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  • 1
    Online Resource
    Online Resource
    Psoriasis : diagnosis and management (2015)
    Chichester, England :Wiley Blackwell,
    Details
    UID:
    almafu_9959328509702883
    Format: 1 online resource (289 pages) : , illustrations, tables
    ISBN: 9781118661796 , 1118661796 , 9781118661826 , 1118661826
    Content: Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer's quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the.
    Note: Psoriasis: Diagnosis and Management; Copyright; Contents; List of contributors; Preface; Part I Epidemiology and economic aspects; Chapter 1 Epidemiology and economic aspects; Epidemiology; Social and economic impact; Further reading; Chapter 2 Cost-effective psoriasis management; Health economics in a nutshell; Cost-effectiveness and cost-utility analyses in psoriasis; Further reading; Part II Etiology and pathogenesis; Chapter 3 Microscopic skin alterations; The human skin: a multilayered, dynamic barrier to the environment. , The psoriatic skin: inflammation with epidermal and vascular remodelingFurther reading; Chapter 4 Pathogenesis of psoriasis; Sensitization phase: antigen processing and presentation; Sensitization phase: generation of effector and memory T-cells; Effector phase: infiltration of immune cells into the skin; Effector phase: immune cell activation in the skin; Effector phase: tissue-cell response; Further reading; Chapter 5 Genetics of psoriasis; Further reading; Part III Clinical features/diagnostic procedure; Chapter 6 Plaque psoriasis; Plaque psoriasis. , Plaque psoriasis in special localizationsChapter 7 Gutatte psoriasis; Further reading; Chapter 8 Erythrodermic psoriasis; Further reading; Chapter 9 Pustular psoriasis; Generalized pustular psoriasis (GPP); Generalized pustular psoriasis of pregnancy (GPPP)/Impetigo herpetiformis (IH); Annular psoriasis [erythema annulare centrifugum-type (EACP)]; Psoriasis vulgaris with pustulation; Palmoplantar pustular psoriasis (PPP); Acrodermatitis continua suppurativa (Hallopeau); Further reading; Chapter 10 Nail psoriasis; Clinical picture and pathophysiology; Diagnostic procedure; Burden of disease. , Further readingChapter 11 Psoriatic arthritis; Epidemiology; Clinical picture; Clinical classification of PsA; Diagnostic procedures; Laboratory findings; Imaging; Prognosis; Further reading; Chapter 12 Mucosal presentation of psoriasis; Further reading; Chapter 13 Psoriasis in different life situations; Psoriasis in children; Psoriasis in pregnancy; Psoriasis in the elderly; Further reading; Part IV Evaluation of disease severity; Chapter 14 Evaluation of disease severity-clinical scores and questionnaires; Assessment of skin involvement; Assessment of nail psoriasis. , Assessment of psoriasis arthritis (PsA)Spine assessment; Assessment of enthesitis; Assessment of dactylitis; Imaging techniques; Visual analog scale (VAS); Quality-of-Life (QOL) Questionnaires; Further reading; Appendix; Part V Psoriasis and associated diseases; Chapter 15 Psoriasis and associated diseases; Cardiovascular disease and metabolic syndrome; Obesity; Atherogenic dyslipidemia; Hypertension; Inflammatory bowel disease; Other inflammatory diseases; Psychosocial aspects; Depression; Nicotine use; Alcohol; Conclusion; Further reading; Part VI Therapeutic management.
    Additional Edition: Print version: Psoriasis : diagnosis and management. Chichester, England : Wiley Blackwell, ©2015 ISBN 9780470657362
    Language: English
    Keywords: Electronic books. ; Popular works. ; Electronic books. ; Electronic books. ; Popular works. ; Electronic books. ; Popular works.
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118661796
    URL: Click to View
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118661796
    URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781118661796
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    HU Berlin
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  • 2
    Book
    Book
    Rolle des IL-22-Rezeptors 1 in der Pathogenese der Psoriasis vulgaris / (2018)
    Berlin,
    Details
    UID:
    almafu_BV045904754
    Format: 121 Blätter : , Illustrationen, Diagramme.
    Note: Habilitationsschrift Charité - Universitätsmedizin Berlin 2019
    Additional Edition: Erscheint auch als Online-Ausgabe
    Language: German
    Keywords: Hochschulschrift
    Author information: Sabat, Robert 1969-
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  • 3
    Online Resource
    Online Resource
    Rolle des IL-22-Rezeptors 1 in der Pathogenese der Psoriasis vulgaris / (2018)
    Berlin,
    Details
    UID:
    edocfu_BV045904733
    Format: 1 Online-Ressource (121 Blätter) : , Illustrationen, Diagramme.
    Note: Habilitationsschrift Charité - Universitätsmedizin Berlin 2019
    Additional Edition: Erscheint auch als Druck-Ausgabe
    Language: German
    Keywords: Hochschulschrift
    URN: urn:nbn:de:kobv:188-refubium-24265-7
    URL: Volltext  (kostenfrei)
    Author information: Sabat, Robert 1969-
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    FU Berlin
  • 4
    Online Resource
    Online Resource
    Rolle des IL-22-Rezeptors 1 in der Pathogenese der Psoriasis vulgaris / (2018)
    Berlin,
    Details
    UID:
    edoccha_BV045904733
    Format: 1 Online-Ressource (121 Blätter) : , Illustrationen, Diagramme.
    Note: Habilitationsschrift Charité - Universitätsmedizin Berlin 2019
    Additional Edition: Erscheint auch als Druck-Ausgabe
    Language: German
    Keywords: Hochschulschrift
    URN: urn:nbn:de:kobv:188-refubium-24265-7
    URL: Volltext  (kostenfrei)
    Author information: Sabat, Robert 1969-
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    Charité
  • 5
    Book
    Book
    Herstellung, immunbiochemische und funktionelle Charakterisierung und Anwendungsbeispiele von monoklonalen Antikörpern gegen humanes Interleukin-10 / (2004)
    Details
    UID:
    almahu_BV017962846
    Format: 89 Bl. : Ill., graph. Darst. : 30 cm.
    Note: Beitr. teilw. dt., teilw. engl. - Enth. 5 Sonderabdr. aus verschiedenen Zeitschr. - Berlin, Humboldt-Univ., Diss., 2004
    Language: German
    Subjects: Medicine
    RVK:
    XD 3200
    Keywords: Hochschulschrift
    URL: Inhaltsverzeichnis
    Author information: Sabat, Robert 1969-
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  • 6
    Online Resource
    Online Resource
    BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study (2018)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_30015
    Format: 1 Online-Ressource (9 Seiten)
    Content: Background BK virus (BKV), Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) reactivations are common after kidney transplantation and associated with increased morbidity and mortality. Although CMV might be a risk factor for BKV and EBV, the effects of combined reactivations remain unknown. The purpose of this study is to ascertain the interaction and effects on graft function of these reactivations. Methods 3715 serum samples from 540 kidney transplant recipients were analysed for viral load by qPCR. Measurements were performed throughout eight visits during the first post-transplantation year. Clinical characteristics, including graft function (GFR), were collected in parallel. Findings BKV had the highest prevalence and viral loads. BKV or CMV viral loads over 10,000 copies·mL−1 led to significant GFR impairment. 57 patients had BKV-CMV combined reactivation, both reactivations were significantly associated (p = 0.005). Combined reactivation was associated with a significant GFR reduction one year post-transplantation of 11.7 mL·min−1·1.73 m−2 (p = 0.02) at relatively low thresholds (BKV 〉 1000 and CMV 〉 4000 copies·mL−1). For EBV, a significant association was found with CMV reactivation (p = 0.02), but no GFR reduction was found. Long cold ischaemia times were a further risk factor for high CMV load. Interpretation BKV-CMV combined reactivation has a deep impact on renal function one year post-transplantation and therefore most likely on long-term allograft function, even at low viral loads. Frequent viral monitoring and subsequent interventions for low BKV and/or CMV viraemia levels and/or long cold ischaemia time are recommended. Fund Investigator Initiated Trial; financial support by German Federal Ministry of Education and Research (BMBF).
    Content: Peer Reviewed
    In: Amsterdam [u.a.] : Elsevier, 34, Seiten 113-121
    Language: English
    DOI: 10.18452/29403
    DOI: 10.1016/j.ebiom.2018.07.017
    URN: urn:nbn:de:kobv:11-110-18452/30015-0
    URL: Volltext  (kostenfrei)
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  • 7
    Online Resource
    Online Resource
    A novel approach reveals that HLA class 1 single antigen bead-signatures provide a means of high-accuracy pre-transplant risk assessment of acute cellular rejection in renal transplantation (2019)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_30016
    Format: 1 Online-Ressource (10 Seiten)
    Content: Background Acute cellular rejection (ACR) is associated with complications after kidney transplantation, such as graft dysfunction and graft loss. Early risk assessment is therefore critical for the improvement of transplantation outcomes. In this work, we retrospectively analyzed a pre-transplant HLA antigen bead assay data set that was acquired by the e:KID consortium as part of a systems medicine approach. Results The data set included single antigen bead (SAB) reactivity profiles of 52 low-risk graft recipients (negative complement dependent cytotoxicity crossmatch, PRA 〈 30%) who showed detectable pre-transplant anti-HLA 1 antibodies. To assess whether the reactivity profiles provide a means for ACR risk assessment, we established a novel approach which differs from standard approaches in two aspects: the use of quantitative continuous data and the use of a multiparameter classification method. Remarkably, it achieved significant prediction of the 38 graft recipients who experienced ACR with a balanced accuracy of 82.7% (sensitivity = 76.5%, specificity = 88.9%). Conclusions The resultant classifier achieved one of the highest prediction accuracies in the literature for pre-transplant risk assessment of ACR. Importantly, it can facilitate risk assessment in non-sensitized patients who lack donor-specific antibodies. As the classifier is based on continuous data and includes weak signals, our results emphasize that not only strong but also weak binding interactions of antibodies and HLA 1 antigens contain predictive information. Trial registration ClinicalTrials.gov NCT00724022. Retrospectively registered July 2008.
    Content: Peer Reviewed
    In: Heidelberg : Springer, 20,1
    Language: English
    DOI: 10.18452/29404
    DOI: 10.1186/s12865-019-0291-2
    URN: urn:nbn:de:kobv:11-110-18452/30016-6
    URL: Volltext  (kostenfrei)
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  • 8
    Online Resource
    Online Resource
    Sex-Associated Differences in Cytomegalovirus Prevention: Prophylactic Strategy is Potentially Associated With a Strong Kidney Function Impairment in Female Renal Transplant Patients (2020)
    Berlin : Humboldt-Universität zu Berlin
    Details
    UID:
    edochu_18452_26150
    Format: 1 Online-Ressource (11 Seiten)
    Content: Post-transplantation cytomegalovirus (CMV) syndrome can be prevented using the antiviral drug (val)ganciclovir. (Val)ganciclovir is typically administered following a prophylactic or a pre-emptive strategy. The prophylactic strategy entails early universal administration, the pre-emptive strategy, early treatment in case of infection. However, it is not clear which strategy is superior with respect to transplantation outcome; sex-specific effects of these prevention strategies are not known. We have retrospectively analyzed 540 patients from the multi-centre Harmony study along eight pre-defined visits: 308 were treated according to a prophylactic, 232 according to a pre-emptive strategy. As expected, we observed an association of prophylactic strategy with lower incidence of CMV syndrome, delayed onset and lower viral loads compared to the pre-emptive strategy. However, in female patients, the prophylactic strategy was associated with a strong impairment of glomerular filtration rate one year post-transplant (difference: −11.8 ± 4.3 ml min−1·1.73 m−2, p = 0.006). Additionally, we observed a tendency of higher incidence of acute rejection and severe BK virus reactivation in the prophylactic strategy group. While the prophylactic strategy was more effective for preventing CMV syndrome, our results suggest for the first time that the prophylactic strategy might lead to inferior transplantation outcomes in female patients, providing evidence for a strong association with sex. Further randomized controlled studies are necessary to confirm this potential negative effect.
    Content: Peer Reviewed
    In: Lausanne : Frontiers Media, 11
    Language: English
    DOI: 10.18452/25464
    DOI: 10.3389/fphar.2020.534681
    URN: urn:nbn:de:kobv:11-110-18452/26150-7
    URL: Volltext  (kostenfrei)
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  • 9
    Online Resource
    Online Resource
    Between inflammation and melanoma : the 4th ADF round table (2018)
    Show associated volumes
    Details
    UID:
    gbv_1041212682
    ISSN: 1600-0625
    In: Experimental dermatology, Oxford : Wiley-Blackwell, 1992, 27(2018), 10, Seite 1176-1178, 1600-0625
    In: volume:27
    In: year:2018
    In: number:10
    In: pages:1176-1178
    Language: English
    DOI: 10.1111/exd.13748
    URL: Volltext
    Author information: Wolk, Kerstin 1968-
    Author information: Gaffal, Evelyn 1976-
    Author information: Sabat, Robert 1969-
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