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  • 1
    Language: German
    In: Forensische Psychiatrie, Psychologie, Kriminologie, 2010, Vol.4(1), pp.23-31
    Description: Kann ein Verurteilter, der seine Tat weiterhin leugnet, vorzeitig aus der Haft entlassen werden? Diese Frage haben sich Strafvollstreckungskammern immer wieder zu stellen, denn die Möglichkeit der Aussetzung einer Reststrafe zur Bewährung ist für jeden Strafgefangenen zu prüfen, aber nicht jeder gibt zu, die im Urteil festgestellte Tat begangen zu haben. Im nachfolgenden Beitrag soll am Beispiel einer Entscheidung über die Aussetzung der zeitigen Freiheitsstrafe gemäß § 57 Abs. 1 StGB dargestellt werden, welche Bedeutung dem Leugnen bei der richterlichen Entscheidungsfindung beizumessen ist. Dabei geht es nicht allein um bestimmte Schlüsse, die sich aus der Tatsache des Leugnens für die Prognose ziehen oder auch nicht ziehen lassen. Hiermit haben sich die Vollstreckungsgerichte – häufig unter Hinzuziehung eines Sachverständigen – zwar eingehend auseinanderzusetzen. Ihre rechtliche Prüfung geht allerdings darüber hinaus. Bevor mit der eigentlichen Würdigung des Leugnens begonnen werden kann, muss der juristische Rahmen feststehen, in dem dieser Arbeitsschritt zu erfolgen hat. Deshalb wird auch darauf eingegangen, ob das Gesetz Vorgaben für den Umgang mit dem Leugnen enthält und welche Bedeutung dem Grundsatz der Selbstbelastungsfreiheit bei der vollstreckungsrechtlichen Prüfung zukommt. The article is about the question whether or not a convicted person can be released on probation even though they are denying their offence. According to German Criminal Law, release on probation must be considered (by a special chamber of the court, “Chamber of Execution”; same question for any kind of Parole Board in other countries) in every case as soon as two thirds of the sentence are served, regardless the convicted person does or does not confess their offence. Using a case example, the article will show as to how the convict’s denial becomes a meaningful fact in the decision-making process. Besides referring to certain conclusions about criminal prognosis following from denying – which of course is a main issue with the decision about release, often valued by the help of expert testimony –, the focus will be set on the judicial framework around this question: Does the give provisions on how to deal with denial, and how does the principle “nemo tenetur” (nobody has to charge themselves, harm their defence, nor give evidence against themselves) impact the considerations?
    Keywords: Release on probation ; Criminal prognosis ; Denying the offence ; Nemo tenetur
    ISSN: 1862-7072
    E-ISSN: 1862-7080
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  • 2
    In: Nature Medicine, 2010, Vol.16(2), p.155
    Keywords: Cellular Proteins -- Physiological Aspects ; Cyclophilin -- Physiological Aspects ; Gene Expression -- Physiological Aspects ; Hiv -- Research;
    ISSN: 1078-8956
    E-ISSN: 1546170X
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  • 3
    Language: English
    In: International Journal of Cardiology, 15 June 2015, Vol.189, pp.124-131
    Description: We examined interventionally implanted valved Melody conduits after surgical explantation by means of histology and immunohistochemistry and matched these findings with clinical data in order to assess in vivo biocompatibility and to identify risk factors for graft failure. 9 Melody valves had been implanted in 8 patients (pulmonary n = 7, tricuspid position n = 1). Indication for explantation included significant obstruction in 7 patients and valve insufficiency in 1 patient. 4 of 8 patients had suffered from endocarditis. Mean interval between implantation and explantation was 3.2 (1.8–5.2) years. All explants were worked up using a uniform protocol with fixation in formalin and embedding in methylmethacrylate. All but one valve of the explanted Melody grafts were thin and histologically intact without any pathological findings. Complete neo-endothelialization could be demonstrated by means of immunohistochemistry. All 4 Melody valves from patients with endocarditis showed dense granulocytic infiltrations, 3 of these showed thrombotic material within the valves. This report covers the first series of explanted Melody valves from humans applying a uniform protocol for histopathological examination. Good biocompatibility of the Melody valves could be demonstrated after a mid-term follow-up. Factors for graft failure included endocarditis, outgrowth, and residual stenosis. These findings may have significant implications for the implant procedure as well as care of the patients during long-term follow-up.
    Keywords: Catheterization ; Congenital Heart Defects ; Histopathology ; Implantable Heart Valves ; Medicine
    ISSN: 0167-5273
    E-ISSN: 1874-1754
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  • 4
    Language: English
    In: Quaternary International, 16 November 2012, Vol.279-280, pp.437-437
    Keywords: Geology
    ISSN: 1040-6182
    E-ISSN: 1873-4553
    Source: ScienceDirect Journals (Elsevier)
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  • 5
    Language: English
    In: Quaternary International, 16 November 2012, Vol.279-280, pp.436-437
    Keywords: Geology
    ISSN: 1040-6182
    E-ISSN: 1873-4553
    Source: ScienceDirect Journals (Elsevier)
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  • 6
    Language: English
    In: The Journal of cell biology, 22 August 2011, Vol.194(4), pp.581-96
    Description: Cytokines and stress-inducing stimuli signal through c-Jun N-terminal kinase (JNK) using a diverse and only partially defined set of downstream effectors. In this paper, the decapping complex subunit DCP1a was identified as a novel JNK target. JNK phosphorylated DCP1a at residue S315 in vivo and in vitro and coimmunoprecipitated and colocalized with DCP1a in processing bodies (P bodies). Sustained JNK activation by several different inducers led to DCP1a dispersion from P bodies, whereas IL-1 treatment transiently increased P body number. Inhibition of TAK1-JNK signaling also affected the number and size of P bodies and the localization of DCP1a, Xrn1, and Edc4. Transcriptome analysis further identified a central role for DCP1a in IL-1-induced messenger ribonucleic acid (mRNA) expression. Phosphomimetic mutation of S315 stabilized IL-8 but not IκBα mRNA, whereas overexpressed DCP1a blocked IL-8 transcription and suppressed p65 NF-κB nuclear activity. Collectively, these data reveal DCP1a as a multifunctional regulator of mRNA expression and suggest a novel mechanism controlling the subcellular localization of DCP1a in response to stress or inflammatory stimuli.
    Keywords: Cytoplasmic Granules -- Enzymology ; Endoribonucleases -- Metabolism ; Jnk Mitogen-Activated Protein Kinases -- Metabolism ; Trans-Activators -- Metabolism
    ISSN: 00219525
    E-ISSN: 1540-8140
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  • 7
    Article
    Article
    Language: German
    In: JOT Journal für Oberflächentechnik, 10/2017, Vol.57(10), pp.98-99
    ISSN: 0940-8789
    E-ISSN: 2192-869X
    Source: Springer (via CrossRef)
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  • 8
    Language: English
    In: Journal of Infectious Diseases, Oct 1, 2015, Vol.212(7), p.S247(11)
    Keywords: Ebola Virus -- Research ; Macrophages -- Research ; Antiviral Agents -- Dosage And Administration
    ISSN: 0022-1899
    Source: Cengage Learning, Inc.
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  • 9
    Language: English
    In: Quaternary International, 02 July 2016, Vol.407, pp.47-63
    Description: Along the Algarve coast, multi-proxy investigations of four estuaries detail the Holocene landscape evolution through high-resolution pollen and sediment analyses. This approach focuses on palynological results and enables the reconstruction of differentiated human impact around the studied archives between the Neolithic and modern times. During the Chalcolithic and Phoenician periods anthropogenic land use increases clearly and triggers erosional processes in the catchment. The increased agricultural area and the change in land use methods since the beginning of the second Islamic epoch form the actual landscape. According to the palynological results, since 8200 cal BP highly variable climatic conditions in terms of moisture availability have occurred during the entire Holocene. Arid periods occurred during the early Holocene prior to 8000 cal BP, around 7000 cal BP and between 6400 and 6200 cal BP. During the mid Holocene, two further dry periods with very different duration could be identified between 5000 and 3300 cal BP and between 2800 and 2500 cal BP. Finally, during the late Holocene between 1300 and 1050 cal BP and between 700 and 500 cal BP, further arid periods appeared. In conclusion, climatic and anthropogenic influences caused erosion in the catchments and in this way silting up of the estuaries along the Portuguese Algarve coast.
    Keywords: Pollen ; Vegetation History ; Human Impact ; Climate ; Portugal ; Geology
    ISSN: 1040-6182
    E-ISSN: 1873-4553
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  • 10
    Language: English
    In: Fertility and Sterility, May 2014, Vol.101(5), pp.1477-1484.e3
    Description: To assess the capacity of human frozen-thawed ovarian follicles matured in xenografts to form metaphase II (MII) oocytes after xenotransplantation and exogenous stimulation. Prospective controlled animal study. University hospital gynecology research unit. Ovarian fragments were obtained from 17 women with malignant diseases who wished to cryopreserve ovarian tissue for later pregnancy before chemotherapy. Eighty-eight female severe combined immunodeficient (SCID) mice. Cryopreserved human ovarian tissue was grafted into oophorectomized SCID mice. The mice were divided into three groups: Group A received hMG alone every 2 days for a maximum of 24 weeks; group B additionally received nRH agonist (GnRHa) every 4 weeks; and group C was an untreated control group. Follicular density, morphology, proliferation, oocyte maturation, malignant cell contamination. Follicle survival and development were similar in all three groups. No significant interactions between the stimulation protocols and grafting duration were noted. Three MII oocytes were observed in grafted follicles. Two MII oocytes were harvested without stimulation. None of the mice showed signs of reintroduced malignancy, nor did microscopic evaluation of the grafts raise any suspicion of residual malignant disease. After xenotransplantation, human primordial follicles can be matured to MII oocytes even without stimulation. Administering human gonadotropin and GnRHa does not enhance the developmental capacity of xenografted oocytes. The optimal stimulation schedule for grafted tissue remains unknown.
    Keywords: Ovarian Tissue Cryopreservation ; Xenotransplantation ; Metaphase II Oocyte ; Gonadotropin Stimulation ; Malignant Cell Contamination ; Medicine
    ISSN: 0015-0282
    E-ISSN: 1556-5653
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