UID:
edoccha_9961427410802883
Format:
1 videorecording (51 min., 42 sec.)
,
005142
Content:
Audio-visual presentation : What is 'evolutionary genetics'? ; Evolution, genetic variation and association analyses ; Withinspecies diversity and population genetics ; Human genetic diversity and phenotypic variation ; Human community 'metagenomics'.
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/129/.
,
Introduction -- What is 'evolutionary genetic epidemiology'? -- Goals of evolutionary genetic epidemiology -- Evolutionary-mediated human disease phenotypes -- Genetic dissection of complex traits -- How are genetic association studies pursued? (1) -- How are genetic association studies pursued? (2) -- Whole genome association (WGA) studies -- Recent large-scale WGA initiatives in the US -- Combining evolution with association studies -- Polymorphism: the 'wheat' and the 'chaffe' -- Population stratification and false positive results -- Genetic heterogeneity and false negative results -- Evolutionary conservation and putative functionality -- Genetic variation in CHGA gene -- DNA sequence vs. structural conservation -- Human genetic background heterogeneity -- Genotypic/phenotypic differentiation maintenance -- Shifting balance of evolution theory -- Classical 'supervised' studies -- Contemporary 'unsupervised' studies -- Use of tree diagrams to represent genetic diversity -- Diseases differ in frequency across populations -- Lactase phenotype and population differentiation -- ASPM gene and population differentiation -- Overcoming stratification/heterogeneity problem -- Sorting out genetic backgrounds of individuals -- Race, genetic background, and drug prescriptions -- Race and analysis of genetic variation -- Ancestry informative markers (AIMs) -- Example admixture studies using AIMs -- Global map of skin pigmentation levels -- Melanin content and individual ancestry -- The "evolution" of human communities -- Genetic demography variation in local community -- Community metagenomic analysis -- Conclusions -- The Schork laboratory: 2006-2008.
Language:
English
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