Format:
5
ISSN:
1550-7408
Content:
Pin1-type peptidyl-prolyl cis/trans isomerases (PPIases) isomerise the peptide bond of specific phosphorylated (Ser/Thr)-Pro residues, regulating various cellular events. Previously, we reported a Pin1-type PPIase in Trypanosoma cruzi, but little is known about its function and subcellular localization. Immunofluorescence analysis revealed that in contrast with Pin1-like proteins from diverse organisms, TcPin1 mainly localized in the cytoplasm and was excluded from the nuclei. In addition, RNAi-mediated downregulation of TbPin1 in Trypanosoma brucei did not abolish cell proliferation. Using yeast two-hybrid assay, we identified a MORN domain-containing protein as putative Pin1-binding partners. These data suggest that Pin1-mediated signaling mechanism plays a different role in protozoan parasites.
Note:
First published: 03 December 2012
,
Gesehen am 17.02.2021
In:
The journal of eukaryotic microbiology, Oxford [u.a.] : Wiley-Blackwell, 1954, 60(2013), 1, Seite 101-105, 1550-7408
In:
volume:60
In:
year:2013
In:
number:1
In:
pages:101-105
In:
extent:5
Language:
English
URL:
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