UID:
edoccha_9960074190802883
Format:
1 online resource (1872 pages)
Edition:
Second edition.
ISBN:
0-12-816387-9
Content:
"The detection and measurement of the dynamic interactions of proteins within the living cell are critical to the understanding of cell physiology and pathophysiology. The field of molecular imaging of living subjects continues to expand and has seen dramatic advances in chemistry, engineering and biomedical applications. Molecular Imaging: Principles and Practice, Second Edition provides the first point of entry to the research for all scientists interested in this multi-disciplinary field. Molecular imaging is very diverse: new investigators, collaborators, and students entering this field need an authoritative reference to bring this field together. Editors Brian Ross and Sam Gambhir designed this revision precisely to fill this need"--
Note:
9780128163870v1_WEB -- Front Cover -- Molecular Imaging: Principles and Practice -- Molecular Imaging: Principles and Practice -- Copyright -- Acknowledgments -- In Honor -- Contents of Volume 1 -- Contents of Volume 2 -- Contributors -- Preface -- Overview -- 1 - General Principles of Molecular Imaging -- Molecular Imaging Strategies -- Molecular Imaging Probes -- Molecular Imaging In Vivo Model Systems -- Molecular Imaging Quantification -- Image Formation -- Pharmacokinetics of Molecular Imaging Probes -- Properties of the Field in Which the Subject Is placed -- Output Signal From Molecular Imaging Probes -- Signal Penetration Through Subject -- Efficiency of Signal Detection by Imaging Instrument -- Subject Preparation -- Noise -- Conclusion -- I - Molecular Imaging Technologies -- 2 - Positron Emission Tomography-Magnetic Resonance Imaging -- Introduction -- Synergy and Strengths of Integrated PET-MR -- Disadvantages and Limitations of PET-MR -- Technological Challenges and Solutions -- Motion Management and Correction -- External Motion Tracking and Monitoring -- PET Data-driven Motion Detection -- MR-driven Motion Correction -- Attenuation Correction -- Protocols -- MRI Contrast Agents -- Whole-Body MRI/Diffusion-Weighted Imaging -- Summary -- References -- 3 - SPECT and SPECT/CT -- Introduction -- Imaging Single-photon Emitting Radionuclides -- The Gamma Camera -- General Principles of SPECT Acquisition With Multihead Cameras -- SPECT Acquisition -- Tomographic Reconstruction -- Iterative Image Reconstruction -- Quantitative SPECT -- Corrections for Attenuation -- Scatter Correction -- Correction for Effects of Limited Resolution -- Motion Correction -- Activity Calibration -- SPECT/CT -- Conversion of CT Numbers to Attenuation Coefficients -- CT Artifacts -- Registration Accuracy -- Cardiac-specific SPECT -- Theranostics.
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Recent Developments -- General Discussion -- Conclusions -- References -- 4 - Principles of Micro X-ray Computed Tomography -- Background -- System Components -- X-ray Source -- X-ray Detectors -- Reconstruction Algorithms -- Protocol Considerations -- Anesthesia -- Radiation Dose -- Contrast Media -- Cardiorespiratory Gating -- Applications -- Applications of Noncontrast-Enhanced Micro-CT -- Bone Imaging -- Lung Imaging -- Applications of Contrast-Enhanced Micro-CT -- Vascular Imaging -- Cardiac Imaging -- Liver Imaging -- Cancer Imaging -- Molecular Imaging With Micro-CT -- Spectral Micro-CT -- Theragnostics -- Multimodality Imaging -- Conclusions -- References -- 5 - Small-Animal SPECT, SPECT/CT, and SPECT/MRI -- Introduction -- History -- Radionuclides, Radiotracers, and Applications -- Radiotracers and Applications -- Commercial Small-Animal SPECT Instruments -- Basic Principles -- Image Formation and Reconstruction in SPECT and CT -- Sampling -- γ-ray Detection and Imaging -- Image Formation Apertures: Basic Collimator Design -- Parallel-Hole Collimator -- Pinhole Aperture -- Image Degradations -- Photon Attenuation -- Compton Scattering -- Counting Noise -- Accounting for Degradations: Advanced SPECT Reconstruction -- Performance Optimization and Design Trends -- Performance Optimization -- Design Trends -- Toward High-Resolution Detectors -- Research Instruments -- SPECT/CT and SPECT/MR -- SPECT/CT -- SPECT/MR -- Future Directions -- New Imaging Sensors -- Adaptive SPECT Imaging -- Conclusions -- References -- 6 - Instrumentation and Methods to Combine Small-Animal PET With Other Imaging Modalities -- Introduction -- Preclinical PET -- Review of Small-Animal PET Imaging System Technology -- Small-Animal PET System Design Issues -- PET System Performance Issues -- Multimodality PET Imaging -- Introduction.
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Software-Based Registration and Fusion of Multimodality Images -- Hardware-Based Approaches to Combine Small-Animal PET With Other Modalities -- PET/CT -- PET/SPECT/CT -- PET/MRI -- PET/Optical -- Concluding Remarks -- Acknowledgments -- References -- 7 - Functional Imaging Using Bioluminescent Reporter Genes in Living Subjects -- Bioluminescence in Nature -- Bioluminescence as a Light Source in Molecular Imaging -- Imaging Rodent Models of Human Biology and Disease -- Basic Concepts and Methods -- Generating Signals and Sources of Noise -- Enzyme Reporters -- Detection -- Cellular and Molecular Biology as a Basis for In Vivo Optical Imaging -- Reporter Genes -- Correlative Cell Culture Assays -- Bioluminescent Reporters and Their Substrates for In Vivo Use -- Luciferase Enzymes -- Substrates and Their Bioavailability -- Multifunctional Reporter Genes -- Gene Transfer -- BRET -- Other BRET Pairs -- Determinants of Data Quality -- Applications of BLI: BLI in the Development of New Therapeutic Strategies -- Applications of BLI: Enabling Advances in Clinical Imaging Modalities -- Improved Delivery Tools -- Using BLI to Improve Our Understanding of Mammalian Biology -- Summary and Future of Bioluminescent Reporters in Living Animals -- References -- 8 - Principles and Practice of Intraoperative Fluorescence Imaging -- Introduction -- Fluorescence-Guided Surgery Technique Principles -- Clinically Available Contrast Agents and Their Applications -- ICG -- MB -- 5-ALA -- Fluorescence-Guided Surgery Systems -- Open Fluorescence-Guided Surgery Systems -- Endoscopic Fluorescence-Guided Surgery Systems -- Multichannel Fluorescence-Guided Surgery Systems -- Standardization of Fluorescence-Guided Surgery Systems and Methods -- Conclusions and Future Perspectives -- References -- 9 - Molecular Endoscopic Imaging in Cancer.
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Concept and Components of Molecular Endoscopic Imaging -- Components: Molecular Probes -- Components: Endoscopic Devices -- Molecular Endoscopic Imaging in Malignant and Premalignant Lesions of the Upper Gastrointestinal Tract -- Barrett's Esophagus -- Molecular Imaging in the Stomach -- Molecular Endoscopic Imaging in Malignant and Premalignant Lesions of the Lower Gastrointestinal Tract -- Inflammatory Bowel Disease -- Molecular Endoscopic Imaging of Sporadic Colorectal Cancer -- Summary -- References -- 10 - Intravital Microscopy -- Why Intravital Microscopy? -- A Short History of IVM -- Sources of Image Contrast -- Bright Field Illumination and Related Conventional Techniques -- Fluorescence -- Nonlinear Imaging Modalities -- Fluorescent Probes -- Intravital Stains -- Functionalized Fluorochromes -- Fluorescent Proteins -- Autofluorescence -- IVM Instrumentation -- Bright Field Microscopy -- Widefield Fluorescence Microscopy -- Laser Scanning Microscopy -- Multiphoton Microscopy -- Signal Detection -- IVM models -- Anesthesia -- Surgery -- Immobilization -- Tissue Homeostasis -- Pitfalls -- Applications of IVM -- Cellular Migration and Interaction -- Cellular Signaling -- Physiological and Pathophysiological Functions -- Cellular Growth and Differentiation -- Host-pathogen Interface -- Correlative-IVM: Combining IVM With Other Experimental Approaches -- IVM in the Age of Next Generation Sequencing -- IVM and Ultrastructural Analysis -- Breaking the Diffraction Barrier In Vivo -- IVM in Diagnosis -- Outlook -- References -- 11 - Ultrasound -- Introduction -- Ultrasound Fundamentals -- Resolution -- Reflectivity and Signal Strength -- Microbubble Reflectivity -- Ultrasound Pulse Sequencing -- Ultrasound Instruments for Molecular Imaging -- Molecular Imaging With Ultrasound -- Molecular Imaging With Diagnostic Frequency Ultrasound.
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Molecular Imaging With Microultrasound -- Clinical Translation of Ultrasound Molecular Imaging -- Molecular Photoacoustic Imaging -- Conclusions -- Acknowledgments -- References -- 12 - Hybrid PET-CT-Ultrasound Imaging -- Background and Rationale -- Importance of In Vivo Multiparametric Imaging -- Why Combining PET-CT With Ultrasound Makes a Difference -- PETRUS: Physical Principles and Technical Conception -- PETRUS Assembling Elements -- Automating Ultrasonic Acquisition: From Manual to Robotics -- Precise US Probe Tracking in the PET-CT Reference System -- Performance Evaluation of the PET Component of PETRUS -- NEMA Protocol With/Without US Probe -- In Vivo Measurements -- Multiple Modes of Ultrasound: A Brief Presentation of Ultrafast Ultrasound Imaging -- PETRUS Applications -- Oncology -- Bivariate Analysis for Tumor Phenotyping -- Longitudinal Follow-up of the Effect of the Antiangiogenic Drug Sunitinib on the Metabolism and Microarchitecture of a Meta ... -- Multiparametric Quantification -- Tumor Heterogeneity: Concurrent Vascular-Metabolic Imaging Shows That New Vessels Grow Preferentially in Regions With High ... -- Toward Definition of Early Imaging Biomarkers of Resistance to Sunitinib Treatment -- Cardiology -- Conclusion and Perspectives -- Acknowledgments -- References -- 13 - Photoacoustic Molecular Imaging: Principles and Practice -- Introduction -- Principles of PAT -- Implementations of PAT -- Quantitative Spectroscopic PA Imaging -- Novel PAT Technologies for Molecular Imaging -- Optimization of Detection Sensitivity for Molecular PA Imaging -- Maximization of the PA Signal Generation -- Development of Novel PA Molecular Probes -- Improvement in the Accuracy of Signal Unmixing -- Novel Biomedical Applications of PA Molecular Imaging -- PAT of the Brain -- PAT of Cancers -- Conclusion and Discussion -- Acknowledgments.
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References.
Additional Edition:
ISBN 0-12-816386-0
Language:
English
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