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  • 1
    Article
    Article
    Language: English
    In: Science (New York, N.Y.), 12 September 2014, Vol.345(6202), pp.1234-7
    Description: Harvard University stem cell scientist Amy Wagers was "pathologically shy" as a child, but she has found her voice as one of the protagonists in the hunt for rejuvenating factors in blood that reverse some of the effects of aging. Using an unusual lab tool known as parabiosis, in which a young and old mouse share the same circulation, Wagers and others have begun to identify factors prevalent in the blood of young animals that can reanimate stem cells in the tissues and organs of older animals, including the heart, brain, and skeletal muscle. Buoyed by these striking (albeit preliminary) results, clinicians are now gearing up to test the regenerative potential of "young blood" in humans. [PUBLICATION ]
    Keywords: Aging ; Blood ; Rejuvenation -- Physiology
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 2
    Article
    Article
    Language: English
    In: Science (New York, N.Y.), 02 December 2016, Vol.354(6316), pp.1101
    Description: The structure and properties of the proton in water are of fundamental importance in many areas of chemistry and biology. The high mobility of the proton in an aqueous solution is understood in terms of its "hopping" between neighboring water molecules, as suggested by the two-century-old Grotthuss mechanism. The barrier for this process intimately depends on the proton's surrounding environment, which is manifested by the connectivity of the immediate hydrogen-bonding network as well as its dynamics caused by thermal fluctuations. On page 1131 of this issue, Wolke et al. (1) shed new light on the role that the proton's water neighbors play toward facilitating positive charge translocation within a hydrogen-bonded network in a cold water cluster.
    Keywords: Spying ; Hydrogen Bonding ; Clusters ; Fluctuation ; Networks ; Aqueous Solutions ; Cold Water ; Biology ; Miscellaneous Sciences (So) ; (An);
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 3
    Language: English
    In: Science (New York, N.Y.), 11 November 2011, Vol.334(6057), pp.766-7
    Description: The fossil records of some living organisms show that they were once more abundant and widespread than today. These organisms are sometimes called "living fossils," especially when their morphology closely resembles that of their fossils. Classic examples are coelacanths, the Ginkgo tree, and cycads (see the figure). On page 796 of this issue, Nagalingum et al. show that today's cycads evolved from a small number of ancestor species that lived no more than around 12 million years ago.
    Keywords: Biological Evolution ; Cycadopsida ; Fossils ; Genetic Speciation
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 4
    Article
    Article
    Language: English
    In: Science, 09/18/2015, Vol.349(6254), pp.1292-1293
    Description: The contemporary scientific community largely takes for granted the safety of recombinant DNA technology and its utility for practical application. It was not always so. The two books under review probe the science, politics, legal parameters, and practical repercussions of the...
    Keywords: Communities ; Politics ; Legal ; Ethics ; Safety ; Deoxyribonucleic Acid ; Recombinant ; Biotechnology ; Miscellaneous Sciences (So) ; (An);
    ISSN: 0036-8075
    E-ISSN: 1095-9203
    Source: American Association for the Advancement of Science (via CrossRef)
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  • 5
    Article
    Article
    Language: English
    In: Science (New York, N.Y.), 18 September 2015, Vol.349(6254), pp.1274-8
    Description: Scientists are seeking the Food and Drug Administration's blessing for an unprecedented clinical trial--the first test of a drug to specifically target the process of human aging. In some 3000 elderly people, Nir Barzilai of the Albert Einstein School of Medicine in the Bronx, New York, and his colleagues plan to conduct a trial in which half the subjects would get a placebo and half would get an old (indeed, ancient) drug for type 2 diabetes called metformin, which has been shown to modify aging in some animal studies. Because there is still no accepted biomarker for aging, the drug's success would be judged by whether it can delay the development of several diseases whose incidence increases dramatically with age: cardiovascular disease, cancer, and cognitive decline, along with mortality. When it comes to these diseases, Barzilai says, "Aging is a bigger risk factor than all of the other factors combined."
    Keywords: Aging -- Drug Effects ; Hypoglycemic Agents -- Pharmacology ; Metformin -- Pharmacology
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 6
    Language: English
    In: Science, July 8, 2011, Vol.333(6039), p.178(4)
    Description: Major advances in observational astronomy over the past 20 years have revotutionized our view of cosmic history, transforming our understanding of how the hot, smooth, early universe evolved into the complex and beautiful universe of stars and galaxies in which we now live. I describe how astronomers have used a range of complementary techniques to map out the rise and fail of star formation over 95% of cosmic time, back to the current observational frontier only ~500 million years after the Big Bang. 10.1126/science.1200644
    Keywords: Star Formation -- Observations ; Astronomical Research -- Methods ; Astronomical Research -- History
    ISSN: 0036-8075
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  • 7
    Language: English
    In: Science (New York, N.Y.), 03 August 2012, Vol.337(6094), pp.536-8
    Description: Numerical simulations have revealed two types of physical structures, made from curved spacetime, that are attached to black holes: tendexes, which stretch or squeeze anything they encounter, and vortexes, which twist adjacent inertial frames relative to each other. When black holes collide, their tendexes and vortexes interact and oscillate (a form of nonlinear dynamics of curved spacetime). These oscillations generate gravitational waves, which can give kicks up to 4000 kilometers per second to the merged black hole. The gravitational waves encode details of the spacetime dynamics and will soon be observed and studied by the Laser Interferometer Gravitational Wave Observatory and its international partners.
    Keywords: Black Holes (Astronomy) -- Models ; Black Holes (Astronomy) -- Natural History ; Spacetime -- Models;
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 8
    Language: English
    In: Science (New York, N.Y.), 22 June 2012, Vol.336(6088), pp.1523-5
    Description: A new U.S. policy for dual-use life science research defines what is permissible by scientists and the government. However, further negotiations will be needed as governments realize the consequences of such boundaries for research and society.
    Keywords: Government Regulation ; Public Policy ; Publishing ; Biomedical Research -- Legislation & Jurisprudence
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 9
    In: Nature, 2015
    Keywords: Animals–Metabolism ; Female–Pathology ; Humans–Prevention & Control ; Male–Prevention & Control ; Melanoma–Prevention & Control ; Neoplasm Metastasis–Prevention & Control ; Oxidative Stress–Prevention & Control;
    ISSN: 0028-0836
    E-ISSN: 14764687
    Source: Nature Publishing Group
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  • 10
    Article
    Article
    Language: English
    In: Science, 07/13/2012, Vol.337(6091), pp.133-133
    Description: The HIV pandemic remains a great global health challenge. With an estimated 33.3 million people living with HIV today, is there really hope of achieving the vision of an AIDS-free generation? Optimists argue that strong political will and generous funding are the essential elements. But skeptics point to the deep-seated structural inadequacies in many health care systems, especially in Africa, where the need is greatest. However, both sides agree that a potential combination of therapeutic and prophylactic antiretroviral strategies brings the prospect of HIV control within reach. And this month, the International AIDS Conference in Washington, DC, “Turning the Tide Together,” will attempt to galvanize concerted global action to focus the world's attention on this challenge.
    Keywords: Sciences (General) ; Biology;
    ISSN: 0036-8075
    E-ISSN: 1095-9203
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