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Berlin Brandenburg

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  • 1
    Language: English
    In: The Journal of infectious diseases, 01 August 2015, Vol.212(3), pp.343-4
    Keywords: HIV ; Hepatitis C ; Antiviral Therapy ; Patient-Related Outcomes ; Antiviral Agents -- Therapeutic Use ; Coinfection -- Virology ; HIV Infections -- Virology ; Hepatitis C, Chronic -- Drug Therapy ; Ribavirin -- Therapeutic Use ; Uridine Monophosphate -- Analogs & Derivatives
    ISSN: 00221899
    E-ISSN: 1537-6613
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  • 2
    Language: English
    In: Journal of the American Academy of Child & Adolescent Psychiatry, 10/2018, Vol.57(10), S, p.S20
    Description: Somatization contributes to repeat medical consultations and costly diagnostic procedures. These patients follow a circuitous pathway with visits to primary care providers, specialists, and emergency departments desperate to find explanations to their symptoms. We present a multilevel evaluation framework to assess the burden of care and impact of interventions.
    Keywords: Medical Diagnosis ; Primary Care ; Patient Assessment ; Patient Handling ; Medical Treatment ; Accident and Emergency Departments ; Somatization ; Specialists ; Medical Personnel ; Primary Care;
    ISSN: 08908567
    E-ISSN: 15275418
    Source: Elsevier (via CrossRef)
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  • 3
    Language: English
    In: Social Science & Medicine, March 2010, Vol.70(6), pp.850-858
    Description: The goal of this study was to assess the relationship between student- and school-level factors and student health and wellbeing outcomes, and to estimate the variability present at each of the student and school levels for each of three selected health-related outcomes. The data are from the 2006 Canadian Health Behaviour in School-aged children (HBSC) study in which Grades 6–10 students ( = 9670) and administrators ( = 187) were surveyed. The three outcome measures are Self-Rated Health (SRH), Emotional Wellbeing (EWB), and Subjective Health Complaints (SHC). Individual and school-level effects on the three outcomes were estimated using multi-level modeling. Both individual and school-level factors were associated with students' health. Gender, family wealth, family structure, academic achievement and neighbourhood were significant student-level predictors. We identified random associations between the student-level variables and reported health outcomes. These random effects indicate that the relationships between these student variables and health are not consistent across schools. Student Problem Behaviours at the school were significant predictors of SRH and SHC, while Student Aggression and the school's average socioeconomic standing were significant school-level predictors of EWB. Findings suggest that the environment and disciplinary climate in schools can predict student health and wellbeing outcomes, and may have important implications for school initiatives aimed at students who are struggling both emotionally and academically.
    Keywords: Adolescent ; Health ; Wellbeing ; Neighbourhood ; School ; Multilevel ; Canada ; Medicine ; Social Sciences (General) ; Public Health
    ISSN: 0277-9536
    E-ISSN: 1873-5347
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  • 4
    Language: English
    In: Trends in Neurosciences, October 2012, Vol.35(10), pp.629-637
    Description: Emerging evidence suggests that chronic pain is a disease that can alter brain function. Imaging studies have demonstrated structural remapping and functional reorganization of brain circuits under various pain conditions. In parallel, preclinical models have demonstrated that chronic pain causes long-term neuroplasticity. For example, thalamo–cortical oscillations are dysregulated and neurons in the sensory thalamus undergo ectopic firing linked to misexpression of membrane ion channels. In theory, physiological changes at the single-unit, multi-unit, and circuitry levels can be used as predictors of pain, and possibly to guide targeted neuromodulation of specific brain regions for therapeutic purposes. Therefore, multidisciplinary research into the mechanisms of pain-related phenomena in the brain may offer insights into novel approaches for the diagnosis, monitoring, and management of persistent pain.
    Keywords: Pain ; Brain ; Neurotechnology ; Pharmacotherapy ; Neuroplasticity ; Channelopathy ; Medicine ; Anatomy & Physiology
    ISSN: 0166-2236
    E-ISSN: 1878-108X
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  • 5
    Language: English
    In: Nature, 28 January 2016, Vol.529(7587), pp.474-5
    Description: After taking into account the known physiological properties of different ion-channel proteins and testing the effects of channel stimulators and inhibitors, the authors concluded that the channel responsible is TRPA1 - a widely expressed member of the family of transient receptor potential (TRP) channels...
    Keywords: Protons ; Brain Ischemia -- Metabolism ; Calcium -- Metabolism ; Myelin Sheath -- Metabolism ; Transient Receptor Potential Channels -- Metabolism
    ISSN: 00280836
    E-ISSN: 1476-4687
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  • 6
    Language: English
    In: Drugs, 2015, Vol.75(16), pp.1833-1842
    Description: The introduction of therapeutic agents such as irinotecan, oxaliplatin, and more recently biologic agents such as vascular endothelial growth factor and epidermal growth factor receptor (EGFR) inhibitors has significantly improved survival of patients with metastatic colorectal cancer. These novel agents have also contributed to added toxicities. Therefore, several studies have evaluated the role of maintenance therapy with less intensive regimens in patients who experienced stable disease or treatment response following induction therapy as a strategy to reduce toxicity and improve quality of life. The success of such strategies, however, requires assurance that their survival would not be compromised. We therefore reviewed studies that have explored the various strategies of treatment de-escalation with an emphasis on survival and toxicity outcomes. Recent studies evaluated the role of maintenance therapy with chemotherapy only, chemotherapy plus bevcizumab, bevacizumab only, and EGFR inhibitors. Current evidence suggests that maintenance strategies offer significant benefit to patients by providing continuous clinical benefit while minimizing the risks associated with continuous therapy. Strategies to improve selection of patients for maintenance therapy versus identifying subgroups of patients that will benefit from a chemotherapy-free interval need to continue to be studied. Finally, as our understanding of the molecular and genetic drivers of colorectal cancer continues to expand, refining these strategies to include more target-specific agents should become more routine.
    Keywords: Antibodies, Monoclonal, Humanized -- Therapeutic Use ; Antineoplastic Agents -- Therapeutic Use ; Antineoplastic Combined Chemotherapy Protocols -- Therapeutic Use ; Bevacizumab -- Therapeutic Use ; Colorectal Neoplasms -- Drug Therapy ; Erbb Receptors -- Antagonists & Inhibitors ; Maintenance Chemotherapy -- Methods;
    ISSN: 0012-6667
    E-ISSN: 1179-1950
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  • 7
    Language: English
    In: Science (New York, N.Y.), 10 August 2012, Vol.337(6095), pp.749-53
    Description: The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
    Keywords: Motor Activity ; Astrocytes -- Metabolism ; Cerebellar Cortex -- Cytology ; Receptors, Ampa -- Metabolism
    ISSN: 00368075
    E-ISSN: 1095-9203
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  • 8
    Language: English
    In: Current Opinion in Neurobiology, December 2013, Vol.23(6), pp.1065-1072
    Description: In vertebrates, the myelination of long axons by oligodendrocytes and Schwann cells enables rapid impulse propagation. However, myelin sheaths are not only passive insulators. Oligodendrocytes are also known to support axonal functions and long-term integrity. Some of the underlying mechanisms have now been identified. It could be shown that oligodendrocytes can survive by aerobic glycolysis. Myelinating oligodendrocytes release lactate through the monocarboxylate transporter MCT1. Lactate is then utilized by axons for mitochondrial ATP generation. Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails. These include neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.
    Keywords: Anatomy & Physiology
    ISSN: 0959-4388
    E-ISSN: 1873-6882
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  • 9
    Language: English
    In: Third World Quarterly, 01 November 2016, Vol.37(11), pp.1957-1971
    Description: In his closing keynote address for the TWAIL Cairo Conference, Professor Georges Abi-Saab engages with the conference theme 'On Praxis and the Intellectual' by considering the diverse roles that can be played by Third World international law intellectuals in trying to transform theory into...
    Keywords: Third World ; International Law ; Praxis ; Strategy ; Tactics ; Twail ; Economics
    ISSN: 0143-6597
    E-ISSN: 1360-2241
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  • 10
    In: International Journal of Gynecology & Obstetrics, October 2012, Vol.119, pp.S240-S240
    Keywords: Medicine;
    ISSN: 0020-7292
    E-ISSN: 1879-3479
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