Kooperativer Bibliotheksverbund

Berlin Brandenburg

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  • 1
    In: Natural Gas & Electricity, November 2017, Vol.34(4), pp.29-32
    Description: The Federal Energy Regulatory Commission's (FERC's) handling of proposed natural gas and hydropower facilities has always been controversial.
    Keywords: Erdgas ; Wasserenergie ; Umweltpolitik ; Zertifikat ; Gereinigtes Wasser ; Economics;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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  • 2
    In: The New England Journal of Medicine, 2018, Vol.378(1), pp.48-59
    Description: Key Clinical Points Acute Pyelonephritis Acute pyelonephritis has the potential to cause sepsis, septic shock, and death. Urine culture is the cardinal confirmatory diagnostic test. Imaging is recommended at the time of presentation for patients with sepsis or septic shock, known or suspected urolithiasis, a urine pH of 7.0 or higher, or a new decrease in the glomerular filtration rate to 40 ml per minute or lower. Subsequent imaging is indicated in patients whose condition worsens or does not improve after 24 to 48 hours of therapy. The rising prevalence of Escherichia coli resistant to fluoroquinolones and trimethoprim–sulfamethoxazole complicates empirical oral therapy. In patients who receive oral treatment from the outset, depending on the likelihood of resistance, an initial dose of a supplemental, long-acting, parenteral antimicrobial agent (e.g., an aminoglycoside, ceftriaxone, or ertapenem) may be appropriate, and close follow-up is warranted. Assessment of illness severity, underlying host status, and the patient’s psychosocial situation and estimation of the likelihood of pathogen resistance to relevant antimicrobial agents are critical in decisions regarding patient disposition and treatment. Decisions regarding disposition and treatment in patients with pyelonephritis should be guided by assessment of the likelihood of pathogen resistance to antimicrobial agents and by patient factors (e.g., illness severity, coexisting conditions, and psychosocial situation).
    Keywords: Escherichia Coli ; Urogenital System ; Patients ; Urinary Tract Diseases ; Womens Health ; Bladder ; Sepsis ; Antibiotics ; Urinary Tract Infections ; Urine ; Antimicrobial Agents ; Inflammation ; Kidneys ; Antimicrobial Agents ; Pyelonephritis ; Urinalysis;
    ISSN: 0028-4793
    E-ISSN: 1533-4406
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  • 3
    In: Natural Gas & Electricity, January 2018, Vol.34(6), pp.29-32
    Description: Back in May 2015, I presented a paper in Houston on the resilience of natural gas and oil pipelines and their relationship to the power sector. The audience was polite, but few people were interested in resilience. How things have changed!
    Keywords: Energieversorgung (Öffentlich) ; Kraftwerk ; Kohlekraftwerk ; Atomkraftwerk ; Netzspannungsschwankung ; Netzstabilität (Energienetz) ; Gaspipeline ; Emission (Schadstoff) ; Umweltverträglichkeitsprüfung ; Economics;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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  • 4
    Article
    Article
    In: Natural Gas & Electricity, March 2018, Vol.34(8), pp.26-32
    Description: The National Environmental Policy Act (NEPA) turned 48 with the new year. I thought it would be a good idea to sit back and ponder whether NEPA has resulted in “environmentally responsible projects” or is just a long‐winded compliance exercise, and an expensive one at that.
    Keywords: Environmental Impact Statements;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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  • 5
    In: The Journal of Infectious Diseases, 2016, Vol. 213(6), pp.901-903
    Description: Use of antivirulence therapy has assumed that inhibition of bacterial fitness at the site of infection without directly affecting viability will minimize the development of resistance. However, selection for resistant strains is much more likely to occur at sites of colonization or in the environment following excretion of the therapeutic agent. Data are needed regarding whether the drug's target promotes fitness among bacteria in (drug-exposed) niches other than sites of infection. Furthermore, in vivo studies of resistance selection should assess off-target selection for resistance (eg, within the microbiome). Only when such data are available can the risk for development of resistance be gauged appropriately.
    Keywords: Antivirulence Therapy ; Antimicrobial Resistance ; Antimicrobial Targets ; Virulence Factors ; Microbiome ; Resistance Selection
    ISSN: 0022-1899
    E-ISSN: 1537-6613
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  • 6
    Language: English
    In: Journal of Infectious Diseases, March 15, 2016, Vol.213(6), p.901(3)
    Keywords: Anti-Infective Agents – Dosage and Administration ; Infection – Care and Treatment
    ISSN: 0022-1899
    Source: Cengage Learning, Inc.
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  • 7
    Language: English
    In: PLoS ONE, 2011, Vol.6(10), p.e26734
    Description: A new hypervirulent (hypermucoviscous) clinical variant of Klebsiella pneumoniae (hvKP) has emerged over the last decade. Our goal is to identify new mechanisms, which increase the virulence hvKP compared to “classic” K. pneumoniae (cKP). ; Various growth assays were performed in human ascites, human serum, and laboratory medium with the hvKP strain hvKP1 (wt), randomly chosen blood isolates of cKP strains (cKP1-4), and mutant constructs deficient in the secretion of selected compounds. An in vivo mouse model that mimics infection due to hvKP and a quantitative siderophore assay were also used. It was established that a molecule(s)/factor(s) was secreted by hvKP1 significantly enhanced its growth and/or survival in human ascites. This molecule(s)/factor(s) also increased the growth and/or survival of hvKP1 in serum ex vivo and in an in vivo mouse model that measures metastatic spread after subcutaneous challenge, thereby further establishing biologic significance. Although features such as a size of 〈3kD, heat stability, and growth characteristics in ascites suggested this molecule(s) was a quorum-sensing compound, data presented demonstrates that this molecule(s)/factor(s) is involved in iron uptake and is likely a siderophore(s) or another iron-acquisition molecule. Although it is known that iron acquisition is critical for virulence, a novel aspect of this observation is that hvKP1 produces quantitatively more siderophores that appear to be biologically more active (increased affinity for iron or more resistant to host factors) than those produced by cKP strains. ; The data presented delineates a new mechanism by which hvKP increases its pathogenic potential compared to cKP strains. This paradigm may be broadly applicable to other extraintestinal gram-negative bacilli.
    Keywords: Research Article ; Biology ; Medicine ; Immunology ; Infectious Diseases ; Microbiology ; Gastroenterology And Hepatology
    E-ISSN: 1932-6203
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  • 8
    In: Natural Gas & Electricity, May 2018, Vol.34(10), pp.18-23
    Description: The Federal Energy Regulatory Commission's review of its policy statement on natural gas pipelines is not unusual or surprising.
    Keywords: Gas Pipelines;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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  • 9
    In: Natural Gas & Electricity, November 2018, Vol.35(4), pp.28-32
    Description: Implementation of the National Environmental Policy Act (NEPA) has over the years produced a lot of paper, delays, and a propensity to resolve disputes in the courts rather than through mediation. Current attempts by the Council on Environmental Quality (CEQ) to revise the NEPA regulations and procedures will fail unless a cooling‐off period coupled with dispute resolution with state agencies is established.
    Keywords: Mediation ; Environmental Impact Statements;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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  • 10
    In: Natural Gas & Electricity, August 2018, Vol.35(1), pp.26-29
    Description: Recent headlines about New York and New Jersey opposing oil and gas production off the Atlantic Coast would have us believe that coastal states have turned a cold shoulder to offshore energy development. Nothing could be further from the truth. In fact, these states and others in New England are hoping that offshore wind development will diversify their electric‐generating fleets and wean them off natural gas.
    Keywords: Natural Gas;
    ISSN: 1545-7893
    E-ISSN: 1545-7907
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