Format:
1 Online-Ressource (XXI, 98 Seiten, Seite XXII-LXIV, 4617 KB)
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Illustrationen, Diagramme
Content:
Over the last decades, interest in the impact of the intestinal microbiota on host health has steadily increased. Diet is a major factor that influences the gut microbiota and thereby indirectly affects human health. For example, a high fat diet rich in saturated fatty acids led to an intestinal proliferation of the colitogenic bacterium Bilophila (B.) wadsworthia by stimulating the release of the bile acid taurocholate (TC). TC contains the sulfonated head group taurine, which undergoes conversion to sulfide (H2S) by B. wadsworthia. In a colitis prone murine animal model (IL10 / mice), the bloom of B. wadsworthia was accompanied by an exacerbation of intestinal inflammation. B. wadsworthia is able to convert taurine and also other sulfonates to H2S, indicating the potential association of sulfonate utilization and the stimulation of colitogenic bacteria. This potential link raised the question, whether dietary sulfonates or their sulfonated metabolites stimulate the growth of colitogenic bacteria such as B. wadsworthia and whether ...
Note:
Dissertation Universität Potsdam 2022
Additional Edition:
Erscheint auch als Druck-Ausgabe Rausch, Theresa Role of intestinal bacteria in the conversion of dietary sulfonates Potsdam, 2022
Language:
English
Keywords:
Hochschulschrift
DOI:
10.25932/publishup-57403
URN:
urn:nbn:de:kobv:517-opus4-574036
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