UID:
edocfu_9961565578302883
Format:
1 online resource (257 pages)
Edition:
First edition.
ISBN:
1-83916-750-5
,
1-83916-751-3
Content:
Highlighting the potential of microalgae as a sustainable source of biochemicals this book covers the applications of synthetic biology to improve microalgae as a biotechnological resource.
Note:
Cover -- Preface -- Contents -- Chapter 1 Microalgae as a Renewable and Sustainable Source of High Value Metabolites -- 1.1 Introduction -- 1.2 Microalgae as a Source of Lipids and PUFAs -- 1.3 Microalgae as a Source of Pigments -- 1.3.1 Chlorophylls -- 1.3.2 Phycobiliproteins -- 1.3.3 Carotenoids -- 1.4 Microalgae as a Source of Polysaccharides -- 1.5 Microalgae as a Source of Proteins and Amino Acids -- 1.6 Microalgae as a Source of Vitamins -- 1.7 Microalgae as a Source of Phytosterols -- 1.8 Microalgae as a Source of Polyphenols -- 1.9 Renewability and Sustainability Aspect of Microalgae -- 1.10 Conclusion -- References -- Chapter 2 Recent Advances and Challenges in Establishing Commercial Scale Multi-product Microalgal Biorefineries -- 2.1 Introduction -- 2.2 Technical Advances and Challenges in Establishing a SustainableMicroalgae-basedMultiproduct Biorefinery -- 2.2.1 Strain Selection and Improvement -- 2.2.2 Cultivation Techniques and Enhancement Strategies -- 2.2.3 Downstream Processing ofMicroalgal Biomass -- 2.3 Role of Modelling Tools in the Development of Commercial Microalgal Biorefineries -- 2.3.1 Increasing the Technical Efficiency ofUpstream and Downstream Processes Through Computer-aided Modelling -- 2.3.2 Mitigating the Environmental Impacts of Microalgal Biorefineries -- 2.3.3 Improving the Economic Viability of Microalgal Biorefineries -- 2.3.4 Optimizing the Design of Microalgal Biorefineries -- 2.3.5 Combining Modelling Tools in Biorefinery Sustainability Assessment -- 2.4 Future Research -- 2.4.1 Advanced Digitalization Prospect in Microalgal Biorefineries -- 2.4.2 Considering Social Aspects in theDevelopment of Commercial Scale Microalgal Biorefineries -- 2.5 Conclusion and Recommendations -- Abbreviations -- Acknowledgements -- References.
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Chapter 3 Understanding Metabolic Pathways and Their Network toAugment Microalgal Strain Performance for Industrially Important Metabolite Production -- 3.1 Introduction -- 3.2 Metabolites of Interest -- 3.2.1 Carotenoids -- 3.2.2 Lipids and Fatty Acids -- 3.2.3 Phycocyanin -- Abbreviations -- Acknowledgements -- References -- Chapter 4 Advances in the Resources to Augment Microalgal GeneticEngineering: Omics- based Resources, Mutant Libraries, and High- throughput Screening Techniques -- 4.1 Introduction -- 4.2 Microalgae as a Synthetic Biology Platform -- 4.3 Omics-based Resources of Microalgae -- 4.3.1 Genomic Resources -- 4.3.2 Transcriptomic Resources -- 4.3.3 Proteomic Resources -- 4.3.4 Metabolomic Resources -- 4.4 Mutant Libraries of Microalgae -- 4.5 High Throughput Screening Approaches for Microalgae -- 4.6 Conclusion -- References -- Chapter 5 Recent Advances in Microalgal Genome Editing withSpecial Emphasis on CRISPR Mediated Modification Systems -- 5.1 Introduction -- 5.2 Microalgal Engineering -- 5.3 Applications of CRISPR in Microalgae -- 5.4 Trait Engineering by CRISPR for the Alternative Fuel and Synthetic Biology Industry -- 5.5 Bottlenecks for Applying the CRISPR System in Algae -- 5.6 Conclusion -- Acknowledgements -- References -- Chapter 6 Microalgae as a Sustainable Synthetic-biology Platform forthe Production of Recombinant Proteins: Advantages, Bottlenecks, and Case Studies -- 6.1 Introduction -- 6.2 Transformation Technologies for Protein Expression in Microalgae -- 6.3 Chloroplast Transformation in Microalgae -- 6.4 Transformation Vectors and Promoters -- 6.5 Signal Peptides for Targeting Heterologous Proteins to Intended Organelles/Extracellular Matrix -- 6.6 Production of Therapeutic Molecules from Algae -- 6.7 Technology Landscape for Recombinant Proteins from Algae -- 6.8 Concluding Remarks -- References.
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Chapter 7 Genetic Engineering of Microalgae for EnhancedPhotosynthetic Efficiency, CO2 Fixation, and Fuel-based Products -- 7.1 Introduction -- 7.2 Lipid Yielding Microalgae -- 7.3 Microalgal Genetic Engineering -- 7.3.1 Genetic Engineering for High Biomass and Lipid Production in Algae -- 7.3.2 Genetic Engineering Strategies to Enhance CO2 Sequestration -- 7.4 Modification of Light-harvesting Complexes -- 7.4.1 Extending the Range of PAR -- 7.5 Increasing Resistance Towards Oxidative Damage -- 7.6 Improving Calvin Cycle Enzymes -- 7.6.1 Improving Calvin Cycle Enzymes: RuBisCo -- 7.6.2 Improving Calvin Cycle Enzymes: RuBisCo Activase -- 7.7 Improving CCMs -- 7.8 Introduction of Alternate Carbon Fixation Pathways -- 7.8.1 Pathways for CO2 Assimilation -- 7.8.2 Reduce CO2 Escape -- 7.9 Production of Biofuel from Microalgae -- References -- Chapter 8 Genetic Engineering of Microalgae for Non-fuel, High- value Biochemicals of Industrial Significance -- 8.1 Introduction -- 8.2 Microalgal Transformation Strategies -- 8.3 Transformation Methods -- 8.3.1 SiC (Silicon Carbide) Mediated Transformation -- 8.3.2 Agitation-based Transformation Technique -- 8.3.3 Electroporation -- 8.3.4 Microparticle Bombardment (Particle Gun Delivery Method) -- 8.3.5 Agrobacterium-mediated Transformation -- 8.3.6 Bacterial Conjugation -- 8.3.7 Enzyme-mediated Transformation -- 8.3.8 Other Methods -- 8.4 Recent Advances in Microalgal Genetic Engineering -- 8.4.1 Long Chain Polyunsaturated Fatty Acids -- 8.4.2 Carotenoids -- 8.4.3 Antibiotics -- 8.4.4 Proteins -- 8.4.5 Antibody Production -- 8.4.6 Vaccines -- 8.5 Conclusion -- References -- Chapter 9 Use of Genetically Modified Algae: Consumption SafetyChallenges, Current Legislations, and Socio- economic and Environmental Concerns -- 9.1 Introduction.
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9.2 Consumption Safety Challenges and Socio-economic and Environmental Concerns -- 9.3 Current Legislations -- 9.4 Future Perspectives -- Acknowledgements -- References -- Chapter 10 Microalgal Product Basket: Portfolio Positioning AcrossFood, Feed and Fuel Segments with Industrial Growth Projections -- 10.1 Introduction -- 10.2 Microalgal Product Portfolio for the Functional Food and Nutraceuticals Sector -- 10.2.1 Antioxidants from Microalgae -- 10.2.2 Polyunsaturated Fatty Acids (PUFAs) -- 10.2.3 Microalgal Proteins and Polysaccharides -- 10.3 Microalgae Animal Feed Product Portfolio -- 10.4 Microalgae in the Cosmetics and Personal Care Sector -- 10.5 Microalgae for the Agriculture Sector -- 10.6 Microalgae for the Fuel and Industrial Products Sector -- 10.7 Challenges Associated with Microalgae Bioprocessing -- 10.8 Conclusion and Key Takeaways -- Conflict of Interest -- Acknowledgements -- References -- Subject Index.
Additional Edition:
ISBN 1-83916-562-6
Language:
English
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