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  • 1
    Language: English
    In: Trends in Pharmacological Sciences, October 2012, Vol.33(10), pp.522-530
    Description: The transcription factors nuclear factor-κB (NF-κB) and activating protein-1 (AP-1) are critical regulators of stress responses, immunity, inflammation and cancer. A large variety of cellular stimuli utilize these signaling pathways through a common upstream kinase transforming growth factor-β-activated kinase 1 (TAK1). TAK1 was originally identified as a mitogen-activated kinase kinase kinase (MAP3K) activated by transforming growth factor-β (TGF-β); however, it has been characterized as a key regulator in inflammatory and immune signaling pathways. In addition, microbial proteins and components of host cell signaling scramble for the TAK1 complex in innate immunity. This review highlights the recent advances in the activation mechanisms and physiological functions of TAK1. Research targeting TAK1 raises the potential for new therapeutic options for inflammatory disorders, including cancer.
    Keywords: Pharmacy, Therapeutics, & Pharmacology
    ISSN: 0165-6147
    E-ISSN: 1873-3735
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  • 2
    Language: English
    In: Catalysis Today, August 1, 2015, Vol.251, p.96(7)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cattod.2014.11.004 Byline: Hiroaki Sakurai, Kenji Koga, Masato Kiuchi Abstract: Author Affiliation: (a) National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan (b) National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan Article History: Received 2 August 2014; Revised 26 October 2014; Accepted 5 November 2014
    Keywords: Gold
    ISSN: 0920-5861
    Source: Cengage Learning, Inc.
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  • 3
    Language: English
    In: Catalysis Today, 01 August 2015, Vol.251, pp.96-102
    Description: Gold nanoparticles were deposited on two kinds of solid acids, i.e., amorphous SiO –Al O and cation-exchange resin Amberlyst-15; the resultant materials exhibited high activity as metal–acid bifunctional catalysts. SiO –Al O was impregnated with a chloride-free alkaline Au(III) solution containing Na and then dried. After calcination at 623 K, gold nanoparticles with diameters of 4.2 nm (measured by X-ray diffraction) were deposited at a Au loading of 1.0 wt%. By replacing the Na ions with H ions through ammonium ion-exchange and heating, an acidic Au/SiO –Al O catalyst was obtained. In Amberlyst-15, gold nanoparticles with diameters of 7.3 nm were deposited after impregnation and drying. Subsequent ion-exchange with dilute sulfuric acid generated the acidic form of the Au/Amberlyst-15 catalyst, which showed an esterification activity equivalent to that of the original Amberlyst-15. The catalyst exhibited high activity for the direct conversion of cellobiose to gluconic acid, which requires both acid hydrolysis and oxidation. A 45% yield of gluconic acid was obtained after 24 h of reaction under ambient air at 373 K, with an apparent synergistic effect between the gold nanoparticles and acidic resin surface.
    Keywords: Gold Nanoparticles ; Sio2–Al2o3 ; Amberlyst-15 ; Bifunctional Catalysis ; Cellobiose ; Gluconic Acid ; Engineering ; Chemistry
    ISSN: 0920-5861
    E-ISSN: 1873-4308
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  • 4
    Language: English
    In: Proceedings of the National Academy of Sciences of the United States of America, 2011, Vol.108(44), pp.18038-18043
    Description: In the sex-pheromone communication systems of moths, odorant receptor (Or) specificity as well as higher olfactory information processing in males should be finely tuned to the pheromone of conspecific females. Accordingly, male sex-pheromone preference should have diversified along with the diversification of female sex pheromones; however, the genetic mechanisms that facilitated the diversification of male preference are not well understood. Here, we explored the mechanisms involved in a drastic shift in sex-pheromone preference in the silkmoth Bombyx mori using spli mutants in which the genomic structure of the gene Bmacj6, which encodes a class IV POU domain transcription factor, is disrupted or its expression is repressed. B. mori females secrete an ∼11:1 mixture of bombykol and bombykal. Bombykol alone elicits full male courtship behavior, whereas bombykal alone shows no apparent activity. In the spli mutants, the behavioral responsiveness of males to bombykol was markedly reduced, whereas bombykal alone evoked full courtship behavior. The reduced response of spli males to bombykol was explained by the paucity of bombykol receptors on the male antennae. It was also found that, in the spli males, neurons projecting into the toroid, a compartment in the brain where bombykol receptor neurons normally project, responded strongly to bombykal. The present study highlights a POU domain transcription factor, Bmacj6, which may have caused a shift of sex-pheromone preference in B. mori through Or gene choice and/or axon targeting. ; p. 18038-18043.
    Keywords: Genes ; Odor Compounds ; Antennae ; Males ; Transcription Factors ; Receptors ; Females ; Mutants ; Communications Technology ; Sex Pheromones ; Neurons ; Brain ; Bombyx Mori ; Courtship ; Moths
    ISSN: 0027-8424
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  • 5
    Language: English
    In: Tetrahedron Letters, 26 June 2013, Vol.54(26), pp.3402-3405
    Description: Mycosphines A–D ( – ), comprising a class of new short-branched fatty acid dimers, were found in the cultures of an endophytic fungus, sp., isolated from . The structures, including the absolute stereochemistries were determined by spectroscopic analysis, single crystal X-ray diffraction, and vibrational circular dichroism (VCD).
    Keywords: Endophytic Fungi ; Aloe Arborescens ; Mycosphaerella Sp ; Secondary Metabolites ; Vcd ; Epigenetics ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 6
    Language: English
    In: Tetrahedron Letters, 2012, Vol.53(6), pp.654-656
    Description: During the course of screening natural products for the inhibitors of tumor cell invasion, pterocidin, a linear polyketide with a δ-lactone terminus, was rediscovered from a strain of a marine sediment-origin. A series of -based configuration analyses and NOESY analysis, coupled with chemical derivatization and chiral anisotropy analysis, established the absolute stereochemistry of five asymmetric centers in this compound.
    Keywords: Pterocidin ; Absolute Configuration ; Invasion Inhibitor ; Streptomyces ; Chemistry
    ISSN: 0040-4039
    E-ISSN: 1873-3581
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  • 7
    In: Chemical Communications, 2016, Vol.52(93), pp.13612-13615
    Description: Hydrogen was efficiently evolved from glycerol aqueous solution upon vertical photoirradiation of a Pt/TiO 2 or Au/TiO 2 bed under aerobic conditions. Granular photocatalysts were easily deposited, leading to high H 2 selectivity (8095%), whereas glycerol oxidation with CO 2 evolution became dominant when suspended powder photocatalysts were used.
    Keywords: Chemistry;
    ISSN: 1359-7345
    E-ISSN: 1364-548X
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  • 8
    Language: English
    In: Applied Catalysis A, General, July 10, 2013, Vol.462-463, p.236(11)
    Description: To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.apcata.2013.05.016 Byline: Hiroaki Sakurai, Kenji Koga, Yasuo Iizuka, Masato Kiuchi Abstract: Author Affiliation: (a) National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Ikeda, Osaka 563-8577, Japan (b) National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan (c) CREST, Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan Article History: Received 14 February 2013; Accepted 12 May 2013
    ISSN: 0926-860X
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Chemistry – A European Journal, 14 December 2012, Vol.18(51), pp.16302-16309
    Description: Desulfurization of fuels is receiving more and more attention all over the world due to the increase of stringent environmental regulations and fuel specifications. The metal–organic framework (MOF) is a new class of crystalline materials, and high porosity, one of the most important properties of MOFs, plays a central role in the functional properties. However, the investigation of MOFs, being employed as sorbents for adsorptive desulfurization, is still scarce. In this regard, we have constructed a new 3D porous compound by using rigidly designed carboxylate ligands, which, for the first time, exhibit an unusual triple molecular necklace‐like helix. The N sorption isotherms of show that it has a large Brunauer–Emmett–Teller (BET) surface area and pore volume. With the stable pore structure and appropriate pore sizes, compound has been used as a sorbent for adsorptive desulfurization. The results indicate that compound shows an excellent adsorption property and, more importantly, displays excellent stability, repeatability, and regenerability. Thus, the design and synthesis of targeted MOFs with appropriate pore size and increased interactions between organosulfur compounds and ligands/metals from MOFs is crucial for adsorptive desulfurization, which might be an effective guide to find an efficient and green adsorbent for desulfurization. : By using rigidly designed carboxylate ligands, a new 3D porous metal–organic framework (MOF) involving an unusual triple molecular necklace‐like helix has been constructed for the first time (see figure). It exhibits excellent adsorptive desulfurization properties with high stability, repeatability, and regenerability.
    Keywords: Desulfurization ; Gas Adsorption ; Ligands ; Metal‐Organic Frameworks ; Regeneration
    ISSN: 0947-6539
    E-ISSN: 1521-3765
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  • 10
    Language: English
    In: Journal of Strength and Conditioning Research, 2016, Vol.30(4), p.980(9)
    Description: We aimed to investigate whether a linear regression formula based on the relationship between joint torque and angular velocity measured using a high-speed video camera and image measurement software is effective for estimating 1 repetition maximum (1RM) and isometric peak torque in knee extension. Subjects comprised 20 healthy men (mean [+ or -] SD; age, 27.4 [+ or -] 4.9 years; height, 170.3 [+ or -] 4.4 cm; and body weight, 66.1 [+ or -] 10.9 kg). The exercise load ranged from 40% to 150% 1 RM. Peak angular velocity (PAV) and peak torque were used to estimate 1RM and isometric peak torque. To elucidate the relationship between force and velocity in knee extension, the relationship between the relative proportion of 1RM (% 1 RM) and PAV was examined using simple regression analysis. The concordance rate between the estimated value and actual measurement of 1 RM and isometric peak torque was examined using intraclass correlation coefficients (ICCs). Reliability of the regression line of PAV and % 1 RM was 0.95. The concordance rate between the actual measurement and estimated value of 1 RM resulted in an [ICC.sub.(2,1)] of 0.93 and that of isometric peak torque had an [ICC.sub.(2,1)] [degrees]f 0.87 and 0.86 for 6 and 3 levels of load, respectively. Our method for estimating 1 RM was effective for decreasing the measurement time and reducing patients' burden. Additionally, isometric peak torque can be estimated using 3 levels of load, as we obtained the same results as those reported previously. We plan to expand the range of subjects and examine the generalizability of our results. KEY WORDS resistance training, joint torque, angular velocity, two-dimensional movement analysis, Bland-Altman analysis
    Keywords: Knee Muscles – Mechanical Properties ; Torque – Measurement ; Weight Training – Physiological Aspects
    ISSN: 1064-8011
    Source: Cengage Learning, Inc.
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