Format:
Online-Ressource (V, 177 p. 14 illus., 8 illus. in color, digital)
ISBN:
9781461432357
Series Statement:
SpringerLink
Content:
This book will be a comprehensive study of the lymphatic system and its immunological role. It will begin with lymphatic capillaries, their origin and development. It will treat lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section will address lymph nodes, subcortical circulation and the conduit system. It will discuss organs with no lymphatic system, such as the brain. Finally, it will cover lymph composition and cells in the lymph. While primarily basic research, the volume will touch upon elements of the clinical, as well, broad
Note:
Includes bibliographical references and index
,
Contents; Chapter 1: Introduction; Chapter 2: Lymphangiogenesis; 2.1 Introduction; 2.1.1 Structure and Function of the Lymphatic Vasculature; 2.2 Physiological Lymphangiogenesis; 2.2.1 Embryonic Development of the Lymphatic Vasculature; 2.2.2 Lymphangiogenic Growth Factors: Sprouting, Proliferation, and Migration; 2.2.3 Remodeling and Maturation of the Primitive Lymphatic Vasculature; 2.2.4 Experimental Models for Physiological Lymphangiogenesis; 2.3 Pathological Lymphangiogenesis; 2.3.1 Lymphatic Malfunction in Primary and Secondary Lymphedema
,
2.3.2 Lymphangiogenesis in Inflammation and Immune Dysfunction2.3.3 Lymphangiogenesis in Cancer Progression and Metastasis; 2.3.4 Lymphangiogenesis in Lymphovascular Tumors; 2.4 Conclusions; References; Chapter 3: Microvascular Fluid Filtration and Lymph Formation; 3.1 Introduction; 3.2 Further Experimental Evidence for Starling's Proposal; 3.3 The Relation Between Capillary Pressure and the Arterial and Venous Pressures; 3.4 Quantitative Expressions of Microvascular Fluid Filtration; 3.5 Measurement of the Extravascular Pressures
,
3.6 Most Venous Microvessels Appear to Filter Fluid Not Absorb It3.7 Fluid Exchange Under Transient and Steady State Conditions; 3.8 Steady State Fluid Uptake in Specialized Microcirculations; 3.9 Net Filtration Calculated from Starling Pressures Overestimates Lymph Flow; 3.10 Osmotic Pressure Differences Across the Endothelial Ultrafilter; 3.11 Further Developments; 3.12 Conclusions; References; Chapter 4: Cellular Composition of Lymph; 4.1 Introduction; 4.2 Foundational Observations; 4.3 The Disequilibrium of Lymphocyte Recirculation into Afferent Lymph
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4.4 Dendritic Cells in Afferent Lymph4.5 Trafficking into Efferent Lymph; 4.6 Concluding Remarks; References; Chapter 5: The Lymph Proteome, Peptidome, and Degradome; 5.1 Introduction; 5.2 Lymph Formation; 5.3 Lymph and Plasma Proteome; 5.4 Plasma Peptidome and Degradome; 5.5 Lymph Peptidome and Degradome; 5.6 Conclusions; References; Chapter 6: Aging and Lymphatic Contractility: Current Status; References; Chapter 7: Lymph and Lymphatic Capillaries in Cancer; 7.1 Introduction; 7.2 Lymph and the Tumor Microenvironment
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7.3 Physical Effects Created as a Result of Tumor-Associated Lymphatic Drainage and Lymph Flow7.4 Lymph Effects on the Tumor Immune Response; 7.5 Lymph Measurement in Tumors; 7.6 Lymph and Lymphatics as Therapeutic Targets; 7.7 Concluding Remarks; References; Chapter 8: The Brain and the Lymphatic System; 8.1 Introduction; 8.2 Interstitial Fluid; 8.3 Cerebrospinal Fluid; 8.3.1 Pulsatile CSF Flow; 8.3.2 The Arachnoid Projections; 8.3.3 Aquaporins; 8.3.4 Lymphatic Drainage of CSF; 8.3.5 Anatomical Brain-Lymphatic Relationships; 8.3.6 ISF-CSF Connections
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8.3.7 Quantitative Analysis of Lymphatic CSF Absorption
Additional Edition:
ISBN 9781461432340
Additional Edition:
Druckausg. Immunology of the lymphatic system New York, NY : Springer, 2013 ISBN 9781461432340
Language:
English
Subjects:
Medicine
Keywords:
Lymphsystem
;
Immunbiologie
DOI:
10.1007/978-1-4614-3235-7
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