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Berlin Brandenburg

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  • 1
    In: Clinical Genetics, December 2013, Vol.84(6), pp.560-565
    Description: Synaptopathies constitute a group of neurological diseases including autism spectrum disorders () and intellectual disability (). They have been associated with mutations in genes encoding proteins important for the formation and stabilization of synapses, such as –3. Loss‐of‐function mutations in the genes have been identified in individuals with and suggesting that other factors modify the neurological phenotype. We report a boy with severe , behavioral anomalies, and language impairment who carries a balanced triple translocation 46,,t(11;17;19)(q13.3;q25.1;q13.42). The 11q13.3 breakpoint was found to disrupt the gene. The patient also carries copy number variations at 15q13.3 and 10q22.11 encompassing and two synaptic genes. The gene encoding α7‐nicotinic acetylcholine receptor subunit and the gene encoding G‐protein‐regulated inducer of neurite growth 2 were duplicated. Co‐occurrence of a mutation and a duplication in two reported patients with and as well as in the patient with t(11;17;19), severe and behavior problems suggests convergence of these genes on a common synaptic pathway. Our results strengthen the oligogenic inheritance model and highlight the presence of a large effect mutation and modifier genes collectively determining phenotypic expression of the synaptopathy.
    Keywords: Autism ; Chromosomal Rearrangement ; Intellectual Disability ; Modifier Gene ; Shank ; Synaptopathy
    ISSN: 0009-9163
    E-ISSN: 1399-0004
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  • 2
    Language: English
    In: Journal of Controlled Release, 28 September 2015, Vol.214, pp.76-84
    Description: Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6 months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, -Fe O ) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography–computer tomography (SPECT–CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
    Keywords: Rhsa Nanoparticles ; Maghemite ; T-PA-Ligands to Galectins ; T-Papeptide1lac ; Single Photon Emission Computed Tomography–Computer Tomography (Spect–CT) ; Handheld Gamma Camera ; Magnetic Resonance Imaging (Mri) ; Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0168-3659
    E-ISSN: 1873-4995
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  • 3
    Language: English
    In: Acta horticulturae, 2010, Issue 869, pp.207-217
    Description: Paper presented at the Ninth International Protea Research Symposium, held September 3-6, 2008, Stellenbosch, South Africa. Includes references ; p. 207-217.
    Keywords: Cut Flower Preservatives ; Postharvest Physiology ; Marketing Strategies ; Postharvest Diseases ; Desiccation (Plant Physiology) ; Marketing ; Sucrose ; Cut Foliage ; Photosynthates ; Controlled Atmosphere Storage ; Shipping ; Vase Life ; Glucose ; Leucadendron ; Carbohydrates ; Storage Time ; Incidence ; Postharvest Treatment ; Profitability
    ISSN: 0567-7572
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 4
    Language: English
    In: Psychopharmacology, 2006, Vol.184(1), pp.122-129
    Description: Byline: Richard P. Bazinet (1), Margaret T. Weis (2), Stanley I. Rapoport (1), Thad A. Rosenberger (1,3) Keywords: Valproate; Bipolar disorder; Arachidonic acid; Acyl--CoA synthetase; Docosahexaenoic acid; Kinetics Abstract: Rationale Several drugs used to treat bipolar disorder (lithium and carbamazepine), when administered chronically to rats, reduce the turnover of arachidonic acid, but not docosahexaenoic acid, in brain phospholipids by decreasing the activity of an arachidonic acid-selective phospholipase A.sub.2. Although chronic valproic acid produces similar effects on brain arachidonic acid and docosahexaenoic acid turnover, it does not alter phospholipase A.sub.2 activity, suggesting that it targets a different enzyme in the turnover pathway. Materials and methods/Results By isolating rat brain microsomal long-chain fatty acyl--CoA synthetases (Acsl), we show in vitro that valproic acid is a non-competitive inhibitor of Acsl, as it reduces the maximal velocity of the reaction without changing the affinity of the substrate for the enzyme. While valproic acid inhibited the synthesis of arachidonoyl--CoA, palmitoyl--CoA, and docosahexaenoyl--CoA, the K i .sub.for inhibition of arachidonoyl--CoA synthesis (14.1 mM) was approximately one fifth the K .sub.i for inhibiting palmitoyl--CoA (85.4 mM) and docosahexaenoyl--CoA (78.2 mM) synthesis. As chronic administration of valproic acid in bipolar disorder achieves whole-brain levels of 1.0 to 1.5 mM, inhibition of arachidonoyl--CoA formation can occur at brain concentrations that are therapeutically relevant to this disease. Furthermore, brain microsomal Acsl did not produce valproyl--CoA. Conclusions This study shows that valproic acid acts as a non-competitive inhibitor of brain microsomal Acsl, and that inhibition is substrate-selective. The study supports the hypothesis that valproic acid acts in bipolar disorder by reducing the brain arachidonic acid cascade, by inhibiting arachidonoyl--CoA formation. Author Affiliation: (1) Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA (2) Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Center, Amarillo, TX, 79106, USA (3) Department of Pharmacology, Physiology, and Therapeutics, School of Medicine and Health Sciences, University of North Dakota, 501 North Columbia Road, Rm. 3742A, Grand Forks, ND, 58203, USA Article History: Registration Date: 15/11/2005 Received Date: 31/08/2005 Accepted Date: 10/11/2005 Online Date: 13/12/2005
    Keywords: Valproate ; Bipolar disorder ; Arachidonic acid ; Acyl–CoA synthetase ; Docosahexaenoic acid ; Kinetics
    ISSN: 0033-3158
    E-ISSN: 1432-2072
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  • 5
    Language: English
    In: Plant physiology, January 1996, Vol.110(1), pp.301-10
    Description: The possible involvement of Ca2+ as a second messenger in snapdragon (Antirrhinum majus L.) shoot gravitropism, as well as the role of ethylene in this bending response, were analyzed in terms of stem curvature and gravity-induced asymmetric ethylene production rates, ethylene-related metabolites, and invertase activity across the stem. Application of Ca2+ chelators (ethylenediaminetetraacetic acid, trans-1,2-cyclohexane dinitro-N,N,N',N'-tetraacetic acid, 1,2-bis(2-aminophenoxy)ethane-N,N,N',N',-tetraacetic acid) or a Ca2+ antagonist (LaCl3) to the spikes caused a significant loss of their gravitropic response following horizontal placement. Conversely, the Ca2+ ionophore A23187 or the agonist Bay K-8644 increased gravibending. Longitudinally halved stem sections had significantly higher amounts of ethylene, 1-aminocyclopropane-1-carboxylic acid, and 1-(malonylamino) cyclopropane-1-carboxylic acid compared with vertical controls, with the extra production arising exclusively from the lower half of the stem. trans-1,2-cyclohexane dinitro-N,N,N',N'-tetraacetic acid pretreatment completely abolished the gravity-induced ethylene gradient across the stem, thereby leading to a significant reduction of the curvature. Similarly, reduction of the ethylene produced in the gravistimulated with CoCl2 or inhibition of its action by silver thiosulfate or 2,5-norbornadiene significantly inhibited the subsequent gravibending. Silver thiosulfate and CoCl2 also abolished the gravity-induced gradient of invertase activity across the stem, which is associated with the asymmetric stem elongation. These results suggest that cytosolic Ca2+ may regulate auxin action in snapdragon spikes, manifested as increased ethylene production, which is, in turn, intimately correlated with stem bending. Therefore, both hormones seem to play significant roles in induction and progress of the gravibending of snapdragon spikes.
    Keywords: Amino Acids, Cyclic ; Plant Development ; Calcium -- Physiology ; Ethylenes -- Biosynthesis ; Gravitropism -- Physiology ; Indoleacetic Acids -- Physiology ; Plant Stems -- Drug Effects
    ISSN: 0032-0889
    E-ISSN: 15322548
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  • 6
    Language: English
    In: Plant physiology, 1996, Vol.(1), pp.301-310
    Description: The possible involvement of Ca2+ as a second messenger in snapdragon (Antirrhinum majus L.) shoot gravitropism, as well as the role of ethylene in this bending response, were analyzed in terms of stem curvature and gravity-induced asymmetric ethylene production rates, ethylene-related metabolites, and invertase activity across the stem. Application of Ca2+ chelators (ethylenediaminetetraacetic acid, trans-1,2-cyclohexane dinitro-N,N,N',N'tetraacetic acid, 1,2-bis(2-aminophenoxy)ethane-N,N,N',N' -tetraacetic acid) or a Ca2+ antagonist (LaCl3) to the spikes caused a significant loss of their gravitropic response following horizontal placement. Conversely, the Ca2+ ionophore A23187 or the agonist Bay K-8644 increased gravibending. Longitudinally halved stem sections had significantly higher amounts of ethylene, 1-aminocyclopropane-1 -carboxylic acid, and 1-(malonylamino) cyclopropane-1-carboxylic acid compared with vertical controls, with the extra production arising exclusively from the lower half of the stem. trans-1,2-cyclohexane dinitro-N,N,N',N'-tetraacetic acid pretreatment completely abolished the gravity-induced ethylene gradient across the stem, thereby leading to a significant reduction of the curvature. Similarly, reduction of the ethylene produced in the gravistimulated stems with CoCl2 or inhibition of its action by silver thiosulfate or 2,5-norbornadiene significantly inhibited the subsequent gravibending. Silver thiosulfate and CoCl2 also abolished the gravity-induced gradient of invertase activity across the stem, which is associated with the asymmetric stem elongation. These results suggest that cytosolic Ca2+ may regulate auxin action in snapdragon spikes, manifested as increased ethylene production, which is, in turn, intimately correlated with stem bending. Therefore, both hormones seem to play significant roles in induction and progress of the gravibending of snapdragon spikes ; references
    Keywords: Antirrhinum ; Tige ; Epi ; Gravite ; Tropisme ; Ethylene ; Biosynthese ; Metabolite ; Calcium ; Chelateur ; Croissance ; Fructofuranosidase ; Activite Enzymatique ; Substance De Croissance Vegetale ; Analyse Quantitative ; Antirrhinum ; Tallo ; Espigas ; Gravidez ; Tropismo ; Etileno ; Biosintesis ; Metabolitos ; Calcio ; Quelatos ; Crecimiento ; Fructofuranosidasa ; Actividad Enzimatica ; Sustancias De Crecimiento Vegetal ; Analisis Cuantitativo
    ISSN: 0032-0889
    Source: AGRIS (Food and Agriculture Organization of the United Nations)
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  • 7
    Language: English
    In: International Journal of Nanomedicine, 01 December 2013, Vol.2013(Issue 1), pp.4745-4756
    Description: Jennifer Vandooren,1 Nele Berghmans,1 Chris Dillen,1 Ilse Van Aelst,1 Isabelle Ronsse,1 Liron Limor Israel,2 Ina Rosenberger,3 Jörg Kreuter,3 Jean-Paul Lellouche,2 Shulamit Michaeli,4 Erica Locatelli,5 Mauro Comes Franchini,5 Miren K Aiertza,6 Laura Sánchez-Abella,6 Iraida Loinaz,6 Dylan R Edwards,7 Louis Shenkman,8 Ghislain Opdenakker1 1Rega Institute for Medical Research, University of Leuven, Leuven, Belgium; 2Department of Chemistry and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat Gan, Tel Aviv, Israel; 3Institut für Pharmazeutische Technologie, Johann Wolfgang Goethe-Universität, Frankfurt, Germany; 4The Mina and Everard Goodman Faculty of Life Sciences and Advanced Materials and Nanotechnology Institute, Bar-Ilan University, Ramat Gan, Tel Aviv, Israel; 5Department of Industrial Chemistry Toso Montanari, University of Bologna, Bologna, Italy; 6New Materials Department, Fundación CIDETEC, San Sebastián, Spain; 7School of Biological Sciences, University of East Anglia, Norwich, UK; 8Tel Aviv University, Ramat Aviv, Tel Aviv, Israel Abstract: The need for test systems for nanoparticle biocompatibility, toxicity, and inflammatory or adaptive immunological responses is paramount. Nanoparticles should be free of microbiological and chemical contaminants, and devoid of toxicity. Nevertheless, in the absence of contamination, these particles may still induce undesired immunological effects in vivo, such as enhanced autoimmunity, hypersensitivity reactions, and fibrosis. Here we show that artificial particles of specific sizes affect immune cell recruitment as tested in a dermal air pouch model in mice. In addition, we demonstrate that the composition of nanoparticles may influence immune cell recruitment in vivo. Aside from biophysical characterizations in terms of hydrodynamic diameter, zeta potential, concentration, and atomic concentration of metals, we show that - after first-line in vitro assays - characterization of cellular and molecular effects by dermal air pouch analysis is straightforward and should be included in the quality control of nanoparticles. We demonstrate this for innate immunological effects such as neutrophil recruitment and the production of immune-modulating matrix metalloproteases such as MMP-9; we propose the use of air pouch leukocytosis analysis as a future standard assay. Keywords: nanoparticles, biocompatibility, toxicity, air pouch, immunologyA Letter to the Editor has been received and published for this article.
    Keywords: Engineering
    ISSN: 1178-2013
    E-ISSN: 1178-2013
    Source: Directory of Open Access Journals (DOAJ)
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  • 8
    Language: English
    In: Plant physiology, 1998, Vol.118(2), pp.483-492
    Description: The putative Ca2+ -channel blocker LaCl3 prevented the gravitropic bending of cut snapdragon (Antirrhinum majus L.) spikes (S. Philosoph-Hadas, S. Meir, I. Rosenberger, A.H. Halevy [1996] Plant Physiol 110: 301-310) and inhibited stem curvature to a greater extent than vertical and horizontal stem elongation at the bending zone. This might indicate that LaCl3, which modulates cytosolic Ca2+, does not influence general stem-growth processes but may specifically affect other gravity-associated processes occurring at the stem-bending zone. Two such specific gravity-dependent events were found to occur in the bending zone of snapdragon spikes: sedimentation of starch-containing chloroplasts at the bottom of stem cortex cells, as seen in cross-sections, and establishment of an ethylene gradient across the stem. Our results show that the lateral sedimentation of chloroplasts associated with gravity sensing was prevented in cross-sections taken from the bending zone of LaCl3-treated and subsequently gravistimulated spikes and that LaCl3 completely prevented the gravity-induced, asymmetric ethylene production established across the stem-bending zone. These data indicate that LaCl3 inhibits stem curvature of snapdragon spikes by preventing several gravity-dependent processes. Therefore, we propose that the gravitropic response of shoots could be mediated through a Ca2+ -dependent pathway involving modulation of cytosolic Ca2+ at various stages. ; Includes references ; p. 483-492.
    Keywords: Calcium ; Cortex ; Antirrhinum Majus ; Developmental Stages ; Cytosol ; Starch ; Ethylene ; Lanthanum ; Chemical Constituents Of Plants ; Gravitropism ; Inflorescences ; Quantitative Analysis ; Plant Anatomy ; Chlorides ; Stems ; Cell Growth ; Gravity ; Chloroplasts ; Inhibition ; Amyloplast Sedimentation
    ISSN: 0032-0889
    E-ISSN: 15322548
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  • 9
    Language: English
    In: Water Research, 01 February 2013, Vol.47(2), pp.463-482
    Description: Rheological behaviour is an important fluid property that severely impacts its flow behaviour and many aspects related to this. In the case of activated sludge, the apparent viscosity has an influence on e.g. pumping, hydrodynamics, mass transfer rates, sludge–water separation (settling and filtration). It therefore is an important property related to process performance, including process economics. To account for this, rheological behaviour is being included in process design, necessitating its measurement. However, measurements and corresponding protocols in literature are quite diverse, leading to varying results and conclusions. In this paper, a vast amount of papers are critically reviewed with respect to this and important flaws are highlighted with respect to rheometer choice, rheometer settings and measurement protocol. The obtained rheograms from experimental efforts have frequently been used to build viscosity models. However, this is not that straightforward and a lot of errors can be detected with respect to good modelling practice, including fair model selection criteria, qualitative parameter estimations and proper model validation. These important steps are however recurrently violated, severely affecting the model reliability and predictive power. This is illustrated with several examples. In conclusion, dedicated research is required to improve the rheological measurements and the models derived from them. At this moment, there is no guidance with respect to proper rheological measurements. Moreover, the rheological models are not very trustworthy and remain very “black box”. More insight in the physical background needs to be gained. A model-based approach with dedicated experimental data collection is the key to address this. ► Rheological behaviour of activated sludge is an important fluid property. ► Reported literature on AS rheological measurements and modelling is inconclusive. ► Protocols for proper rheological measurements are absent in literature. ► Good modelling practice is often violated when modelling AS rheological behaviour. ► More profound knowledge on AS rheology is needed.
    Keywords: Rheology ; Activated Sludge ; Apparent Viscosity ; Rheometer ; Measurement Protocol ; Good Modelling Practice ; Membrane Bioreactor ; Engineering
    ISSN: 0043-1354
    E-ISSN: 1879-2448
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  • 10
    Language: English
    In: International Journal of Public Health, 2013, Vol.58(3), pp.409-415
    Description: Byline: A. Sudzinova (1,2), I. Nagyova (2,3), M. Studencan (1), J. Rosenberger (2), Z. Skodova (4), H. Vargova (1,2), B. Middel (5), S. A. Reijneveld (5), J. P. Dijk (2,5) Keywords: Roma; Coronary heart disease; Medical risk factors; Coronary angiography Abstract: Objectives Coronary heart disease (CHD) is the most common cause of mortality and morbidity world-wide. Evidence on ethnic differences between the Roma and non-Roma regarding medical risk factors is scarce. The aim of this study was to assess differences in medical risk factors and the severity of CHD in Roma compared with non-Roma CHD patients, adjusted for gender, age and education. Methods Six hundred seventy four patients were included in this cross-sectional study (132 Roma, 542 non-Roma). Data on medical risk factors, symptoms, medication and severity of CHD were obtained from medical records. After matching Roma and non-Roma according to education, linear and logistic regression analyses with adjustments for gender and age were used. Results Compared with non-Roma, Roma patients had significantly more risk factors and more severe types of CHD. They were treated less frequently with statins and beta-blockers, were more frequently left on pharmacotherapy and surgically revascularised. These differences remained after controlling for education, gender and age. Conclusions Roma CHD patients have a worse risk profile at entry of care and seem to be undertreated compared with non-Roma CHD patients. Author Affiliation: (1) East Slovakian Institute for Cardiac and Vascular Diseases, Cardiology Clinic, Ondavska 8, Kosice, 040 01, Slovak Republic (2) Graduate School Kosice Institute for Society and Health, Safarik University, Kosice, Slovak Republic (3) Department of Social Medicine, Medical Faculty, Institute of Public Health, Safarik University, Kosice, Slovak Republic (4) Jessenius Faculty of Medicine, Institute of Non-medical Study Programmes, Comenius University, Martin, Slovak Republic (5) Department of Community and Occupational Health, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Article History: Registration Date: 20/03/2013 Received Date: 08/09/2012 Accepted Date: 20/03/2013 Online Date: 31/03/2013
    Keywords: Roma ; Coronary heart disease ; Medical risk factors ; Coronary angiography
    ISSN: 1661-8556
    E-ISSN: 1661-8564
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