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Berlin Brandenburg

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  • 1
    In: The New England Journal of Medicine, 2014, Vol.370(12), pp.1148-1148
    Description: A 69-year-old woman presented with bilateral digital necrosis. One year earlier, new-onset Sjögren's syndrome and painful Raynaud's phenomenon had developed. Nifedipine and topical nitroglycerin failed to improve symptoms. A 69-year-old woman presented with bilateral digital necrosis, which had developed over a period of 2 months (Panels A and B). One year earlier, new-onset Sjögren's syndrome and painful Raynaud's phenomenon had developed. Nifedipine and topical nitroglycerin failed to improve symptoms. The patient did not smoke. Her family history was notable for Waldenström's macroglobulinemia. Laboratory studies were positive for cryoglobulins, and serum protein electrophoresis with the use of immunofixation revealed a monoclonal IgM spike at 345 mg per deciliter with kappa light-chain restriction. Tests for hepatitis C virus, serum viscosity, and lymphocyte counts were normal. The patient received a diagnosis . . .
    Keywords: Nifedipine ; Ischemia ; Nitroglycerin ; Sjogren'S Syndrome;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 2
    Article
    Article
    In: Academic Medicine, 2015, Vol.90(7), pp.960-960
    Keywords: Attitude to Death ; Clinical Clerkship ; Professional-Family Relations ; Professional-Patient Relations ; Students, Medical -- Psychology ; Traumatology -- Education;
    ISSN: 1040-2446
    E-ISSN: 1938808X
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  • 3
    Language: English
    In: 2015, Vol.10(5), p.e0127050
    Description: There is growing awareness of the need to explore patient reported outcomes in clinical trials. In the Scandinavian Surgical Outcomes Research Group we are conducting several clinical trials in cooperation between Danish and Swedish surgical researchers, and we use questionnaires aimed at patients from both countries. In relation to this and similar international cooperation, the validity and reliability of translated questionnaires are central aspects. ; The purpose of this study was to explore which methodological measures were used in studies reporting translation of questionnaires. Furthermore, we wanted to make some methodological suggestions for clinical researchers who are faced with having to translate a questionnaire. ; We designed a research study based on a survey of the literature and extracted data from published studies reporting the methodological process when translating questionnaires on health related quality of life for different diseases. ; We retrieved 187 studies and out of theses we included 52 studies. The psychometric properties of the translated versions were validated using different tests. The focus was on internal validity (96%), reliability (67%) criterion validity (81%), and construct validity (62%). For internal validity Cronbach's alpha was used in 94% of the studies. ; This study shows that there seems to be a consensus regarding the translation process (especially for internal validity) although most researchers did not use a translation guide. Moreover, we recommended that clinical researchers should consider three steps covering the process of translation, the qualitative validation as well as the quantitative validation.
    Keywords: Research Article
    E-ISSN: 1932-6203
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  • 4
    In: PLoS ONE, 2014, Vol.9(7)
    Description: Background In general, there is a need for testing new interventions in large randomized controlled trials. Depending on the research question it may be advantageous to establish multicenter studies as a way of organizing clinical trials in order to increase study power. Main Objectives The object of this study was to investigate the development in the organization of multicenter studies, the distribution of studies within different clinical specialties, across continents, and investigate the differences related to testing various interventions. Methods and Materials A literature search was done in MEDLINE for multicenter studies published in 1995, 2000, 2005, and 2010, respectively. Data extraction identified data related to clinical specialties, interventions, participating patients, departments, countries, and continents. Results The number of multicenter studies increased from 112 in 1995 to 1,273 in 2010, with a larger share of multicenter studies being performed in Europe and North America. The pharmacological interventions were primarily being tested in medical studies followed by the device tests predominantly in surgical studies. The number of included patients as well as the number of participating departments increased during the time span, though the increase in studies was most evident in Europe and North America compared with the rest of the world.
    Keywords: Research Article ; Biology And Life Sciences ; Medicine And Health Sciences ; Physical Sciences ; Research And Analysis Methods
    E-ISSN: 1932-6203
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  • 5
    In: PLoS ONE, 2014, Vol.9(3)
    Description: Introduction Adaptation to living with a stoma is complex, and studies have shown that stoma creation has a great impact on patients' health related quality of life. The objective was to explore the effect of a structured patient education program on health related quality of life. Therefore, we implemented interventions aimed at increasing health related quality of life during and after hospital admission. Materials and Methods We designed a case/control study aimed at adult patients admitted to the surgical ward for stoma creation, irrespective of type of stoma or reason for creation of stoma. We included 50 patients in the study. Health related quality of life was measured before hospital discharge, three months and six months after stoma creation. The program included educational interventions involving lay-teachers, alongside health professional teachers. Results We found a significant rise in health related quality of life in the intervention group (P〈0.001) and no significant change in the control group (P = 0.144). However, we found no significant differences when comparing between groups at 3 and 6 months ( p  = 0.12 and p  =  0.63, respective). Additionally, there were differences in scores in health related quality of life baseline ( p = 0.045 ) with lower scores in the intervention group compared with the intervention group. However, there were no significant differences in the demographic variables at baseline Conclusions Educational activities aimed at increase in knowledge and focusing on patients' psychosocial needs may lead to a rise in patients' health related quality of life. When patients with a stoma attend a structured patient education program it is possible to improve their health related quality of life compared with patients with a stoma, who do not attend the program. Trial Registration ClinicalTrials.gov NCT01154725
    Keywords: Research Article ; Medicine ; Social And Behavioral Sciences
    E-ISSN: 1932-6203
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  • 6
    Language: English
    In: The American Journal of Surgery, June 2017, Vol.213(6), pp.1153-1159
    Description: For the repair of inguinal hernias, several surgical methods have been presented where the purpose is to place a mesh in the preperitoneal plane through an open access. The aim of this systematic review was to describe preperitoneal repairs with emphasis on the technique. A systematic review was conducted and reported according to the PRISMA statement. PubMed, Cochrane library and Embase were searched systematically. Studies were included if they provided clinical data with more than 30 days follow up following repair of an inguinal hernia with an open preperitoneal mesh technique. A total of 67 articles were included, describing nine different methods: Kugel, TREPP, TIPP, Onstep, Horton/Florence, Nyhus, Ugahary, Read, and Stoppa. In general, results regarding pain, recurrences and complications seem promising. It was not possible to conduct a meta-analysis. Open preperitoneal techniques with placement of a mesh through an open approach seem promising compared with the standard anterior techniques. This systematic review provides an overview of these techniques together with a description of surgical methods and clinical outcomes.
    Keywords: Hernia, Inguinal–Surgery ; Herniorrhaphy–Surgery ; Humans–Surgery ; Surgical Mesh–Surgery ; Abridged;
    ISSN: 0002-9610
    E-ISSN: 1879-1883
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  • 7
    Language: English
    In: Urology, 2011, Vol.78(1), pp.180-182
    Description: Acute urinary retention (AUR) is unusual in children. We report for the first time a case of recurrent urinary retention due to massive hematocolpos resulting from an imperforate hymen in a 14-year-old girl. In case of AUR in adolescent girls, clinicians should keep in mind that imperforate hymen may be a causative factor and this condition may easily be treated surgically, but follow-up is still necessary to ensure that there is no recurrence.
    Keywords: Medicine
    ISSN: 0090-4295
    E-ISSN: 1527-9995
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  • 8
    In: Scandinavian Journal of Caring Sciences, September 2017, Vol.31(3), pp.547-553
    Description: Byline: Jannie Laursen, Malene Broholm, Jacob Rosenberg Keywords: quality study; focus group interview; relatives; health professionals; teamwork; organisational resources Background Health professionals must often balance between different rationalities within the hospital organisation. Having adequate time with patients, shorter waiting time and the ability to greater professional autonomy have been shown to help provide a higher quality of care. Empathy and sympathy appear to be crucial components for the health professionals and their relationship to patients. Aim The aim of this study was to explore health professionals' experiences of relatives to critically ill patients in order to identify aspects that may facilitate a better understanding of this teamwork. Methods The study was descriptive and exploratory and had a qualitative design with a phenomenological/hermeneutic orientation for the interviews. Focus group was the chosen methodology. The study comprised 19 health professionals in four focus groups. Results Two themes emerged from the interviews: the hospital culture does not integrate relatives, and health professionals felt that relatives took their resources and saw them as an obstacle in their daily work. Conclusion and implications for practice Health professionals felt divided between the system and the individual sphere, which makes it difficult for them to integrate relatives more and see them as participants in a natural teamwork for the benefit of the patient.
    Keywords: Quality Study ; Focus Group Interview ; Relatives ; Health Professionals ; Teamwork ; Organisational Resources
    ISSN: 0283-9318
    E-ISSN: 1471-6712
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  • 9
    Language: English
    In: BMJ : British Medical Journal, 26 September 2012, Vol.345
    Description: To evaluate the effect of postoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) on anastomotic leakage requiring reoperation after colorectal resection.
    Keywords: Anastomotic Leak -- Etiology ; Anti-Inflammatory Agents, Non-Steroidal -- Adverse Effects ; Colorectal Neoplasms -- Surgery ; Colorectal Surgery -- Adverse Effects ; Cyclooxygenase 2 Inhibitors -- Adverse Effects ; Diclofenac -- Adverse Effects ; Postoperative Complications -- Drug Therapy;
    ISSN: 09598138
    E-ISSN: 1756-1833
    E-ISSN: 17561833
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  • 10
    In: Journal of Clinical Nursing, May 2013, Vol.22(9-10), pp.1343-1352
    Description: To examine patients' experiences of impact of a temporary stoma on their everyday life. Furthermore, we wanted to generate new knowledge and comprehension of learning how to live with a temporary stoma. There are many aspects, largely unexplored, that may influence patients' adaptation to life with a stoma. Amongst these, being in a temporary state is relatively unexplored and may have a restrictive impact on patients' adaptation. Focus group interviews conducted with seven patients with temporary stoma were set up with a hermeneutic phenomenological perspective. Data were processed using qualitative content analysis. The creation of a temporary stoma led to feelings of uncertainty related to being in an undecided situation. Stoma creation led to feelings of stigma and worries about disclosure. Patients proposed group-based patient education with lay educators with a stoma to make sure that information about the stoma was based on real-life experiences. Creation of a temporary stoma was linked to uncontrollable feelings of uncertainty. Professionals should assist patients with focus on coping strategies, as they are associated with positive re-evaluation of the situation. Introducing a coherent and structured learning environment involving both lay educators with a stoma and group-based learning would be useful. Nurses and other health professionals should support patients in problem-focused coping strategies. These strategies may be supported when patients have a high sense of coherence. Furthermore, patients' disclosure of the stoma as a way to master feelings of stigma should be facilitated. Stoma education is central for patients, and group-based learning that involves lay educators with a stoma is seen as a way to empower patients with temporary stomas. 66 references
    Keywords: Empowerment ; Focus Group Interviews ; Nursing ; Patient Education ; Patient Experiences ; Qualitative Research ; Temporary Stomas ; Uncertainty
    ISSN: 0962-1067
    E-ISSN: 1365-2702
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