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  • 1
    Language: English
    In: Science (New York, N.Y.), 14 May 2010, Vol.328(5980), pp.852-6
    Description: Mycobacterium tuberculosis has a penetrance of its host population that would be the envy of most human pathogens. About one-third of the human population would have a positive skin test for the infection and is thus thought to harbor the bacterium. Globally, 22 "high-burden" countries account for more than 80% of the active tuberculosis cases in the world, which shows the inequitable distribution of the disease. There is no effective vaccine against infection, and current drug therapies are fraught with problems, predominantly because of the protracted nature of the treatment and the increasing occurrence of drug resistance. Here we focus on the biology of the host-pathogen interaction and discuss new and evolving strategies for intervention.
    Keywords: Antitubercular Agents ; Bcg Vaccine ; Mycobacterium Tuberculosis ; Tuberculosis
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 2
    Language: English
    In: FEBS Letters, 14 December 2012, Vol.586(24), pp.4332-4338
    Description: ► MmCDF3 selectively binds zinc and cadmium at two binding sites. ► Removal of His-tag is vital for maintaining CDF function. ► An extended N-terminus may act as an alternative “B” binding site in truncated CDFs. ► Zn binding is inhibited by the presence of Cd suggesting shared binding sites. Cation diffusion facilitators (CDFs) have been described as requiring the C-terminal cytoplasmic domain for their function. With the identification of smaller proteins lacking the cytoplasmic portion but displaying sequential characteristics of CDFs, this assumption should be reconsidered. Here we describe the results showing that the MmCDF3, a 23-kDa protein lacking a C-terminal domain, interacts selectively with zinc and cadmium. Isothermal titration calorimetry (ITC) binding results indicate that the truncated CDF may have an alternative means of acquiring ions from the cytoplasm in the form of an extended N-terminus, a feature common to putative cation efflux proteins of a similar size.
    Keywords: Cation Diffusion Facilitator ; Zinc Transporter ; Membrane Protein ; Isothermal Titration Calorimetry ; Maricaulis Maris ; Biology ; Chemistry ; Anatomy & Physiology
    ISSN: 0014-5793
    E-ISSN: 1873-3468
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  • 3
    Article
    Article
    Language: English
    In: Nature, 6/2017, Vol.546(7656), pp.44-45
    Description: A gene has been identified that underpins the capacity of mycobacterial cells to divide to produce physiologically different daughter cells. This finding has implications for drug treatment of tuberculosis.
    Keywords: Mutation ; Antibiotics ; Tuberculosis ; Bacteria ; Cell Division ; Microbiology ; Genes;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
    Source: Nature Publishing Group (via CrossRef)
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  • 4
    Language: English
    In: Physical therapy, February 2012, Vol.92(2), pp.227-35
    Description: A growing body of research suggests that greater continuity of health care is positively associated with improved outcomes of patients. However, few studies have examined this issue in the context of physical therapy. The purpose of this study was to evaluate whether the level of continuity in the provider (provider continuity) of physical therapy services was related to outcomes in a population of patients receiving home health care. This was a retrospective observational study. Clinical and administrative records were retrieved for a population of adult patients receiving physical therapy services from a large, urban, not-for-profit certified home health care agency in 2009. Descriptive and multivariable analyses were used to examine how the level of provider continuity, calculated by use of a formula that models dispersion in contact between the patient and the providers of physical therapy services, varied across characteristics and outcomes of patients. Logistic regression analyses indicated that patients with lower levels of provider continuity had significantly higher odds of hospitalization (odds ratio [OR]=2.06, 95% confidence interval [CI]=1.90-2.23) and lower odds of improvements in the number of activity limitations (OR=0.85, 95% CI=0.80-0.92) and in the severity of activity limitations (OR=0.85, 95% CI=0.78-0.93) between the beginning and the end of the home health care episode. Baseline clinical characteristics associated with continuity of care suggest some level of indication bias. Outcome measures for activities of daily living were limited to patients who were not hospitalized during their home health stay. These findings build upon research suggesting that continuity in the patient-provider relationship is an important determinant of outcomes of patients.
    Keywords: Continuity of Patient Care ; Home Care Services ; Outcome and Process Assessment (Health Care) ; Physical Therapy Modalities ; Professional-Patient Relations
    ISSN: 00319023
    E-ISSN: 1538-6724
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  • 5
    In: Nature, 2017, Vol.546(7656), p.44
    Keywords: Mycobacteria -- Health Aspects;
    ISSN: 0028-0836
    E-ISSN: 1476-4687
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  • 6
    Language: English
    In: Journal of the American Chemical Society, March 30, 2011, Vol.133(12), p.4182-4185
    Description: The article discusses the synthesis of a new label-free mass spectrometry and optical detection-based biosensor with lipid-functionalized gold nanorods. The application of the biosensor for the detection of low-abundance lipophilic analytes in complex mixtures is also discussed.
    Keywords: Biosensors -- Usage ; Nanorods -- Chemical Properties ; Spectroscopy -- Usage
    ISSN: 0002-7863
    Source: Cengage Learning, Inc.
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  • 7
    Article
    Article
    Language: English
    In: BMJ: British Medical Journal, 4 August 2012, Vol.345(7868), pp.36-36
    Keywords: Medicine;
    ISSN: 09598138
    E-ISSN: 17561833
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  • 8
    Language: English
    In: The Journal of biological chemistry, 07 December 2018, Vol.293(49), pp.18804-18827
    Description: On January 21, 2017, I received an E-mail from Herb Tabor that I had been simultaneously hoping for and dreading for several years: an invitation to write a "Reflections" article for the On the one hand, I was honored to receive an invitation from Herb, a man I have admired for over 40 years, known for 24 years, and worked with as a member of the Editorial Board and Associate Editor of the for 17 years. On the other hand, the invitation marked the waning of my career as an academic scientist. With these conflicting emotions, I wrote this article with the goals of recording my career history and recognizing the many mentors, trainees, and colleagues who have contributed to it and, perhaps with pretension, with the desire that students who are beginning a career in research will find inspiration in the path I have taken and appreciate the importance of luck.
    Keywords: Androgen ; Androgens ; Bile Acid ; Bile Acids ; Cholesterol ; Genetic Disease ; Genetic Disorders ; Lipid ; Lipids ; Protein Synthesis ; Vitamin D ; Molecular Biology -- History
    ISSN: 00219258
    E-ISSN: 1083-351X
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  • 9
    Language: English
    In: Victorian Studies, Autumn, 2013, Vol.56(1), p.7(24)
    Keywords: Liberalism -- Criticism And Interpretation ; Essayists -- Works ; Ethics -- Criticism And Interpretation
    ISSN: 0042-5222
    Source: Cengage Learning, Inc.
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  • 10
    In: Nature, 2013, Vol.502(7470), p.S7
    Description: The difficulty of finding a new combination is more than additive, as each drug must not interfere with the others or with the antiretrovirals used to treat HIV infection (a common co-infection in sub-Saharan Africa). [...]even if a pharmaceutical company discovers one effective new TB drug (a big if),...
    Keywords: Pharmaceutical Industry ; Tuberculosis ; Antibiotics ; Drug Resistance ; Infections ; Federal Funding ; Clinical Trials ; Intellectual Property ; Counterfeiting;
    ISSN: 0028-0836
    E-ISSN: 14764687
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