Format:
1 Online-Ressource (xii, 117 Seiten, 7302 KB)
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Content:
Deoxyribonucleic acid (DNA) is the carrier of human genetic information and is exposed to environmental influences such as the ultraviolet (UV) fraction of sunlight every day. The photostability of the DNA against UV light is astonishing. Even if the DNA bases have a strong absorption maximum at around 260 nm/4.77 eV, their quantum yield of photoproducts remains very low 1. If the photon energies exceed the ionization energy (IE) of the nucleobases ( ̴ 8-9 eV) 2, the DNA can be severely damaged. Photoexcitation and -ionization reactions occur, which can induce strand breaks in the DNA. The efficiency of the excitation and ionization induced strand breaks in the target DNA sequences are represented by cross sections. If Si as a substrate material is used in the VUV irradiation experiments, secondary electrons with an energy below 3.6 eV are generated from the substrate. This low energy electrons (LEE) are known to induce dissociative electron attachment (DEA) in DNA and with it DNA strand breakage very efficiently. LEEs play an ...
Note:
Dissertation Universität Potsdam 2018
Additional Edition:
Erscheint auch als Druck-Ausgabe Vogel, Stefanie Sequence dependency of photon- and electron induced DNA strand breaks Potsdam, 2018
Language:
English
Keywords:
Hochschulschrift
URN:
urn:nbn:de:kobv:517-opus4-419669
URL:
https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-419669
URL:
https://d-nb.info/121945799X/34
Author information:
Bald, Ilko 1980-
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