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  • 1
    Book
    Book
    Crossroads between innate and adaptive immunity II (2009)
    New York, NY : Springer-Verlag
    Details
    UID:
    kobvindex_ZLB14990599
    Format: XIII, 132 Seiten , Ill., graph. Darst. , 235 mm x 155 mm
    Edition: 1. ed.
    ISBN: 9780387793108 , 0387793100
    Series Statement: Advances in experimental medicine and biology 633
    Note: Tetx engl.
    Language: English
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  • 2
    Online Resource
    Online Resource
    Memory T Cells (2010)
    New York, NY : Landes Bioscience and Springer Science+Business Media, LLC
    Details
    UID:
    gbv_644978546
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
    ISBN: 9781441964519
    Series Statement: Advances in Experimental Medicine and Biology 684
    Content: Immunological memory has fascinated microbiologists and immunologists for decades as one of the new frontiers to conquer to better understand the response to pathogens, cancer and vaccination. Over the past decade, attention has turned to the intrinsic properties of the memory T cells themselves, as it has become clear that the eradication of both infected cells and tumors requires T cells. This book is an attempt to capture the wave of discoveries associated with these recent studies. Its chapters represent a wide collection of topics related to memory T cells by laboratories that have invested their skills and knowledge to understand the biology and the principles upon which memory T cells are generated, maintained and expanded upon re-encounter with antigen. Ultimately, these studies are all aimed at a better understanding of the function of memory T cells in protection against disease.
    Note: Includes bibliographical references and index , Title page; Copyright page; DEDICATION; PREFACE; ABOUT THE EDITORS; PARTICIPANTS; Table of Contents; ACKNOWLEDGEMENTS; Chapter 1 MEMORY TH1/TH2 CELL GENERATION CONTROLLED BY SCHNURRI-2; Chapter 2 TRANSCRIPTIONAL REGULATION DURING CD8 T-CELL IMMUNE RESPONSES; Chapter 3 THE ROLE OF INTERLEUKIN-2 IN MEMORY CD8 CELL DIFFERENTIATION; Chapter 4 THE ROLE OF INFLAMMATION IN THE GENERATION AND MAINTENANCE OF MEMORY T CELLS; Chater 5 THE ROLE OF OX40 (CD134) IN T-CELL MEMORY GENERATION; Chapter 6 THE ROLE OF PRECURSOR FREQUENCY IN THE DIFFERENTIATION OF MEMORY T CELLS: MEMORY BY NUMBERS , Chapter 7 CD8 T-CELL MEMORY DIFFERENTIATION DURING ACUTE AND CHRONIC VIRAL INFECTIONSChapter 8 LONGEVITY OF T-CELL MEMORY FOLLOWING ACUTE VIRAL INFECTION; Chapter 9 PRINCIPLES OF MEMORY CD8 T-CELLS GENERATION IN RELATION TO PROTECTIVE IMMUNITY; Chapter 10 Contents 10. MEMORY T CELLS IN RHESUS MACAQUES; Chapter 11 MEMORY T-CELL SUBSETS IN PARASITIC INFECTIONS; Chapter 12 ANTIGEN SPECIFIC MEMORY T CELLS AND THEIR PUTATIVE NEED FOR THE GENERATION OF SUSTAINED ANTI-TUMOR RESPONSES; Chapter 13 MEMORY T-CELL RESPONSES AND SURVIVAL IN HUMAN CANCER: REMEMBER TO STAY ALIVE , Chapter 14 ANALYSIS OF VACCINE-INDUCED T CELLS IN HUMANS WITH CANCERChapter 15 MEMORY T-CELL HOMEOSTASIS AND SENESCENCE DURING AGING; INDEX; , Memory Th1/Th2 cell generation controlled by Schnurri-2 / Toshinori Nakayama and Motoko Y. Kimura -- Transcriptional regulation during CD8 T-cell immune responses / Ivana Munitic ... [et al.] -- The role of interleukin-2 in memory CD8 cell differentiation / Onur Boyman, Jae-Ho Cho and Jonathan Sprent -- The role of inflammation in the generation and maintenance of memory T cells / Noah S. Butler and John T. Harty -- The role of OX40 (CD134) in T-cell memory generation / Andrew D. Weinberg -- The role of precursor frequency in the differentiation of memory T cells: memory by numbers / Amanda L. Marzo, Ryan T. Sowell and Bernadette Scott -- CD8 T-cell memory differentiation during acute and chronic viral infections / Vandana Kalia, Surojit Sarkar and Rafi Ahmed -- Longevity of T-cell memory following acute viral infection / Joshua M. Walker and Mark K. Slifka -- Principles of memory CD8 T-cells generation in relation to protective immunity / Maurizio Zanetti, Paola Castiglioni and Elizabeth Ingulli , Memory T cells in rhesus macaques / Monica Vaccari and Genoveffa Franchini -- Memory T-cell subsets in parasitic infections / Sara Colpitts and Phillip Scott -- Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responses / Kory L. Alderson and William J. Murphy -- Memory T-cell responses and survival in human cancer: remember to stay alive / Matthieu Camus and Jerome Galon -- Analysis of vaccine-induced T cells in humans with cancer / Stefanie L. Slezak ... [et al.] -- Memory T-cell homeostasis and senescence during aging / Sian M. Henson and Arne N. Akbar. , Electronic reproduction; Available via World Wide Web
    Additional Edition: ISBN 9781441964502
    Language: English
    DOI: 10.1007/978-1-4419-6451-9
    URL: Volltext  (lizenzpflichtig)
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  • 3
    Online Resource
    Online Resource
    Crossroads between Innate and Adaptive Immunity III (2012)
    New York, NY : Springer Science+Business Media, LLC
    Details
    UID:
    gbv_668045108
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. 2012 Springer-11642
    Edition: Springer eBook Collection. Biomedical and Life Sciences
    ISBN: 9781441956323
    Series Statement: Advances in Experimental Medicine and Biology 780
    Additional Edition: ISBN 9781441956316
    Language: English
    DOI: 10.1007/978-1-4419-5632-3
    URL: Volltext  (lizenzpflichtig)
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  • 4
    Online Resource
    Online Resource
    Crossroads between Innate and Adaptive Immunity II (2009)
    New York, NY : Springer-Verlag New York
    Details
    UID:
    gbv_1648443788
    Format: Online-Ressource (digital)
    ISBN: 9780387793115 , 9780387793108
    Series Statement: Advances in Experimental Medicine and Biology 633
    Content: Aegean Conferences is an independent, nonprofit, educational organization directed and managed by the scientific community. The board is made up of nine researchers/scientists in various disciplines from Harvard, Brown, University of Pennsylvania, UCSD, Princeton, Biovista and the Foundation for Biomedical Research Academy of Athens. The board both invites and approves unsolicited proposals for Conferences in all fields of Science, Engineering, Arts, and Humanities. The purpose of the Conferences is to bring together individuals with common interests to examine the emerging and most advanced aspects of their particular field. This volume will include mini-reviews derived from work to be presented at the Aegean Conference: Second Crossroads between Innate and Adaptive Immunity, in Crete, Greece, June 17-22, 2007. This meeting is designed to serve as a forum to discuss the most recent progress in complement research as it pertains to human disease pathogenesis and therapeutics. The rapid pace of development in complement basic research and the advent and application of new experimental approaches in this field have now allowed us to take an integrated view of the in vivo biology of the complement system. The availability of new reagents (e.g. synthetic and recombinant inhibitors) and animal models (e.g. transgenic and knockout mice) has enabled us to address, in an in vivo setting, its involvement in various pathophysiological conditions. Such studies are shedding new light on the pathogenetic mechanism of complement-related diseases such as autoimmune diseases and inflammatory tissue damage as well as defining new areas of high interest such as the developmental biology of complement. They also provide the basis for developing new therapeutic strategies for these diseases through manipulation of in vivo complement activity. This volume will serve as a resource where the latest development in these specific areas will be discussed in a more focused and detailed manner.
    Note: "Contains minireviews derived from work presented at the Aegena Conference: "Second Crossroads between Innate and Adaptive Immunity," which took place ... Rhodes, Greece , Includes bibliographical references and index , Schoenberger_FM.pdf; Schoenberger_Ch01.pdf; Schoenberger_Ch02.pdf; Schoenberger_Ch03.pdf; Schoenberger_Ch04.pdf; Schoenberger_Ch05.pdf; Schoenberger_Ch06.pdf; Schoenberger_Ch07.pdf; Schoenberger_Ch08.pdf; Schoenberger_Ch09.pdf; Schoenberger_Ch10.pdf; Schoenberger_Index.pdf
    Additional Edition: ISBN 9780387793108
    Additional Edition: Buchausg. u.d.T. ISBN 978-0-387-79310-8
    Language: English
    DOI: 10.1007/978-0-387-79311-5
    URL: Volltext
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 5
    Online Resource
    Online Resource
    Crossroads between Innate and Adaptive Immunity (2007)
    Boston, MA : Springer Science+Business Media, LLC
    Details
    UID:
    gbv_1647110823
    Format: Online-Ressource (XX, 232 p. 39 illus, digital)
    ISBN: 9780387348148
    Series Statement: Advances in Experimental Medicine and Biology 590
    Content: "This compilation presents mini-reviews derived from work presented at the Aegean Conference: ""First Crossroads between Innate and Adaptive Immunity,"" which occurred in October, 2005 at the Hilton Conference Center on the island of Rhodes, Greece. The conference included sessions dedicated to host recognition of and response to pathogens, innate immune networks, antigen presentation, and adaptive immune responses, each headlined by a leading scientist."
    Content: Presents minireviews derived from work presented at the Aegean Conference: "First Crossroads between Innate and Adaptive Immunity," which occurred October 9-14, 2005 at the Hilton Conference Center on the island of Rhodes, Greece
    Note: "Proceedings of the First Crossroads between Innate and Adaptive Immunity Conference, held in Rhodes, Greece, October 9-14, 2005."--T.p. verso , Includes bibliographical references and index , Front Matter; Signal Transduction in DC Differentiation: Winged Messengers and Achilles' Heel; Shaping Naive and Memory Cd8+ T Cell Responses in Pathogen Infections Through Antigen Presentation; Understanding the Role of Innate Immunity in the Mechanism of Action of the Live Attenuated Yellow Fever Vaccine 17D; The Function of Local Lymphoid Tissues in Pulmonary Immune Responses; The Yin and Yang of Adaptive Immunity in Allogeneic Hematopoietic Cell Transplantation: Donor Antigen-Presenting Cells Can Either Augment or Inhibit Donor T Cell Alloreactivity , It's Only Innate Immunity But I Like itInnate Tumor Immune Surveillance; Regulation of Adaptive Immunity by Cells of the Innate Immune System: Bone Marrow Natural Killer Cells Inhibit T Cell Proliferation; Induction and Maintenance of Cd8+ T Cells Specific for Persistent Viruses; Germinal Center-Derived B Cell Memory; CD28 and Cd27 Costimulation of Cd8+ T Cells: A Story of Survival; CD38: An Ecto-Enzyme at the Crossroads of Innate and Adaptive Immune Responses; Vascular Leukocytes: a Population with Angiogenic and Immunossuppressive Properties Highly Represented in Ovarian Cancer , CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer CellsReceptors and Pathways in Innate Antifungal Immunity; Back Matter
    Additional Edition: ISBN 9780387348131
    Additional Edition: Buchausg. u.d.T. Crossroads between innate and adaptive immunity New York : Springer Science+Business Media, 2007 ISBN 0387348131
    Additional Edition: ISBN 9780387348131
    Language: English
    Subjects: Medicine
    RVK:
    XD 3005
    Keywords: Angeborene Immunität ; T-Lymphozyt ; Immunreaktion ; Angeborene Immunität ; T-Lymphozyt ; Immunreaktion ; Konferenzschrift
    DOI: 10.1007/978-0-387-34814-8
    URL: Volltext
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 6
    Online Resource
    Online Resource
    Crossroads Between Innate and Adaptive Immunity IV (2013)
    New York, NY : Springer
    Details
    UID:
    gbv_1652148981
    Format: Online-Ressource (XII, 136 p. 15 illus., 3 illus. in color, digital)
    ISBN: 9781461462170
    Series Statement: Advances in Experimental Medicine and Biology 785
    Content: This volume presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity. The importance of the crosstalk between innate immunity and the adaptive immune response has only recently started to be appreciated. Although it is well recognized that dendritic cells, NK cells, NK-T cells and T cells are all critical for the host response to pathogens, the respective fields that study the biology of these immune cells tend to exist in parallel worlds with minimum exchange of information and ideas. This fragmentation hinders the integration of these fields towards a unified theory of host response. The Aegean Conference “Crossroads between Innate and Adaptive Immunity” brought together leading international scientists and experts to address critical areas of Innate and Adaptive immunity something necessary for the development of more efficient scientific exchange and crosspollination between these fields. This conference attracted scientists from all over the world to discuss their latest findings on the various aspects of Innate and Adaptive immunity. The conference had limited participation and a scientific and social program that maximized scientific interchange through lecture presentations, poster sessions and informal discussions.
    Note: Description based upon print version of record , Crossroads Between Innate and Adaptive Immunity IV; Preface; Acknowledgements; Contents; Contributors; 1: Vita-PAMPs: Signatures of Microbial Viability; 1.1 Introduction; 1.2 Live Versus Dead Pathogens: Role of Virulence Factors; 1.3 Microbial Viability Detection: Growth and Metabolism; 1.4 Detection of Microbial Viability Independently of Microbial Growth; 1.5 Features of Bacterial mRNAs; 1.6 Bacterial mRNA and Innate Immunity; 1.7 Vita-PAMPs and Adaptive Immunity; 1.8 PRRs That Orchestrate the Response to Bacterial Viability; 1.9 Conclusions; References , 2: Innate Lymphoid Cells in Immunity and Disease2.1 Introduction; 2.2 Phenotype of ILCs; 2.2.1 NK Cell Phenotype; 2.2.2 Ror g t-Dependent ILC Phenotype; 2.2.3 Type 2 ILC Phenotype; 2.3 Development of ILCs; 2.3.1 Inhibitor of DNA Binding 2 (Id2): An Early Common "Switch" for ILCs; 2.3.2 NK Cells Development; 2.3.3 Ror g t-Dependent ILCs Development; 2.3.4 Type 2 ILCs Development; 2.4 ILC Roles in the Host Organism; 2.4.1 NK Cells: Cytolytic Activity and Cytokine Production; 2.4.2 LTi Cells and Organogenesis of Lymphoid Structures , 2.4.3 Ror g t-Dependent ILCs: IL-17 and IL-22 Producers for Intestinal Homeostasis2.4.4 Type 2 ILCs: Protective Response Against Helminths; 2.4.5 Wound Healing; 2.4.6 Dysregulation of ILCs: Autoimmunity, Allergy, and Fibrosis; 2.5 Conclusion; References; 3: Tuning Cross-Presentation of Apoptotic T Cells in Immunopathology; 3.1 Introduction; 3.2 CD40 Ligand Expression on Apoptotic T Cells Abrogates Tolerance; 3.3 Apoptotic T Cells Are Source of Immunogenic Self-Antigens; 3.4 Relevance of Cross-Presentation of Apoptotic Epitopes in Clinical Setting; 3.5 Conclusion; References , 4: Regulation of Type 2 Immunity by Basophils4.1 Basophil Development and Homeostasis; 4.2 The Role of Basophils for Differentiation of Th2 Cells; 4.3 Basophils as Mediators of Allergic Responses; 4.4 Protective Immunity Against Ticks and Helminths; 4.5 Conclusion; References; 5: Crosstalk Between Adaptive and Innate Immune Cells Leads to High Quality Immune Protection at the Mucosal Borders; 5.1 Introduction; 5.2 Effector and Central Memory T Cells Form Distinct Subsets; 5.3 An Innate-Adaptive Crosstalk Drives the Selective Accumulation of Mucosal T EM , 5.3.1 Activation-Induced CD8 a a Rescues CD8 ab Primary Effector T Cells from AICD5.3.2 Activation-Induced CD8 a a Rescues CD8 a b Primary Effector T Cells from TICD; 5.3.3 Activation-Induced CD8 a a Rescues CD8 a b Secondary Effector T Cells from TICD; 5.4 Conclusion; 5.5 Future Prospective; References; 6: The Interaction Between Filarial Parasites and Human Monocyte/Macrophage Populations; 6.1 Background; 6.1.1 Lymphatic Filariasis; 6.1.2 Macrophages and Their Role in Inflammation; 6.2 Induction of AAM F s in Filarial Infections; 6.2.1 Animal Models; 6.2.2 Humans , 6.3 Implications in Clinical Settings , ​Is Transcription the Dominant Force during Dynamic Changes in Gene Expression? -- MicroRNAs: Key Components of Immune Regulation -- KIR/HLA: Genetic Clues for a Role of NK cells in the Control of HIV -- Natural Killer cell Licensing during Viral Infection -- Bridging Innate NK cell Functions with Adaptive Immunity -- Control of Innate Immunity by Memory CD4 T cells -- Strategies and Implications for Prime-Boost Vaccinations to Generate Memory CD8 T Cells -- Blimp1: Driving Terminal Differentiation to a T -- A new Role for Myeloid HO-1 in the Innate to Adaptive Crosstalk and Immune Homeostasis -- Impact of Differential Glycosylation on IgG Activity -- Murine Model of Chronic Respiratory Inflammation -- Incorporation of Innate Immune Effector Mechanisms in the Formulation of a Vaccine Against HIV-1 -- Influenza Vaccines: What do we Want and How can we Get it?.​.
    Additional Edition: ISBN 9781461462163
    Additional Edition: Buchausg. u.d.T. ISBN 978-1-461-46216-3
    Language: English
    Subjects: Biology
    RVK:
    WF 9820
    DOI: 10.1007/978-1-4614-6217-0
    URL: Volltext
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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