on IRS-1 -- AKT inhibition effects on tyrosine kinases -- mTOR inhibition leads to PI3K activation -- mTOR inhibition effects in vivo -- Model: mTOR vs. AKT regulated feedback -- Combining AKT and HER/EGFR inhibition -- Combining AKT and HSP90 inhibition -- Clinical uses of AKT inhibitors -- Summary -- Acknowledgments.
Language:
English
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